Keap1 Rat (+)-albicanol multiple interactions ISO Keap1 (Mus musculus) 6480464 albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 mRNA] and albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 protein] CTD PMID:33761044 Keap1 Rat (-)-ephedrine multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Ephedrine inhibits the reaction [Bleomycin results in increased expression of KEAP1 protein] CTD PMID:37778983 Keap1 Rat (-)-epigallocatechin 3-gallate multiple interactions ISO KEAP1 (Homo sapiens) 6480464 epigallocatechin gallate promotes the reaction [arsenite results in increased expression of KEAP1 mRNA] CTD PMID:29572906 Keap1 Rat (-)-epigallocatechin 3-gallate increases expression ISO KEAP1 (Homo sapiens) 6480464 epigallocatechin gallate results in increased expression of KEAP1 protein CTD PMID:35218280 Keap1 Rat (R)-lipoic acid increases expression ISO KEAP1 (Homo sapiens) 6480464 Thioctic Acid results in increased expression of KEAP1 protein CTD PMID:19033392 Keap1 Rat (R)-lipoic acid multiple interactions ISO Keap1 (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein] CTD PMID:34252510 Keap1 Rat (R,R,R)-alpha-tocopherol multiple interactions ISO KEAP1 (Homo sapiens) 6480464 alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 mRNA] and alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:36058301 Keap1 Rat 1,2-dimethylhydrazine multiple interactions ISO Keap1 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KEAP1 mRNA CTD PMID:22206623 Keap1 Rat 1,2-naphthoquinone affects response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the susceptibility to 1 and 2-naphthoquinone CTD PMID:21384861 Keap1 Rat 1,2-naphthoquinone increases metabolic processing ISO Keap1 (Mus musculus) 6480464 1 and 2-naphthoquinone results in increased metabolism of KEAP1 protein CTD PMID:21384861 and PMID:25807370 Keap1 Rat 1-chloro-2,4-dinitrobenzene multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein] more ... CTD PMID:19033392 and PMID:25742418 Keap1 Rat 1-chloro-2,4-dinitrobenzene decreases expression ISO Keap1 (Mus musculus) 6480464 Dinitrochlorobenzene results in decreased expression of KEAP1 mRNA CTD PMID:28219650 Keap1 Rat 1-chloro-2,4-dinitrobenzene increases expression ISO KEAP1 (Homo sapiens) 6480464 Dinitrochlorobenzene results in increased expression of KEAP1 protein CTD PMID:19033392 Keap1 Rat 1-chloro-2,4-dinitrobenzene affects metabolic processing ISO Keap1 (Mus musculus) 6480464 Dinitrochlorobenzene affects the metabolism of KEAP1 protein CTD PMID:18785192 Keap1 Rat 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO Keap1 (Mus musculus) 6480464 1 more ... CTD PMID:33368846 and PMID:38016618 Keap1 Rat 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression ISO Keap1 (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:38016618 Keap1 Rat 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO Keap1 (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:33368846 Keap1 Rat 1-naphthyl isothiocyanate decreases expression ISO Keap1 (Mus musculus) 6480464 1-Naphthylisothiocyanate results in decreased expression of KEAP1 mRNA and 1-Naphthylisothiocyanate results in decreased expression of KEAP1 protein CTD PMID:36008890 and PMID:37348807 Keap1 Rat 1-naphthyl isothiocyanate multiple interactions ISO Keap1 (Mus musculus) 6480464 liquiritin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of KEAP1 protein] CTD PMID:36008890 Keap1 Rat 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole decreases export ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein results in decreased export of bisbenzimide ethoxide trihydrochloride CTD PMID:25841332 Keap1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Keap1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of KEAP1 mRNA CTD PMID:21570461 Keap1 Rat 2,4-di-tert-butylphenol multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [SAG compound co-treated with 2 and 4-di-tert-butylphenol co-treated with Fibroblast Growth Factor 2] results in increased expression of KEAP1 mRNA CTD PMID:36682590 Keap1 Rat 2,4-dinitrotoluene affects expression EXP 6480464 2 and 4-dinitrotoluene affects the expression of KEAP1 mRNA CTD PMID:21346803 Keap1 Rat 2,5-dihydroxybenzoic acid multiple interactions ISO Keap1 (Mus musculus) 6480464 2 and 5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of KEAP1 mRNA] CTD PMID:37120126 Keap1 Rat 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO Keap1 (Mus musculus) 6480464 8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased degradation of KEAP1 protein] more ... CTD PMID:35691465 Keap1 Rat 2-tert-butylhydroquinone increases expression ISO KEAP1 (Homo sapiens) 6480464 2-tert-butylhydroquinone results in increased expression of KEAP1 protein CTD PMID:19033392 Keap1 Rat 2-tert-butylhydroquinone multiple interactions EXP 6480464 2-tert-butylhydroquinone promotes the reaction [thallium nitrate results in decreased expression of KEAP1 protein] CTD PMID:31726083 Keap1 Rat 2-tert-butylhydroquinone increases expression EXP 6480464 2-tert-butylhydroquinone results in increased expression of KEAP1 protein CTD PMID:31726083 Keap1 Rat 2-tert-butylhydroquinone decreases response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein mutant form results in decreased susceptibility to 2-tert-butylhydroquinone CTD PMID:23589329 Keap1 Rat 2-tert-butylhydroquinone multiple interactions ISO KEAP1 (Homo sapiens) 6480464 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein] more ... CTD PMID:18417180 and PMID:23589329 Keap1 Rat 2-tert-butylhydroquinone multiple interactions ISO Keap1 (Mus musculus) 6480464 2-tert-butylhydroquinone inhibits the reaction [2 more ... CTD PMID:18512965 more ... Keap1 Rat 2-tert-butylhydroquinone affects binding ISO Keap1 (Mus musculus) 6480464 2-tert-butylhydroquinone binds to KEAP1 protein CTD PMID:19808700 Keap1 Rat 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO KEAP1 (Homo sapiens) 6480464 3 more ... CTD PMID:24709675 Keap1 Rat 3,3',4,4',5-pentachlorobiphenyl affects expression ISO Keap1 (Mus musculus) 6480464 3 more ... CTD PMID:31563530 Keap1 Rat 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO KEAP1 (Homo sapiens) 6480464 3 more ... CTD PMID:24709675 Keap1 Rat 3,4-methylenedioxymethamphetamine decreases expression ISO Keap1 (Mus musculus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of KEAP1 mRNA CTD PMID:26251327 Keap1 Rat 3,4-methylenedioxymethamphetamine increases methylation ISO Keap1 (Mus musculus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of KEAP1 promoter CTD PMID:26251327 Keap1 Rat 3,5-diethoxycarbonyl-1,4-dihydrocollidine affects response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 gene affects the susceptibility to 3 more ... CTD PMID:30215777 Keap1 Rat 3,5-diethoxycarbonyl-1,4-dihydrocollidine multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 gene mutant form promotes the reaction [3 more ... CTD PMID:30825315 Keap1 Rat 3,5-diethoxycarbonyl-1,4-dihydrocollidine decreases response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 gene mutant form results in decreased susceptibility to 3 more ... CTD PMID:30825315 Keap1 Rat 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of KEAP1 protein CTD PMID:34915118 Keap1 Rat 3-methyladenine decreases expression ISO KEAP1 (Homo sapiens) 6480464 3-methyladenine results in decreased expression of KEAP1 protein CTD PMID:29781141 Keap1 Rat 3-methylcholanthrene increases expression ISO Keap1 (Mus musculus) 6480464 Methylcholanthrene results in increased expression of KEAP1 mRNA CTD PMID:23712962 Keap1 Rat 3-phenylprop-2-enal affects expression ISO Keap1 (Mus musculus) 6480464 cinnamaldehyde affects the expression of KEAP1 mRNA CTD PMID:28219650 Keap1 Rat 3-phenylprop-2-enal increases expression ISO KEAP1 (Homo sapiens) 6480464 cinnamaldehyde results in increased expression of KEAP1 protein CTD PMID:19033392 Keap1 Rat 4,4'-diaminodiphenylmethane decreases expression ISO Keap1 (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of KEAP1 mRNA CTD PMID:18648102 Keap1 Rat 4,4'-dipyridyl disulfide multiple interactions ISO Keap1 (Mus musculus) 6480464 4 more ... CTD PMID:15865434 Keap1 Rat 4,4'-sulfonyldiphenol increases expression ISO Keap1 (Mus musculus) 6480464 bisphenol S results in increased expression of KEAP1 mRNA and bisphenol S results in increased expression of KEAP1 protein CTD PMID:36541330 Keap1 Rat 4,4'-sulfonyldiphenol decreases methylation ISO KEAP1 (Homo sapiens) 6480464 bisphenol S results in decreased methylation of KEAP1 gene CTD PMID:31601247 Keap1 Rat 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2 and 6-dinitrotoluene affects the expression of KEAP1 mRNA CTD PMID:21346803 Keap1 Rat 5-aza-2'-deoxycytidine increases expression ISO KEAP1 (Homo sapiens) 6480464 Decitabine results in increased expression of KEAP1 mRNA CTD PMID:20124447 Keap1 Rat 5-aza-2'-deoxycytidine multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [Decitabine affects the methylation of KEAP1 promoter] which affects the expression of KEAP1 mRNA more ... CTD PMID:18555005 and PMID:26409248 Keap1 Rat 5-fluorouracil affects response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein affects the susceptibility to Fluorouracil CTD PMID:18692501 Keap1 Rat 7,12-dimethyltetraphene increases expression EXP 6480464 9 more ... CTD PMID:24995432 and PMID:33759307 Keap1 Rat 7,12-dimethyltetraphene multiple interactions EXP 6480464 betulin inhibits the reaction [9 more ... CTD PMID:24995432 and PMID:33759307 Keap1 Rat 7,8-dihydroxycoumarin decreases expression ISO KEAP1 (Homo sapiens) 6480464 daphnetin results in decreased expression of KEAP1 protein CTD PMID:30738023 Keap1 Rat [6]-Shogaol decreases expression ISO KEAP1 (Homo sapiens) 6480464 shogaol metabolite results in decreased expression of KEAP1 protein and shogaol results in decreased expression of KEAP1 protein CTD PMID:25148906 Keap1 Rat [6]-Shogaol multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein] more ... CTD PMID:23899529 Keap1 Rat [6]-Shogaol increases alkylation ISO KEAP1 (Homo sapiens) 6480464 shogaol results in increased alkylation of KEAP1 protein CTD PMID:25148906 Keap1 Rat acrolein multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein and Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein] CTD PMID:19608619 Keap1 Rat acrolein increases expression ISO Keap1 (Mus musculus) 6480464 Acrolein results in increased expression of KEAP1 protein CTD PMID:30608172 Keap1 Rat acrolein multiple interactions ISO Keap1 (Mus musculus) 6480464 [Ovalbumin co-treated with Acrolein] results in increased expression of KEAP1 protein CTD PMID:30608172 Keap1 Rat acrylamide affects expression EXP 6480464 Acrylamide affects the expression of KEAP1 protein CTD PMID:29426002 Keap1 Rat acrylamide increases expression ISO Keap1 (Mus musculus) 6480464 Acrylamide results in increased expression of KEAP1 mRNA CTD PMID:34896238 Keap1 Rat acrylamide multiple interactions EXP 6480464 [Acrylamide co-treated with INS protein] results in increased expression of KEAP1 mRNA CTD PMID:38604440 Keap1 Rat acrylamide multiple interactions ISO Keap1 (Mus musculus) 6480464 [NLRP3 gene mutant form affects the susceptibility to Acrylamide] which results in increased expression of KEAP1 protein and Acrylamide inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA] CTD PMID:32014472 and PMID:34896238 Keap1 Rat acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of KEAP1 mRNA CTD PMID:38604440 Keap1 Rat Aescin increases expression ISO Keap1 (Mus musculus) 6480464 Escin results in increased expression of KEAP1 protein CTD PMID:36905866 Keap1 Rat Aescin multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of KEAP1 protein] CTD PMID:36905866 Keap1 Rat Aescin multiple interactions ISO Keap1 (Mus musculus) 6480464 Escin inhibits the reaction [Dietary Fats results in increased expression of KEAP1 protein] more ... CTD PMID:36905866 Keap1 Rat aflatoxin B1 multiple interactions ISO Keap1 (Mus musculus) 6480464 Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 mRNA] and Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 protein] CTD PMID:35063475 Keap1 Rat aflatoxin B1 multiple interactions EXP 6480464 [Aflatoxin B1 co-treated with caryophyllene] results in increased expression of KEAP1 protein CTD PMID:34506763 Keap1 Rat aflatoxin B1 decreases expression ISO Keap1 (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of KEAP1 mRNA and Aflatoxin B1 results in decreased expression of KEAP1 protein CTD PMID:35063475 Keap1 Rat aldehydo-D-glucose multiple interactions ISO Keap1 (Mus musculus) 6480464 [NFE2L2 protein co-treated with KEAP1 protein] affects the abundance of Glucose CTD PMID:23017736 Keap1 Rat aldehydo-D-glucose multiple interactions ISO KEAP1 (Homo sapiens) 6480464 solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 mRNA] and solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 protein] CTD PMID:37586544 Keap1 Rat aldehydo-D-glucose increases expression ISO KEAP1 (Homo sapiens) 6480464 Glucose results in increased expression of KEAP1 mRNA and Glucose results in increased expression of KEAP1 protein CTD PMID:37586544 Keap1 Rat aldehydo-D-glucose multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of KEAP1 protein more ... CTD PMID:35191607 Keap1 Rat all-trans-retinoic acid multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [Tretinoin co-treated with arsenic trioxide] results in increased expression of KEAP1 mRNA CTD PMID:15894607 Keap1 Rat all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of KEAP1 protein CTD PMID:30267739 Keap1 Rat alpha,alpha-trehalose multiple interactions EXP 6480464 Trehalose inhibits the reaction [cadmium acetate results in decreased expression of KEAP1 protein] CTD PMID:29140578 Keap1 Rat alpha-D-galactose multiple interactions ISO Keap1 (Mus musculus) 6480464 albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 mRNA] and albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 protein] CTD PMID:33761044 Keap1 Rat alpha-D-galactose increases expression ISO Keap1 (Mus musculus) 6480464 Galactose results in increased expression of KEAP1 mRNA and Galactose results in increased expression of KEAP1 protein CTD PMID:33761044 Keap1 Rat Altertoxin II multiple interactions ISO KEAP1 (Homo sapiens) 6480464 altertoxin II results in increased expression of and affects the localization of KEAP1 protein CTD PMID:27178040 Keap1 Rat amiodarone decreases expression EXP 6480464 Amiodarone results in decreased expression of KEAP1 mRNA CTD PMID:17991464 Keap1 Rat amitraz multiple interactions EXP 6480464 KEAP1 protein affects the reaction [amitraz results in decreased expression of CAT protein] more ... CTD PMID:31029719 Keap1 Rat amitraz increases expression EXP 6480464 amitraz results in increased expression of KEAP1 protein CTD PMID:31029719 Keap1 Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of KEAP1 mRNA CTD PMID:16483693 Keap1 Rat Ammothamnine multiple interactions ISO Keap1 (Mus musculus) 6480464 [oxymatrine inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in increased stability of and results in increased localization of NFE2L2 protein and oxymatrine inhibits the reaction [KEAP1 protein binds to NFE2L2 protein] CTD PMID:37196756 Keap1 Rat andrographolide decreases expression ISO KEAP1 (Homo sapiens) 6480464 andrographolide results in decreased expression of KEAP1 mRNA and andrographolide results in decreased expression of KEAP1 protein CTD PMID:29355602 and PMID:35724838 Keap1 Rat anethole multiple interactions EXP 6480464 anethole inhibits the reaction [Isoproterenol results in increased expression of KEAP1 mRNA] and anethole inhibits the reaction [Isoproterenol results in increased expression of KEAP1 protein] CTD PMID:35430261 Keap1 Rat anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO KEAP1 (Homo sapiens) 6480464 pyrazolanthrone inhibits the reaction [pachastrissamine analog promotes the reaction [KEAP1 protein binds to SQSTM1 protein]] CTD PMID:35123989 Keap1 Rat aristolochic acid A multiple interactions ISO Keap1 (Mus musculus) 6480464 bardoxolone methyl inhibits the reaction [aristolochic acid I results in increased expression of KEAP1 protein] CTD PMID:24530882 Keap1 Rat aristolochic acid A decreases expression EXP 6480464 aristolochic acid I results in decreased expression of KEAP1 mRNA and aristolochic acid I results in decreased expression of KEAP1 protein CTD PMID:36037877 Keap1 Rat aristolochic acid A multiple interactions EXP 6480464 Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 mRNA] and Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 protein] CTD PMID:36037877 Keap1 Rat aristolochic acid A increases expression ISO KEAP1 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of KEAP1 mRNA CTD PMID:33212167 Keap1 Rat aristolochic acid A increases expression ISO Keap1 (Mus musculus) 6480464 aristolochic acid I results in increased expression of KEAP1 protein CTD PMID:24530882 Keap1 Rat arotinoid acid multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [4-(2-(5 more ... CTD PMID:34480604 Keap1 Rat arsane affects response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the susceptibility to Arsenic CTD PMID:19808700 Keap1 Rat arsane increases methylation ISO KEAP1 (Homo sapiens) 6480464 Arsenic results in increased methylation of KEAP1 promoter CTD PMID:29247444 Keap1 Rat arsane affects binding ISO Keap1 (Mus musculus) 6480464 Arsenic binds to KEAP1 protein CTD PMID:19808700 Keap1 Rat arsane increases expression ISO KEAP1 (Homo sapiens) 6480464 Arsenic results in increased expression of KEAP1 mRNA and Arsenic results in increased expression of KEAP1 protein CTD PMID:14567983 Keap1 Rat arsenic atom increases expression ISO KEAP1 (Homo sapiens) 6480464 Arsenic results in increased expression of KEAP1 mRNA and Arsenic results in increased expression of KEAP1 protein CTD PMID:14567983 Keap1 Rat arsenic atom increases methylation ISO KEAP1 (Homo sapiens) 6480464 Arsenic results in increased methylation of KEAP1 promoter CTD PMID:29247444 Keap1 Rat arsenic atom affects response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the susceptibility to Arsenic CTD PMID:19808700 Keap1 Rat arsenic atom affects binding ISO Keap1 (Mus musculus) 6480464 Arsenic binds to KEAP1 protein CTD PMID:19808700 Keap1 Rat arsenite(3-) decreases expression ISO KEAP1 (Homo sapiens) 6480464 arsenite results in decreased expression of KEAP1 mRNA and arsenite results in decreased expression of KEAP1 protein CTD PMID:22476201 Keap1 Rat arsenite(3-) affects response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein affects the susceptibility to arsenite CTD PMID:22476201 Keap1 Rat arsenite(3-) multiple interactions ISO KEAP1 (Homo sapiens) 6480464 epigallocatechin gallate promotes the reaction [arsenite results in increased expression of KEAP1 mRNA] more ... CTD PMID:22476201 and PMID:29572906 Keap1 Rat arsenite(3-) increases expression ISO KEAP1 (Homo sapiens) 6480464 arsenite results in increased expression of KEAP1 mRNA and arsenite results in increased expression of KEAP1 protein CTD PMID:22476201 and PMID:29572906 Keap1 Rat arsenous acid decreases response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:22684020 Keap1 Rat arsenous acid multiple interactions ISO Keap1 (Mus musculus) 6480464 18alpha and 20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate inhibits the reaction [Arsenic Trioxide results in increased expression of KEAP1 protein] CTD PMID:33846815 Keap1 Rat arsenous acid increases expression ISO Keap1 (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of KEAP1 protein CTD PMID:33846815 Keap1 Rat arsenous acid multiple interactions EXP 6480464 crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein] CTD PMID:32920515 Keap1 Rat arsenous acid increases expression ISO KEAP1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of KEAP1 mRNA and Arsenic Trioxide results in increased expression of KEAP1 protein CTD PMID:15894607 more ... Keap1 Rat arsenous acid affects response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 gene mutant form affects the susceptibility to Arsenic Trioxide CTD PMID:30815697 Keap1 Rat arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of KEAP1 protein CTD PMID:24634002 and PMID:32920515 Keap1 Rat arsenous acid increases response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 mRNA results in increased susceptibility to Arsenic Trioxide CTD PMID:26708503 Keap1 Rat arsenous acid multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of KEAP1 mRNA more ... CTD PMID:15894607 more ... Keap1 Rat arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of KEAP1 mRNA CTD PMID:29223816 Keap1 Rat atrazine decreases expression ISO KEAP1 (Homo sapiens) 6480464 Atrazine results in decreased expression of KEAP1 mRNA CTD PMID:22378314 Keap1 Rat atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of KEAP1 mRNA and Atrazine results in decreased expression of KEAP1 protein CTD PMID:34624533 Keap1 Rat atrazine decreases expression ISO Keap1 (Mus musculus) 6480464 Atrazine results in decreased expression of KEAP1 mRNA and Atrazine results in decreased expression of KEAP1 protein CTD PMID:30360616 more ... Keap1 Rat atrazine multiple interactions ISO Keap1 (Mus musculus) 6480464 Lycopene inhibits the reaction [Atrazine results in decreased expression of KEAP1 mRNA] and Lycopene inhibits the reaction [Atrazine results in decreased expression of KEAP1 protein] CTD PMID:30360616 and PMID:36216167 Keap1 Rat aureusidin decreases expression EXP 6480464 aureusidin results in decreased expression of KEAP1 mRNA and aureusidin results in decreased expression of KEAP1 protein CTD PMID:31790703 Keap1 Rat azathioprine affects response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the susceptibility to Azathioprine CTD PMID:21803983 Keap1 Rat bafilomycin A1 multiple interactions ISO KEAP1 (Homo sapiens) 6480464 bafilomycin A1 promotes the reaction [pachastrissamine analog promotes the reaction [KEAP1 protein binds to SQSTM1 protein]] CTD PMID:35123989 Keap1 Rat baicalin multiple interactions ISO Keap1 (Mus musculus) 6480464 baicalin inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:38016618 Keap1 Rat Bardoxolone methyl increases expression ISO KEAP1 (Homo sapiens) 6480464 bardoxolone methyl results in increased expression of KEAP1 protein CTD PMID:27358234 Keap1 Rat Bardoxolone methyl decreases expression ISO KEAP1 (Homo sapiens) 6480464 bardoxolone methyl results in decreased expression of KEAP1 mRNA CTD PMID:35724838 Keap1 Rat Bardoxolone methyl multiple interactions ISO Keap1 (Mus musculus) 6480464 bardoxolone methyl inhibits the reaction [aristolochic acid I results in increased expression of KEAP1 protein] CTD PMID:24530882 Keap1 Rat belinostat decreases expression ISO KEAP1 (Homo sapiens) 6480464 belinostat results in decreased expression of KEAP1 mRNA CTD PMID:19606018 Keap1 Rat benzene decreases expression ISO KEAP1 (Homo sapiens) 6480464 Benzene results in decreased expression of KEAP1 mRNA CTD PMID:33064461 Keap1 Rat benzene increases expression ISO Keap1 (Mus musculus) 6480464 Benzene results in increased expression of KEAP1 protein CTD PMID:36306860 Keap1 Rat benzene-1,2,4-triol increases expression ISO KEAP1 (Homo sapiens) 6480464 hydroxyhydroquinone results in increased expression of KEAP1 mRNA CTD PMID:17572062 Keap1 Rat benzo[a]pyrene increases expression ISO Keap1 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of KEAP1 mRNA CTD PMID:21569818 and PMID:22228805 Keap1 Rat benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of KEAP1 protein CTD PMID:36736873 Keap1 Rat benzo[a]pyrene increases expression ISO KEAP1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of KEAP1 mRNA CTD PMID:20106945 more ... Keap1 Rat benzo[a]pyrene decreases expression ISO KEAP1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of KEAP1 mRNA and Benzo(a)pyrene results in decreased expression of KEAP1 protein CTD PMID:20498004 and PMID:25946486 Keap1 Rat benzo[a]pyrene diol epoxide I decreases expression ISO KEAP1 (Homo sapiens) 6480464 7 more ... CTD PMID:19150397 Keap1 Rat benzoquinones multiple interactions ISO Keap1 (Mus musculus) 6480464 Benzoquinones analog binds to and results in increased metabolism of KEAP1 protein CTD PMID:21651925 Keap1 Rat betulin multiple interactions EXP 6480464 betulin inhibits the reaction [9 more ... CTD PMID:33759307 Keap1 Rat bis(2-ethylhexyl) phthalate multiple interactions ISO Keap1 (Mus musculus) 6480464 Lycopene inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of KEAP1 mRNA] more ... CTD PMID:35917956 and PMID:36610486 Keap1 Rat bis(2-ethylhexyl) phthalate increases expression ISO Keap1 (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of KEAP1 protein CTD PMID:36610486 Keap1 Rat bis(2-ethylhexyl) phthalate decreases expression ISO Keap1 (Mus musculus) 6480464 Diethylhexyl Phthalate results in decreased expression of KEAP1 mRNA and Diethylhexyl Phthalate results in decreased expression of KEAP1 protein CTD PMID:35917956 Keap1 Rat bisdemethoxycurcumin multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 protein inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA] CTD PMID:17535857 Keap1 Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of KEAP1 mRNA CTD PMID:25181051 Keap1 Rat bisphenol A increases expression ISO Keap1 (Mus musculus) 6480464 bisphenol A results in increased expression of KEAP1 mRNA CTD PMID:32156529 Keap1 Rat bisphenol A decreases expression EXP 6480464 bisphenol A analog results in decreased expression of KEAP1 mRNA and bisphenol A analog results in decreased expression of KEAP1 protein CTD PMID:35427877 Keap1 Rat bisphenol A multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [[ginger extract results in increased abundance of Oils and Volatile] which co-treated with bisphenol A] affects the expression of KEAP1 protein CTD PMID:33376534 Keap1 Rat bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of KEAP1 gene CTD PMID:28505145 Keap1 Rat bleomycin A2 multiple interactions EXP 6480464 celastrol inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein] CTD PMID:26768587 Keap1 Rat bleomycin A2 increases expression ISO KEAP1 (Homo sapiens) 6480464 Bleomycin results in increased expression of KEAP1 protein CTD PMID:37778983 Keap1 Rat bleomycin A2 multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Ephedrine inhibits the reaction [Bleomycin results in increased expression of KEAP1 protein] CTD PMID:37778983 Keap1 Rat bleomycin A2 decreases expression EXP 6480464 Bleomycin results in decreased expression of KEAP1 protein CTD PMID:26768587 Keap1 Rat bromosulfophthalein decreases glutathionylation ISO Keap1 (Mus musculus) 6480464 KEAP1 protein results in decreased glutathionylation of Sulfobromophthalein CTD PMID:19246623 Keap1 Rat bromosulfophthalein decreases transport ISO Keap1 (Mus musculus) 6480464 KEAP1 protein results in decreased transport of Sulfobromophthalein CTD PMID:19246623 Keap1 Rat Brusatol multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [KEAP1 protein results in decreased expression of NFE2L2 protein] which results in decreased susceptibility to brusatol more ... CTD PMID:21205897 and PMID:32682831 Keap1 Rat Brusatol multiple interactions EXP 6480464 brusatol inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KEAP1 protein] CTD PMID:34695510 Keap1 Rat buspirone multiple interactions EXP 6480464 Buspirone inhibits the reaction [Methotrexate results in increased expression of KEAP1 mRNA] CTD PMID:37341015 Keap1 Rat C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of KEAP1 mRNA CTD PMID:19167457 Keap1 Rat cadmium atom increases degradation EXP 6480464 Cadmium results in increased degradation of KEAP1 protein CTD PMID:27658547 Keap1 Rat cadmium atom increases expression ISO Keap1 (Mus musculus) 6480464 Cadmium results in increased expression of KEAP1 mRNA CTD PMID:37270049 Keap1 Rat cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KEAP1 mRNA more ... CTD PMID:34695510 and PMID:36718047 Keap1 Rat cadmium dichloride decreases expression ISO Keap1 (Mus musculus) 6480464 Cadmium Chloride results in decreased expression of KEAP1 mRNA CTD PMID:20061341 Keap1 Rat cadmium dichloride decreases expression ISO KEAP1 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of KEAP1 mRNA and Cadmium Chloride results in decreased expression of KEAP1 protein CTD PMID:35122928 and PMID:38568856 Keap1 Rat cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of KEAP1 protein CTD PMID:35122928 Keap1 Rat cadmium dichloride affects folding ISO Keap1 (Mus musculus) 6480464 Cadmium Chloride affects the folding of KEAP1 protein CTD PMID:30261176 Keap1 Rat cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of KEAP1 mRNA more ... CTD PMID:34695510 and PMID:36718047 Keap1 Rat cadmium dichloride affects binding ISO Keap1 (Mus musculus) 6480464 Cadmium Chloride binds to KEAP1 protein CTD PMID:19808700 and PMID:26827822 Keap1 Rat cadmium dichloride multiple interactions ISO Keap1 (Mus musculus) 6480464 [Cadmium Chloride affects the reaction [NFE2L2 protein binds to KEAP1 protein]] affects the localization of [NFE2L2 protein binds to KEAP1 protein] more ... CTD PMID:18512965 more ... Keap1 Rat carbendazim multiple interactions EXP 6480464 Chitosan inhibits the reaction [carbendazim results in increased expression of KEAP1 mRNA] CTD PMID:35705592 Keap1 Rat carbendazim increases expression EXP 6480464 carbendazim results in increased expression of KEAP1 mRNA CTD PMID:35705592 Keap1 Rat carbon disulfide decreases expression EXP 6480464 Carbon Disulfide results in decreased expression of KEAP1 protein CTD PMID:27530093 Keap1 Rat carbon monoxide multiple interactions ISO Keap1 (Mus musculus) 6480464 Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:18845810 Keap1 Rat CCCP multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [[Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in decreased activity of NFE2L2 protein more ... CTD PMID:30715550 Keap1 Rat celastrol multiple interactions EXP 6480464 celastrol inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein] CTD PMID:26768587 Keap1 Rat CGP 52608 multiple interactions ISO KEAP1 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to KEAP1 gene] CTD PMID:28238834 Keap1 Rat chalcones decreases expression EXP 6480464 Chalcones analog results in decreased expression of KEAP1 protein CTD PMID:23963778 Keap1 Rat CHIR 99021 multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [4-(2-(5 more ... CTD PMID:34480604 Keap1 Rat chitosan multiple interactions EXP 6480464 Chitosan inhibits the reaction [carbendazim results in increased expression of KEAP1 mRNA] CTD PMID:35705592 Keap1 Rat chlorambucil multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil and Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil] CTD PMID:19608619 Keap1 Rat chloroacetaldehyde increases expression ISO KEAP1 (Homo sapiens) 6480464 chloroacetaldehyde results in increased expression of KEAP1 mRNA CTD PMID:25596134 Keap1 Rat choline multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of CD36 mRNA] more ... CTD PMID:20350562 Keap1 Rat cidofovir anhydrous increases expression ISO KEAP1 (Homo sapiens) 6480464 Cidofovir results in increased expression of KEAP1 mRNA CTD PMID:25596134 Keap1 Rat cisplatin multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of KEAP1 mRNA and [KEAP1 protein results in decreased stability of NFE2L2 protein] which results in increased susceptibility to Cisplatin CTD PMID:20530669 and PMID:27392435 Keap1 Rat cisplatin affects expression EXP 6480464 Cisplatin affects the expression of KEAP1 protein CTD PMID:30125553 Keap1 Rat cisplatin increases expression ISO KEAP1 (Homo sapiens) 6480464 Cisplatin results in increased expression of KEAP1 mRNA CTD PMID:25596134 and PMID:27594783 Keap1 Rat cisplatin increases response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein results in increased susceptibility to Cisplatin CTD PMID:25841332 Keap1 Rat Clivoline increases expression ISO KEAP1 (Homo sapiens) 6480464 clivorine results in increased expression of KEAP1 mRNA CTD PMID:25881548 Keap1 Rat clodronic acid increases expression ISO KEAP1 (Homo sapiens) 6480464 Clodronic Acid results in increased expression of KEAP1 mRNA CTD PMID:25596134 Keap1 Rat clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KEAP1 mRNA CTD PMID:17602206 Keap1 Rat cobalt atom multiple interactions ISO Keap1 (Mus musculus) 6480464 Zinc inhibits the reaction [Cobalt binds to KEAP1 protein] CTD PMID:15865434 Keap1 Rat cobalt atom affects binding ISO Keap1 (Mus musculus) 6480464 Cobalt binds to KEAP1 protein CTD PMID:15865434 Keap1 Rat cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of KEAP1 mRNA CTD PMID:24386269 Keap1 Rat cobalt dichloride affects response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein affects the susceptibility to cobaltous chloride CTD PMID:29966676 Keap1 Rat cobalt dichloride multiple interactions ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein inhibits the reaction [cobaltous chloride results in increased expression of GCLC mRNA] more ... CTD PMID:29966676 Keap1 Rat colistin increases expression ISO Keap1 (Mus musculus) 6480464 Colistin results in increased expression of KEAP1 mRNA and Colistin results in increased expression of KEAP1 protein CTD PMID:34560125 Keap1 Rat copper atom multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which affects the expression of KEAP1 mRNA and [Chelating Agents binds to Copper] which results in increased expression of KEAP1 mRNA CTD PMID:30911355 Keap1 Rat copper(0) multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which affects the expression of KEAP1 mRNA and [Chelating Agents binds to Copper] which results in increased expression of KEAP1 mRNA CTD PMID:30911355 Keap1 Rat copper(II) sulfate multiple interactions ISO Keap1 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Copper Sulfate results in decreased expression of KEAP1 mRNA] more ... CTD PMID:37353053 Keap1 Rat copper(II) sulfate decreases expression ISO Keap1 (Mus musculus) 6480464 Copper Sulfate results in decreased expression of KEAP1 mRNA and Copper Sulfate results in decreased expression of KEAP1 protein CTD PMID:37353053 Keap1 Rat cortisol multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [4-(2-(5 more ... CTD PMID:34480604 Keap1 Rat crocin-1 multiple interactions EXP 6480464 crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein] CTD PMID:32920515 Keap1 Rat CU-O LINKAGE decreases expression ISO KEAP1 (Homo sapiens) 6480464 cupric oxide results in decreased expression of KEAP1 mRNA CTD PMID:32285662 Keap1 Rat cumene hydroperoxide multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide and Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide] CTD PMID:19608619 Keap1 Rat curcumin multiple interactions ISO Keap1 (Mus musculus) 6480464 Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 mRNA] more ... CTD PMID:17535857 and PMID:35063475 Keap1 Rat curcumin decreases expression EXP 6480464 Curcumin analog results in decreased expression of KEAP1 protein and Curcumin results in decreased expression of KEAP1 protein CTD PMID:30946834 Keap1 Rat curcumin multiple interactions EXP 6480464 Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein] more ... CTD PMID:30946834 and PMID:36037877 Keap1 Rat curcumin multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of KEAP1 mRNA] and Curcumin inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein] CTD PMID:31521693 and PMID:34758851 Keap1 Rat curcumin increases expression ISO KEAP1 (Homo sapiens) 6480464 Curcumin results in increased expression of KEAP1 mRNA CTD PMID:23710286 Keap1 Rat curcumin decreases expression ISO Keap1 (Mus musculus) 6480464 Curcumin analog results in decreased expression of KEAP1 protein CTD PMID:26991801 Keap1 Rat curcumin decreases expression ISO KEAP1 (Homo sapiens) 6480464 Curcumin results in decreased expression of KEAP1 mRNA CTD PMID:31521693 Keap1 Rat cyclophosphamide multiple interactions EXP 6480464 Quercetin inhibits the reaction [Cyclophosphamide results in decreased expression of KEAP1 mRNA] CTD PMID:37419146 Keap1 Rat cyclophosphamide decreases expression EXP 6480464 Cyclophosphamide results in decreased expression of KEAP1 mRNA CTD PMID:37419146 Keap1 Rat cyclosporin A increases expression ISO KEAP1 (Homo sapiens) 6480464 Cyclosporine results in increased expression of KEAP1 mRNA CTD PMID:25596134 Keap1 Rat cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of KEAP1 mRNA CTD PMID:25596134 Keap1 Rat D-glucose multiple interactions ISO Keap1 (Mus musculus) 6480464 [NFE2L2 protein co-treated with KEAP1 protein] affects the abundance of Glucose CTD PMID:23017736 Keap1 Rat D-glucose multiple interactions ISO KEAP1 (Homo sapiens) 6480464 solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 mRNA] and solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 protein] CTD PMID:37586544 Keap1 Rat D-glucose increases expression ISO KEAP1 (Homo sapiens) 6480464 Glucose results in increased expression of KEAP1 mRNA and Glucose results in increased expression of KEAP1 protein CTD PMID:37586544 Keap1 Rat D-glucose multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of KEAP1 protein more ... CTD PMID:35191607 Keap1 Rat decabromodiphenyl ether increases expression ISO KEAP1 (Homo sapiens) 6480464 decabromobiphenyl ether results in increased expression of KEAP1 mRNA and decabromobiphenyl ether results in increased expression of KEAP1 protein CTD PMID:34571075 and PMID:35266255 Keap1 Rat decabromodiphenyl ether decreases expression ISO KEAP1 (Homo sapiens) 6480464 decabromobiphenyl ether results in decreased expression of KEAP1 protein CTD PMID:33675858 Keap1 Rat decabromodiphenyl ether multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Luteolin inhibits the reaction [decabromobiphenyl ether results in decreased expression of KEAP1 protein] CTD PMID:33675858 Keap1 Rat deguelin increases expression ISO KEAP1 (Homo sapiens) 6480464 deguelin results in increased expression of KEAP1 mRNA CTD PMID:33512557 Keap1 Rat demethoxycurcumin multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 protein inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA] CTD PMID:17535857 Keap1 Rat Dendrobine multiple interactions ISO KEAP1 (Homo sapiens) 6480464 dendrobine inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 mRNA] more ... CTD PMID:36058301 Keap1 Rat deoxynivalenol multiple interactions ISO Keap1 (Mus musculus) 6480464 Selenomethionine inhibits the reaction [deoxynivalenol results in increased expression of KEAP1 protein] CTD PMID:38040082 Keap1 Rat deoxynivalenol decreases expression ISO Keap1 (Mus musculus) 6480464 deoxynivalenol results in decreased expression of KEAP1 mRNA CTD PMID:34400200 Keap1 Rat deoxynivalenol increases expression ISO Keap1 (Mus musculus) 6480464 deoxynivalenol results in increased expression of KEAP1 protein CTD PMID:38040082 Keap1 Rat diallyl disulfide decreases expression ISO Keap1 (Mus musculus) 6480464 diallyl disulfide results in decreased expression of KEAP1 protein CTD PMID:34896185 Keap1 Rat diallyl disulfide multiple interactions ISO Keap1 (Mus musculus) 6480464 diallyl disulfide promotes the reaction [lipopolysaccharide and Escherichia coli O111 B4 results in decreased expression of KEAP1 protein] CTD PMID:34896185 Keap1 Rat diallyl trisulfide decreases expression EXP 6480464 diallyl trisulfide results in decreased expression of KEAP1 protein CTD PMID:23453443 Keap1 Rat diallyl trisulfide multiple interactions ISO KEAP1 (Homo sapiens) 6480464 diallyl trisulfide promotes the reaction [KEAP1 mutant form affects the localization of NFE2L2 protein] CTD PMID:24489685 Keap1 Rat diallyl trisulfide affects binding ISO KEAP1 (Homo sapiens) 6480464 diallyl trisulfide binds to KEAP1 protein CTD PMID:24489685 Keap1 Rat diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of KEAP1 mRNA CTD PMID:29223816 Keap1 Rat diarsenic trioxide multiple interactions ISO Keap1 (Mus musculus) 6480464 18alpha and 20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate inhibits the reaction [Arsenic Trioxide results in increased expression of KEAP1 protein] CTD PMID:33846815 Keap1 Rat diarsenic trioxide increases expression ISO Keap1 (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of KEAP1 protein CTD PMID:33846815 Keap1 Rat diarsenic trioxide multiple interactions EXP 6480464 crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein] CTD PMID:32920515 Keap1 Rat diarsenic trioxide increases expression ISO KEAP1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of KEAP1 mRNA and Arsenic Trioxide results in increased expression of KEAP1 protein CTD PMID:15894607 more ... Keap1 Rat diarsenic trioxide increases response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 mRNA results in increased susceptibility to Arsenic Trioxide CTD PMID:26708503 Keap1 Rat diarsenic trioxide multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of KEAP1 mRNA more ... CTD PMID:15894607 more ... Keap1 Rat diarsenic trioxide affects response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 gene mutant form affects the susceptibility to Arsenic Trioxide CTD PMID:30815697 Keap1 Rat diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of KEAP1 protein CTD PMID:24634002 and PMID:32920515 Keap1 Rat diarsenic trioxide decreases response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:22684020 Keap1 Rat Dibutyl phosphate affects expression ISO KEAP1 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of KEAP1 mRNA CTD PMID:37042841 Keap1 Rat dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of KEAP1 mRNA CTD PMID:21266533 Keap1 Rat dibutyl phthalate decreases expression ISO Keap1 (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of KEAP1 mRNA CTD PMID:17361019 Keap1 Rat dichloroacetyl chloride increases expression ISO Keap1 (Mus musculus) 6480464 2 more ... CTD PMID:32073640 Keap1 Rat dichloroacetyl chloride multiple interactions ISO Keap1 (Mus musculus) 6480464 2-tert-butylhydroquinone inhibits the reaction [2 more ... CTD PMID:32073640 Keap1 Rat diethyl maleate increases expression ISO KEAP1 (Homo sapiens) 6480464 diethyl maleate results in increased expression of KEAP1 mRNA and diethyl maleate results in increased expression of KEAP1 protein CTD PMID:27358234 more ... Keap1 Rat diethyl phthalate increases expression ISO Keap1 (Mus musculus) 6480464 diethyl phthalate results in increased expression of KEAP1 protein CTD PMID:37942807 Keap1 Rat diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of KEAP1 mRNA CTD PMID:37077353 Keap1 Rat dihydroartemisinin affects binding ISO KEAP1 (Homo sapiens) 6480464 artenimol analog binds to KEAP1 protein CTD PMID:26340163 Keap1 Rat dimercaprol affects binding ISO Keap1 (Mus musculus) 6480464 Dimercaprol binds to KEAP1 protein CTD PMID:19808700 Keap1 Rat dioscin multiple interactions EXP 6480464 dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:28082111 Keap1 Rat diosmetin multiple interactions EXP 6480464 diosmetin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of KEAP1 protein] more ... CTD PMID:35191607 Keap1 Rat dioxygen decreases expression ISO KEAP1 (Homo sapiens) 6480464 Oxygen deficiency results in decreased expression of KEAP1 mRNA and Oxygen deficiency results in decreased expression of KEAP1 protein CTD PMID:25596134 and PMID:34023435 Keap1 Rat dioxygen multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [Ozone co-treated with Oxygen] inhibits the reaction [KEAP1 protein results in increased degradation of NFE2L2 protein] and [Ozone co-treated with Oxygen] results in increased expression of KEAP1 protein CTD PMID:26270818 and PMID:29864481 Keap1 Rat dioxygen multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of KEAP1 protein more ... CTD PMID:29139225 and PMID:35191607 Keap1 Rat dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of KEAP1 protein CTD PMID:29139225 Keap1 Rat diquat multiple interactions ISO Keap1 (Mus musculus) 6480464 [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA more ... CTD PMID:22762311 Keap1 Rat diquat decreases expression ISO Keap1 (Mus musculus) 6480464 Diquat results in decreased expression of KEAP1 protein CTD PMID:36851058 Keap1 Rat disodium selenite multiple interactions EXP 6480464 Sodium Selenite inhibits the reaction [Sodium Fluoride results in decreased expression of KEAP1 mRNA] CTD PMID:36736877 Keap1 Rat divanadium pentaoxide decreases expression ISO KEAP1 (Homo sapiens) 6480464 vanadium pentoxide results in decreased expression of KEAP1 mRNA CTD PMID:17459161 Keap1 Rat dorsomorphin multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Keap1 Rat doxorubicin decreases response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein results in decreased susceptibility to Doxorubicin CTD PMID:22684020 Keap1 Rat doxorubicin increases expression ISO KEAP1 (Homo sapiens) 6480464 Doxorubicin results in increased expression of KEAP1 mRNA CTD PMID:29803840 Keap1 Rat doxorubicin increases expression ISO Keap1 (Mus musculus) 6480464 Doxorubicin results in increased expression of KEAP1 protein CTD PMID:29775573 and PMID:36811345 Keap1 Rat doxorubicin multiple interactions ISO Keap1 (Mus musculus) 6480464 indole-3-carbinol inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] and naringin inhibits the reaction [Doxorubicin results in decreased expression of KEAP1 protein] CTD PMID:29775573 and PMID:36811345 Keap1 Rat doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of KEAP1 protein CTD PMID:28082111 and PMID:37030624 Keap1 Rat doxorubicin multiple interactions EXP 6480464 dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] and SIRT1 protein affects the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:28082111 and PMID:37030624 Keap1 Rat doxorubicin increases response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 mRNA results in increased susceptibility to Doxorubicin CTD PMID:26708503 Keap1 Rat doxorubicin multiple interactions ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein results in decreased export of and results in increased susceptibility to Doxorubicin CTD PMID:25841332 Keap1 Rat doxorubicin affects response to substance EXP 6480464 KEAP1 protein affects the susceptibility to Doxorubicin CTD PMID:24211725 Keap1 Rat doxorubicin increases degradation EXP 6480464 Doxorubicin results in increased degradation of KEAP1 protein CTD PMID:24211725 Keap1 Rat doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of KEAP1 protein CTD PMID:24211725 Keap1 Rat elemental selenium increases expression ISO KEAP1 (Homo sapiens) 6480464 Selenium results in increased expression of KEAP1 mRNA CTD PMID:19244175 Keap1 Rat ethanol multiple interactions ISO Keap1 (Mus musculus) 6480464 [dihydromyricetin co-treated with Ethanol] results in decreased expression of KEAP1 protein CTD PMID:28419832 Keap1 Rat ethanol affects splicing ISO Keap1 (Mus musculus) 6480464 Ethanol affects the splicing of KEAP1 mRNA CTD PMID:30319688 Keap1 Rat ethionamide multiple interactions ISO KEAP1 (Homo sapiens) 6480464 KEAP1 mRNA inhibits the reaction [Ethionamide results in increased susceptibility to arsenic trioxide] CTD PMID:26708503 Keap1 Rat ethylene glycol bis(2-aminoethyl)tetraacetic acid multiple interactions ISO Keap1 (Mus musculus) 6480464 Egtazic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 Keap1 Rat ethylenediaminetetraacetic acid multiple interactions ISO Keap1 (Mus musculus) 6480464 Edetic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 Keap1 Rat etoposide decreases response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein results in decreased susceptibility to Etoposide CTD PMID:22684020 Keap1 Rat etoposide multiple interactions ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein affects the reaction [Etoposide results in increased expression of CDKN1A protein] CTD PMID:27982581 Keap1 Rat etoposide increases response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 mRNA results in increased susceptibility to Etoposide CTD PMID:26708503 Keap1 Rat falcarindiol decreases activity EXP 6480464 falcarindiol results in decreased activity of KEAP1 protein CTD PMID:20026152 Keap1 Rat falcarindiol affects folding EXP 6480464 falcarindiol affects the folding of KEAP1 protein CTD PMID:20026152 Keap1 Rat falcarindiol multiple interactions EXP 6480464 falcarindiol binds to and results in increased alkylation of KEAP1 protein more ... CTD PMID:20026152 Keap1 Rat farrerol decreases expression ISO Keap1 (Mus musculus) 6480464 farrerol results in decreased expression of KEAP1 protein CTD PMID:26111761 Keap1 Rat fenofibrate multiple interactions ISO Keap1 (Mus musculus) 6480464 Fenofibrate inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein] CTD PMID:36905866 Keap1 Rat finasteride increases expression EXP 6480464 Finasteride results in increased expression of KEAP1 mRNA CTD PMID:24136188 Keap1 Rat flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of KEAP1 mRNA CTD PMID:18035473 Keap1 Rat flutamide increases expression EXP 6480464 Flutamide results in increased expression of KEAP1 mRNA CTD PMID:24136188 Keap1 Rat folic acid multiple interactions ISO Keap1 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KEAP1 mRNA CTD PMID:22206623 Keap1 Rat fumonisin B1 decreases expression ISO KEAP1 (Homo sapiens) 6480464 fumonisin B1 results in decreased expression of KEAP1 mRNA and fumonisin B1 results in decreased expression of KEAP1 protein CTD PMID:33496827 Keap1 Rat fumonisin B1 decreases expression ISO Keap1 (Mus musculus) 6480464 fumonisin B1 results in decreased expression of KEAP1 mRNA CTD PMID:35697133 Keap1 Rat fumonisin B1 multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [fumonisin B1 results in increased methylation of KEAP1 promoter] which results in decreased expression of KEAP1 mRNA CTD PMID:33496827 Keap1 Rat fumonisin B1 increases methylation ISO KEAP1 (Homo sapiens) 6480464 fumonisin B1 results in increased methylation of KEAP1 promoter CTD PMID:33496827 Keap1 Rat galactose multiple interactions ISO Keap1 (Mus musculus) 6480464 albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 mRNA] and albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 protein] CTD PMID:33761044 Keap1 Rat galactose increases expression ISO Keap1 (Mus musculus) 6480464 Galactose results in increased expression of KEAP1 mRNA and Galactose results in increased expression of KEAP1 protein CTD PMID:33761044 Keap1 Rat gefitinib increases expression ISO KEAP1 (Homo sapiens) 6480464 gefitinib results in increased expression of KEAP1 mRNA CTD PMID:27639429 Keap1 Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of KEAP1 mRNA CTD PMID:33387578 Keap1 Rat ginsenoside Rg1 multiple interactions ISO Keap1 (Mus musculus) 6480464 ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein] CTD PMID:29964319 Keap1 Rat gliclazide multiple interactions EXP 6480464 Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA] and Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein] CTD PMID:21439372 Keap1 Rat glucose multiple interactions ISO Keap1 (Mus musculus) 6480464 [NFE2L2 protein co-treated with KEAP1 protein] affects the abundance of Glucose CTD PMID:23017736 Keap1 Rat glucose multiple interactions ISO KEAP1 (Homo sapiens) 6480464 solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 mRNA] and solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 protein] CTD PMID:37586544 Keap1 Rat glucose increases expression ISO KEAP1 (Homo sapiens) 6480464 Glucose results in increased expression of KEAP1 mRNA and Glucose results in increased expression of KEAP1 protein CTD PMID:37586544 Keap1 Rat glucose multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of KEAP1 protein more ... CTD PMID:35191607 Keap1 Rat glutathione multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione more ... CTD PMID:19608619 and PMID:21972102 Keap1 Rat glutathione increases abundance ISO Keap1 (Mus musculus) 6480464 KEAP1 gene mutant form results in increased abundance of Glutathione CTD PMID:26827822 Keap1 Rat glutathione multiple interactions EXP 6480464 Glutathione inhibits the reaction [falcarindiol binds to and results in increased alkylation of KEAP1 protein] CTD PMID:20026152 Keap1 Rat glutathione multiple interactions ISO Keap1 (Mus musculus) 6480464 [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA more ... CTD PMID:20800667 more ... Keap1 Rat glyburide multiple interactions EXP 6480464 Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of KEAP1 mRNA] and Glyburide inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 and PMID:36510688 Keap1 Rat glyphosate increases expression ISO KEAP1 (Homo sapiens) 6480464 Glyphosate results in increased expression of KEAP1 mRNA CTD PMID:36625791 Keap1 Rat hemin decreases expression ISO Keap1 (Mus musculus) 6480464 Hemin results in decreased expression of KEAP1 protein CTD PMID:27777014 Keap1 Rat hesperetin affects binding ISO KEAP1 (Homo sapiens) 6480464 hesperetin binds to KEAP1 protein CTD PMID:37487865 Keap1 Rat hexadecanoic acid multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [Palmitic Acid co-treated with Oleic Acid] results in increased expression of KEAP1 protein and Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of KEAP1 protein] CTD PMID:36905866 Keap1 Rat hexaflumuron decreases expression EXP 6480464 hexafluoron results in decreased expression of KEAP1 mRNA CTD PMID:34993831 Keap1 Rat homocysteine increases expression ISO KEAP1 (Homo sapiens) 6480464 Homocysteine results in increased expression of KEAP1 protein CTD PMID:22964297 Keap1 Rat hydrogen peroxide increases expression ISO KEAP1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of KEAP1 mRNA and Hydrogen Peroxide results in increased expression of KEAP1 protein CTD PMID:31705858 and PMID:36058301 Keap1 Rat hydrogen peroxide multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] more ... CTD PMID:30104959 and PMID:32275923 Keap1 Rat hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of KEAP1 protein CTD PMID:32275923 Keap1 Rat hydrogen peroxide multiple interactions ISO KEAP1 (Homo sapiens) 6480464 4-((alpha-L-rhamnosyloxy)benzyl)isothiocyanate inhibits the reaction [Hydrogen Peroxide results in decreased expression of KEAP1 mRNA] more ... CTD PMID:25742418 more ... Keap1 Rat hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of KEAP1 protein CTD PMID:30104959 Keap1 Rat hydrogen peroxide decreases expression ISO KEAP1 (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of KEAP1 mRNA and Hydrogen Peroxide results in decreased expression of KEAP1 protein CTD PMID:23410634 more ... Keap1 Rat hydrogen peroxide multiple interactions ISO Keap1 (Mus musculus) 6480464 Hydrogen Peroxide promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]] CTD PMID:15865434 Keap1 Rat hydrogen sulfide multiple interactions EXP 6480464 [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] and [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in increased expression of KEAP1 protein] CTD PMID:32064027 Keap1 Rat hydroquinone decreases expression ISO KEAP1 (Homo sapiens) 6480464 hydroquinone results in decreased expression of KEAP1 protein CTD PMID:36646296 Keap1 Rat hydroquinone decreases expression ISO Keap1 (Mus musculus) 6480464 hydroquinone results in decreased expression of KEAP1 protein CTD PMID:23290930 Keap1 Rat hypochlorous acid increases expression ISO Keap1 (Mus musculus) 6480464 Hypochlorous Acid results in increased expression of KEAP1 mRNA CTD PMID:17980396 Keap1 Rat ifosfamide increases expression ISO KEAP1 (Homo sapiens) 6480464 Ifosfamide results in increased expression of KEAP1 mRNA CTD PMID:25596134 Keap1 Rat imidacloprid decreases expression EXP 6480464 imidacloprid results in decreased expression of KEAP1 mRNA CTD PMID:34993831 Keap1 Rat indole-3-methanol multiple interactions ISO Keap1 (Mus musculus) 6480464 indole-3-carbinol inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:29775573 Keap1 Rat indometacin multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] more ... CTD PMID:11909699 Keap1 Rat iron(III) citrate multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [trigonelline co-treated with ferric citrate] results in decreased expression of KEAP1 mRNA CTD PMID:29959986 Keap1 Rat isoniazide decreases expression ISO Keap1 (Mus musculus) 6480464 Isoniazid results in decreased expression of KEAP1 mRNA CTD PMID:33771660 Keap1 Rat isoprenaline decreases expression EXP 6480464 Isoproterenol results in decreased expression of KEAP1 mRNA CTD PMID:30303030 Keap1 Rat isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of KEAP1 mRNA and Isoproterenol results in increased expression of KEAP1 protein CTD PMID:35430261 Keap1 Rat isoprenaline multiple interactions EXP 6480464 [Isoproterenol co-treated with POSTN protein] results in decreased expression of KEAP1 mRNA more ... CTD PMID:30303030 and PMID:35430261 Keap1 Rat ketoconazole increases expression EXP 6480464 Ketoconazole results in increased expression of KEAP1 mRNA CTD PMID:37077353 Keap1 Rat L-ascorbic acid multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in decreased expression of KEAP1 mRNA more ... CTD PMID:28285367 more ... Keap1 Rat L-ascorbic acid decreases expression ISO KEAP1 (Homo sapiens) 6480464 Ascorbic Acid results in decreased expression of KEAP1 protein CTD PMID:31610155 Keap1 Rat L-ascorbic acid 2-phosphate multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of KEAP1 mRNA CTD PMID:34480604 Keap1 Rat L-methionine multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of CD36 mRNA] more ... CTD PMID:20350562 Keap1 Rat lansoprazole increases oxidation EXP 6480464 Lansoprazole results in increased oxidation of KEAP1 protein CTD PMID:19628634 Keap1 Rat lanthanum trichloride increases expression ISO Keap1 (Mus musculus) 6480464 lanthanum chloride results in increased expression of KEAP1 protein CTD PMID:33098623 Keap1 Rat lead diacetate multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein more ... CTD PMID:31610155 Keap1 Rat lead diacetate multiple interactions ISO Keap1 (Mus musculus) 6480464 [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of KEAP1 mRNA more ... CTD PMID:38180308 Keap1 Rat lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of KEAP1 mRNA CTD PMID:33862172 Keap1 Rat lead(0) multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein more ... CTD PMID:31610155 Keap1 Rat lead(0) multiple interactions ISO Keap1 (Mus musculus) 6480464 [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of KEAP1 mRNA more ... CTD PMID:38180308 Keap1 Rat leflunomide increases expression EXP 6480464 leflunomide results in increased expression of KEAP1 mRNA CTD PMID:24136188 Keap1 Rat Liensinine multiple interactions ISO KEAP1 (Homo sapiens) 6480464 liensinine inhibits the reaction [Lipopolysaccharides results in increased expression of KEAP1 protein] CTD PMID:38692452 Keap1 Rat Liensinine multiple interactions ISO Keap1 (Mus musculus) 6480464 liensinine inhibits the reaction [Lipopolysaccharides results in increased expression of KEAP1 protein] CTD PMID:38692452 Keap1 Rat linsidomine affects response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 mRNA affects the susceptibility to linsidomine CTD PMID:16092930 Keap1 Rat lipoic acid increases expression ISO KEAP1 (Homo sapiens) 6480464 Thioctic Acid results in increased expression of KEAP1 protein CTD PMID:19033392 Keap1 Rat lipoic acid multiple interactions ISO Keap1 (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein] CTD PMID:34252510 Keap1 Rat lipopolysaccharide multiple interactions ISO KEAP1 (Homo sapiens) 6480464 liensinine inhibits the reaction [Lipopolysaccharides results in increased expression of KEAP1 protein] CTD PMID:38692452 Keap1 Rat lipopolysaccharide multiple interactions ISO Keap1 (Mus musculus) 6480464 8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased degradation of KEAP1 protein] more ... CTD PMID:35691465 and PMID:38692452 Keap1 Rat lipopolysaccharide increases expression ISO Keap1 (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of KEAP1 protein CTD PMID:38692452 Keap1 Rat lipopolysaccharide increases expression ISO KEAP1 (Homo sapiens) 6480464 Lipopolysaccharides results in increased expression of KEAP1 protein CTD PMID:38692452 Keap1 Rat liproxstatin-1 increases expression ISO KEAP1 (Homo sapiens) 6480464 liproxstatin-1 results in increased expression of KEAP1 protein CTD PMID:37507096 Keap1 Rat liquiritin multiple interactions ISO Keap1 (Mus musculus) 6480464 liquiritin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of KEAP1 protein] CTD PMID:36008890 Keap1 Rat luteolin multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Luteolin inhibits the reaction [decabromobiphenyl ether results in decreased expression of KEAP1 protein] CTD PMID:33675858 Keap1 Rat lycopene multiple interactions ISO Keap1 (Mus musculus) 6480464 Lycopene inhibits the reaction [Atrazine results in decreased expression of KEAP1 mRNA] more ... CTD PMID:30360616 more ... Keap1 Rat lycopene increases expression ISO Keap1 (Mus musculus) 6480464 Lycopene results in increased expression of KEAP1 mRNA CTD PMID:36216167 Keap1 Rat manganese(II) chloride affects expression ISO Keap1 (Mus musculus) 6480464 manganese chloride affects the expression of KEAP1 protein CTD PMID:25288107 Keap1 Rat manganese(II) chloride multiple interactions ISO Keap1 (Mus musculus) 6480464 Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein] CTD PMID:25288107 Keap1 Rat melatonin multiple interactions ISO Keap1 (Mus musculus) 6480464 Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein] CTD PMID:25288107 Keap1 Rat melatonin decreases expression ISO Keap1 (Mus musculus) 6480464 Melatonin results in decreased expression of KEAP1 protein CTD PMID:25288107 Keap1 Rat menadione multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Vitamin K 3 CTD PMID:19608619 Keap1 Rat menadione decreases expression ISO KEAP1 (Homo sapiens) 6480464 Vitamin K 3 results in decreased expression of KEAP1 mRNA CTD PMID:23410634 Keap1 Rat mercury dibromide increases expression ISO KEAP1 (Homo sapiens) 6480464 mercuric bromide results in increased expression of KEAP1 mRNA CTD PMID:26272509 Keap1 Rat mercury dibromide multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA CTD PMID:27188386 Keap1 Rat metformin multiple interactions EXP 6480464 Metformin inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA] and Metformin inhibits the reaction [Streptozocin results in increased expression of KEAP1 protein] CTD PMID:33639173 Keap1 Rat metformin multiple interactions ISO Keap1 (Mus musculus) 6480464 Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of KEAP1 mRNA] CTD PMID:37120126 Keap1 Rat metformin decreases expression EXP 6480464 Metformin results in decreased expression of KEAP1 mRNA CTD PMID:25596134 Keap1 Rat methotrexate multiple interactions EXP 6480464 Buspirone inhibits the reaction [Methotrexate results in increased expression of KEAP1 mRNA] CTD PMID:37341015 Keap1 Rat methotrexate increases expression EXP 6480464 Methotrexate results in increased expression of KEAP1 mRNA CTD PMID:37341015 Keap1 Rat microcystin-LR affects binding ISO KEAP1 (Homo sapiens) 6480464 cyanoginosin LR binds to KEAP1 protein CTD PMID:20722399 Keap1 Rat monascin multiple interactions ISO KEAP1 (Homo sapiens) 6480464 monascin inhibits the reaction [S100B protein results in increased expression of KEAP1 protein] CTD PMID:23331247 Keap1 Rat N'-(2,4-dimethylphenyl)-N-methylformamidine increases expression EXP 6480464 U 40481 results in increased expression of KEAP1 protein CTD PMID:31029719 Keap1 Rat N'-(2,4-dimethylphenyl)-N-methylformamidine multiple interactions EXP 6480464 KEAP1 protein affects the reaction [U 40481 results in decreased expression of CAT protein] more ... CTD PMID:31029719 Keap1 Rat N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine multiple interactions ISO Keap1 (Mus musculus) 6480464 N more ... CTD PMID:15865434 Keap1 Rat N-acetyl-1,4-benzoquinone imine multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine] CTD PMID:19246624 Keap1 Rat N-acetyl-1,4-benzoquinone imine affects metabolic processing ISO Keap1 (Mus musculus) 6480464 N-acetyl-4-benzoquinoneimine affects the metabolism of KEAP1 protein CTD PMID:18785192 Keap1 Rat N-acetyl-L-cysteine multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein] and Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] CTD PMID:11909699 and PMID:19033392 Keap1 Rat N-acetyl-L-cysteine multiple interactions ISO Keap1 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Copper Sulfate results in decreased expression of KEAP1 mRNA] more ... CTD PMID:37353053 and PMID:37369159 Keap1 Rat N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:30104959 Keap1 Rat N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO Keap1 (Mus musculus) 6480464 [2-tert-butylhydroquinone co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [NFE2L2 protein binds to KEAP1 protein] and benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:18512965 Keap1 Rat N-methyl-4-phenylpyridinium multiple interactions ISO Keap1 (Mus musculus) 6480464 [1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein and baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein] CTD PMID:38016618 Keap1 Rat N-methylnicotinate multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [trigonelline co-treated with ferric citrate] results in decreased expression of KEAP1 mRNA CTD PMID:29959986 Keap1 Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KEAP1 mRNA CTD PMID:17602206 Keap1 Rat NADP zwitterion affects abundance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the abundance of NADP CTD PMID:21775727 Keap1 Rat NADP(+) affects abundance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the abundance of NADP CTD PMID:21775727 Keap1 Rat naphthalene-1,2-diol multiple interactions ISO Keap1 (Mus musculus) 6480464 Glutathione inhibits the reaction [1 and 2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein] CTD PMID:25807370 Keap1 Rat naphthalene-1,2-diol increases metabolic processing ISO Keap1 (Mus musculus) 6480464 1 and 2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein CTD PMID:25807370 Keap1 Rat naringin multiple interactions ISO Keap1 (Mus musculus) 6480464 naringin inhibits the reaction [Doxorubicin results in decreased expression of KEAP1 protein] CTD PMID:36811345 Keap1 Rat nefazodone increases expression EXP 6480464 nefazodone results in increased expression of KEAP1 mRNA CTD PMID:24136188 Keap1 Rat nickel atom increases expression ISO KEAP1 (Homo sapiens) 6480464 Nickel results in increased expression of KEAP1 protein CTD PMID:19033392 Keap1 Rat nicotinamide multiple interactions EXP 6480464 [Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA more ... CTD PMID:21439372 Keap1 Rat nicotinamide multiple interactions ISO Keap1 (Mus musculus) 6480464 2 more ... CTD PMID:33949241 and PMID:37120126 Keap1 Rat ochratoxin A decreases expression ISO KEAP1 (Homo sapiens) 6480464 ochratoxin A results in decreased expression of KEAP1 mRNA CTD PMID:32905824 Keap1 Rat oleic acid multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [Palmitic Acid co-treated with Oleic Acid] results in increased expression of KEAP1 protein and Escin inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of KEAP1 protein] CTD PMID:36905866 Keap1 Rat oxidopamine affects response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 mRNA affects the susceptibility to Oxidopamine CTD PMID:16092930 Keap1 Rat ozone increases expression ISO Keap1 (Mus musculus) 6480464 [Ozone results in increased expression of HIF1A] which results in increased expression of KEAP1 CTD PMID:24040961 Keap1 Rat ozone multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [Ozone co-treated with Oxygen] inhibits the reaction [KEAP1 protein results in increased degradation of NFE2L2 protein] and [Ozone co-treated with Oxygen] results in increased expression of KEAP1 protein CTD PMID:26270818 and PMID:29864481 Keap1 Rat p-chloromercuribenzoic acid increases expression ISO KEAP1 (Homo sapiens) 6480464 p-Chloromercuribenzoic Acid results in increased expression of KEAP1 mRNA CTD PMID:26272509 Keap1 Rat p-chloromercuribenzoic acid multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA CTD PMID:27188386 Keap1 Rat paclitaxel multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [KEAP1 protein results in decreased stability of NFE2L2 protein] which results in increased susceptibility to Paclitaxel CTD PMID:20530669 Keap1 Rat paeoniflorin multiple interactions ISO Keap1 (Mus musculus) 6480464 peoniflorin inhibits the reaction [Particulate Matter results in increased expression of KEAP1 protein] CTD PMID:38705442 Keap1 Rat paracetamol increases expression ISO KEAP1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of KEAP1 mRNA CTD PMID:25881548 Keap1 Rat paracetamol increases expression ISO Keap1 (Mus musculus) 6480464 Acetaminophen results in increased expression of KEAP1 protein CTD PMID:33949241 Keap1 Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of KEAP1 mRNA CTD PMID:33387578 Keap1 Rat paracetamol affects expression ISO Keap1 (Mus musculus) 6480464 Acetaminophen affects the expression of KEAP1 protein CTD PMID:29331651 Keap1 Rat paracetamol decreases response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 gene mutant form results in decreased susceptibility to Acetaminophen CTD PMID:16293230 and PMID:25499718 Keap1 Rat paracetamol decreases expression ISO KEAP1 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of KEAP1 mRNA CTD PMID:21420995 Keap1 Rat paracetamol increases response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 results in increased susceptibility to Acetaminophen CTD PMID:20404090 Keap1 Rat paracetamol affects sulfation ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the sulfation of Acetaminophen CTD PMID:19246624 Keap1 Rat paracetamol affects glucuronidation ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the glucuronidation of Acetaminophen CTD PMID:19246624 Keap1 Rat paracetamol multiple interactions ISO Keap1 (Mus musculus) 6480464 ABCC3 protein affects the reaction [KEAP1 protein affects the glucuronidation of Acetaminophen] and Niacinamide inhibits the reaction [Acetaminophen results in increased expression of KEAP1 protein] CTD PMID:19246624 and PMID:33949241 Keap1 Rat paracetamol affects glutathionylation ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the glutathionylation of Acetaminophen CTD PMID:19246624 Keap1 Rat paraquat increases expression EXP 6480464 Paraquat results in increased expression of KEAP1 protein CTD PMID:32064027 Keap1 Rat paraquat decreases expression ISO KEAP1 (Homo sapiens) 6480464 Paraquat results in decreased expression of KEAP1 protein CTD PMID:37507096 Keap1 Rat paraquat multiple interactions EXP 6480464 [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] more ... CTD PMID:32064027 Keap1 Rat pentachlorophenol increases expression ISO Keap1 (Mus musculus) 6480464 Pentachlorophenol results in increased expression of KEAP1 mRNA CTD PMID:23892564 Keap1 Rat perfluorohexanesulfonic acid decreases expression ISO Keap1 (Mus musculus) 6480464 perfluorohexanesulfonic acid results in decreased expression of KEAP1 mRNA CTD PMID:37995155 Keap1 Rat perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of KEAP1 mRNA CTD PMID:20621739 Keap1 Rat perillyl aldehyde multiple interactions ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein inhibits the reaction [perillaldehyde results in increased expression of TXN mRNA] CTD PMID:19123792 Keap1 Rat phalloidin multiple interactions ISO Keap1 (Mus musculus) 6480464 [KEAP1 gene mutant form results in decreased susceptibility to Phalloidine] which results in decreased expression of CXCL1 mRNA more ... CTD PMID:25280775 Keap1 Rat phalloidin decreases response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 gene mutant form results in decreased susceptibility to Phalloidine CTD PMID:25280775 Keap1 Rat phenobarbital multiple interactions ISO Keap1 (Mus musculus) 6480464 KEAP1 protein affects the reaction [Phenobarbital results in increased expression of CYP2A5 mRNA] CTD PMID:22859313 Keap1 Rat phenylarsine oxide affects binding ISO Keap1 (Mus musculus) 6480464 oxophenylarsine binds to KEAP1 protein CTD PMID:19786557 and PMID:19808700 Keap1 Rat phenylmercury acetate increases expression ISO KEAP1 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of KEAP1 mRNA CTD PMID:26272509 Keap1 Rat phenylmercury acetate multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA CTD PMID:27188386 Keap1 Rat phlorizin increases expression ISO Keap1 (Mus musculus) 6480464 Phlorhizin results in increased expression of KEAP1 mRNA CTD PMID:22538082 Keap1 Rat pirinixic acid multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KEAP1 mRNA CTD PMID:19710929 Keap1 Rat poly(ethylene) multiple interactions ISO Keap1 (Mus musculus) 6480464 [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of KEAP1 mRNA more ... CTD PMID:38180308 Keap1 Rat poly(vinyl chloride) multiple interactions ISO Keap1 (Mus musculus) 6480464 [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of KEAP1 mRNA more ... CTD PMID:38180308 Keap1 Rat porphyrins increases expression ISO KEAP1 (Homo sapiens) 6480464 Porphyrins results in increased expression of KEAP1 mRNA CTD PMID:31385236 Keap1 Rat potassium dichromate multiple interactions ISO Keap1 (Mus musculus) 6480464 Potassium Dichromate affects the localization of and results in decreased ubiquitination of KEAP1 protein and Potassium Dichromate inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:17420218 Keap1 Rat pterostilbene multiple interactions ISO Keap1 (Mus musculus) 6480464 pterostilbene inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:26700463 Keap1 Rat quercetin multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Quercetin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KEAP1 protein] and Quercetin results in increased metabolism of and results in increased degradation of and results in decreased expression of KEAP1 protein CTD PMID:17462537 and PMID:27050144 Keap1 Rat quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Cyclophosphamide results in decreased expression of KEAP1 mRNA] CTD PMID:37419146 Keap1 Rat quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of KEAP1 protein CTD PMID:25339115 Keap1 Rat quercetin increases expression ISO Keap1 (Mus musculus) 6480464 Quercetin results in increased expression of KEAP1 mRNA CTD PMID:23295412 Keap1 Rat quercetin 3-O-beta-D-glucofuranoside multiple interactions EXP 6480464 isoquercitrin inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 Keap1 Rat quercetin 3-O-beta-D-glucopyranoside multiple interactions EXP 6480464 isoquercitrin inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 Keap1 Rat quercitrin increases expression ISO KEAP1 (Homo sapiens) 6480464 quercitrin results in increased expression of KEAP1 mRNA CTD PMID:25193878 Keap1 Rat quinolinic acid multiple interactions EXP 6480464 Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein] more ... CTD PMID:30876764 Keap1 Rat reactive oxygen species increases expression ISO KEAP1 (Homo sapiens) 6480464 Reactive Oxygen Species results in increased expression of KEAP1 mRNA CTD PMID:25800948 Keap1 Rat resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA] more ... CTD PMID:21439372 and PMID:23551926 Keap1 Rat resveratrol multiple interactions ISO Keap1 (Mus musculus) 6480464 Resveratrol inhibits the reaction [Rotenone results in increased expression of KEAP1 protein] CTD PMID:34391968 Keap1 Rat resveratrol multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [Resveratrol co-treated with Plant Extracts] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of KEAP1 protein] more ... CTD PMID:16948474 more ... Keap1 Rat rosmarinic acid decreases expression ISO KEAP1 (Homo sapiens) 6480464 Rosmarinic Acid results in decreased expression of KEAP1 protein CTD PMID:31610155 Keap1 Rat rosmarinic acid multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein] CTD PMID:31610155 Keap1 Rat rotenone decreases response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 gene mutant form results in decreased susceptibility to Rotenone CTD PMID:19167360 Keap1 Rat rotenone increases expression ISO Keap1 (Mus musculus) 6480464 Rotenone results in increased expression of KEAP1 protein CTD PMID:34391968 and PMID:35919817 Keap1 Rat rotenone multiple interactions ISO Keap1 (Mus musculus) 6480464 Resveratrol inhibits the reaction [Rotenone results in increased expression of KEAP1 protein] CTD PMID:34391968 Keap1 Rat rotenone decreases expression ISO Keap1 (Mus musculus) 6480464 Rotenone results in decreased expression of KEAP1 mRNA CTD PMID:23186747 Keap1 Rat S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein] more ... CTD PMID:19608619 Keap1 Rat SB 431542 multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Keap1 Rat SCH772984 multiple interactions ISO KEAP1 (Homo sapiens) 6480464 SCH772984 inhibits the reaction [pachastrissamine analog promotes the reaction [KEAP1 protein binds to SQSTM1 protein]] CTD PMID:35123989 Keap1 Rat scutellarin multiple interactions ISO Keap1 (Mus musculus) 6480464 scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of KEAP1 mRNA] and scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of KEAP1 protein] CTD PMID:34610774 Keap1 Rat selenium atom increases expression ISO KEAP1 (Homo sapiens) 6480464 Selenium results in increased expression of KEAP1 mRNA CTD PMID:19244175 Keap1 Rat selenomethionine multiple interactions ISO Keap1 (Mus musculus) 6480464 Selenomethionine inhibits the reaction [deoxynivalenol results in increased expression of KEAP1 protein] CTD PMID:38040082 Keap1 Rat silibinin multiple interactions EXP 6480464 Silybin inhibits the reaction [sodium arsenite results in increased expression of KEAP1] CTD PMID:24062023 Keap1 Rat silicon atom multiple interactions ISO Keap1 (Mus musculus) 6480464 Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein] CTD PMID:34252510 Keap1 Rat silicon atom increases expression ISO Keap1 (Mus musculus) 6480464 Silicon results in increased expression of KEAP1 protein CTD PMID:34252510 Keap1 Rat silicon dioxide multiple interactions ISO KEAP1 (Homo sapiens) 6480464 tanshinone promotes the reaction [Silicon Dioxide results in decreased expression of KEAP1 protein] CTD PMID:32097614 Keap1 Rat silicon dioxide decreases expression ISO KEAP1 (Homo sapiens) 6480464 Silicon Dioxide results in decreased expression of KEAP1 protein CTD PMID:32097614 Keap1 Rat sirolimus increases expression ISO KEAP1 (Homo sapiens) 6480464 Sirolimus results in increased expression of KEAP1 protein CTD PMID:29781141 Keap1 Rat sirolimus multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Sirolimus inhibits the reaction [Resveratrol inhibits the reaction [Particulate Matter affects the expression of KEAP1 protein]] CTD PMID:29781141 Keap1 Rat sodium arsenite multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Decitabine inhibits the reaction [sodium arsenite results in decreased expression of KEAP1 protein] more ... CTD PMID:18417180 more ... Keap1 Rat sodium arsenite increases methylation ISO KEAP1 (Homo sapiens) 6480464 sodium arsenite results in increased methylation of KEAP1 promoter CTD PMID:26409248 Keap1 Rat sodium arsenite increases expression ISO KEAP1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of KEAP1 mRNA CTD PMID:38568856 Keap1 Rat sodium arsenite affects folding ISO Keap1 (Mus musculus) 6480464 sodium arsenite affects the folding of KEAP1 protein CTD PMID:30261176 Keap1 Rat sodium arsenite decreases expression ISO KEAP1 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of KEAP1 protein CTD PMID:26409248 and PMID:28229933 Keap1 Rat sodium arsenite affects expression EXP 6480464 sodium arsenite affects the expression of KEAP1 mRNA CTD PMID:25625412 Keap1 Rat sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of KEAP1 CTD PMID:24062023 Keap1 Rat sodium arsenite multiple interactions EXP 6480464 silybin inhibits the reaction [sodium arsenite results in increased expression of KEAP1] CTD PMID:24062023 Keap1 Rat sodium arsenite increases expression ISO Keap1 (Mus musculus) 6480464 sodium arsenite results in increased expression of KEAP1 mRNA and sodium arsenite results in increased expression of KEAP1 protein CTD PMID:26371860 and PMID:35679981 Keap1 Rat sodium arsenite multiple interactions ISO Keap1 (Mus musculus) 6480464 ATG7 gene mutant form inhibits the reaction [sodium arsenite results in increased degradation of KEAP1 protein] more ... CTD PMID:16785233 more ... Keap1 Rat sodium arsenite affects localization ISO KEAP1 (Homo sapiens) 6480464 sodium arsenite affects the localization of KEAP1 protein CTD PMID:23589329 Keap1 Rat sodium dichromate decreases expression ISO Keap1 (Mus musculus) 6480464 sodium bichromate results in decreased expression of KEAP1 mRNA CTD PMID:22155349 Keap1 Rat sodium fluoride decreases expression EXP 6480464 Sodium Fluoride results in decreased expression of KEAP1 mRNA CTD PMID:36736877 Keap1 Rat sodium fluoride multiple interactions EXP 6480464 Sodium Selenite inhibits the reaction [Sodium Fluoride results in decreased expression of KEAP1 mRNA] CTD PMID:36736877 Keap1 Rat solanesol multiple interactions ISO KEAP1 (Homo sapiens) 6480464 solanesol inhibits the reaction [Glucose results in increased expression of KEAP1 mRNA] more ... CTD PMID:25645596 and PMID:37586544 Keap1 Rat sterigmatocystin affects expression EXP 6480464 Sterigmatocystin affects the expression of KEAP1 mRNA CTD PMID:34126181 Keap1 Rat streptozocin multiple interactions EXP 6480464 [Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of KEAP1 mRNA more ... CTD PMID:21439372 more ... Keap1 Rat streptozocin increases expression ISO Keap1 (Mus musculus) 6480464 Streptozocin results in increased expression of KEAP1 mRNA CTD PMID:34896238 Keap1 Rat streptozocin multiple interactions ISO Keap1 (Mus musculus) 6480464 2 more ... CTD PMID:34610774 more ... Keap1 Rat streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of KEAP1 mRNA CTD PMID:30817903 Keap1 Rat streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of KEAP1 mRNA and Streptozocin results in increased expression of KEAP1 protein CTD PMID:32662907 and PMID:33639173 Keap1 Rat sulforaphane increases expression ISO KEAP1 (Homo sapiens) 6480464 sulforaphane results in increased expression of KEAP1 protein CTD PMID:19033392 Keap1 Rat sulforaphane decreases expression ISO KEAP1 (Homo sapiens) 6480464 sulforaphane results in decreased expression of KEAP1 mRNA CTD PMID:35724838 Keap1 Rat sulforaphane decreases response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein mutant form results in decreased susceptibility to sulforaphane CTD PMID:23589329 Keap1 Rat sulforaphane multiple interactions ISO Keap1 (Mus musculus) 6480464 sulforaphane inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein] more ... CTD PMID:15865434 more ... Keap1 Rat sulforaphane multiple interactions EXP 6480464 sulforaphane promotes the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:22558124 Keap1 Rat sulforaphane increases response to substance ISO Keap1 (Mus musculus) 6480464 KEAP1 protein results in increased susceptibility to sulforaphane CTD PMID:22558124 Keap1 Rat sulforaphane increases response to substance ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein results in increased susceptibility to sulforaphane CTD PMID:22558124 Keap1 Rat sulforaphane increases metabolic processing ISO KEAP1 (Homo sapiens) 6480464 sulforaphane results in increased metabolism of KEAP1 protein CTD PMID:21391649 Keap1 Rat sulforaphane multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Iodoacetamide inhibits the reaction [sulforaphane results in increased metabolism of KEAP1 protein] more ... CTD PMID:18417180 more ... Keap1 Rat sulindac decreases expression EXP 6480464 Sulindac results in decreased expression of KEAP1 mRNA CTD PMID:24136188 Keap1 Rat T-2 toxin decreases expression ISO KEAP1 (Homo sapiens) 6480464 T-2 Toxin results in decreased expression of KEAP1 mRNA and T-2 Toxin results in decreased expression of KEAP1 protein CTD PMID:35842139 Keap1 Rat tangeretin multiple interactions EXP 6480464 tangeretin inhibits the reaction [9 more ... CTD PMID:24995432 Keap1 Rat Tanshinone I multiple interactions ISO KEAP1 (Homo sapiens) 6480464 tanshinone promotes the reaction [Silicon Dioxide results in decreased expression of KEAP1 protein] CTD PMID:32097614 Keap1 Rat temozolomide increases expression ISO KEAP1 (Homo sapiens) 6480464 Temozolomide results in increased expression of KEAP1 mRNA CTD PMID:31758290 Keap1 Rat tert-butyl hydroperoxide increases expression ISO KEAP1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of KEAP1 protein CTD PMID:27050144 Keap1 Rat tert-butyl hydroperoxide multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KEAP1 protein] and Quercetin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KEAP1 protein] CTD PMID:27050144 Keap1 Rat tetrachloromethane increases expression ISO Keap1 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of KEAP1 protein CTD PMID:29964319 Keap1 Rat tetrachloromethane multiple interactions ISO Keap1 (Mus musculus) 6480464 ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein] and sulforaphane inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein] CTD PMID:29964319 Keap1 Rat thapsigargin increases expression ISO KEAP1 (Homo sapiens) 6480464 Thapsigargin results in increased expression of KEAP1 protein CTD PMID:27358234 Keap1 Rat thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of KEAP1 mRNA CTD PMID:34492290 Keap1 Rat thiophenes multiple interactions ISO KEAP1 (Homo sapiens) 6480464 Thiophenes inhibits the reaction [KEAP1 gene mutant form promotes the reaction [lipopolysaccharide and E coli O55-B5 results in increased expression of IL6 mRNA]] CTD PMID:23906629 Keap1 Rat Tiron multiple interactions ISO Keap1 (Mus musculus) 6480464 1 more ... CTD PMID:33368846 Keap1 Rat trabectedin increases expression ISO KEAP1 (Homo sapiens) 6480464 Trabectedin results in increased expression of KEAP1 protein CTD PMID:36396105 Keap1 Rat trans-anethole multiple interactions EXP 6480464 anethole inhibits the reaction [Isoproterenol results in increased expression of KEAP1 mRNA] and anethole inhibits the reaction [Isoproterenol results in increased expression of KEAP1 protein] CTD PMID:35430261 Keap1 Rat trans-piceid multiple interactions ISO KEAP1 (Homo sapiens) 6480464 polydatin inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:31705858 Keap1 Rat trans-piceid multiple interactions ISO Keap1 (Mus musculus) 6480464 polydatin inhibits the reaction [TSHR protein results in increased expression of KEAP1 protein] CTD PMID:31705858 Keap1 Rat trans-rhaponticin multiple interactions EXP 6480464 rhapontin inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA] and rhapontin inhibits the reaction [Streptozocin results in increased expression of KEAP1 protein] CTD PMID:32662907 Keap1 Rat tributylstannane decreases expression ISO Keap1 (Mus musculus) 6480464 tributyltin results in decreased expression of KEAP1 protein CTD PMID:36858641 Keap1 Rat Tributyltin oxide affects localization ISO KEAP1 (Homo sapiens) 6480464 bis(tri-n-butyltin)oxide affects the localization of KEAP1 protein CTD PMID:21601586 Keap1 Rat tricetin increases expression ISO KEAP1 (Homo sapiens) 6480464 tricetin results in increased expression of KEAP1 mRNA and tricetin results in increased expression of KEAP1 protein CTD PMID:31176653 Keap1 Rat trichloroethene multiple interactions ISO Keap1 (Mus musculus) 6480464 sulforaphane inhibits the reaction [Trichloroethylene results in increased expression of KEAP1 mRNA] CTD PMID:32073640 Keap1 Rat trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of KEAP1 mRNA CTD PMID:33387578 Keap1 Rat trichloroethene increases expression ISO Keap1 (Mus musculus) 6480464 Trichloroethylene results in increased expression of KEAP1 mRNA CTD PMID:32073640 Keap1 Rat trichostatin A affects expression ISO KEAP1 (Homo sapiens) 6480464 trichostatin A affects the expression of KEAP1 mRNA CTD PMID:28542535 Keap1 Rat trilobatin multiple interactions EXP 6480464 trilobatin inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:30104959 Keap1 Rat Triptolide decreases expression ISO KEAP1 (Homo sapiens) 6480464 triptolide results in decreased expression of KEAP1 protein CTD PMID:30682494 and PMID:36990132 Keap1 Rat triptonide decreases expression ISO Keap1 (Mus musculus) 6480464 triptonide results in decreased expression of KEAP1 mRNA CTD PMID:33045310 Keap1 Rat troglitazone multiple interactions ISO KEAP1 (Homo sapiens) 6480464 KEAP1 protein promotes the reaction [troglitazone results in increased susceptibility to arsenic trioxide] CTD PMID:22684020 Keap1 Rat tyloxapol increases expression ISO Keap1 (Mus musculus) 6480464 tyloxapol results in increased expression of KEAP1 protein CTD PMID:36905866 Keap1 Rat tyloxapol multiple interactions ISO Keap1 (Mus musculus) 6480464 Escin inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein] and Fenofibrate inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein] CTD PMID:36905866 Keap1 Rat valdecoxib increases expression EXP 6480464 valdecoxib results in increased expression of KEAP1 mRNA CTD PMID:24136188 Keap1 Rat valproic acid decreases expression ISO Keap1 (Mus musculus) 6480464 Valproic Acid results in decreased expression of KEAP1 mRNA CTD PMID:21427059 Keap1 Rat valproic acid affects expression ISO KEAP1 (Homo sapiens) 6480464 Valproic Acid affects the expression of KEAP1 mRNA CTD PMID:25979313 Keap1 Rat valproic acid decreases expression ISO KEAP1 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of KEAP1 mRNA CTD PMID:22083351 and PMID:29154799 Keap1 Rat vitamin D decreases expression ISO KEAP1 (Homo sapiens) 6480464 Vitamin D results in decreased expression of KEAP1 protein CTD PMID:30698894 Keap1 Rat XAV939 multiple interactions ISO KEAP1 (Homo sapiens) 6480464 [[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of KEAP1 mRNA and [[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in decreased expression of KEAP1 mRNA CTD PMID:34480604 Keap1 Rat zinc atom multiple interactions ISO Keap1 (Mus musculus) 6480464 4 more ... CTD PMID:15865434 Keap1 Rat zinc atom affects binding ISO Keap1 (Mus musculus) 6480464 Zinc binds to KEAP1 protein CTD PMID:15865434 Keap1 Rat zinc dichloride affects folding ISO Keap1 (Mus musculus) 6480464 zinc chloride affects the folding of KEAP1 protein CTD PMID:30261176 Keap1 Rat zinc dichloride multiple interactions ISO Keap1 (Mus musculus) 6480464 zinc chloride promotes the reaction [KEAP1 protein binds to KEAP1 protein] CTD PMID:30261176 Keap1 Rat zinc(0) multiple interactions ISO Keap1 (Mus musculus) 6480464 4 more ... CTD PMID:15865434 Keap1 Rat zinc(0) affects binding ISO Keap1 (Mus musculus) 6480464 Zinc binds to KEAP1 protein CTD PMID:15865434