Enc1 (ectodermal-neural cortex 1) - Rat Genome Database

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Gene: Enc1 (ectodermal-neural cortex 1) Rattus norvegicus
Analyze
Symbol: Enc1
Name: ectodermal-neural cortex 1
RGD ID: 1303152
Description: Involved in positive regulation of neuron projection development. Located in chromatin; neuronal cell body; and nuclear lumen. Orthologous to human ENC1 (ectodermal-neural cortex 1); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ectoderm-neural cortex protein 1; Nrpb; nuclear restrict protein in brain
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8230,285,274 - 30,297,194 (+)NCBIGRCr8
mRatBN7.2228,550,670 - 28,562,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl228,550,464 - 28,562,713 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx235,605,171 - 35,617,034 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0233,699,505 - 33,711,368 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0228,519,264 - 28,531,129 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0228,049,217 - 28,061,023 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl228,049,217 - 28,061,029 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0247,160,036 - 47,171,842 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4227,720,805 - 27,733,168 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1227,364,788 - 27,653,537 (+)NCBI
Celera224,591,966 - 24,603,770 (+)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
adenine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
Archazolid B  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carmustine  (EXP)
casticin  (ISO)
cefaloridine  (EXP)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
DDT  (EXP)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
isoprenaline  (ISO)
kainic acid  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
leflunomide  (EXP,ISO)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (EXP)
nefazodone  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
Nutlin-3  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
phenethyl isothiocyanate  (EXP)
phenylmercury acetate  (ISO)
phorone  (EXP)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tioguanine  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. ENC-1: a novel mammalian kelch-related gene specifically expressed in the nervous system encodes an actin-binding protein. Hernandez MC, etal., J Neurosci 1997 May 1;17(9):3038-51.
4. NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation. Kim TA, etal., J Cell Biol. 1998 May 4;141(3):553-66.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15983046   PMID:19372205   PMID:19424503   PMID:19682578   PMID:27039095  


Genomics

Comparative Map Data
Enc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8230,285,274 - 30,297,194 (+)NCBIGRCr8
mRatBN7.2228,550,670 - 28,562,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl228,550,464 - 28,562,713 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx235,605,171 - 35,617,034 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0233,699,505 - 33,711,368 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0228,519,264 - 28,531,129 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0228,049,217 - 28,061,023 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl228,049,217 - 28,061,029 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0247,160,036 - 47,171,842 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4227,720,805 - 27,733,168 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1227,364,788 - 27,653,537 (+)NCBI
Celera224,591,966 - 24,603,770 (+)NCBICelera
Cytogenetic Map2q12NCBI
ENC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38574,627,409 - 74,640,728 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl574,627,406 - 74,641,424 (-)EnsemblGRCh38hg38GRCh38
GRCh37573,923,234 - 73,936,553 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36573,958,990 - 73,972,273 (-)NCBINCBI36Build 36hg18NCBI36
Build 34573,958,990 - 73,972,273NCBI
Celera569,818,021 - 69,832,031 (-)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef569,128,052 - 69,142,065 (-)NCBIHuRef
CHM1_1573,355,796 - 73,369,813 (-)NCBICHM1_1
T2T-CHM13v2.0575,108,382 - 75,121,693 (-)NCBIT2T-CHM13v2.0
Enc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391397,377,613 - 97,389,548 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1397,377,613 - 97,389,542 (+)EnsemblGRCm39 Ensembl
GRCm381397,241,105 - 97,253,040 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1397,241,105 - 97,253,034 (+)EnsemblGRCm38mm10GRCm38
MGSCv371398,011,060 - 98,022,995 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361398,341,869 - 98,353,733 (+)NCBIMGSCv36mm8
Celera13100,873,931 - 100,885,879 (+)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.66NCBI
Enc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542526,017,684 - 26,029,262 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542526,017,684 - 26,029,262 (+)NCBIChiLan1.0ChiLan1.0
ENC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2440,671,223 - 40,684,243 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1538,824,858 - 38,837,878 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0540,668,899 - 40,682,887 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1541,276,022 - 41,290,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl541,281,115 - 41,282,884 (+)Ensemblpanpan1.1panPan2
ENC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1257,175,851 - 57,184,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl257,182,480 - 57,184,249 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha254,153,002 - 54,164,687 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0257,699,330 - 57,711,010 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl257,701,049 - 57,710,976 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1254,763,393 - 54,775,077 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0255,526,509 - 55,538,190 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0256,423,533 - 56,435,224 (-)NCBIUU_Cfam_GSD_1.0
Enc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213188,837,852 - 188,850,667 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365492,008,363 - 2,020,948 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365492,008,365 - 2,020,948 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl283,678,521 - 83,691,400 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1283,678,518 - 83,691,812 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2285,271,292 - 85,284,204 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1468,980,137 - 68,994,112 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl468,987,452 - 68,989,218 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604917,758,086 - 17,772,066 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624924281,327 - 294,248 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624924281,251 - 294,248 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Enc1
42 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:344
Count of miRNA genes:203
Interacting mature miRNAs:264
Transcripts:ENSRNOT00000022144
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000022144   ⟹   ENSRNOP00000022144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl228,550,464 - 28,562,713 (+)Ensembl
Rnor_6.0 Ensembl228,049,217 - 28,061,029 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106862   ⟹   ENSRNOP00000079907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl228,552,137 - 28,562,576 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115766   ⟹   ENSRNOP00000077290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl228,550,792 - 28,562,713 (+)Ensembl
RefSeq Acc Id: NM_001003401   ⟹   NP_001003401
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8230,285,274 - 30,297,194 (+)NCBI
mRatBN7.2228,550,670 - 28,562,591 (+)NCBI
Rnor_6.0228,049,217 - 28,061,023 (+)NCBI
Rnor_5.0247,160,036 - 47,171,842 (+)NCBI
RGSC_v3.4227,720,805 - 27,733,168 (+)RGD
Celera224,591,966 - 24,603,770 (+)RGD
Sequence:
RefSeq Acc Id: XM_063281492   ⟹   XP_063137562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8230,286,804 - 30,297,189 (+)NCBI
RefSeq Acc Id: NP_001003401   ⟸   NM_001003401
- UniProtKB: Q6DKY8 (UniProtKB/TrEMBL),   A0A8I5Y5L9 (UniProtKB/TrEMBL),   Q2V9T0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022144   ⟸   ENSRNOT00000022144
Ensembl Acc Id: ENSRNOP00000079907   ⟸   ENSRNOT00000106862
Ensembl Acc Id: ENSRNOP00000077290   ⟸   ENSRNOT00000115766
RefSeq Acc Id: XP_063137562   ⟸   XM_063281492
- Peptide Label: isoform X1
- UniProtKB: Q2V9T0 (UniProtKB/TrEMBL),   A0A8I5Y5L9 (UniProtKB/TrEMBL),   Q6DKY8 (UniProtKB/TrEMBL)
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6DKY8-F1-model_v2 AlphaFold Q6DKY8 1-589 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691088
Promoter ID:EPDNEW_R1613
Type:multiple initiation site
Name:Enc1_1
Description:ectodermal-neural cortex 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0228,049,233 - 28,049,293EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303152 AgrOrtholog
BioCyc Gene G2FUF-54754 BioCyc
Ensembl Genes ENSRNOG00000016541 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022144 ENTREZGENE
  ENSRNOT00000022144.6 UniProtKB/TrEMBL
  ENSRNOT00000106862 ENTREZGENE
  ENSRNOT00000106862.1 UniProtKB/TrEMBL
  ENSRNOT00000115766.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
  Potassium Channel Kv1.1, Chain A UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  ENC1 UniProtKB/TrEMBL
  ENC1_BACK UniProtKB/TrEMBL
  Kelch-like_gigaxonin UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
KEGG Report rno:294674 UniProtKB/TrEMBL
NCBI Gene 294674 ENTREZGENE
PANTHER ECTODERM-NEURAL CORTEX PROTEIN 1 UniProtKB/TrEMBL
  KELCH PROTEIN UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PhenoGen Enc1 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016541 RatGTEx
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF117281 UniProtKB/TrEMBL
UniProt A0A8I5Y5L9 ENTREZGENE, UniProtKB/TrEMBL
  Q2V9T0 ENTREZGENE, UniProtKB/TrEMBL
  Q6DKY8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Enc1  ectodermal-neural cortex 1      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Enc1  ectodermal-neural cortex 1      Symbol and Name status set to provisional 70820 PROVISIONAL