Prkcb (protein kinase C, beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Prkcb (protein kinase C, beta) Rattus norvegicus
Analyze
Symbol: Prkcb
Name: protein kinase C, beta
RGD ID: 3396
Description: Enables diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including negative regulation of insulin receptor signaling pathway; positive regulation of odontogenesis of dentin-containing tooth; and response to vitamin D. Located in brush border membrane and centrosome. Used to study hyperglycemia; hypertension; and silicosis. Biomarker of congestive heart failure; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta); PARTICIPATES IN insulin signaling pathway; interleukin-2 signaling pathway; protein kinase C (PKC) signaling pathway; INTERACTS WITH (+)-pilocarpine; (9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PKC-beta; Pkcb; Prkcb1; Protein kinase C beta; protein kinase C beta I; protein kinase C beta II; protein kinase C beta type; protein kinase C, beta 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,263,397 - 186,594,743 (+)NCBIGRCr8
mRatBN7.21176,832,173 - 177,163,539 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,832,226 - 177,163,536 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,160,371 - 185,491,641 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01192,346,335 - 192,677,604 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,030,688 - 185,362,219 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01192,233,569 - 192,575,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,233,910 - 192,574,831 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01199,295,067 - 199,639,140 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,117,512 - 181,459,856 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,257,931 - 181,599,763 (+)NCBI
Celera1174,677,501 - 174,871,327 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-naphthoflavone  (EXP)
alpha-Zearalanol  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bryostatin 1  (ISO)
bupivacaine  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
choline  (EXP,ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clopidogrel  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
daidzein  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dicofol  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
fluorescein 5-isothiocyanate  (ISO)
fluvoxamine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (EXP,ISO)
haloperidol  (EXP)
hydrogen peroxide  (EXP)
indometacin  (ISO)
inulin  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
losartan  (EXP)
mercury dibromide  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
Mezerein  (ISO)
ML-7  (EXP)
morphine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nicotine  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenethyl isothiocyanate  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pterostilbene  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
resveratrol  (ISO)
Riluzole  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
sotrastaurin  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
T-2 toxin  (EXP)
tamibarotene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
tetrodotoxin  (EXP)
thapsigargin  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanillic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
apoptotic process  (IEA)
B cell activation  (IEA,ISO,ISS)
B cell receptor signaling pathway  (IEA,ISO,ISS)
calcium ion transport  (IEA,ISO)
cellular response to carbohydrate stimulus  (IEA,ISO)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
dibenzo-p-dioxin metabolic process  (IEP)
intracellular calcium ion homeostasis  (IEA,ISO)
intracellular signal transduction  (IBA)
negative regulation of glucose transmembrane transport  (IEA,ISO,ISS)
negative regulation of insulin receptor signaling pathway  (IDA)
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  (IEA,ISO)
positive regulation of angiogenesis  (IEA,ISO,ISS)
positive regulation of B cell receptor signaling pathway  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of insulin secretion  (IEA,ISO)
positive regulation of odontogenesis of dentin-containing tooth  (IEP)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (IEA,ISO,ISS)
post-translational protein modification  (IEA,ISO,ISS)
presynaptic modulation of chemical synaptic transmission  (IEA,ISO)
protein phosphorylation  (IEA,ISO)
regulation of dopamine secretion  (IMP)
regulation of glucose transmembrane transport  (ISO,ISS)
regulation of growth  (IMP)
regulation of synaptic vesicle exocytosis  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
response to angiotensin  (IDA)
response to ethanol  (IEP)
response to glucose  (IEP)
response to vitamin D  (IEP)
response to xenobiotic stimulus  (IMP)

Cellular Component
brush border membrane  (IDA)
calyx of Held  (IEA,ISO)
centrosome  (IDA)
cytoplasm  (IEA,ISO)
cytosol  (IDA,ISO)
membrane  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO)
presynaptic cytosol  (IEA,ISO)
spectrin  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Role of protein kinase C beta in phorbol ester-induced c-fos gene expression in neurons of normotensive and spontaneously hypertensive rat brains. Amemiya T, etal., Brain Res. 2005 Apr 8;1040(1-2):129-36.
2. Age-dependent activation of PKC isoforms by angiotensin II in the proximal nephron. Boesch DM and Garvin JL, Am J Physiol Regul Integr Comp Physiol 2001 Sep;281(3):R861-7.
3. Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart. Bowling N, etal., Circulation. 1999 Jan 26;99(3):384-91.
4. Centrosomal anchoring of protein kinase C betaII by pericentrin controls microtubule organization, spindle function, and cytokinesis. Chen D, etal., J Biol Chem. 2004 Feb 6;279(6):4829-39. Epub 2003 Nov 1.
5. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. Chen D, etal., J Biol Chem. 2007 Nov 16;282(46):33776-87. Epub 2007 Sep 24.
6. Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells. Corsini E, etal., Br J Dermatol. 2009 Jan;160(1):16-25. Epub 2008 Oct 11.
7. Resistance to acute silicosis in senescent rats: role of alveolar macrophages. Corsini E, etal., Chem Res Toxicol. 2003 Dec;16(12):1520-7.
8. Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}. Devaraj S, etal., Diabetes. 2005 Jan;54(1):85-91.
9. Effect of ageing on the expression of protein kinase C and its activation by 1,25(OH)2-vitamin D3 in rat skeletal muscle. Facchinetti MM and de Boland AR, Cell Signal. 1999 Jan;11(1):39-44.
10. Altered protein kinase C activation associated with rat embryonic dysmorphogenesis. Gareskog M and Wentzel P, Pediatr Res. 2004 Dec;56(6):849-57. Epub 2004 Oct 20.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects. Ghanim H, etal., Diabetologia. 2007 Feb;50(2):278-85. Epub 2006 Dec 16.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-beta I and -delta. Goldberg HJ, etal., J Biol Chem 2002 Sep 13;277(37):33833-41.
15. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Holmes K, etal., Cell Signal. 2007 Oct;19(10):2003-12. Epub 2007 Jun 12.
16. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Housey GM, etal., Cell 1988 Feb 12;52(3):343-54.
17. Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family. Housey GM, etal., Proc Natl Acad Sci U S A 1987 Feb;84(4):1065-9.
18. Agents that act by different mechanisms modulate the activity of protein kinase CbetaII isozyme in the rat spinal cord during peripheral inflammation. Igwe OJ Neuroscience. 2006;138(1):313-28. Epub 2005 Dec 19.
19. Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta. Inagaki K, etal., J Mol Cell Cardiol. 2002 Oct;34(10):1377-85.
20. Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta. Johnson LA, etal., J Biol Chem. 2005 Mar 25;280(12):10914-9. Epub 2005 Jan 12.
21. Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. Kaneto H, etal., J Biol Chem. 2002 Feb 1;277(5):3680-5. Epub 2001 Nov 19.
22. Inhibition of PKCbeta improves glucocorticoid-induced insulin resistance in rat adipocytes. Kawai Y, etal., IUBMB Life. 2002 Dec;54(6):365-70.
23. Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. Kelly DJ, etal., Diabetes 2003 Feb;52(2):512-8.
24. Cloning and expression of multiple protein kinase C cDNAs. Knopf JL, etal., Cell 1986 Aug 15;46(4):491-502.
25. Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats. Koide Y, etal., Hypertens Res. 2003 May;26(5):421-6.
26. Differential effects of systemic ethanol administration on protein kinase cepsilon, gamma, and beta isoform expression, membrane translocation, and target phosphorylation: reversal by chronic ethanol exposure. Kumar S, etal., J Pharmacol Exp Ther. 2006 Dec;319(3):1366-75. Epub 2006 Sep 22.
27. Protein-protein interaction of zinc finger LIM domains with protein kinase C. Kuroda S, etal., J Biol Chem 1996 Dec 6;271(49):31029-32.
28. Translocation of PKC-betaII is mediated via RACK-1 in the neuronal cells following dioxin exposure. Lee HG, etal., Neurotoxicology. 2007 Mar;28(2):408-14. Epub 2006 May 5.
29. Diagnostic role of Wnt pathway gene promoter methylation in non small cell lung cancer. Liu S, etal., Oncotarget. 2017 May 30;8(22):36354-36367. doi: 10.18632/oncotarget.16754.
30. Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure. Mahadev K and Vemuri MC, Arch Biochem Biophys. 1998 Aug 15;356(2):249-57.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Eukaryotic initiation factor 6 mediates a continuum between 60S ribosome biogenesis and translation. Miluzio A, etal., EMBO Rep. 2009 May;10(5):459-65. doi: 10.1038/embor.2009.70. Epub 2009 Apr 17.
33. Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption. Morgan EL, etal., J Physiol. 2007 Apr 15;580(Pt. 2):593-604. Epub 2007 Feb 1.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
36. Protein kinase C betaII peptide inhibitor exerts cardioprotective effects in rat cardiac ischemia/reperfusion injury. Omiyi D, etal., J Pharmacol Exp Ther. 2005 Aug;314(2):542-51. Epub 2005 May 5.
37. Cloning of rat brain protein kinase C complementary DNA. Ono Y, etal., FEBS Lett 1986 Jul 28;203(2):111-5.
38. Two types of complementary DNAs of rat brain protein kinase C. Heterogeneity determined by alternative splicing. Ono Y, etal., FEBS Lett 1986 Oct 6;206(2):347-52.
39. High glucose-induced membrane translocation of PKC betaI is associated with Arf6 in glomerular mesangial cells. Padival AK, etal., Mol Cell Biochem. 2004 Mar;258(1-2):129-35.
40. Phosphoinositide 3-kinase mediates protein kinase C beta II mRNA destabilization in rat A10 smooth muscle cell cultures exposed to high glucose. Patel NA, etal., Arch Biochem Biophys 2002 Jul 1;403(1):111-20.
41. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
42. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C. Rodriguez MM, etal., FEBS Lett 1999 Jul 9;454(3):240-6.
46. Expression of protein kinase C isoforms in cardiac hypertrophy and heart failure due to volume overload. Sentex E, etal., Can J Physiol Pharmacol. 2006 Feb;84(2):227-38.
47. Signal transduction mechanisms in Alzheimer disease. Shimohama S and Matsushima H, Alzheimer Dis Assoc Disord. 1995;9 Suppl 2:15-22.
48. PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Su TT, etal., Nat Immunol 2002 Aug;3(8):780-6.
49. Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus. Tang FR, etal., Hippocampus. 2004;14(1):87-98.
50. The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane. Tracy S, etal., J Biol Chem. 1995 May 5;270(18):10587-94.
51. RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function. Vallentin A and Mochly-Rosen D, J Biol Chem. 2007 Jan 19;282(3):1650-7. Epub 2006 Nov 22.
52. Evidence for the involvement of a phospholipase C--protein kinase C signaling pathway in insulin stimulated glucose transport in skeletal muscle. Wright DC, etal., Life Sci 2003 May 23;73(1):61-71.
53. N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats. Xia Z, etal., Cardiovasc Res. 2007 Mar 1;73(4):770-82. Epub 2006 Nov 30.
54. Obligatory role of protein kinase Cbeta and MARCKS in vesicular trafficking in living neurons. Yang H, etal., Hypertension 2002 Feb;39(2 Pt 2):567-72.
55. In vivo expression of classic PKC isoforms in the rat dental follicle as related to tooth eruption. Yao S and Wise G, Connect Tissue Res. 2004;45(4-5):216-21.
56. Changes in protein kinase C (PKC) activity, isozyme translocation, and GAP-43 phosphorylation in the rat hippocampal formation after a single-trial contextual fear conditioning paradigm. Young E, etal., Hippocampus 2002;12(4):457-64.
57. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
58. Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy. Zhou H, etal., Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.
Additional References at PubMed
PMID:1299012   PMID:3576226   PMID:7929424   PMID:7961692   PMID:8034726   PMID:8327493   PMID:8631738   PMID:8749392   PMID:8889548   PMID:9514928   PMID:9817842   PMID:10365161  
PMID:10499500   PMID:10534118   PMID:10617144   PMID:10722046   PMID:10871288   PMID:11118818   PMID:11123317   PMID:11278415   PMID:11306676   PMID:11738801   PMID:11805327   PMID:11880265  
PMID:12391145   PMID:12551925   PMID:12618484   PMID:12766174   PMID:12826667   PMID:12904329   PMID:14613966   PMID:14682474   PMID:14715497   PMID:15037605   PMID:15042584   PMID:15322124  
PMID:15545601   PMID:15632189   PMID:15737652   PMID:15741241   PMID:16051606   PMID:16131649   PMID:16179609   PMID:16301747   PMID:16585392   PMID:16837815   PMID:17118565   PMID:17363743  
PMID:17531159   PMID:17678882   PMID:17694297   PMID:17711990   PMID:18001287   PMID:18056970   PMID:18315563   PMID:18323529   PMID:18440322   PMID:18497307   PMID:19057126   PMID:19091746  
PMID:19351495   PMID:19587355   PMID:19605547   PMID:19854265   PMID:19900507   PMID:20197783   PMID:20228790   PMID:20458337   PMID:20599775   PMID:20874717   PMID:21071702   PMID:21215369  
PMID:21228767   PMID:21424759   PMID:21575103   PMID:21658591   PMID:21700703   PMID:21704734   PMID:22479367   PMID:22531886   PMID:22587992   PMID:22797313   PMID:22865386   PMID:22871113  
PMID:23295407   PMID:23403203   PMID:23686852   PMID:23775122   PMID:24151077   PMID:24269213   PMID:24355769   PMID:24466133   PMID:25659900   PMID:25678708   PMID:25849791   PMID:25915883  
PMID:25982116   PMID:26199377   PMID:26660275   PMID:27402227   PMID:28534945   PMID:30053369   PMID:30701683   PMID:32048876   PMID:32357304   PMID:32866516   PMID:35192161   PMID:36066426  


Genomics

Comparative Map Data
Prkcb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81186,263,397 - 186,594,743 (+)NCBIGRCr8
mRatBN7.21176,832,173 - 177,163,539 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,832,226 - 177,163,536 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1185,160,371 - 185,491,641 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01192,346,335 - 192,677,604 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,030,688 - 185,362,219 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01192,233,569 - 192,575,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,233,910 - 192,574,831 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01199,295,067 - 199,639,140 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,117,512 - 181,459,856 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,257,931 - 181,599,763 (+)NCBI
Celera1174,677,501 - 174,871,327 (+)NCBICelera
Cytogenetic Map1q36NCBI
PRKCB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381623,835,983 - 24,220,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1623,835,983 - 24,220,611 (+)EnsemblGRCh38hg38GRCh38
GRCh371623,847,304 - 24,231,932 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,754,823 - 24,139,063 (+)NCBINCBI36Build 36hg18NCBI36
Build 341623,754,822 - 24,139,063NCBI
Celera1622,625,642 - 23,009,889 (+)NCBICelera
Cytogenetic Map16p12.2-p12.1NCBI
HuRef1621,938,281 - 22,322,666 (+)NCBIHuRef
CHM1_11624,859,040 - 25,244,985 (+)NCBICHM1_1
T2T-CHM13v2.01624,111,361 - 24,497,130 (+)NCBIT2T-CHM13v2.0
Prkcb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,888,327 - 122,233,625 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7121,887,974 - 122,233,625 (+)EnsemblGRCm39 Ensembl
GRCm387122,289,104 - 122,634,402 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,288,751 - 122,634,402 (+)EnsemblGRCm38mm10GRCm38
MGSCv377129,432,639 - 129,777,916 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367122,080,445 - 122,419,795 (+)NCBIMGSCv36mm8
Celera7122,177,656 - 122,520,472 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.75NCBI
Prkcb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554932,395,109 - 2,710,934 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554932,395,494 - 2,710,522 (+)NCBIChiLan1.0ChiLan1.0
PRKCB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21825,253,309 - 25,633,275 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11629,772,855 - 30,153,604 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01613,888,936 - 14,268,759 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11624,091,284 - 24,466,701 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1624,091,289 - 24,466,203 (+)Ensemblpanpan1.1panPan2
PRKCB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1621,742,970 - 22,064,360 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl621,742,973 - 22,065,185 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha623,304,828 - 23,630,068 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0621,880,650 - 22,206,417 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl621,880,653 - 22,206,393 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1621,685,773 - 22,010,753 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0621,587,647 - 21,912,745 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0621,982,425 - 22,308,075 (-)NCBIUU_Cfam_GSD_1.0
Prkcb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344120,339,861 - 120,631,378 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365018,437,715 - 8,728,716 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365018,410,273 - 8,729,238 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl321,995,231 - 22,383,264 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1321,995,227 - 22,383,628 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2322,949,682 - 23,174,763 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,558,608 - 21,940,536 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl521,558,441 - 21,943,864 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660687,834,678 - 8,241,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkcb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247828,974,765 - 9,287,702 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247828,974,995 - 9,287,609 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkcb
2264 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:412
Count of miRNA genes:221
Interacting mature miRNAs:275
Transcripts:ENSRNOT00000016418, ENSRNOT00000016442
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat

Markers in Region
D1Smu9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,061,421 - 177,061,592 (+)MAPPERmRatBN7.2
Rnor_6.01192,471,881 - 192,472,051NCBIRnor6.0
Rnor_5.01199,535,728 - 199,535,898UniSTSRnor5.0
RGSC_v3.41181,356,209 - 181,356,379UniSTSRGSC3.4
Celera1174,768,747 - 174,768,917UniSTS
Cytogenetic Map1q36UniSTS
D1Rat170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,061,447 - 177,061,563 (+)MAPPERmRatBN7.2
Rnor_6.01192,471,907 - 192,472,022NCBIRnor6.0
Rnor_5.01199,535,754 - 199,535,869UniSTSRnor5.0
RGSC_v3.41181,356,234 - 181,356,350RGDRGSC3.4
RGSC_v3.41181,356,235 - 181,356,350UniSTSRGSC3.4
RGSC_v3.11181,496,149 - 181,496,265RGD
Celera1174,768,773 - 174,768,888UniSTS
SHRSP x BN Map189.1199RGD
SHRSP x BN Map189.1199UniSTS
Cytogenetic Map1q36UniSTS
D1Got399  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,968,788 - 176,968,947 (+)MAPPERmRatBN7.2
Rnor_6.01192,379,361 - 192,379,519NCBIRnor6.0
Rnor_5.01199,443,417 - 199,443,575UniSTSRnor5.0
RGSC_v3.41181,263,910 - 181,264,068UniSTSRGSC3.4
Celera1174,676,987 - 174,677,145UniSTS
Cytogenetic Map1q36UniSTS
RH144428  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,900,557 - 176,900,794 (+)MAPPERmRatBN7.2
Rnor_6.01192,303,475 - 192,303,711NCBIRnor6.0
Rnor_5.01199,367,739 - 199,367,975UniSTSRnor5.0
Rnor_5.01199,012,168 - 199,012,404UniSTSRnor5.0
RGSC_v3.41181,195,201 - 181,195,437UniSTSRGSC3.4
Celera1174,609,316 - 174,609,552UniSTS
Cytogenetic Map1q36UniSTS
BE108217  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,157,000 - 177,157,150 (+)MAPPERmRatBN7.2
Rnor_6.01192,568,801 - 192,568,950NCBIRnor6.0
Rnor_5.01199,632,602 - 199,632,751UniSTSRnor5.0
RGSC_v3.41181,453,321 - 181,453,470UniSTSRGSC3.4
Celera1174,864,789 - 174,864,938UniSTS
Cytogenetic Map1q36UniSTS
AI044240  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,163,226 - 177,163,429 (+)MAPPERmRatBN7.2
Rnor_6.01192,575,027 - 192,575,229NCBIRnor6.0
Rnor_5.01199,638,828 - 199,639,030UniSTSRnor5.0
RGSC_v3.41181,459,547 - 181,459,749UniSTSRGSC3.4
Celera1174,871,015 - 174,871,217UniSTS
RH 3.4 Map11378.39UniSTS
Cytogenetic Map1q36UniSTS
RH94487  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,163,390 - 177,163,490 (+)MAPPERmRatBN7.2
Rnor_6.01192,575,191 - 192,575,290NCBIRnor6.0
Rnor_5.01199,638,992 - 199,639,091UniSTSRnor5.0
RGSC_v3.41181,459,711 - 181,459,810UniSTSRGSC3.4
Celera1174,871,179 - 174,871,278UniSTS
Cytogenetic Map1q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001172305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH002228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM383786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB576043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK838368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U62762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000016418   ⟹   ENSRNOP00000016417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1176,832,730 - 177,163,528 (+)Ensembl
Rnor_6.0 Ensembl1192,233,910 - 192,568,687 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000016442   ⟹   ENSRNOP00000016442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1176,832,815 - 177,129,783 (+)Ensembl
Rnor_6.0 Ensembl1192,233,910 - 192,574,831 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078705   ⟹   ENSRNOP00000073511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1176,832,226 - 177,163,536 (+)Ensembl
Rnor_6.0 Ensembl1192,379,543 - 192,568,745 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094409   ⟹   ENSRNOP00000081034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1176,832,226 - 177,163,536 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096083   ⟹   ENSRNOP00000077705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1176,832,815 - 177,163,536 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110215   ⟹   ENSRNOP00000082450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1176,832,226 - 177,163,536 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116223   ⟹   ENSRNOP00000094736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1176,832,226 - 177,125,024 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117718   ⟹   ENSRNOP00000077459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1176,832,730 - 177,163,528 (+)Ensembl
RefSeq Acc Id: NM_001172305   ⟹   NP_001165776
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,263,906 - 186,594,743 (+)NCBI
mRatBN7.21176,832,685 - 177,163,539 (+)NCBI
Rnor_6.01192,233,780 - 192,575,339 (+)NCBI
Rnor_5.01199,295,067 - 199,639,140 (+)NCBI
Celera1174,677,501 - 174,871,327 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012713   ⟹   NP_036845
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,263,906 - 186,588,950 (+)NCBI
mRatBN7.21176,832,685 - 177,157,748 (+)NCBI
Rnor_6.01192,233,780 - 192,569,544 (+)NCBI
Rnor_5.01199,295,067 - 199,639,140 (+)NCBI
RGSC_v3.41181,117,512 - 181,459,856 (+)RGD
Celera1174,677,501 - 174,865,532 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101232   ⟹   XP_038957160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,263,399 - 186,594,743 (+)NCBI
mRatBN7.21176,832,174 - 177,163,539 (+)NCBI
RefSeq Acc Id: XM_039101234   ⟹   XP_038957162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,263,397 - 186,594,743 (+)NCBI
mRatBN7.21176,832,173 - 177,163,539 (+)NCBI
RefSeq Acc Id: XM_039101236   ⟹   XP_038957164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81186,391,509 - 186,594,743 (+)NCBI
mRatBN7.21176,960,297 - 177,163,539 (+)NCBI
RefSeq Acc Id: NP_036845   ⟸   NM_012713
- Peptide Label: isoform 1
- UniProtKB: F1LS42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001165776   ⟸   NM_001172305
- Peptide Label: isoform 2
- UniProtKB: F1LS42 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016442   ⟸   ENSRNOT00000016442
Ensembl Acc Id: ENSRNOP00000016417   ⟸   ENSRNOT00000016418
Ensembl Acc Id: ENSRNOP00000073511   ⟸   ENSRNOT00000078705
RefSeq Acc Id: XP_038957162   ⟸   XM_039101234
- Peptide Label: isoform X2
- UniProtKB: P68403 (UniProtKB/Swiss-Prot),   F1LS42 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957160   ⟸   XM_039101232
- Peptide Label: isoform X1
- UniProtKB: F1LS42 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957164   ⟸   XM_039101236
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K5Q0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081034   ⟸   ENSRNOT00000094409
Ensembl Acc Id: ENSRNOP00000082450   ⟸   ENSRNOT00000110215
Ensembl Acc Id: ENSRNOP00000094736   ⟸   ENSRNOT00000116223
Ensembl Acc Id: ENSRNOP00000077459   ⟸   ENSRNOT00000117718
Ensembl Acc Id: ENSRNOP00000077705   ⟸   ENSRNOT00000096083
Protein Domains
AGC-kinase C-terminal   C2   Phorbol-ester/DAG-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P68403-F1-model_v2 AlphaFold P68403 1-671 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690386
Promoter ID:EPDNEW_R903
Type:multiple initiation site
Name:Prkcb_1
Description:protein kinase C, beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01192,379,538 - 192,379,598EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3396 AgrOrtholog
BIND 134040
BioCyc Gene G2FUF-57541 BioCyc
Ensembl Genes ENSRNOG00000012061 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055008014 UniProtKB/Swiss-Prot
  ENSRNOG00060030161 UniProtKB/Swiss-Prot
  ENSRNOG00065013001 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016418 UniProtKB/TrEMBL
  ENSRNOT00000016418.7 UniProtKB/Swiss-Prot
  ENSRNOT00000016442.9 UniProtKB/TrEMBL
  ENSRNOT00000078705 UniProtKB/TrEMBL
  ENSRNOT00000078705.2 UniProtKB/Swiss-Prot
  ENSRNOT00000094409.1 UniProtKB/TrEMBL
  ENSRNOT00000096083.1 UniProtKB/TrEMBL
  ENSRNOT00000110215.1 UniProtKB/TrEMBL
  ENSRNOT00000116223.1 UniProtKB/TrEMBL
  ENSRNOT00000117718.1 UniProtKB/TrEMBL
  ENSRNOT00055013848 UniProtKB/Swiss-Prot
  ENSRNOT00060053332 UniProtKB/Swiss-Prot
  ENSRNOT00065021344 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cPKC_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_C_a/b/g UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser_Thr_kinase_AGC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25023 UniProtKB/Swiss-Prot
NCBI Gene 25023 ENTREZGENE
PANTHER PROTEIN KINASE C UniProtKB/TrEMBL
  PROTEIN KINASE C BETA TYPE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkcb PhenoGen
PIRSF PKC_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS C2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAGPEDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012061 RatGTEx
  ENSRNOG00055008014 RatGTEx
  ENSRNOG00060030161 RatGTEx
  ENSRNOG00065013001 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K5Q0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5XW57_RAT UniProtKB/TrEMBL
  A0A8I5Y861_RAT UniProtKB/TrEMBL
  A0A8I5ZQS9_RAT UniProtKB/TrEMBL
  A0A8I5ZUY0_RAT UniProtKB/TrEMBL
  A0A8I6AM65_RAT UniProtKB/TrEMBL
  F1LS36_RAT UniProtKB/TrEMBL
  F1LS42 ENTREZGENE, UniProtKB/TrEMBL
  KPCB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P04410 UniProtKB/Swiss-Prot
  P04411 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Prkcb  protein kinase C, beta  Prkcb1  protein kinase C, beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Prkcb1  protein kinase C, beta 1    Protein kinase C beta  Name updated 629478 APPROVED
2002-06-10 Prkcb1  Protein kinase C beta      Symbol and Name status set to approved 70586 APPROVED