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Gene: RPS6KA4 (ribosomal protein S6 kinase A4) Homo sapiens
Symbol: RPS6KA4
Name: ribosomal protein S6 kinase A4
Description: Exhibits ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including histone-serine phosphorylation; interleukin-1-mediated signaling pathway; and positive regulation of histone modification. Localizes to cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 90 kDa ribosomal protein S6 kinase 4; mitogen- and stress-activated protein kinase 2; MSK2; nuclear mitogen- and stress-activated protein kinase 2; ribosomal protein kinase B; ribosomal protein S6 kinase alpha 4; ribosomal protein S6 kinase alpha-4; ribosomal protein S6 kinase, 90kDa, polypeptide 4; RSK-B; RSKB; S6K-alpha-4
Mus musculus (house mouse) : Rps6ka4 (ribosomal protein S6 kinase, polypeptide 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rps6ka4 (ribosomal protein S6 kinase A4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rps6ka4 (ribosomal protein S6 kinase A4)
Pan paniscus (bonobo/pygmy chimpanzee) : RPS6KA4 (ribosomal protein S6 kinase A4)
Canis lupus familiaris (dog) : RPS6KA4 (ribosomal protein S6 kinase A4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rps6ka4 (ribosomal protein S6 kinase A4)
Sus scrofa (pig) : RPS6KA4 (ribosomal protein S6 kinase A4)
Chlorocebus sabaeus (African green monkey) : RPS6KA4 (ribosomal protein S6 kinase A4)
Heterocephalus glaber (naked mole-rat) : Rps6ka4 (ribosomal protein S6 kinase A4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1164,359,148 - 64,372,215 (+)EnsemblGRCh38hg38GRCh38
GRCh381164,359,162 - 64,372,215 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371164,126,625 - 64,139,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,883,201 - 63,896,263 (+)NCBINCBI36hg18NCBI36
Build 341163,883,200 - 63,896,262NCBI
Celera1161,452,629 - 61,465,691 (+)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1160,454,630 - 60,467,467 (+)NCBIHuRef
CHM1_11164,009,642 - 64,022,700 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RPS6KA4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316377
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.