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Gene: Psen1 (presenilin 1) Rattus norvegicus
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Symbol: Psen1
Name: presenilin 1
Description: Exhibits endopeptidase activity. Involved in animal organ development; negative regulation of neuron apoptotic process; and proteolysis. Localizes to several cellular components, including the cytoplasm; integral component of presynaptic membrane; and sarcolemma. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1U; frontotemporal dementia; hidradenitis suppurativa; and neurodegenerative disease (multiple). Orthologous to human PSEN1 (presenilin 1); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-hydroxy-5alpha-androstan-3-one; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: presenilin-1; PS-1
Orthologs:
Homo sapiens (human) : PSEN1 (presenilin 1)  HGNC  Alliance
Mus musculus (house mouse) : Psen1 (presenilin 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Psen1 (presenilin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PSEN1 (presenilin 1)
Canis lupus familiaris (dog) : PSEN1 (presenilin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Psen1 (presenilin 1)
Sus scrofa (pig) : PSEN1 (presenilin 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06107,169,514 - 107,221,000 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06118,324,910 - 118,373,090 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46107,737,543 - 107,776,357 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16107,729,188 - 107,781,021 (+)NCBI
Celera6101,163,513 - 101,199,486 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Psen1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3425
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-09-17
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.