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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631362
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapkapk2
Name: MAPK activated protein kinase 2
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapkapk2decreases expressionISOMAPKAPK2 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of MAPKAPK2 mRNAPMID:20458559
Mapkapk2increases activityISOMAPKAPK2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased activity of MAPKAPK2 proteinPMID:12239215
Mapkapk2multiple interactionsISOMAPKAPK2 (Homo sapiens)6480464CTDMAPK11 protein modified form inhibits the reaction [Arsenic Trioxide results in increased activity of MAPKAPK2 protein]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased activity of MAPKAPK2 protein]PMID:12239215
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