Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RPS6KA4 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPS6KA4 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPS6KA4 mRNA and Tetrachlorodibenzodioxin promotes the reaction [RPS6KA4 protein binds to CYP1A1 enhancer] | CTD | PMID:17942748 and PMID:24519526 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Rps6ka4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RPS6KA4 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of RPS6KA4 mRNA | CTD | PMID:21570461 | 2-palmitoylglycerol | increases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of RPS6KA4 mRNA | CTD | PMID:37199045 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | EXP | | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of RPS6KA4 mRNA | CTD | PMID:16054899 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RPS6KA4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of RPS6KA4 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | RPS6KA4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of RPS6KA4 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | affects methylation | EXP | | 6480464 | bisphenol S affects the methylation of RPS6KA4 gene | CTD | PMID:31683443 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Rps6ka4 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of RPS6KA4 mRNA | CTD | PMID:36041667 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | RPS6KA4 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of RPS6KA4 gene | CTD | PMID:31601247 | 4,4'-sulfonyldiphenol | decreases methylation | EXP | | 6480464 | bisphenol S results in decreased methylation of RPS6KA4 exon | CTD | PMID:33297965 | acrylamide | increases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of RPS6KA4 mRNA | CTD | PMID:32763439 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of RPS6KA4 mRNA | CTD | PMID:16604517 | all-trans-retinoic acid | increases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of RPS6KA4 mRNA | CTD | PMID:33167477 | aristolochic acid A | increases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of RPS6KA4 mRNA | CTD | PMID:33212167 | arsenous acid | increases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of RPS6KA4 mRNA | CTD | PMID:29633893 | benzo[a]pyrene | decreases methylation | EXP | | 6480464 | Benzo(a)pyrene results in decreased methylation of RPS6KA4 exon and Benzo(a)pyrene results in decreased methylation of RPS6KA4 intron | CTD | PMID:27901495 | bis(2-chloroethyl) sulfide | increases expression | EXP | | 6480464 | Mustard Gas results in increased expression of RPS6KA4 mRNA | CTD | PMID:18955075 | bis(2-ethylhexyl) phthalate | increases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of RPS6KA4 mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | ISO | Rps6ka4 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of RPS6KA4 mRNA | CTD | PMID:33296240 and PMID:34947998 | bisphenol A | multiple interactions | ISO | Rps6ka4 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of RPS6KA4 mRNA | CTD | PMID:36041667 | bisphenol F | multiple interactions | ISO | Rps6ka4 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of RPS6KA4 mRNA | CTD | PMID:36041667 | C60 fullerene | increases expression | ISO | Rps6ka4 (Rattus norvegicus) | 6480464 | fullerene C60 results in increased expression of RPS6KA4 mRNA | CTD | PMID:19167457 | cadmium dichloride | decreases expression | ISO | Rps6ka4 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in decreased expression of RPS6KA4 mRNA | CTD | PMID:33453195 | caffeine | affects phosphorylation | ISO | RPS6KA4 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of RPS6KA4 protein | CTD | PMID:35688186 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes and Carbon analog results in increased expression of RPS6KA4 mRNA | CTD | PMID:25554681 | cobalt dichloride | decreases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of RPS6KA4 mRNA | CTD | PMID:19320972 | copper atom | multiple interactions | ISO | RPS6KA4 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of RPS6KA4 mRNA | CTD | PMID:30911355 | copper(0) | multiple interactions | ISO | RPS6KA4 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of RPS6KA4 mRNA | CTD | PMID:30911355 | coumarin | increases phosphorylation | ISO | RPS6KA4 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of RPS6KA4 protein | CTD | PMID:35688186 | dexamethasone | multiple interactions | EXP | | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of RPS6KA4 mRNA | CTD | PMID:16054899 | dexamethasone | multiple interactions | ISO | RPS6KA4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of RPS6KA4 mRNA | CTD | PMID:28628672 | diarsenic trioxide | increases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of RPS6KA4 mRNA | CTD | PMID:29633893 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of RPS6KA4 mRNA | CTD | PMID:21266533 | doxorubicin | decreases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of RPS6KA4 mRNA | CTD | PMID:29803840 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RPS6KA4 mRNA | CTD | PMID:22206623 | FR900359 | decreases phosphorylation | ISO | RPS6KA4 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of RPS6KA4 protein | CTD | PMID:37730182 | indometacin | multiple interactions | ISO | RPS6KA4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of RPS6KA4 mRNA | CTD | PMID:28628672 | iron dichloride | decreases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | ferrous chloride results in decreased expression of RPS6KA4 mRNA | CTD | PMID:35984750 | methotrexate | affects expression | EXP | | 6480464 | Methotrexate affects the expression of RPS6KA4 mRNA | CTD | PMID:18502557 | N-methyl-4-phenylpyridinium | increases expression | ISO | Rps6ka4 (Rattus norvegicus) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of RPS6KA4 mRNA | CTD | PMID:28801915 | nickel atom | increases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | Nickel results in increased expression of RPS6KA4 mRNA | CTD | PMID:24768652 and PMID:25583101 | obeticholic acid | decreases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | obeticholic acid results in decreased expression of RPS6KA4 mRNA | CTD | PMID:27939613 | ozone | multiple interactions | ISO | RPS6KA4 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of RPS6KA4 mRNA | CTD | PMID:35430440 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of RPS6KA4 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | Rps6ka4 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of RPS6KA4 mRNA | CTD | PMID:33387578 | silicon dioxide | increases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of RPS6KA4 mRNA | CTD | PMID:25895662 | sodium arsenite | affects expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | sodium arsenite affects the expression of RPS6KA4 mRNA | CTD | PMID:34032870 | Soman | increases expression | ISO | Rps6ka4 (Rattus norvegicus) | 6480464 | Soman results in increased expression of RPS6KA4 mRNA | CTD | PMID:19281266 | sunitinib | increases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of RPS6KA4 mRNA | CTD | PMID:31533062 | temozolomide | decreases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of RPS6KA4 mRNA | CTD | PMID:31758290 | trovafloxacin | decreases expression | EXP | | 6480464 | trovafloxacin results in decreased expression of RPS6KA4 mRNA | CTD | PMID:35537566 | tunicamycin | decreases expression | EXP | | 6480464 | Tunicamycin results in decreased expression of RPS6KA4 mRNA | CTD | PMID:17127020 | valproic acid | increases methylation | ISO | RPS6KA4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of RPS6KA4 gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | RPS6KA4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of RPS6KA4 mRNA | CTD | PMID:29154799 | vinclozolin | increases methylation | ISO | Rps6ka4 (Rattus norvegicus) | 6480464 | vinclozolin results in increased methylation of RPS6KA4 gene | CTD | PMID:31079544 | |