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Gene: Prkcb (protein kinase C, beta) Rattus norvegicus
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Symbol: Prkcb
Name: protein kinase C, beta
Description: Exhibits protein kinase C activity. Involved in several processes, including dibenzo-p-dioxin metabolic process; negative regulation of insulin receptor signaling pathway; and response to vitamin D. Localizes to the brush border membrane; centrosome; and cytosol. Used to study hyperglycemia; hypertension; and silicosis. Biomarker of congestive heart failure; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta); PARTICIPATES IN insulin signaling pathway; interleukin-2 signaling pathway; protein kinase C (PKC) signaling pathway; INTERACTS WITH (+)-pilocarpine; (9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione; (RS)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: PKC-beta; Pkcb; Prkcb1; Protein kinase C beta; protein kinase C beta I; protein kinase C beta II; protein kinase C beta type; protein kinase C, beta 1
Orthologs:
Homo sapiens (human) : PRKCB (protein kinase C beta)  HGNC  Alliance
Mus musculus (house mouse) : Prkcb (protein kinase C, beta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkcb (protein kinase C beta)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKCB (protein kinase C beta)
Canis lupus familiaris (dog) : PRKCB (protein kinase C beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkcb (protein kinase C beta)
Sus scrofa (pig) : PRKCB (protein kinase C beta)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01192,233,569 - 192,575,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01199,295,067 - 199,639,140 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,117,512 - 181,459,856 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11181,257,931 - 181,599,763 (+)NCBI
Celera1174,677,501 - 174,871,327 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Prkcb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3396
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.