Csnk2a1 (casein kinase 2 alpha 1) - Rat Genome Database

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Gene: Csnk2a1 (casein kinase 2 alpha 1) Rattus norvegicus
Analyze
Symbol: Csnk2a1
Name: casein kinase 2 alpha 1
RGD ID: 621663
Description: Enables ribonucleoprotein complex binding activity. Involved in several processes, including liver regeneration; regulation of protein localization to plasma membrane; and response to testosterone. Part of chromatin. Biomarker of myocardial infarction. Orthologous to several human genes including CSNK2A1 (casein kinase 2 alpha 1); PARTICIPATES IN E-cadherin signaling pathway; mitochondrial autophagy pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: casein kinase 2, alpha 1 polypeptide; casein kinase II subunit alpha; casein kinase II, alpha 1 polypeptide; CK II alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23140,709,984 - 140,756,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,709,991 - 140,756,696 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3144,614,755 - 144,658,895 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,198,587 - 153,242,728 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03150,938,676 - 150,982,746 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03147,713,808 - 147,760,375 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,713,821 - 147,757,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,061,948 - 154,108,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43142,564,754 - 142,609,311 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13142,470,349 - 142,514,931 (+)NCBI
Celera3139,476,391 - 139,506,459 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aconitine  (EXP,ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
alternariol  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
ATP  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium dichloride  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
chloroprene  (EXP)
cilostazol  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
haloperidol  (EXP)
ionomycin  (ISO)
ivermectin  (ISO)
KT 5720  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
potassium dichromate  (ISO)
pyrithione  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
retinyl acetate  (ISO)
rotenone  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
staurosporine  (ISO)
sulindac  (EXP,ISO)
tamoxifen  (ISO)
trichloroethene  (EXP)
undecane  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning of cDNAs encoding the alpha and beta subunits of rat casein kinase 2 (CK-2): investigation of molecular regulation of CK-2 by androgens in rat ventral prostate. Ahmed K, etal., Cell Mol Biol Res 1993;39(5):451-62.
2. Differential localization of alpha' and beta subunits of protein kinase CK2 during rat spermatogenesis. Alvarado-Diaz CP, etal., Cell Tissue Res. 2009 Oct;338(1):139-49. doi: 10.1007/s00441-009-0847-1. Epub 2009 Aug 27.
3. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. De Felice FG, etal., Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1971-6. doi: 10.1073/pnas.0809158106. Epub 2009 Feb 2.
4. Regulation of protein kinase CK2 isoform expression during rat brain development. Diaz-Nido J, etal., Cell Mol Biol Res. 1994;40(5-6):581-5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Kramerov AA, etal., Am J Pathol. 2006 May;168(5):1722-36.
7. Role of autophosphorylation in regulation of protein kinase CK2 from rat neuronal chromatin. Kulikova OG and Reikhardt BA, Biochemistry (Mosc). 1998 Dec;63(12):1400-6.
8. Protein kinase CK2: signaling and tumorigenesis in the mammary gland. Landesman-Bollag E, etal., Mol Cell Biochem 2001 Nov;227(1-2):153-65.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Changes in the activity of nuclear protein kinase CK2 during rat liver regeneration. Pancetti F, etal., Biochem Biophys Res Commun. 1996 Jan 5;218(1):35-9.
12. Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2. Pancetti F, etal., Biochem Biophys Res Commun. 1999 Jun 24;260(1):17-22.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. The tight association of protein kinase CK2 with plasma membranes is mediated by a specific domain of its regulatory beta-subunit. Sarrouilhe D, etal., Biochim Biophys Acta. 1998 Jun 22;1403(2):199-210.
20. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Wei H, etal., Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90. doi: 10.1016/j.bbamcr.2015.03.013. Epub 2015 Apr 1.
21. Differential gene expression in infarct scar and viable myocardium from rat heart following coronary ligation. Xu YJ, etal., J Cell Mol Med. 2004 Jan-Mar;8(1):85-92.
Additional References at PubMed
PMID:2752008   PMID:8598227   PMID:8940188   PMID:9268364   PMID:11035045   PMID:11704824   PMID:11972058   PMID:12432063   PMID:12477932   PMID:12700239   PMID:15284227   PMID:15342635  
PMID:15723517   PMID:16193064   PMID:17728463   PMID:17827154   PMID:18191828   PMID:18413716   PMID:18548200   PMID:19542537   PMID:19662498   PMID:19765564   PMID:20067794   PMID:20387789  
PMID:20625391   PMID:20864032   PMID:21282530   PMID:21559479   PMID:21630459   PMID:22206666   PMID:22406621   PMID:24013921   PMID:24457960   PMID:25931508   PMID:28031292   PMID:28927755  
PMID:29476059   PMID:30699359   PMID:33065005  


Genomics

Comparative Map Data
Csnk2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23140,709,984 - 140,756,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,709,991 - 140,756,696 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3144,614,755 - 144,658,895 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,198,587 - 153,242,728 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03150,938,676 - 150,982,746 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03147,713,808 - 147,760,375 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,713,821 - 147,757,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,061,948 - 154,108,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43142,564,754 - 142,609,311 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13142,470,349 - 142,514,931 (+)NCBI
Celera3139,476,391 - 139,506,459 (+)NCBICelera
Cytogenetic Map3q41NCBI
CSNK2A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3820472,498 - 543,790 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl20472,498 - 543,835 (-)EnsemblGRCh38hg38GRCh38
GRCh3720453,142 - 524,434 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3620411,338 - 472,482 (-)NCBINCBI36Build 36hg18NCBI36
Build 3420411,337 - 472,482NCBI
Celera20558,168 - 619,315 (-)NCBICelera
Cytogenetic Map20p13NCBI
HuRef20414,534 - 475,783 (-)NCBIHuRef
CHM1_120463,361 - 524,481 (-)NCBICHM1_1
T2T-CHM13v2.020516,232 - 587,494 (-)NCBIT2T-CHM13v2.0
Csnk2a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,068,468 - 152,123,772 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,068,759 - 152,123,772 (+)EnsemblGRCm39 Ensembl
GRCm382152,226,535 - 152,281,856 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,226,839 - 152,281,852 (+)EnsemblGRCm38mm10GRCm38
MGSCv372152,052,576 - 152,107,588 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362151,918,392 - 151,973,288 (+)NCBIMGSCv36mm8
Celera2158,043,147 - 158,095,936 (+)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.83NCBI
Csnk2a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955597326,601 - 397,112 (-)NCBIChiLan1.0ChiLan1.0
CSNK2A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1201,568,135 - 1,629,104 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v020689,494 - 752,092 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.120459,070 - 521,126 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl20456,629 - 521,126 (-)Ensemblpanpan1.1panPan2
CSNK2A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12420,333,593 - 20,390,341 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2419,985,091 - 20,044,278 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,024,162 - 21,083,612 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,024,195 - 21,083,217 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12420,299,232 - 20,358,675 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02420,405,477 - 20,464,884 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02420,835,744 - 20,895,178 (+)NCBIUU_Cfam_GSD_1.0
Csnk2a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640169,535,585 - 169,588,246 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648517,966,993 - 18,021,191 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSNK2A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11734,692,960 - 34,748,067 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21739,413,860 - 39,467,386 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CSNK2A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1255,982,259 - 56,047,023 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660787,905,841 - 7,970,771 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csnk2a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247411,566,380 - 1,635,365 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Csnk2a1
83 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:117
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000007558
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat

Markers in Region
RH143208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23140,736,366 - 140,736,600 (+)MAPPERmRatBN7.2
Rnor_6.03147,739,986 - 147,740,219NCBIRnor6.0
Rnor_5.03154,088,127 - 154,088,360UniSTSRnor5.0
RGSC_v3.43142,591,544 - 142,591,777UniSTSRGSC3.4
Celera3139,488,691 - 139,488,924UniSTS
RH 3.4 Map31267.6UniSTS
Cytogenetic Map3q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 39 11 8
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007558   ⟹   ENSRNOP00000007558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3140,710,040 - 140,755,226 (+)Ensembl
Rnor_6.0 Ensembl3147,713,821 - 147,757,862 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113326   ⟹   ENSRNOP00000092799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3140,709,991 - 140,756,696 (+)Ensembl
RefSeq Acc Id: NM_053824   ⟹   NP_446276
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23140,710,075 - 140,754,135 (+)NCBI
Rnor_6.03147,713,883 - 147,757,753 (+)NCBI
Rnor_5.03154,061,948 - 154,108,516 (+)NCBI
RGSC_v3.43142,564,754 - 142,609,311 (+)RGD
Celera3139,476,391 - 139,506,459 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235220   ⟹   XP_006235282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23140,709,984 - 140,756,757 (+)NCBI
Rnor_6.03147,713,808 - 147,760,375 (+)NCBI
Rnor_5.03154,061,948 - 154,108,516 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235221   ⟹   XP_006235283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23140,709,999 - 140,754,206 (+)NCBI
Rnor_6.03147,713,808 - 147,757,794 (+)NCBI
Rnor_5.03154,061,948 - 154,108,516 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104108   ⟹   XP_038960036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23140,727,746 - 140,754,206 (+)NCBI
RefSeq Acc Id: XM_039104109   ⟹   XP_038960037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23140,724,106 - 140,754,206 (+)NCBI
RefSeq Acc Id: XM_039104110   ⟹   XP_038960038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23140,710,169 - 140,754,206 (+)NCBI
RefSeq Acc Id: XM_039104111   ⟹   XP_038960039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23140,713,929 - 140,754,206 (+)NCBI
RefSeq Acc Id: XM_039104112   ⟹   XP_038960040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23140,709,988 - 140,754,206 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446276   ⟸   NM_053824
- UniProtKB: Q5BKC1 (UniProtKB/Swiss-Prot),   P19139 (UniProtKB/Swiss-Prot),   A6KHM3 (UniProtKB/TrEMBL),   A0A8L2Q2R7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235283   ⟸   XM_006235221
- Peptide Label: isoform X1
- UniProtKB: Q5BKC1 (UniProtKB/Swiss-Prot),   P19139 (UniProtKB/Swiss-Prot),   A6KHM3 (UniProtKB/TrEMBL),   A0A8L2Q2R7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235282   ⟸   XM_006235220
- Peptide Label: isoform X1
- UniProtKB: Q5BKC1 (UniProtKB/Swiss-Prot),   P19139 (UniProtKB/Swiss-Prot),   A6KHM3 (UniProtKB/TrEMBL),   A0A8L2Q2R7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007558   ⟸   ENSRNOT00000007558
RefSeq Acc Id: XP_038960040   ⟸   XM_039104112
- Peptide Label: isoform X1
- UniProtKB: P19139 (UniProtKB/Swiss-Prot),   Q5BKC1 (UniProtKB/Swiss-Prot),   A6KHM3 (UniProtKB/TrEMBL),   A0A8L2Q2R7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960038   ⟸   XM_039104110
- Peptide Label: isoform X1
- UniProtKB: P19139 (UniProtKB/Swiss-Prot),   Q5BKC1 (UniProtKB/Swiss-Prot),   A6KHM3 (UniProtKB/TrEMBL),   A0A8L2Q2R7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960039   ⟸   XM_039104111
- Peptide Label: isoform X1
- UniProtKB: P19139 (UniProtKB/Swiss-Prot),   Q5BKC1 (UniProtKB/Swiss-Prot),   A6KHM3 (UniProtKB/TrEMBL),   A0A8L2Q2R7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960037   ⟸   XM_039104109
- Peptide Label: isoform X1
- UniProtKB: P19139 (UniProtKB/Swiss-Prot),   Q5BKC1 (UniProtKB/Swiss-Prot),   A6KHM3 (UniProtKB/TrEMBL),   A0A8L2Q2R7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960036   ⟸   XM_039104108
- Peptide Label: isoform X1
- UniProtKB: P19139 (UniProtKB/Swiss-Prot),   Q5BKC1 (UniProtKB/Swiss-Prot),   A6KHM3 (UniProtKB/TrEMBL),   A0A8L2Q2R7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092799   ⟸   ENSRNOT00000113326
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19139-F1-model_v2 AlphaFold P19139 1-391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692531
Promoter ID:EPDNEW_R3056
Type:initiation region
Name:Csnk2a1_1
Description:casein kinase 2 alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03147,713,827 - 147,713,887EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621663 AgrOrtholog
BioCyc Gene G2FUF-47279 BioCyc
Ensembl Genes ENSRNOG00000005276 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007558.6 UniProtKB/TrEMBL
  ENSRNOT00000113326 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7367296 IMAGE-MGC_LOAD
InterPro CK2_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116549 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108626 IMAGE-MGC_LOAD
NCBI Gene 116549 ENTREZGENE
PANTHER CASEIN KINASE II SUBUNIT ALPHA-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24054 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Csnk2a1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005276 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q2R7 ENTREZGENE, UniProtKB/TrEMBL
  A6KHM3 ENTREZGENE, UniProtKB/TrEMBL
  CSK21_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BKC1 ENTREZGENE
UniProt Secondary Q5BKC1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Csnk2a1  casein kinase 2 alpha 1  Csnk2a1  casein kinase 2, alpha 1 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Csnk2a1  casein kinase 2, alpha 1 polypeptide  Csnk2a1  casein kinase II, alpha 1 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Csnk2a1  casein kinase II, alpha 1 polypeptide      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Csnk2a1  casein kinase II, alpha 1 polypeptide      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation transcription is regulated by androgen, regulation is not an early androgen response but occurs in later stages of androgen mediated cell proliferation 727982