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Gene: Prkcb (protein kinase C, beta) Rattus norvegicus
Symbol: Prkcb
Name: protein kinase C, beta
RGD ID: 3396
Description: Exhibits protein kinase C activity. Involved in several processes, including dibenzo-p-dioxin metabolic process; negative regulation of insulin receptor signaling pathway; and response to vitamin D. Localizes to brush border membrane; centrosome; and cytosol. Used to study hyperglycemia; hypertension; and silicosis. Biomarker of congestive heart failure; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta); PARTICIPATES IN insulin signaling pathway; interleukin-2 signaling pathway; protein kinase C (PKC) signaling pathway; INTERACTS WITH (+)-pilocarpine; (9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: PKC-beta; Pkcb; Prkcb1; Protein kinase C beta; protein kinase C beta I; protein kinase C beta II; protein kinase C beta type; protein kinase C, beta 1
Homo sapiens (human) : PRKCB (protein kinase C beta)  HGNC  Alliance
Mus musculus (house mouse) : Prkcb (protein kinase C, beta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkcb (protein kinase C beta)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKCB (protein kinase C beta)
Canis lupus familiaris (dog) : PRKCB (protein kinase C beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkcb (protein kinase C beta)
Sus scrofa (pig) : PRKCB (protein kinase C beta)
Chlorocebus sabaeus (African green monkey) : PRKCB (protein kinase C beta)
Heterocephalus glaber (naked mole-rat) : Prkcb (protein kinase C beta)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01192,233,569 - 192,575,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,233,910 - 192,574,831 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01199,295,067 - 199,639,140 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,117,512 - 181,459,856 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11181,257,931 - 181,599,763 (+)NCBI
Celera1174,677,501 - 174,871,327 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Prkcb
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3396
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.