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Gene: Timp4 (TIMP metallopeptidase inhibitor 4) Rattus norvegicus
Symbol: Timp4
Name: TIMP metallopeptidase inhibitor 4
Description: Predicted to have metalloendopeptidase inhibitor activity; protease binding activity; and zinc ion binding activity. Involved in several processes, including ovulation cycle; response to lipopolysaccharide; and response to peptide hormone. Localizes to extracellular space and sarcomere. Biomarker of abdominal aortic aneurysm; congestive heart failure; and renal hypertension. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human TIMP4 (TIMP metallopeptidase inhibitor 4); INTERACTS WITH (S)-nicotine; 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: LOC680130; metalloproteinase inhibitor 4; similar to Metalloproteinase inhibitor 4 precursor (TIMP-4) (Tissue inhibitor of metalloproteinases-4); TIMP-4; Timp4_mapped; tissue inhibitor of metalloproteinase 4; tissue inhibitor of metalloproteinase 4 (mapped); tissue inhibitor of metalloproteinases 4
Homo sapiens (human) : TIMP4 (TIMP metallopeptidase inhibitor 4)  HGNC  Alliance
Mus musculus (house mouse) : Timp4 (tissue inhibitor of metalloproteinase 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Timp4 (TIMP metallopeptidase inhibitor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TIMP4 (TIMP metallopeptidase inhibitor 4)
Canis lupus familiaris (dog) : TIMP4 (TIMP metallopeptidase inhibitor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Timp4 (TIMP metallopeptidase inhibitor 4)
Sus scrofa (pig) : TIMP4 (TIMP metallopeptidase inhibitor 4)
Chlorocebus sabaeus (African green monkey) : TIMP4 (TIMP metallopeptidase inhibitor 4)
Heterocephalus glaber (naked mole-rat) : Timp4 (TIMP metallopeptidase inhibitor 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04147,156,948 - 147,163,467 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,156,948 - 147,163,467 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,445,694 - 210,452,213 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,375,072 - 151,381,591 (-)NCBIRGSC3.4rn4RGSC3.4
Celera4137,199,851 - 137,206,370 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Timp4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69077
Created: 2001-11-08
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.