Rps6ka3 (ribosomal protein S6 kinase A3) - Rat Genome Database

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Gene: Rps6ka3 (ribosomal protein S6 kinase A3) Rattus norvegicus
Analyze
Symbol: Rps6ka3
Name: ribosomal protein S6 kinase A3
RGD ID: 1563860
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein kinase binding activity; and ribosomal protein S6 kinase activity. Predicted to be involved in several processes, including negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to lipopolysaccharide; and toll-like receptor signaling pathway. Predicted to be located in cytosol and nucleolus. Predicted to be active in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3); PARTICIPATES IN platelet-derived growth factor signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; long term potentiation; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC501560; RGD1563860; ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase polypeptide 3; similar to ribosomal protein S6 kinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X35,517,306 - 35,623,296 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX35,517,306 - 35,623,207 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX36,654,891 - 36,760,704 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X40,118,536 - 40,224,348 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X35,284,577 - 35,390,389 (-)NCBIRnor_WKY
Rnor_6.0X37,469,736 - 37,576,055 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX37,469,937 - 37,575,624 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X37,777,188 - 37,880,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X56,722,878 - 56,825,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX36,172,781 - 36,274,458 (-)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
diarsenic trioxide  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
genistein  (ISO)
glycitein  (ISO)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lycopene  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
nickel atom  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenytoin  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulfates  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP,ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (ISO)
nucleolus  (ISO)
nucleoplasm  (IBA,ISO)
ribosome  (IEA)

References

References - curated
# Reference Title Reference Citation
1. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation. Merienne K, etal., Nat Genet. 1999 May;22(1):13-4.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. Trivier E, etal., Nature. 1996 Dec 12;384(6609):567-70.
Additional References at PubMed
PMID:12016217   PMID:15632090   PMID:17906627   PMID:18402937   PMID:22065586  


Genomics

Comparative Map Data
Rps6ka3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X35,517,306 - 35,623,296 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX35,517,306 - 35,623,207 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX36,654,891 - 36,760,704 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X40,118,536 - 40,224,348 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X35,284,577 - 35,390,389 (-)NCBIRnor_WKY
Rnor_6.0X37,469,736 - 37,576,055 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX37,469,937 - 37,575,624 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X37,777,188 - 37,880,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X56,722,878 - 56,825,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX36,172,781 - 36,274,458 (-)NCBICelera
Cytogenetic MapXq14NCBI
RPS6KA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X20,149,911 - 20,267,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX20,149,911 - 20,267,519 (-)EnsemblGRCh38hg38GRCh38
GRCh37X20,168,029 - 20,285,027 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X20,077,950 - 20,194,671 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X19,927,686 - 20,044,407NCBI
CeleraX24,292,410 - 24,377,495 (-)NCBICelera
Cytogenetic MapXp22.12NCBI
HuRefX17,910,375 - 17,994,979 (-)NCBIHuRef
CHM1_1X20,198,431 - 20,315,161 (-)NCBICHM1_1
T2T-CHM13v2.0X19,732,804 - 19,849,991 (-)NCBIT2T-CHM13v2.0
Rps6ka3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X158,038,652 - 158,151,240 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX157,993,303 - 158,151,240 (+)EnsemblGRCm39 Ensembl
GRCm38X159,255,665 - 159,368,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX159,210,307 - 159,368,244 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X155,694,052 - 155,801,417 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X154,600,225 - 154,707,590 (+)NCBIMGSCv36mm8
CeleraX142,502,588 - 142,610,345 (+)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX73.27NCBI
Rps6ka3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955509600,284 - 701,837 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955509600,415 - 701,833 (-)NCBIChiLan1.0ChiLan1.0
RPS6KA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X21,953,743 - 22,074,469 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X12,772,368 - 12,893,062 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X20,131,474 - 20,251,244 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX20,133,898 - 20,251,244 (-)Ensemblpanpan1.1panPan2
RPS6KA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X15,991,623 - 16,079,689 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX15,998,172 - 16,074,749 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X16,014,242 - 16,126,834 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX16,018,291 - 16,223,711 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X16,063,855 - 16,176,430 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X16,071,626 - 16,184,200 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X16,133,724 - 16,246,281 (-)NCBIUU_Cfam_GSD_1.0
Rps6ka3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X9,152,237 - 9,260,014 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366243,897,791 - 4,000,558 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366243,897,878 - 4,005,664 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6KA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX16,452,405 - 16,576,859 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X16,452,401 - 16,576,854 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X17,719,536 - 17,833,531 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6KA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X18,614,664 - 18,730,591 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX18,620,159 - 18,730,581 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605620,472,991 - 20,589,270 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rps6ka3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248294,983,282 - 5,087,485 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248294,978,181 - 5,087,493 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rps6ka3
239 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:122
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000008938
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat

Markers in Region
RH144512  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X35,574,449 - 35,574,584 (-)MAPPERmRatBN7.2
Rnor_6.0X37,518,533 - 37,518,667NCBIRnor6.0
Rnor_5.0X37,823,441 - 37,823,575UniSTSRnor5.0
RGSC_v3.4X56,776,439 - 56,776,573UniSTSRGSC3.4
CeleraX36,225,755 - 36,225,889UniSTS
RH 3.4 MapX520.0UniSTS
Cytogenetic MapXq21UniSTS
A010B08  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X35,548,043 - 35,548,309 (-)MAPPERmRatBN7.2
Rnor_6.0X37,544,779 - 37,545,044NCBIRnor6.0
Rnor_5.0X37,849,687 - 37,849,952UniSTSRnor5.0
RGSC_v3.4X56,749,904 - 56,750,169UniSTSRGSC3.4
CeleraX36,199,413 - 36,199,678UniSTS
Cytogenetic MapXq21UniSTS
RH142521  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X35,615,816 - 35,615,951 (-)MAPPERmRatBN7.2
Rnor_6.0X37,476,825 - 37,476,959NCBIRnor6.0
Rnor_5.0X37,783,256 - 37,783,390UniSTSRnor5.0
RGSC_v3.4X56,817,524 - 56,817,658UniSTSRGSC3.4
CeleraX36,267,020 - 36,267,154UniSTS
RH 3.4 MapX520.41UniSTS
Cytogenetic MapXq21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 32 16 19 16 8 10 74 35 34 11 8
Low 3 25 25 25 1 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001192004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000008938   ⟹   ENSRNOP00000008938
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX35,517,306 - 35,623,068 (-)Ensembl
Rnor_6.0 EnsemblX37,469,937 - 37,575,624 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094638   ⟹   ENSRNOP00000079976
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX35,517,306 - 35,578,194 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105976   ⟹   ENSRNOP00000088908
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX35,517,306 - 35,569,965 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109787   ⟹   ENSRNOP00000083965
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX35,517,306 - 35,623,068 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110641   ⟹   ENSRNOP00000096596
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX35,517,306 - 35,623,207 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113332   ⟹   ENSRNOP00000097889
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX35,517,306 - 35,623,207 (-)Ensembl
RefSeq Acc Id: NM_001192004   ⟹   NP_001178933
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X35,517,306 - 35,623,070 (-)NCBI
Rnor_6.0X37,469,736 - 37,571,933 (+)NCBI
Rnor_5.0X37,777,188 - 37,880,963 (+)NCBI
CeleraX36,172,781 - 36,274,458 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256923   ⟹   XP_006256985
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X35,517,306 - 35,577,800 (-)NCBI
Rnor_6.0X37,515,007 - 37,576,055 (+)NCBI
Rnor_5.0X37,777,188 - 37,880,963 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773192   ⟹   XP_008771414
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X35,517,306 - 35,600,553 (-)NCBI
Rnor_6.0X37,484,797 - 37,576,055 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602129   ⟹   XP_017457618
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X35,517,306 - 35,623,296 (-)NCBI
Rnor_6.0X37,469,951 - 37,576,055 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602130   ⟹   XP_017457619
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X35,517,306 - 35,623,295 (-)NCBI
Rnor_6.0X37,469,951 - 37,576,055 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602132   ⟹   XP_017457621
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X35,517,306 - 35,600,522 (-)NCBI
Rnor_6.0X37,484,797 - 37,576,055 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099974   ⟹   XP_038955902
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X35,517,306 - 35,622,979 (-)NCBI
RefSeq Acc Id: XM_039099976   ⟹   XP_038955904
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X35,517,306 - 35,622,979 (-)NCBI
RefSeq Acc Id: XM_039099977   ⟹   XP_038955905
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X35,517,306 - 35,623,293 (-)NCBI
RefSeq Acc Id: XM_039099978   ⟹   XP_038955906
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X35,517,306 - 35,622,979 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001178933   ⟸   NM_001192004
- UniProtKB: D3Z8E0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256985   ⟸   XM_006256923
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZNU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771414   ⟸   XM_008773192
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017457618   ⟸   XM_017602129
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457619   ⟸   XM_017602130
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AR08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457621   ⟸   XM_017602132
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AWX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008938   ⟸   ENSRNOT00000008938
RefSeq Acc Id: XP_038955905   ⟸   XM_039099977
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038955904   ⟸   XM_039099976
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038955906   ⟸   XM_039099978
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038955902   ⟸   XM_039099974
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AWX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079976   ⟸   ENSRNOT00000094638
RefSeq Acc Id: ENSRNOP00000088908   ⟸   ENSRNOT00000105976
RefSeq Acc Id: ENSRNOP00000096596   ⟸   ENSRNOT00000110641
RefSeq Acc Id: ENSRNOP00000097889   ⟸   ENSRNOT00000113332
RefSeq Acc Id: ENSRNOP00000083965   ⟸   ENSRNOT00000109787
Protein Domains
AGC-kinase C-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z8E0-F1-model_v2 AlphaFold D3Z8E0 1-740 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563860 AgrOrtholog
BioCyc Gene G2FUF-2484 BioCyc
Ensembl Genes ENSRNOG00000006632 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008938 ENTREZGENE
  ENSRNOP00000008938.5 UniProtKB/TrEMBL
  ENSRNOP00000079976 ENTREZGENE
  ENSRNOP00000079976.1 UniProtKB/TrEMBL
  ENSRNOP00000083965.1 UniProtKB/TrEMBL
  ENSRNOP00000088908 ENTREZGENE
  ENSRNOP00000088908.1 UniProtKB/TrEMBL
  ENSRNOP00000096596 ENTREZGENE
  ENSRNOP00000096596.1 UniProtKB/TrEMBL
  ENSRNOP00000097889 ENTREZGENE
  ENSRNOP00000097889.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008938 ENTREZGENE
  ENSRNOT00000008938.7 UniProtKB/TrEMBL
  ENSRNOT00000094638 ENTREZGENE
  ENSRNOT00000094638.1 UniProtKB/TrEMBL
  ENSRNOT00000105976 ENTREZGENE
  ENSRNOT00000105976.1 UniProtKB/TrEMBL
  ENSRNOT00000109787.1 UniProtKB/TrEMBL
  ENSRNOT00000110641 ENTREZGENE
  ENSRNOT00000110641.1 UniProtKB/TrEMBL
  ENSRNOT00000113332 ENTREZGENE
  ENSRNOT00000113332.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ribosomal_S6_kinase_II UniProtKB/TrEMBL
  RPS6KA3_C UniProtKB/TrEMBL
  RSK_N UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:501560 UniProtKB/TrEMBL
NCBI Gene 501560 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE ALPHA-3 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PhenoGen Rps6ka3 PhenoGen
PIRSF Ribsml_S6_kin_2 UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5ZNU1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AAF4_RAT UniProtKB/TrEMBL
  A0A8I6AR08 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AWX9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G9P7_RAT UniProtKB/TrEMBL
  D3Z8E0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-18 Rps6ka3  ribosomal protein S6 kinase A3  Rps6ka3  ribosomal protein S6 kinase polypeptide 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Rps6ka3  ribosomal protein S6 kinase polypeptide 3  RGD1563860_predicted  similar to ribosomal protein S6 kinase 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563860_predicted  similar to ribosomal protein S6 kinase 2 (predicted)  LOC501560  similar to ribosomal protein S6 kinase 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501560  similar to ribosomal protein S6 kinase 2      Symbol and Name status set to provisional 70820 PROVISIONAL