Kdr (kinase insert domain receptor) - Rat Genome Database
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Gene: Kdr (kinase insert domain receptor) Rattus norvegicus
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Symbol: Kdr
Name: kinase insert domain receptor
RGD ID: 2965
Description: Exhibits growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including generation of neurons; hyaluronan metabolic process; and positive regulation of intracellular signal transduction. Localizes to several cellular components, including neuron projection; neuronal cell body; and plasma membrane. Used to study brain ischemia and cystitis. Biomarker of several diseases, including artery disease (multiple); colitis; impotence; prostate disease (multiple); and retinopathy of prematurity. Human ortholog(s) of this gene implicated in artery disease (multiple); macular degeneration (multiple); pancreatic cancer; and urinary bladder cancer. Orthologous to human KDR (kinase insert domain receptor); PARTICIPATES IN altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression; altered vascular endothelial growth factor signaling pathway involving the main players; vascular endothelial growth factor signaling pathway; INTERACTS WITH (S)-nicotine; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: fetal liver kinase 1; FLK-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); kinase insert domain protein receptor; MGC93590; protein-tyrosine kinase receptor flk-1; vascular endothelial growth factor receptor 2; Vegfr-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21432,217,871 - 32,261,018 (+)NCBI
Rnor_6.0 Ensembl1434,727,623 - 34,787,183 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01434,727,677 - 34,787,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01434,557,361 - 34,618,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1431,512,534 - 31,554,989 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (IEP)
adenocarcinoma  (ISO)
allergic contact dermatitis  (ISO)
amyotrophic lateral sclerosis  (ISO)
angiosarcoma  (ISO)
Animal Mammary Neoplasms  (ISO)
arteriosclerosis  (IEP,ISO)
arteriovenous malformations of the brain  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
Brain Injuries  (IEP,IMP)
brain ischemia  (IMP)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
Capillary Hemangioma, Infantile  (ISO)
cerebral cavernous malformation  (ISO)
Cerebral Hemorrhage  (ISO)
Choroidal Neovascularization  (IDA,IMP,ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (IEP)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
corneal neovascularization  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
cystitis  (IDA)
decubitus ulcer  (ISO)
Diabetic Nephropathies  (ISO)
diffuse scleroderma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (IEP)
Esophageal Neoplasms  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
Hand-Foot Syndrome  (ISO)
herpes simplex virus keratitis  (ISO)
high grade glioma  (ISO)
High Myopia  (ISO)
Hirschsprung Disease 1  (ISO)
hydrophthalmos  (ISO)
hypertension  (IEP,ISO)
Hypoxia-Ischemia, Brain  (IMP)
impotence  (IEP)
inverted papilloma  (ISO)
Kidney Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lathyrism  (IEP)
limited scleroderma  (ISO)
lymphangioma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
macular retinal edema  (ISO)
Mammary Neoplasms, Experimental  (IDA,ISO)
melanoma  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
Neovascularization, Pathologic  (ISO)
Neuralgia  (IEP)
neurilemmoma  (ISO)
neurofibrosarcoma  (ISO)
osteochondrodysplasia  (ISO)
Otitis Media with Effusion  (IEP)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (IEP,IMP)
pancreatic cancer  (ISO)
primary ovarian insufficiency  (ISO)
prostate adenocarcinoma  (IEP,ISO)
prostate cancer  (ISO)
prostatic hypertrophy  (IEP)
psoriasis  (ISO)
pterygium  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP,ISO)
retinal telangiectasia  (ISO)
retinopathy of prematurity  (IEP,ISO)
sarcoma  (ISO)
schizophrenia  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
Stroke  (IMP)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (ISO)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
uremia  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
uveal melanoma  (ISO)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3'-diindolylmethane  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
andrographolide  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
belinostat  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
calcidiol  (EXP)
calcitriol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
Deguelin  (ISO)
demethoxycurcumin  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (EXP)
dioscin  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
embelin  (ISO)
enalapril  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl trans-caffeate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furosemide  (EXP)
gefitinib  (ISO)
genistein  (EXP,ISO)
geraniol  (ISO)
glafenine  (EXP)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
hexachlorobenzene  (ISO)
indoles  (EXP)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lithium chloride  (ISO)
losartan  (EXP)
medroxyprogesterone acetate  (ISO)
melittin  (ISO)
methoxychlor  (EXP)
methyl caffeate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
O-methyleugenol  (ISO)
omeprazole  (EXP,ISO)
orantinib  (ISO)
orlistat  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
PD123319  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
phenytoin  (ISO)
phosgene  (EXP,ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
quercitrin  (ISO)
quinazolines  (ISO)
resveratrol  (ISO)
riddelliine  (EXP)
rosuvastatin calcium  (ISO)
rotenone  (EXP)
saccharin  (ISO)
sarpogrelate  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
superoxide  (ISO)
tanespimycin  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urea  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
WIN 55212-2  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
angiogenesis  (IEA)
branching involved in blood vessel morphogenesis  (IEA,ISO)
branching morphogenesis of an epithelial tube  (ISO)
calcium ion homeostasis  (ISO)
calcium-mediated signaling using intracellular calcium source  (IEA,ISO,ISS)
cell fate commitment  (ISO)
cell maturation  (ISO)
cell migration  (IBA,ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cellular response to hydrogen sulfide  (IEA,ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO,ISS)
embryonic hemopoiesis  (ISO,ISS)
endocardium development  (ISO)
endochondral bone growth  (IMP)
endothelial cell differentiation  (IBA,ISO)
endothelium development  (ISO,ISS)
ERK1 and ERK2 cascade  (IEA,ISO)
hematopoietic progenitor cell differentiation  (IBA)
hemopoiesis  (ISO)
hyaluronan metabolic process  (IEP)
lung alveolus development  (ISO)
lung development  (ISO)
lymph vessel development  (ISO)
male gonad development  (IDA)
multicellular organism development  (IBA)
negative regulation of apoptotic process  (ISO,ISS)
negative regulation of endothelial cell apoptotic process  (IEA,ISO,ISS)
negative regulation of gene expression  (IEA,ISO)
negative regulation of neuron apoptotic process  (IMP)
neuron projection morphogenesis  (IMP)
obsolete positive regulation of blood vessel diameter  (IGI)
ovarian follicle development  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (IEA,ISO,ISS)
positive regulation of angiogenesis  (IBA,IDA,IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of calcium-mediated signaling  (IMP)
positive regulation of cell migration  (IMP,ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (IEA,IMP,ISO,ISS)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
positive regulation of focal adhesion assembly  (IEA,ISO)
positive regulation of kinase activity  (IBA)
positive regulation of long-term neuronal synaptic plasticity  (IMP)
positive regulation of macroautophagy  (IEA,ISO)
positive regulation of MAPK cascade  (ISO,ISS)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of mitochondrial depolarization  (IEA,ISO)
positive regulation of mitochondrial fission  (IEA,ISO)
positive regulation of neurogenesis  (IEP)
positive regulation of nitric-oxide synthase biosynthetic process  (IEA,ISO,ISS)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA,IMP,ISO)
positive regulation of positive chemotaxis  (IEA,ISO)
positive regulation of protein phosphorylation  (IEA,ISO,ISS)
positive regulation of TOR signaling  (IMP)
positive regulation of vasculogenesis  (ISO,ISS)
post-embryonic camera-type eye morphogenesis  (ISO)
protein autophosphorylation  (IDA,IEA,ISO)
protein kinase B signaling  (IEA,ISO)
regulation of bone development  (ISO)
regulation of cell shape  (IEA,ISO)
regulation of hematopoietic progenitor cell differentiation  (ISO)
response to drug  (IMP)
response to hypoxia  (IMP)
response to oxygen levels  (IEP)
surfactant homeostasis  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
vascular endothelial growth factor receptor signaling pathway  (IEA,IMP,ISO,ISS)
vascular endothelial growth factor receptor-2 signaling pathway  (IEA,ISO)
vascular endothelial growth factor signaling pathway  (IEA,ISO)
vascular wound healing  (IEA,ISO)
vasculogenesis  (ISO,ISS)

Cellular Component

References

References - curated
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93. Pipeline to import KEGG annotations from KEGG into RGD
94. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
95. Pipeline to import SMPDB annotations from SMPDB into RGD
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102. RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
PMID:1323289   PMID:1417831   PMID:7596435   PMID:7681362   PMID:7929439   PMID:7999104   PMID:8356051   PMID:9398617   PMID:9804796   PMID:9837777   PMID:10022831   PMID:10037737  
PMID:10102632   PMID:10600473   PMID:10705382   PMID:10878616   PMID:11387210   PMID:11950700   PMID:11967019   PMID:12053176   PMID:12477932   PMID:12569129   PMID:12631117   PMID:12753865  
PMID:12820653   PMID:12897140   PMID:12923895   PMID:14766216   PMID:15215251   PMID:15548727   PMID:15601856   PMID:15644447   PMID:15734877   PMID:15919309   PMID:15962004   PMID:16010973  
PMID:16099728   PMID:16375885   PMID:16455951   PMID:16901919   PMID:16944045   PMID:17050862   PMID:17293873   PMID:17418870   PMID:17651752   PMID:17854994   PMID:17889862   PMID:18174522  
PMID:18321563   PMID:18421240   PMID:18462699   PMID:18482723   PMID:18586890   PMID:18772315   PMID:18835919   PMID:18977327   PMID:19033661   PMID:19357264   PMID:19426150   PMID:19513111  
PMID:19575935   PMID:19635461   PMID:19774558   PMID:20080685   PMID:20103598   PMID:20116868   PMID:20228271   PMID:20406889   PMID:20439428   PMID:20497492   PMID:20550877   PMID:20572782  
PMID:20599605   PMID:20637183   PMID:20660291   PMID:20697002   PMID:21418372   PMID:21435466   PMID:21613481   PMID:21885851   PMID:21928073   PMID:22245234   PMID:22265737   PMID:22499991  
PMID:22569153   PMID:22886301   PMID:22949406   PMID:23262137   PMID:23348691   PMID:23456363   PMID:23529610   PMID:23639442   PMID:23684887   PMID:23688497   PMID:23732519   PMID:23798385  
PMID:23826635   PMID:23831211   PMID:24022223   PMID:24063000   PMID:24205206   PMID:24398936   PMID:24623966   PMID:24630601   PMID:24863063   PMID:25195697   PMID:25730004   PMID:25754303  
PMID:25893857   PMID:26509169   PMID:26879375   PMID:27439004   PMID:27733124   PMID:28457321   PMID:28637396   PMID:28958753   PMID:29710417   PMID:30816491   PMID:30873824   PMID:31406128  
PMID:31583245   PMID:32189115  


Genomics

Comparative Map Data
Kdr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21432,217,871 - 32,261,018 (+)NCBI
Rnor_6.0 Ensembl1434,727,623 - 34,787,183 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01434,727,677 - 34,787,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01434,557,361 - 34,618,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1431,512,534 - 31,554,989 (+)NCBICelera
Cytogenetic Map14p11NCBI
KDR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl455,078,481 - 55,125,595 (-)EnsemblGRCh38hg38GRCh38
GRCh38455,078,481 - 55,125,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37455,944,648 - 55,991,762 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37455,944,426 - 55,991,762 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,639,406 - 55,686,519 (-)NCBINCBI36hg18NCBI36
Build 34455,785,576 - 55,832,690NCBI
Celera453,446,341 - 53,493,673 (-)NCBI
Cytogenetic Map4q12NCBI
HuRef451,893,013 - 51,940,346 (-)NCBIHuRef
CHM1_1455,979,683 - 56,027,015 (-)NCBICHM1_1
Kdr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39576,093,487 - 76,139,885 (-)NCBIGRCm39mm39
GRCm38575,932,827 - 75,979,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl575,932,827 - 75,978,458 (-)EnsemblGRCm38mm10GRCm38
MGSCv37576,329,290 - 76,374,453 (-)NCBIGRCm37mm9NCBIm37
MGSCv36576,214,962 - 76,260,125 (-)NCBImm8
Celera573,218,468 - 73,263,674 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map540.23NCBI
Kdr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544715,810,815 - 15,853,583 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544715,810,816 - 15,851,702 (+)NCBIChiLan1.0ChiLan1.0
KDR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1475,377,847 - 75,424,927 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl475,377,375 - 75,427,109 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0468,813,894 - 68,861,018 (+)NCBIMhudiblu_PPA_v0panPan3
KDR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1347,442,764 - 47,485,042 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11347,442,861 - 47,484,574 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Kdr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648217,537,697 - 17,581,320 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KDR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl841,809,116 - 41,856,339 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1841,809,116 - 41,856,379 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2843,919,330 - 43,966,984 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KDR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1713,435,059 - 13,482,236 (+)NCBI
ChlSab1.1 Ensembl713,435,096 - 13,482,771 (+)Ensembl
Kdr
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476114,330,224 - 14,380,680 (+)NCBI

Position Markers
RH128586  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01434,786,739 - 34,786,957NCBIRnor6.0
Rnor_5.01434,617,724 - 34,617,942UniSTSRnor5.0
Celera1431,554,601 - 31,554,819UniSTS
RH 3.4 Map14431.29UniSTS
RH94641  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01434,786,926 - 34,787,096NCBIRnor6.0
Rnor_5.01434,617,911 - 34,618,081UniSTSRnor5.0
Celera1431,554,788 - 31,554,958UniSTS
AU048544  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01434,743,872 - 34,744,135NCBIRnor6.0
Rnor_5.01434,573,535 - 34,573,798UniSTSRnor5.0
Celera1431,528,517 - 31,528,780UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14141333960Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14141333960Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14142766285Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14975643572854397Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin141053997755539977Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)141053997755539977Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)141072926861873323Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1412680424106641756Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141915991938289187Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141916189343957503Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141919154143957628Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)142018938665189386Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)142026622343957628Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)142145756566457565Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143259392686191589Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143303991261783215Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143316331673391571Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:764
Count of miRNA genes:299
Interacting mature miRNAs:387
Transcripts:ENSRNOT00000071405
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 41 31 13 31 4 4 55 35 30 11 4
Low 3 16 10 6 10 4 7 19 10 4
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071405   ⟹   ENSRNOP00000066886
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1434,727,623 - 34,787,183 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085089   ⟹   ENSRNOP00000071349
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1434,727,915 - 34,785,518 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090183   ⟹   ENSRNOP00000069697
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1434,727,677 - 34,787,124 (+)Ensembl
RefSeq Acc Id: NM_013062   ⟹   NP_037194
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21432,217,871 - 32,261,018 (+)NCBI
Rnor_6.01434,727,677 - 34,787,127 (+)NCBI
Rnor_5.01434,557,361 - 34,618,112 (+)NCBI
Celera1431,512,534 - 31,554,989 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037194   ⟸   NM_013062
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000069697   ⟸   ENSRNOT00000090183
RefSeq Acc Id: ENSRNOP00000071349   ⟸   ENSRNOT00000085089
RefSeq Acc Id: ENSRNOP00000066886   ⟸   ENSRNOT00000071405
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699278
Promoter ID:EPDNEW_R9803
Type:single initiation site
Name:Kdr_1
Description:kinase insert domain receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9804  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01434,727,648 - 34,727,708EPDNEW
RGD ID:13699284
Promoter ID:EPDNEW_R9804
Type:single initiation site
Name:Kdr_2
Description:kinase insert domain receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9803  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01434,727,925 - 34,727,985EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2965 AgrOrtholog
Ensembl Genes ENSRNOG00000046829 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000066886 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000069697 UniProtKB/TrEMBL
  ENSRNOP00000071349 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071405 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000085089 UniProtKB/TrEMBL
  ENSRNOT00000090183 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124961 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR-2_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25589 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93590 IMAGE-MGC_LOAD
NCBI Gene 25589 ENTREZGENE
PANTHER PTHR24416:SF45 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR-2_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KDR RGD
PhenoGen Kdr PhenoGen
PRINTS VEGFRECEPTR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC230153
UniProt A0A0G2JW10_RAT UniProtKB/TrEMBL
  O08775 ENTREZGENE
  Q5PQU0_RAT UniProtKB/TrEMBL
  VGFR2_RAT UniProtKB/Swiss-Prot
UniProt Secondary M0RBF2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Kdr  kinase insert domain receptor  Kdr  kinase insert domain protein receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Kdr  kinase insert domain protein receptor    FLK1 kinase insert domain receptor (VEGF receptor 2)  Name updated 625702 APPROVED
2002-06-10 Kdr  FLK1 kinase insert domain receptor (VEGF receptor 2)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in retina 729081
gene_process mediates initiation of vascular growth by angiogenic sprouting; plays a role in endothelial cell proliferation, differentiation, and microvascular permeability 625690
gene_process activation induces vascular permeability 729115