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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631362
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapkapk2
Name: MAPK activated protein kinase 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapkapk2multiple interactionsEXP 6480464CTD[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of MAPKAPK2 mRNAPMID:16401727 PMID:16415329
Mapkapk2increases activityISOMapkapk2 (Mus musculus)6480464CTDLipopolysaccharides results in increased activity of MAPKAPK2 proteinPMID:16431125 PMID:21494017
Mapkapk2increases phosphorylationISOMAPKAPK2 (Homo sapiens)6480464CTDLipopolysaccharides results in increased phosphorylation of MAPKAPK2 proteinPMID:29925859
Mapkapk2multiple interactionsISOMAPKAPK2 (Homo sapiens)6480464CTD3-(4-methylphenylsulfonyl)-2-propenenitrile promotes the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein]; HNRNPD protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein]; Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein]PMID:21135123
Mapkapk2multiple interactionsISOMapkapk2 (Mus musculus)6480464CTDMAPKAPK2 protein affects the reaction [Lipopolysaccharides affects the localization of RELA protein]; MAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased activity of STAT3 protein]; MAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; MAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]; MAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; MAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]; MAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]; MAPKAPK3 protein affects the reaction [MAPKAPK2 protein affects the reaction [Lipopolysaccharides affects the localization of RELA protein]]; MAPKAPK3 protein affects the reaction [MAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased activity of STAT3 protein]]; MAPKAPK3 protein affects the reaction [MAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased activity of MAPKAPK2 protein]; TICAM2 affects the reaction [Lipopolysaccharides results in increased activity of MAPKAPK2 protein]PMID:16431125 PMID:21494017 PMID:21586572
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