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Gene: RPS6KA1 (ribosomal protein S6 kinase A1) Homo sapiens
Symbol: RPS6KA1
Name: ribosomal protein S6 kinase A1
RGD ID: 732451
Description: Exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein serine/threonine kinase activity; and protein serine/threonine/tyrosine kinase activity. Involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of hepatic stellate cell activation; and positive regulation of transcription by RNA polymerase II. Localizes to cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 90 kDa ribosomal protein S6 kinase 1; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); HU-1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; MAPKAPK1; MAPKAPK1A; p90-RSK 1; p90Rsk; p90RSK1; p90S6K; ribosomal protein S6 kinase alpha 1; ribosomal protein S6 kinase alpha-1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; ribosomal S6 kinase 1; RSK; RSK-1; RSK1; s6 protein kinase (rsk-1); S6K-alpha 1; S6K-alpha-1
Mus musculus (house mouse) : Rps6ka1 (ribosomal protein S6 kinase polypeptide 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rps6ka1 (ribosomal protein S6 kinase A1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rps6ka1 (ribosomal protein S6 kinase A1)
Pan paniscus (bonobo/pygmy chimpanzee) : RPS6KA1 (ribosomal protein S6 kinase A1)
Canis lupus familiaris (dog) : RPS6KA1 (ribosomal protein S6 kinase A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rps6ka1 (ribosomal protein S6 kinase A1)
Sus scrofa (pig) : RPS6KA1 (ribosomal protein S6 kinase A1)
Chlorocebus sabaeus (African green monkey) : RPS6KA1 (ribosomal protein S6 kinase A1)
Heterocephalus glaber (naked mole-rat) : Rps6ka1 (ribosomal protein S6 kinase A1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl126,529,761 - 26,575,030 (+)EnsemblGRCh38hg38GRCh38
GRCh38126,529,761 - 26,575,028 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37126,856,249 - 26,901,520 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,728,836 - 26,774,107 (+)NCBINCBI36hg18NCBI36
Build 34126,540,390 - 26,585,662NCBI
Celera125,253,435 - 25,298,712 (+)NCBI
Cytogenetic Map1p36.11NCBI
HuRef125,110,498 - 25,155,787 (+)NCBIHuRef
CHM1_1126,969,231 - 27,014,507 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RPS6KA1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732451
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.