(-)-epigallocatechin 3-gallate decreases expression ISO RGD:731018 6480464 epigallocatechin gallate results in decreased expression of KDR protein, epigallocatechin gallate results in decreased expression of KDR protein modified form CTD PMID:17992120 , PMID:20346928 1,1-dichloroethene decreases expression ISO RGD:10836 6480464 vinylidene chloride results in decreased expression of KDR mRNA CTD PMID:26682919 1,2,4-trimethylbenzene increases expression EXP 6480464 pseudocumene results in increased expression of KDR protein CTD PMID:17337753 1,4-benzoquinone multiple interactions ISO RGD:731018 6480464 quinone analog binds to and results in decreased activity of KDR protein CTD PMID:16302797 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of KDR mRNA CTD PMID:17557909 17beta-estradiol multiple interactions ISO RGD:10836 6480464 2 more ... CTD PMID:17289903 17beta-estradiol increases expression ISO RGD:731018 6480464 Estradiol results in increased expression of KDR mRNA, Estradiol results in increased expression of KDR protein CTD PMID:25982407 , PMID:29890199 17beta-estradiol increases expression ISO RGD:10836 6480464 Estradiol results in increased expression of KDR protein CTD PMID:17289903 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of KDR protein CTD PMID:9214597 17beta-estradiol multiple interactions ISO RGD:731018 6480464 [Estradiol results in increased secretion of VEGFA protein] which results in increased expression of KDR protein, afimoxifene inhibits the reaction [Estradiol results in increased expression of KDR protein] CTD PMID:17289903 , PMID:29890199 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:10836 6480464 [2 more ... CTD PMID:25510870 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO RGD:10836 6480464 2 more ... CTD PMID:30294300 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:10836 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:731018 6480464 Tetrachlorodibenzodioxin results in decreased expression of KDR mRNA CTD PMID:20106945 , PMID:26159488 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of KDR mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of KDR mRNA CTD PMID:24475139 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10836 6480464 Tetrachlorodibenzodioxin affects the expression of KDR mRNA CTD PMID:16962184 , PMID:26377647 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of KDR mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of KDR mRNA CTD PMID:21346803 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine affects expression EXP 6480464 Puromycin Aminonucleoside affects the expression of KDR mRNA CTD PMID:11744811 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression EXP 6480464 Puromycin Aminonucleoside results in increased expression of KDR mRNA, Puromycin Aminonucleoside results in increased expression of KDR protein CTD PMID:14752241 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine decreases expression EXP 6480464 Puromycin Aminonucleoside results in decreased expression of KDR mRNA CTD PMID:17667850 3,3'-diindolylmethane decreases expression ISO RGD:731018 6480464 3, 3'-diindolylmethane analog results in decreased expression of KDR protein CTD PMID:25794856 3,5,6-trichloro-2-pyridinol increases expression ISO RGD:10836 6480464 3 more ... CTD PMID:23220036 , PMID:25137620 3,5,6-trichloropyridine-2-one increases expression ISO RGD:10836 6480464 3 more ... CTD PMID:23220036 , PMID:25137620 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO RGD:731018 6480464 bisindolylmaleimide I inhibits the reaction [AGT protein results in increased expression of KDR mRNA] CTD PMID:15005273 3-methylcholanthrene multiple interactions ISO RGD:10836 6480464 [Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of KDR mRNA CTD PMID:25926378 4,4'-sulfonyldiphenol increases expression ISO RGD:10836 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of KDR mRNA CTD PMID:30951980 4-hydroxyphenyl retinamide increases expression ISO RGD:10836 6480464 Fenretinide results in increased expression of KDR mRNA CTD PMID:28973697 5-azacytidine increases expression EXP 6480464 Azacitidine results in increased expression of KDR mRNA CTD PMID:18037191 5-fluorouracil increases expression ISO RGD:10836 6480464 Fluorouracil results in increased expression of KDR mRNA CTD PMID:26272751 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of KDR mRNA CTD PMID:19483382 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole multiple interactions ISO RGD:10836 6480464 Omeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein] CTD PMID:26272953 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of KDR mRNA CTD PMID:19483382 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of KDR mRNA CTD PMID:25825206 afimoxifene multiple interactions ISO RGD:731018 6480464 afimoxifene inhibits the reaction [Estradiol results in increased expression of KDR protein], afimoxifene inhibits the reaction [glyphosate results in increased expression of KDR protein] CTD PMID:29890199 aflatoxin B1 decreases expression ISO RGD:731018 6480464 Aflatoxin B1 results in decreased expression of KDR mRNA CTD PMID:22100608 , PMID:28943387 aldehydo-D-glucose multiple interactions ISO RGD:10836 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of KDR protein CTD PMID:19228841 aldehydo-D-glucose decreases expression ISO RGD:731018 6480464 Glucose results in decreased expression of KDR mRNA CTD PMID:31655124 all-trans-retinoic acid affects expression ISO RGD:10836 6480464 Tretinoin affects the expression of KDR mRNA CTD PMID:25137620 all-trans-retinoic acid affects expression ISO RGD:731018 6480464 Tretinoin affects the expression of KDR mRNA CTD PMID:31600526 all-trans-retinoic acid increases expression ISO RGD:10836 6480464 Tretinoin results in increased expression of KDR mRNA CTD PMID:26272751 all-trans-retinoic acid multiple interactions ISO RGD:731018 6480464 [Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3, 3-bis(2-aminoethyl)-1-triazene] results in increased expression of KDR protein CTD PMID:23284745 all-trans-retinoic acid decreases expression ISO RGD:731018 6480464 Tretinoin results in decreased expression of KDR mRNA CTD PMID:21934132 all-trans-retinoic acid increases expression ISO RGD:731018 6480464 Tretinoin results in increased expression of KDR mRNA CTD PMID:17170094 amiodarone affects expression EXP 6480464 Amiodarone affects the expression of KDR mRNA CTD PMID:19483382 andrographolide decreases expression ISO RGD:731018 6480464 andrographolide results in decreased expression of KDR mRNA CTD PMID:28651835 andrographolide multiple interactions ISO RGD:731018 6480464 [andrographolide co-treated with KDR protein] inhibits the reaction [VEGFA protein binds to KDR protein], andrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein] CTD PMID:24814888 arsenite(3-) increases methylation ISO RGD:731018 6480464 arsenite results in increased methylation of KDR promoter CTD PMID:23974009 arsenous acid decreases expression ISO RGD:731018 6480464 Arsenic Trioxide results in decreased expression of KDR more ... CTD PMID:18161919 more ... aspartame increases secretion ISO RGD:731018 6480464 Aspartame results in increased secretion of KDR protein CTD PMID:20837131 belinostat multiple interactions ISO RGD:731018 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA CTD PMID:27188386 belinostat increases expression ISO RGD:731018 6480464 belinostat results in increased expression of KDR mRNA CTD PMID:26272509 benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of KDR mRNA CTD PMID:19483382 benzo[a]pyrene decreases expression ISO RGD:731018 6480464 Benzo(a)pyrene results in decreased expression of KDR mRNA CTD PMID:20106945 benzo[a]pyrene increases expression ISO RGD:10836 6480464 Benzo(a)pyrene results in increased expression of KDR mRNA CTD PMID:21964900 , PMID:22610609 benzylpenicillin increases expression ISO RGD:10836 6480464 Penicillin G results in increased expression of KDR mRNA CTD PMID:25137620 benzylpenicillin decreases expression ISO RGD:10836 6480464 Penicillin G results in decreased expression of KDR mRNA CTD PMID:26272751 bis(2-chloroethyl) sulfide decreases expression ISO RGD:731018 6480464 Mustard Gas results in decreased expression of KDR mRNA CTD PMID:16173061 bis(2-chloroethyl) sulfide multiple interactions ISO RGD:731018 6480464 IL10 protein affects the reaction [Mustard Gas affects the expression of KDR mRNA] CTD PMID:16173061 bisphenol A increases expression ISO RGD:731018 6480464 bisphenol A results in increased expression of KDR mRNA, bisphenol A results in increased expression of KDR protein CTD PMID:22045264 , PMID:25982407 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of KDR mRNA CTD PMID:30816183 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Fructose] results in increased expression of KDR mRNA CTD PMID:27622962 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of KDR protein CTD PMID:22649256 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of KDR mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:10836 6480464 bisphenol A results in increased expression of KDR mRNA CTD PMID:26063408 , PMID:30951980 bisphenol A increases secretion ISO RGD:731018 6480464 bisphenol A results in increased secretion of KDR protein CTD PMID:25982407 Bisphenol A diglycidyl ether multiple interactions ISO RGD:731018 6480464 2, 2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]] CTD PMID:21769449 bisphenol F increases expression ISO RGD:10836 6480464 bisphenol F results in increased expression of KDR mRNA CTD PMID:30951980 bortezomib multiple interactions ISO RGD:731018 6480464 [Bortezomib co-treated with sorafenib] results in decreased phosphorylation of KDR protein CTD PMID:16985072 cadmium atom affects activity ISO RGD:731018 6480464 Cadmium affects the activity of KDR protein CTD PMID:21425301 calcidiol decreases expression EXP 6480464 Calcifediol deficiency results in decreased expression of KDR mRNA CTD PMID:17293106 calcitriol decreases expression EXP 6480464 Calcitriol results in decreased expression of KDR protein CTD PMID:19092814 calcium atom multiple interactions ISO RGD:731018 6480464 [VEGFA protein results in increased activity of KDR protein] which results in increased abundance of Calcium, TRPC6 protein promotes the reaction [[VEGFA protein results in increased activity of KDR protein] which results in increased abundance of Calcium] CTD PMID:14551041 calcium atom multiple interactions ISO RGD:10836 6480464 Calcium promotes the reaction [Corticosterone results in decreased expression of KDR protein] CTD PMID:21647420 calcium(0) multiple interactions ISO RGD:731018 6480464 [VEGFA protein results in increased activity of KDR protein] which results in increased abundance of Calcium, TRPC6 protein promotes the reaction [[VEGFA protein results in increased activity of KDR protein] which results in increased abundance of Calcium] CTD PMID:14551041 calcium(0) multiple interactions ISO RGD:10836 6480464 Calcium promotes the reaction [Corticosterone results in decreased expression of KDR protein] CTD PMID:21647420 carbon nanotube decreases expression ISO RGD:10836 6480464 Nanotubes, Carbon analog results in decreased expression of KDR mRNA, Nanotubes, Carbon results in decreased expression of KDR mRNA CTD PMID:25554681 carbon nanotube multiple interactions ISO RGD:10836 6480464 [Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of KDR mRNA CTD PMID:25926378 chlorpyrifos increases expression ISO RGD:10836 6480464 Chlorpyrifos results in increased expression of KDR mRNA CTD PMID:25137620 chlorpyrifos decreases expression ISO RGD:10836 6480464 Chlorpyrifos results in decreased expression of KDR mRNA CTD PMID:20350560 , PMID:23220036 choline multiple interactions ISO RGD:10836 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of KDR mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KDR gene CTD PMID:20938992 clofibrate affects expression EXP 6480464 Clofibrate affects the expression of KDR mRNA CTD PMID:19483382 clofibrate multiple interactions ISO RGD:10836 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of KDR mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KDR mRNA] CTD PMID:17585979 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KDR mRNA CTD PMID:17602206 cobalt dichloride decreases expression ISO RGD:731018 6480464 cobaltous chloride results in decreased expression of KDR mRNA CTD PMID:19320972 copper atom decreases expression EXP 6480464 Copper results in decreased expression of KDR protein CTD PMID:19542178 copper atom increases expression EXP 6480464 Copper results in increased expression of KDR mRNA CTD PMID:30556269 copper atom multiple interactions EXP 6480464 Copper inhibits the reaction [Phenylephrine results in increased expression of KDR protein] CTD PMID:24903162 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of KDR protein CTD PMID:19542178 copper(0) increases expression EXP 6480464 Copper results in increased expression of KDR mRNA CTD PMID:30556269 copper(0) multiple interactions EXP 6480464 Copper inhibits the reaction [Phenylephrine results in increased expression of KDR protein] CTD PMID:24903162 corticosterone multiple interactions ISO RGD:10836 6480464 1 more ... CTD PMID:21647420 corticosterone decreases expression ISO RGD:10836 6480464 Corticosterone results in decreased expression of KDR protein CTD PMID:21647420 crocidolite asbestos increases secretion ISO RGD:731018 6480464 Asbestos, Crocidolite results in increased secretion of KDR protein CTD PMID:21762757 curcumin affects expression ISO RGD:731018 6480464 Curcumin affects the expression of KDR mRNA CTD PMID:17960570 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR mRNA], Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR protein] CTD PMID:23845850 curcumin multiple interactions ISO RGD:10836 6480464 Curcumin inhibits the reaction [Dietary Fats results in increased expression of KDR mRNA] CTD PMID:19297423 cyclophosphamide decreases expression EXP 6480464 Cyclophosphamide results in decreased expression of KDR mRNA, Cyclophosphamide results in decreased expression of KDR protein CTD PMID:19701751 cyclophosphamide increases expression EXP 6480464 Cyclophosphamide results in increased expression of KDR mRNA CTD PMID:18632792 cyclosporin A decreases expression ISO RGD:731018 6480464 Cyclosporine results in decreased expression of KDR mRNA CTD PMID:20106945 cyclosporin A multiple interactions EXP 6480464 Enalapril inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA], Losartan inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of KDR mRNA CTD PMID:12110003 cypermethrin increases expression ISO RGD:10836 6480464 cypermethrin results in increased expression of KDR mRNA CTD PMID:29020013 D-glucose multiple interactions ISO RGD:10836 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of KDR protein CTD PMID:19228841 D-glucose decreases expression ISO RGD:731018 6480464 Glucose results in decreased expression of KDR mRNA CTD PMID:31655124 Deguelin decreases expression ISO RGD:731018 6480464 deguelin metabolite results in decreased expression of KDR protein, deguelin results in decreased expression of KDR protein CTD PMID:19139008 demethoxycurcumin affects expression ISO RGD:731018 6480464 demethoxycurcumin affects the expression of KDR mRNA CTD PMID:17960570 diarsenic trioxide decreases expression ISO RGD:731018 6480464 Arsenic Trioxide results in decreased expression of KDR more ... CTD PMID:18161919 more ... diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of KDR mRNA CTD PMID:17005392 dioscin multiple interactions ISO RGD:731018 6480464 dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein] CTD PMID:25111127 dioxygen multiple interactions ISO RGD:10836 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of KDR mRNA more ... CTD PMID:19228841 more ... dioxygen decreases expression ISO RGD:10836 6480464 Oxygen results in decreased expression of KDR mRNA, Oxygen results in decreased expression of KDR protein CTD PMID:22363622 , PMID:26272953 dioxygen increases phosphorylation ISO RGD:731018 6480464 Oxygen deficiency results in increased phosphorylation of KDR protein CTD PMID:8537383 dioxygen multiple interactions ISO RGD:731018 6480464 KDR protein affects the reaction [Oxygen deficiency results in increased expression of HIF1A protein] CTD PMID:23144690 dorsomorphin multiple interactions ISO RGD:731018 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:731018 6480464 Doxorubicin results in decreased expression of KDR mRNA CTD PMID:29803840 embelin decreases expression ISO RGD:731018 6480464 embelin results in decreased expression of KDR protein CTD PMID:24694877 enalapril multiple interactions EXP 6480464 Enalapril inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 Enterolactone multiple interactions ISO RGD:10836 6480464 2, 3-bis(3'-hydroxybenzyl)butyrolactone inhibits the reaction [Estradiol results in increased expression of KDR protein] CTD PMID:17289903 entinostat multiple interactions ISO RGD:731018 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA CTD PMID:27188386 entinostat decreases expression ISO RGD:10836 6480464 entinostat results in decreased expression of KDR protein CTD PMID:21041383 entinostat increases expression ISO RGD:731018 6480464 entinostat results in increased expression of KDR mRNA CTD PMID:26272509 ethanol increases expression ISO RGD:10836 6480464 Ethanol results in increased expression of KDR mRNA CTD PMID:22198099 ethyl trans-caffeate affects expression ISO RGD:731018 6480464 ethyl caffeate affects the expression of KDR protein CTD PMID:24892518 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of KDR mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:10836 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of KDR mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KDR gene CTD PMID:20938992 fructose multiple interactions EXP 6480464 [bisphenol A co-treated with Fructose] results in increased expression of KDR mRNA CTD PMID:27622962 fumonisin B1 multiple interactions ISO RGD:10836 6480464 fumonisin B1 inhibits the reaction [1 more ... CTD PMID:15313899 furosemide increases expression EXP 6480464 Furosemide results in increased expression of KDR mRNA CTD PMID:16526316 gefitinib multiple interactions ISO RGD:10836 6480464 gefitinib inhibits the reaction [TGFA protein results in decreased expression of KDR mRNA] CTD PMID:18424623 genistein decreases expression ISO RGD:10836 6480464 Genistein results in decreased expression of KDR mRNA CTD PMID:21048042 genistein decreases expression EXP 6480464 Genistein results in decreased expression of KDR protein CTD PMID:22649256 geraniol decreases expression ISO RGD:10836 6480464 geraniol results in decreased expression of KDR protein CTD PMID:26154255 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of KDR mRNA CTD PMID:24136188 glucose multiple interactions ISO RGD:10836 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of KDR protein CTD PMID:19228841 glucose decreases expression ISO RGD:731018 6480464 Glucose results in decreased expression of KDR mRNA CTD PMID:31655124 glycidol decreases expression EXP 6480464 glycidol results in decreased expression of KDR mRNA CTD PMID:24915197 glyphosate multiple interactions ISO RGD:731018 6480464 afimoxifene inhibits the reaction [glyphosate results in increased expression of KDR protein] CTD PMID:29890199 glyphosate increases expression ISO RGD:731018 6480464 glyphosate results in increased expression of KDR protein CTD PMID:29890199 hexachlorobenzene increases expression ISO RGD:731018 6480464 Hexachlorobenzene results in increased expression of KDR protein CTD PMID:26358519 indoles decreases expression EXP 6480464 Indoles results in decreased expression of KDR mRNA CTD PMID:20521778 indoles increases expression EXP 6480464 Indoles results in increased expression of KDR mRNA CTD PMID:20521778 isoprenaline decreases expression ISO RGD:10836 6480464 Isoproterenol results in decreased expression of KDR mRNA CTD PMID:20003209 L-ascorbic acid decreases expression ISO RGD:731018 6480464 Ascorbic Acid results in decreased expression of KDR mRNA CTD PMID:21919647 L-ethionine affects expression EXP 6480464 Ethionine affects the expression of KDR mRNA CTD PMID:19483382 L-methionine multiple interactions ISO RGD:10836 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of KDR mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KDR gene CTD PMID:20938992 lead diacetate decreases expression ISO RGD:10836 6480464 lead acetate results in decreased expression of KDR mRNA CTD PMID:20542052 lithium chloride increases expression ISO RGD:10836 6480464 Lithium Chloride results in increased expression of KDR mRNA CTD PMID:26272751 losartan multiple interactions EXP 6480464 Losartan inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 medroxyprogesterone acetate decreases expression ISO RGD:731018 6480464 Medroxyprogesterone Acetate results in decreased expression of KDR mRNA CTD PMID:18497975 melittin decreases expression ISO RGD:731018 6480464 Melitten results in decreased expression of KDR protein CTD PMID:23110475 methoxychlor increases expression EXP 6480464 Methoxychlor results in increased expression of KDR protein CTD PMID:15503810 methyl caffeate decreases expression ISO RGD:731018 6480464 methyl caffeate analog results in decreased expression of KDR protein CTD PMID:25481497 methylisothiazolinone increases expression ISO RGD:731018 6480464 2-methyl-4-isothiazolin-3-one results in increased expression of KDR mRNA CTD PMID:31629900 methylmercury chloride decreases expression ISO RGD:731018 6480464 methylmercuric chloride results in decreased expression of KDR mRNA CTD PMID:23179753 methylmercury chloride increases expression ISO RGD:731018 6480464 methylmercuric chloride results in increased expression of KDR mRNA CTD PMID:28001369 mifepristone multiple interactions ISO RGD:10836 6480464 Mifepristone inhibits the reaction [Corticosterone results in decreased expression of KDR protein] CTD PMID:21647420 monosodium L-glutamate increases expression EXP 6480464 Sodium Glutamate results in increased expression of KDR protein CTD PMID:28755050 N-acetyl-L-cysteine increases expression ISO RGD:731018 6480464 Acetylcysteine results in increased expression of KDR protein CTD PMID:17992120 N-acetylsphingosine multiple interactions ISO RGD:731018 6480464 sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA] CTD PMID:15741222 N-acetylsphingosine multiple interactions ISO RGD:10836 6480464 N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of KDR protein CTD PMID:15313899 N-ethyl-N-nitrosourea increases expression ISO RGD:10836 6480464 Ethylnitrosourea results in increased expression of KDR protein CTD PMID:28549617 N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of KDR mRNA CTD PMID:19638242 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KDR mRNA CTD PMID:17602206 nickel atom decreases expression ISO RGD:10836 6480464 Nickel analog results in decreased expression of KDR mRNA CTD PMID:25144474 nicotinic acid increases expression ISO RGD:10836 6480464 Niacin results in increased expression of KDR mRNA CTD PMID:17557352 O-methyleugenol decreases expression ISO RGD:731018 6480464 methyleugenol results in decreased expression of KDR mRNA CTD PMID:32234424 omeprazole affects expression EXP 6480464 Omeprazole affects the expression of KDR mRNA CTD PMID:19483382 omeprazole multiple interactions ISO RGD:10836 6480464 Omeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein] CTD PMID:26272953 orantinib multiple interactions ISO RGD:731018 6480464 orantinib results in decreased phosphorylation of and results in decreased activity of KDR protein CTD PMID:16144927 orlistat decreases expression ISO RGD:731018 6480464 orlistat results in decreased expression of KDR protein CTD PMID:17012255 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of KDR mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] affects the expression of KDR mRNA CTD PMID:25729387 ozone decreases expression EXP 6480464 Ozone results in decreased expression of KDR mRNA CTD PMID:16330353 , PMID:31397875 p-menthan-3-ol increases expression ISO RGD:731018 6480464 Menthol results in increased expression of KDR mRNA CTD PMID:26760959 panobinostat multiple interactions ISO RGD:731018 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA CTD PMID:27188386 paracetamol multiple interactions ISO RGD:10836 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of KDR mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KDR mRNA] CTD PMID:17585979 paracetamol decreases expression ISO RGD:731018 6480464 Acetaminophen results in decreased expression of KDR mRNA CTD PMID:29067470 paracetamol increases expression ISO RGD:10836 6480464 Acetaminophen results in increased expression of KDR protein CTD PMID:16565415 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of KDR mRNA, Acetaminophen results in increased expression of KDR protein CTD PMID:17431590 PD123319 multiple interactions EXP 6480464 PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA] CTD PMID:14638905 perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of KDR mRNA CTD PMID:19162173 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of KDR mRNA CTD PMID:19162173 phenylephrine decreases expression EXP 6480464 Phenylephrine results in decreased expression of KDR mRNA CTD PMID:18158353 phenylephrine multiple interactions EXP 6480464 Copper inhibits the reaction [Phenylephrine results in increased expression of KDR protein] CTD PMID:24903162 phenylephrine increases expression EXP 6480464 Phenylephrine results in increased expression of KDR protein CTD PMID:24903162 phenytoin increases expression ISO RGD:10836 6480464 Phenytoin results in increased expression of KDR mRNA CTD PMID:26272751 phosgene affects expression ISO RGD:10836 6480464 Phosgene affects the expression of KDR mRNA CTD PMID:16300373 phosgene decreases expression EXP 6480464 Phosgene results in decreased expression of KDR mRNA, Phosgene results in decreased expression of KDR protein CTD PMID:18645720 pirinixic acid decreases expression ISO RGD:10836 6480464 pirinixic acid results in decreased expression of KDR mRNA CTD PMID:18445702 , PMID:20059764 pirinixic acid multiple interactions ISO RGD:10836 6480464 PPARA protein promotes the reaction [pirinixic acid results in decreased expression of KDR mRNA] CTD PMID:20059764 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of KDR mRNA CTD PMID:19483382 platycodin D decreases phosphorylation ISO RGD:731018 6480464 platycodin D results in decreased phosphorylation of KDR protein CTD PMID:25250884 platycodin D affects binding ISO RGD:731018 6480464 platycodin D binds to KDR protein CTD PMID:25250884 ponatinib decreases activity ISO RGD:731018 6480464 ponatinib analog results in decreased activity of KDR protein, ponatinib results in decreased activity of KDR protein CTD PMID:19878872 , PMID:21561767 potassium dichromate increases expression ISO RGD:10836 6480464 Potassium Dichromate results in increased expression of KDR mRNA CTD PMID:23608068 progesterone increases expression EXP 6480464 Progesterone results in increased expression of KDR mRNA CTD PMID:20726854 progesterone increases expression ISO RGD:731018 6480464 Progesterone results in increased expression of KDR mRNA CTD PMID:18692832 quercetin multiple interactions ISO RGD:731018 6480464 Quercetin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein] CTD PMID:23094058 quercitrin increases expression ISO RGD:731018 6480464 quercitrin results in increased expression of KDR mRNA CTD PMID:25193878 quinazolines multiple interactions ISO RGD:731018 6480464 Quinazolines analog binds to and results in decreased activity of KDR protein CTD PMID:16302797 resveratrol multiple interactions ISO RGD:731018 6480464 [SU 1498 results in decreased activity of KDR protein] inhibits the reaction [resveratrol results in increased secretion of MMP2 protein] more ... CTD PMID:22314268 resveratrol decreases expression ISO RGD:731018 6480464 resveratrol results in decreased expression of KDR mRNA, resveratrol results in decreased expression of KDR protein CTD PMID:17992120 more ... resveratrol increases expression ISO RGD:731018 6480464 resveratrol results in increased expression of KDR mRNA, resveratrol results in increased expression of KDR protein modified form CTD PMID:20696143 , PMID:22314268 riddelliine multiple interactions EXP 6480464 riddelliine results in increased phosphorylation of and results in increased activity of KDR protein CTD PMID:15384251 riddelliine increases expression EXP 6480464 riddelliine results in increased expression of KDR protein CTD PMID:12460743 rosuvastatin calcium multiple interactions ISO RGD:10836 6480464 Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] CTD PMID:27097221 rotenone increases expression EXP 6480464 Rotenone results in increased expression of KDR mRNA CTD PMID:28374803 saccharin increases expression ISO RGD:10836 6480464 Saccharin results in increased expression of KDR mRNA CTD PMID:26272751 sarpogrelate multiple interactions ISO RGD:10836 6480464 sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] CTD PMID:27097221 SB 431542 multiple interactions ISO RGD:731018 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 SB 431542 decreases expression ISO RGD:731018 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of KDR mRNA CTD PMID:25670856 silicon dioxide decreases expression ISO RGD:10836 6480464 Silicon Dioxide results in decreased expression of KDR mRNA CTD PMID:23221170 simvastatin increases expression EXP 6480464 Simvastatin results in increased expression of KDR mRNA, Simvastatin results in increased expression of KDR protein CTD PMID:19109527 simvastatin multiple interactions EXP 6480464 Simvastatin inhibits the reaction [Streptozocin results in increased expression of KDR mRNA], Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of KDR protein] CTD PMID:20821229 simvastatin increases expression ISO RGD:10836 6480464 Simvastatin results in increased expression of KDR mRNA CTD PMID:15572054 sodium arsenite affects localization ISO RGD:731018 6480464 sodium arsenite affects the localization of KDR protein CTD PMID:29044176 sodium arsenite multiple interactions ISO RGD:731018 6480464 DAB2 protein affects the reaction [sodium arsenite affects the localization of KDR protein] CTD PMID:29044176 sorafenib multiple interactions ISO RGD:731018 6480464 [Bortezomib co-treated with sorafenib] results in decreased phosphorylation of KDR protein CTD PMID:16985072 sorafenib decreases phosphorylation ISO RGD:731018 6480464 sorafenib results in decreased phosphorylation of KDR protein CTD PMID:19139124 sphingosine 1-phosphate multiple interactions ISO RGD:731018 6480464 sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA], sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] CTD PMID:15741222 streptozocin multiple interactions EXP 6480464 Simvastatin inhibits the reaction [Streptozocin results in increased expression of KDR mRNA] more ... CTD PMID:20821229 streptozocin multiple interactions ISO RGD:10836 6480464 [Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein more ... CTD PMID:27097221 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of KDR mRNA, Streptozocin results in increased expression of KDR protein CTD PMID:15643138 , PMID:20821229 sunitinib decreases expression ISO RGD:731018 6480464 Sunitinib results in decreased expression of KDR mRNA CTD PMID:31533062 superoxide increases phosphorylation ISO RGD:731018 6480464 Superoxides results in increased phosphorylation of KDR protein CTD PMID:19571580 testosterone decreases expression ISO RGD:10836 6480464 Testosterone results in decreased expression of KDR mRNA CTD PMID:19693291 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of KDR mRNA, Carbon Tetrachloride results in increased expression of KDR protein CTD PMID:23845850 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of KDR mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR mRNA], Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR protein] CTD PMID:23845850 thalidomide multiple interactions ISO RGD:731018 6480464 sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] CTD PMID:15741222 thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of KDR mRNA CTD PMID:19483382 titanium dioxide decreases expression ISO RGD:10836 6480464 titanium dioxide results in decreased expression of KDR mRNA CTD PMID:27760801 toluene increases expression EXP 6480464 Toluene results in increased expression of KDR mRNA CTD PMID:22967744 topotecan increases expression EXP 6480464 Topotecan results in increased expression of KDR mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] affects the expression of KDR mRNA CTD PMID:25729387 trichloroethene multiple interactions ISO RGD:10836 6480464 PPARA protein inhibits the reaction [Trichloroethylene results in increased expression of KDR protein] CTD PMID:15363585 trichloroethene increases expression ISO RGD:10836 6480464 Trichloroethylene results in increased expression of KDR mRNA CTD PMID:15363585 triclosan increases expression ISO RGD:731018 6480464 Triclosan results in increased expression of KDR mRNA CTD PMID:30510588 troglitazone decreases expression ISO RGD:10836 6480464 troglitazone results in decreased expression of KDR mRNA CTD PMID:28973697 troglitazone increases expression ISO RGD:10836 6480464 troglitazone results in increased expression of KDR mRNA CTD PMID:17569031 troglitazone multiple interactions ISO RGD:10836 6480464 [Urethane co-treated with troglitazone] results in increased expression of KDR mRNA CTD PMID:18465119 tunicamycin decreases expression ISO RGD:10836 6480464 Tunicamycin results in decreased expression of KDR mRNA CTD PMID:24370435 undecane increases expression EXP 6480464 undecane results in increased expression of KDR protein CTD PMID:17337753 urea decreases activity ISO RGD:731018 6480464 Urea analog results in decreased activity of KDR protein CTD PMID:16000000 urethane multiple interactions ISO RGD:10836 6480464 [Urethane co-treated with troglitazone] results in increased expression of KDR mRNA CTD PMID:18465119 urethane increases expression ISO RGD:10836 6480464 Urethane results in increased expression of KDR mRNA CTD PMID:18465119 valproic acid increases expression ISO RGD:10836 6480464 Valproic Acid results in increased expression of KDR mRNA CTD PMID:25137620 valproic acid increases expression ISO RGD:731018 6480464 Valproic Acid results in increased expression of KDR mRNA CTD PMID:28001369 valproic acid decreases expression ISO RGD:10836 6480464 Valproic Acid results in decreased expression of KDR mRNA CTD PMID:26272751 valproic acid affects expression ISO RGD:731018 6480464 Valproic Acid affects the expression of KDR mRNA CTD PMID:25979313 valproic acid decreases expression ISO RGD:731018 6480464 Valproic Acid results in decreased expression of KDR mRNA CTD PMID:23179753 valproic acid affects expression ISO RGD:10836 6480464 Valproic Acid affects the expression of KDR mRNA CTD PMID:17963808 valsartan multiple interactions ISO RGD:731018 6480464 Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA] CTD PMID:15005273 valsartan multiple interactions EXP 6480464 Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA] CTD PMID:14638905 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of KDR mRNA CTD PMID:19015723 vorinostat increases expression ISO RGD:731018 6480464 vorinostat results in increased expression of KDR mRNA CTD PMID:26272509 vorinostat multiple interactions ISO RGD:731018 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDR mRNA CTD PMID:27188386 WIN 55212-2 multiple interactions ISO RGD:10836 6480464 fumonisin B1 inhibits the reaction [Win 55212-2 results in decreased phosphorylation of and results in decreased activity of KDR protein], Win 55212-2 results in decreased phosphorylation of and results in decreased activity of KDR protein CTD PMID:15313899 zinc atom decreases expression EXP 6480464 Zinc results in decreased expression of KDR mRNA CTD PMID:17074742 zinc sulfate decreases expression EXP 6480464 Zinc Sulfate results in decreased expression of KDR mRNA CTD PMID:17074742 zinc(0) decreases expression EXP 6480464 Zinc results in decreased expression of KDR mRNA CTD PMID:17074742
Biological Process aging IEP 8549775 RGD branching involved in blood vessel morphogenesis ISO RGD:731018 1624291 (PMID:23688497) RGD PMID:23688497 branching morphogenesis of an epithelial tube ISO RGD:10836 1624291 (MGI:MGI:3613102, PMID:16375885) RGD MGI:MGI:3613102 , PMID:16375885 calcium ion homeostasis ISO RGD:10836 1624291 (MGI:MGI:3047093, PMID:8356051) RGD MGI:MGI:3047093 , PMID:8356051 calcium-mediated signaling using intracellular calcium source ISO RGD:731018 1624291 (PMID:15215251) RGD PMID:15215251 calcium-mediated signaling using intracellular calcium source IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 calcium-mediated signaling using intracellular calcium source ISS UniProtKB:P35968 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cell fate commitment ISO RGD:10836 1624291 (MGI:MGI:2450018, PMID:12569129) RGD MGI:MGI:2450018 , PMID:12569129 cell maturation ISO RGD:10836 1624291 (MGI:MGI:2181852, PMID:12053176) RGD MGI:MGI:2181852 , PMID:12053176 cell migration ISO RGD:10836 1624291 MGI:MGI:103178 (MGI:MGI:3525930 , PMID:15601856) RGD MGI:MGI:3525930 , PMID:15601856 cell migration IBA MGI:MGI:96683 , PANTHER:PTN002814441 13792537 PMID:21873635 GO_Central cell migration involved in sprouting angiogenesis ISO RGD:10836 1624291 (MGI:MGI:4845816, PMID:20660291) RGD MGI:MGI:4845816 , PMID:20660291 cellular response to hydrogen sulfide ISO RGD:731018 1624291 (PMID:26879375) RGD PMID:26879375 cellular response to hydrogen sulfide IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to vascular endothelial growth factor stimulus ISO RGD:731018 1624291 (PMID:10102632), (PMID:11387210), (PMID:15215251), (PMID:19033661), (PMID:23529610) RGD PMID:10102632 more ... cellular response to vascular endothelial growth factor stimulus ISS UniProtKB:P35968 1600115 GO_REF:0000024 UniProt GO_REF:0000024 embryonic hemopoiesis ISO RGD:10836 1624291 (MGI:MGI:74276, PMID:7596435) RGD MGI:MGI:74276 , PMID:7596435 embryonic hemopoiesis ISS UniProtKB:P35918 1600115 GO_REF:0000024 UniProt GO_REF:0000024 endocardium development ISO RGD:10836 1624291 (MGI:MGI:74276, PMID:7596435) RGD MGI:MGI:74276 , PMID:7596435 endochondral bone growth IMP 8549745 RGD endothelial cell differentiation IBA MGI:MGI:96683 , PANTHER:PTN002814441 13792537 PMID:21873635 GO_Central endothelial cell differentiation ISO RGD:10836 1624291 (MGI:MGI:2670246 more ... RGD MGI:MGI:2670246 more ... endothelium development ISO RGD:10836 1624291 (MGI:MGI:74276, PMID:7596435) RGD MGI:MGI:74276 , PMID:7596435 endothelium development ISS UniProtKB:P35918 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ERK1 and ERK2 cascade ISO RGD:731018 1624291 (PMID:24863063) RGD PMID:24863063 ERK1 and ERK2 cascade IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 hematopoietic progenitor cell differentiation IBA MGI:MGI:96677 , PANTHER:PTN001230732 13792537 PMID:21873635 GO_Central hemopoiesis ISO RGD:10836 1624291 MGI:MGI:3530468 (MGI:MGI:3529425 , PMID:15644447) RGD MGI:MGI:3529425 , PMID:15644447 hyaluronan metabolic process IEP 7243103 RGD lung alveolus development ISO RGD:10836 1624291 (MGI:MGI:2181852, PMID:12053176) RGD MGI:MGI:2181852 , PMID:12053176 lung development ISO RGD:10836 1624291 (MGI:MGI:3613102, PMID:16375885) RGD MGI:MGI:3613102 , PMID:16375885 lymph vessel development ISO RGD:10836 1624291 MGI:MGI:3039635 (MGI:MGI:4443218 , PMID:20439428) RGD MGI:MGI:4443218 , PMID:20439428 male gonad development IDA 1581591 RGD multicellular organism development IBA FB:FBgn0003733 more ... 13792537 PMID:21873635 GO_Central negative regulation of apoptotic process ISO RGD:731018 1624291 (PMID:15215251) RGD PMID:15215251 negative regulation of apoptotic process ISS UniProtKB:P35968 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of endothelial cell apoptotic process ISO RGD:731018 1624291 (PMID:9804796) RGD PMID:9804796 negative regulation of endothelial cell apoptotic process IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of endothelial cell apoptotic process ISS UniProtKB:P35968 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of gene expression ISO RGD:731018 1624291 (PMID:26879375) RGD PMID:26879375 negative regulation of gene expression IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of neuron apoptotic process IMP 2292011 motor neurons after hypoxia RGD neuron projection morphogenesis IMP 2292066 positive regulation in cerebral cortical neurons RGD ovarian follicle development ISO RGD:10836 1624291 (MGI:MGI:3709459, PMID:17050862) RGD MGI:MGI:3709459 , PMID:17050862 peptidyl-tyrosine autophosphorylation ISO RGD:10836 1624291 (MGI:MGI:4845816, PMID:20660291) RGD MGI:MGI:4845816 , PMID:20660291 peptidyl-tyrosine phosphorylation IEA GO:0004713 1600115 GO_REF:0000108 GOC GO_REF:0000108 peptidyl-tyrosine phosphorylation IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-tyrosine phosphorylation ISS UniProtKB:P35968 1600115 GO_REF:0000024 UniProt GO_REF:0000024 peptidyl-tyrosine phosphorylation ISO RGD:731018 1624291 (PMID:10037737), (PMID:10102632) RGD PMID:10037737 , PMID:10102632 peptidyl-tyrosine phosphorylation IEA GO:0004714 1600115 GO_REF:0000108 GOC GO_REF:0000108 positive regulation of angiogenesis IDA 1581593 RGD positive regulation of angiogenesis ISO RGD:731018 1624291 (PMID:15215251), (PMID:26879375), (PMID:28637396) RGD PMID:15215251 more ... positive regulation of angiogenesis IBA MGI:MGI:96683 more ... 13792537 PMID:21873635 GO_Central positive regulation of angiogenesis ISO RGD:10836 1624291 (MGI:MGI:4830635, PMID:20406889) RGD MGI:MGI:4830635 , PMID:20406889 positive regulation of blood vessel diameter IGI RGD:731072 2292104 RGD positive regulation of blood vessel endothelial cell migration ISO RGD:731018 1624291 (PMID:22499991), (PMID:23688497), (PMID:26879375) RGD PMID:22499991 more ... positive regulation of BMP signaling pathway ISO RGD:10836 1624291 (MGI:MGI:4830635, PMID:20406889) RGD MGI:MGI:4830635 , PMID:20406889 positive regulation of calcium-mediated signaling IMP 2292019 RGD positive regulation of cell migration IMP 2292001 C6 glioma cells RGD positive regulation of cell migration ISO RGD:731018 1624291 (PMID:15215251), (PMID:7929439) RGD PMID:15215251 , PMID:7929439 positive regulation of cell migration involved in sprouting angiogenesis ISO RGD:731018 1624291 (PMID:18977327), (PMID:24205206) RGD PMID:18977327 , PMID:24205206 positive regulation of cell migration involved in sprouting angiogenesis IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell population proliferation IMP 2292001 C6 glioma cells RGD positive regulation of cell population proliferation ISO RGD:731018 1624291 (PMID:15215251), (PMID:7929439) RGD PMID:15215251 , PMID:7929439 positive regulation of cytosolic calcium ion concentration IMP 2292019 RGD positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway ISO RGD:731018 1624291 (PMID:21885851) RGD PMID:21885851 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of endothelial cell migration ISO RGD:731018 1624291 (PMID:10022831) RGD PMID:10022831 positive regulation of endothelial cell proliferation IMP 2292006 in the hippocampal subgranular zone RGD positive regulation of endothelial cell proliferation IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of endothelial cell proliferation ISS UniProtKB:P35968 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of endothelial cell proliferation ISO RGD:731018 1624291 (PMID:10022831), (PMID:11387210) RGD PMID:10022831 , PMID:11387210 positive regulation of epithelial cell proliferation ISO RGD:10836 1624291 (MGI:MGI:3613102, PMID:16375885) RGD MGI:MGI:3613102 , PMID:16375885 positive regulation of ERK1 and ERK2 cascade ISO RGD:731018 1624291 (PMID:15215251) RGD PMID:15215251 positive regulation of ERK1 and ERK2 cascade IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of ERK1 and ERK2 cascade ISS UniProtKB:P35968 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of focal adhesion assembly ISO RGD:731018 1624291 (PMID:12820653) RGD PMID:12820653 positive regulation of focal adhesion assembly IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of kinase activity IBA PANTHER:PTN001230349 , UniProtKB:Q16832 13792537 PMID:21873635 GO_Central positive regulation of long-term neuronal synaptic plasticity IMP 2292019 RGD positive regulation of macroautophagy ISO RGD:731018 1624291 UniProtKB:P07585 (PMID:23798385) RGD PMID:23798385 positive regulation of macroautophagy IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of MAPK cascade ISO RGD:731018 1624291 (PMID:11387210) RGD PMID:11387210 positive regulation of MAPK cascade ISS UniProtKB:P35968 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of mesenchymal cell proliferation ISO RGD:10836 1624291 (MGI:MGI:3613102, PMID:16375885) RGD MGI:MGI:3613102 , PMID:16375885 positive regulation of mitochondrial depolarization ISO RGD:731018 1624291 UniProtKB:P07585 (PMID:23798385) RGD PMID:23798385 positive regulation of mitochondrial depolarization IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of mitochondrial fission ISO RGD:731018 1624291 UniProtKB:P07585 (PMID:23798385) RGD PMID:23798385 positive regulation of mitochondrial fission IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of neurogenesis IEP 1581594 RGD positive regulation of nitric-oxide synthase biosynthetic process ISO RGD:731018 1624291 (PMID:10600473), (PMID:9837777) RGD PMID:10600473 , PMID:9837777 positive regulation of nitric-oxide synthase biosynthetic process IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of nitric-oxide synthase biosynthetic process ISS UniProtKB:P35968 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of phosphatidylinositol 3-kinase signaling IMP 2292019 RGD positive regulation of phosphatidylinositol 3-kinase signaling IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of phosphatidylinositol 3-kinase signaling ISO RGD:731018 1624291 (PMID:9804796) RGD PMID:9804796 positive regulation of positive chemotaxis ISO RGD:731018 1624291 (PMID:7929439) RGD PMID:7929439 positive regulation of positive chemotaxis IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of protein phosphorylation ISO RGD:731018 1624291 (PMID:19033661) RGD PMID:19033661 positive regulation of protein phosphorylation ISS UniProtKB:P35968 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of TOR signaling IMP 2292019 RGD positive regulation of vasculogenesis ISO RGD:10836 1624291 (MGI:MGI:4359570, PMID:19635461) RGD MGI:MGI:4359570 , PMID:19635461 positive regulation of vasculogenesis ISS UniProtKB:P35918 1600115 GO_REF:0000024 UniProt GO_REF:0000024 post-embryonic camera-type eye morphogenesis ISO RGD:10836 1624291 MGI:MGI:95558 (MGI:MGI:5318610 , PMID:22426483) RGD MGI:MGI:5318610 , PMID:22426483 protein autophosphorylation IDA 2292046 RGD protein autophosphorylation IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein autophosphorylation ISO RGD:731018 1624291 (PMID:10037737), (PMID:10102632), (PMID:19033661) RGD PMID:10037737 more ... protein kinase B signaling ISO RGD:731018 1624291 (PMID:24863063) RGD PMID:24863063 protein kinase B signaling IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of bone development ISO RGD:10836 1624291 MGI:MGI:4422101 (MGI:MGI:5461755 , PMID:22886301) RGD MGI:MGI:5461755 , PMID:22886301 regulation of cell shape ISO RGD:731018 1624291 (PMID:7929439) RGD PMID:7929439 regulation of cell shape IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of hematopoietic progenitor cell differentiation ISO RGD:10836 1624291 (MGI:MGI:5543371, PMID:18772315) RGD MGI:MGI:5543371 , PMID:18772315 response to drug IMP 2292006 antidepressants fluoxetine and desipramine RGD response to hypoxia IMP 2292011 RGD response to oxygen levels IEP 8549762 RGD surfactant homeostasis ISO RGD:10836 1624291 (MGI:MGI:2181852, PMID:12053176) RGD MGI:MGI:2181852 , PMID:12053176 transmembrane receptor protein tyrosine kinase signaling pathway IBA FB:FBgn0003366 more ... 13792537 PMID:21873635 GO_Central vascular endothelial growth factor receptor signaling pathway IMP 2301848 ; 2292019 ; 729081 RGD vascular endothelial growth factor receptor signaling pathway ISS UniProtKB:P35968 1600115 GO_REF:0000024 UniProt GO_REF:0000024 vascular endothelial growth factor receptor signaling pathway ISO RGD:731018 1624291 (PMID:10102632), (PMID:11387210), (PMID:15215251), (PMID:23529610) RGD PMID:10102632 more ... vascular endothelial growth factor receptor signaling pathway IEA InterPro:IPR009136 1600115 GO_REF:0000002 InterPro GO_REF:0000002 vascular endothelial growth factor receptor signaling pathway ISO RGD:10836 1624291 (MGI:MGI:3047093, PMID:8356051) RGD MGI:MGI:3047093 , PMID:8356051 vascular endothelial growth factor receptor-2 signaling pathway ISO RGD:731018 1624291 (PMID:24205206) RGD PMID:24205206 vascular endothelial growth factor receptor-2 signaling pathway IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 vascular endothelial growth factor signaling pathway ISO RGD:731018 1624291 (PMID:23688497) RGD PMID:23688497 vascular endothelial growth factor signaling pathway IEA GO:0005021 1600115 GO_REF:0000108 GOC GO_REF:0000108 vascular wound healing ISO RGD:731018 1624291 (PMID:22499991), (PMID:23688497) RGD PMID:22499991 , PMID:23688497 vasculogenesis ISO RGD:10836 1624291 MGI:MGI:3530468 (MGI:MGI:3529425 more ... RGD MGI:MGI:3529425 more ... vasculogenesis ISS UniProtKB:P35918 1600115 GO_REF:0000024 UniProt GO_REF:0000024 Cellular Component cell junction ISO RGD:10836 1624291 (MGI:MGI:4359570, PMID:19635461) RGD MGI:MGI:4359570 , PMID:19635461 cell junction ISS UniProtKB:P35918 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cell periphery ISO RGD:10836 1624291 (MGI:MGI:3611394, PMID:16099728) RGD MGI:MGI:3611394 , PMID:16099728 cell surface ISO RGD:10836 1624291 (MGI:MGI:5448504, PMID:22265737) RGD MGI:MGI:5448504 , PMID:22265737 cytoplasm IDA 1581591 germ cells, day P0 and P5 testis RGD cytoplasm ISO RGD:10836 1624291 (MGI:MGI:5461755, PMID:22886301) RGD MGI:MGI:5461755 , PMID:22886301 cytoplasm IDA 2292048 RGD cytoplasm IDA 2292047 immature endothelial cells of blood vessels following brain injury RGD early endosome ISO RGD:10836 1624291 (MGI:MGI:4845816 more ... RGD MGI:MGI:4845816 more ... endoplasmic reticulum ISO RGD:731018 1624291 (PMID:23529610) RGD PMID:23529610 endoplasmic reticulum IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 endoplasmic reticulum ISS UniProtKB:P35968 1600115 GO_REF:0000024 UniProt GO_REF:0000024 endosome ISO RGD:731018 1624291 (PMID:23262137) RGD PMID:23262137 endosome IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 external side of plasma membrane ISO RGD:10836 1624291 (MGI:MGI:3777069 more ... RGD MGI:MGI:3777069 more ... Golgi apparatus ISO RGD:731018 1624291 (PMID:23262137) RGD PMID:23262137 Golgi apparatus IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000043 UniProt GO_REF:0000043 integral component of plasma membrane ISO RGD:731018 1624291 (PMID:10102632) RGD PMID:10102632 integral component of plasma membrane IBA FB:FBgn0003366 more ... 13792537 PMID:21873635 GO_Central integral component of plasma membrane IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of plasma membrane ISS UniProtKB:P35968 1600115 GO_REF:0000024 UniProt GO_REF:0000024 membrane raft ISO RGD:731018 1624291 (PMID:23262137) RGD PMID:23262137 membrane raft IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuron projection IDA 2292107 brain neurons RGD neuronal cell body IDA 2292107 brain neurons RGD nucleus ISO RGD:10836 1624291 (MGI:MGI:5461755, PMID:22886301) RGD MGI:MGI:5461755 , PMID:22886301 plasma membrane IDA 2292048 RGD plasma membrane ISO RGD:731018 1624291 (PMID:23262137), (PMID:25825981) RGD PMID:23262137 , PMID:25825981 plasma membrane ISO RGD:10836 1624291 (MGI:MGI:4845816 more ... RGD MGI:MGI:4845816 more ... receptor complex IBA FB:FBgn0015380 more ... 13792537 PMID:21873635 GO_Central sorting endosome ISO RGD:10836 1624291 (MGI:MGI:5490930, PMID:23639442) RGD MGI:MGI:5490930 , PMID:23639442 Molecular Function ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000043 UniProt GO_REF:0000043 cadherin binding IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 cadherin binding ISO RGD:731018 1624291 UniProtKB:P33151 (PMID:11950700), (PMID:25893857) RGD PMID:11950700 , PMID:25893857 growth factor binding IMP 729081 RGD growth factor binding IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 growth factor binding ISO RGD:731018 1624291 UniProtKB:P15692 (PMID:10022831), (PMID:1417831) RGD PMID:10022831 , PMID:1417831 growth factor binding ISO RGD:10836 1624291 PR:Q00731 more ... RGD MGI:MGI:1860784 more ... growth factor binding IEA InterPro:IPR009136 1600115 GO_REF:0000002 InterPro GO_REF:0000002 growth factor binding IPI RGD:731072 2292115 RGD identical protein binding ISO RGD:731018 1624291 UniProtKB:P35968 (PMID:17293873), (PMID:20080685), (PMID:20660291) RGD PMID:17293873 more ... identical protein binding IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 integrin binding ISO RGD:731018 1624291 UniProtKB:P05106 , UniProtKB:P20702 (PMID:10022831), (PMID:30873824) RGD PMID:10022831 , PMID:30873824 integrin binding IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding IPI RGD:2120 2292112 intracellular domain of Kdr RGD protein binding ISO RGD:10836 1624291 PR:P70206 more ... RGD MGI:MGI:3037225 more ... protein binding ISO RGD:731018 1624291 UniProtKB:O14786 more ... RGD PMID:12509223 more ... protein tyrosine kinase activity ISO RGD:731018 1624291 (PMID:10037737), (PMID:15962004), (PMID:7999104), (PMID:9398617) RGD PMID:10037737 more ... transmembrane receptor protein tyrosine kinase activity IBA FB:FBgn0003366 more ... 13792537 PMID:21873635 GO_Central vascular endothelial growth factor binding ISO RGD:731018 1624291 UniProtKB:P15692 (PMID:20660291), (PMID:25825981) RGD PMID:20660291 , PMID:25825981 vascular endothelial growth factor-activated receptor activity IMP 729081 ; 1626621 RGD vascular endothelial growth factor-activated receptor activity IEA UniProtKB:P35968 , ensembl:ENSP000002639231600115 GO_REF:0000107 Ensembl GO_REF:0000107 vascular endothelial growth factor-activated receptor activity ISO RGD:731018 1624291 (PMID:10022831), (PMID:10102632), (PMID:11387210), (PMID:1417831), (PMID:15215251) RGD PMID:10022831 more ... vascular endothelial growth factor-activated receptor activity IEA InterPro:IPR009136 1600115 GO_REF:0000002 InterPro GO_REF:0000002 vascular endothelial growth factor-activated receptor activity ISO RGD:10836 1624291 (MGI:MGI:3047093, PMID:8356051) RGD MGI:MGI:3047093 , PMID:8356051
Gene-Chemical Interaction Annotations
