Keap1 (Kelch-like ECH-associated protein 1) - Rat Genome Database

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Gene: Keap1 (Kelch-like ECH-associated protein 1) Rattus norvegicus
Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
RGD ID: 621619
Description: Predicted to enable several functions, including disordered domain specific binding activity; identical protein binding activity; and ubiquitin ligase-substrate adaptor activity. Involved in several processes, including response to immobilization stress; response to thyroid hormone; and selenium compound metabolic process. Located in adherens junction and focal adhesion. Part of protein-containing complex. Biomarker of diabetic retinopathy; end stage renal disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,4-dinitrotoluene; 2-tert-butylhydroquinone; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytosolic inhibitor of Nrf2; Inrf2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2819,768,375 - 19,777,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,768,375 - 19,777,862 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,787,814 - 23,797,272 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,085,659 - 22,095,117 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,998,059 - 20,007,547 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,250,518 - 22,259,868 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,250,518 - 22,259,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,305,765 - 22,315,026 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,259,178 - 20,266,351 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,259,177 - 20,266,352 (-)NCBI
Celera821,161,976 - 21,171,435 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-albicanol  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-di-tert-butylphenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-dipyridyl disulfide  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
7,8-dihydroxycoumarin  (ISO)
[6]-Shogaol  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha,alpha-trehalose  (EXP)
alpha-D-galactose  (ISO)
amiodarone  (EXP)
amitraz  (EXP)
ammonium chloride  (EXP)
andrographolide  (ISO)
anethole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (EXP,ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP,ISO)
aureusidin  (EXP)
azathioprine  (ISO)
bafilomycin A1  (ISO)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoquinones  (ISO)
betulin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bromosulfophthalein  (ISO)
Brusatol  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon disulfide  (EXP)
carbon monoxide  (ISO)
celastrol  (EXP)
CGP 52608  (ISO)
chalcones  (EXP)
CHIR 99021  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
choline  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
Clivoline  (ISO)
clodronic acid  (ISO)
clofibric acid  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
colistin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
crocin-1  (EXP)
cumene hydroperoxide  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
Dendrobine  (ISO)
deoxynivalenol  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetyl chloride  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dihydroartemisinin  (ISO)
dimercaprol  (ISO)
dioscin  (EXP)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
ethanol  (ISO)
ethionamide  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylenediaminetetraacetic acid  (ISO)
etoposide  (ISO)
falcarindiol  (EXP)
farrerol  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
galactose  (ISO)
gefitinib  (ISO)
gentamycin  (EXP)
ginsenoside Rg1  (ISO)
gliclazide  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glyburide  (EXP)
glyphosate  (ISO)
hemin  (ISO)
hexaflumuron  (EXP)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
ifosfamide  (ISO)
imidacloprid  (EXP)
indole-3-methanol  (ISO)
indometacin  (ISO)
iron(III) citrate  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lansoprazole  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (EXP)
linsidomine  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
lycopene  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
microcystin-LR  (ISO)
monascin  (ISO)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene-1,2-diol  (ISO)
naringin  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nicotinamide  (EXP)
ochratoxin A  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perillyl aldehyde  (ISO)
phalloidin  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
porphyrins  (ISO)
potassium dichromate  (ISO)
pterostilbene  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercitrin  (ISO)
quinolinic acid  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
SCH772984  (ISO)
selenium atom  (ISO)
silibinin  (EXP)
silicon atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
solanesol  (ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (EXP,ISO)
sulindac  (EXP)
T-2 toxin  (ISO)
tangeretin  (EXP)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
Tiron  (ISO)
trabectedin  (ISO)
trans-anethole  (EXP)
trans-piceid  (ISO)
trans-rhaponticin  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
tricetin  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trilobatin  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin D  (ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation. Blake DJ, etal., Am J Respir Cell Mol Biol. 2010 May;42(5):524-36. Epub 2009 Jun 11.
2. Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. Dhakshinamoorthy S and Jaiswal AK, Oncogene 2001 Jun 28;20(29):3906-17.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Goven D, etal., Thorax. 2008 Oct;63(10):916-24. Epub 2008 Jun 17.
5. Oxidative injury induces selective rather than global inhibition of proteasomal activity. Gurusamy N, etal., J Mol Cell Cardiol. 2008 Feb;44(2):419-28. Epub 2007 Oct 22.
6. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
7. The complexity of the Nrf2 pathway: beyond the antioxidant response. Huang Y, etal., J Nutr Biochem. 2015 Dec;26(12):1401-13. doi: 10.1016/j.jnutbio.2015.08.001. Epub 2015 Aug 8.
8. Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis. Ikeda H, etal., Biochem J. 2004 Jun 1;380(Pt 2):515-21.
9. Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. Kim HJ and Vaziri ND, Am J Physiol Renal Physiol. 2010 Mar;298(3):F662-71. Epub 2009 Dec 9.
10. Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA. Kim JH, etal., Free Radic Biol Med. 2012 Aug 1;53(3):629-40. Epub 2012 Apr 27.
11. Differentially expressed genes and morphological changes during lengthened immobilization in rat soleus muscle. Kim JW, etal., Differentiation. 2007 Feb;75(2):147-57.
12. Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis. Kong X, etal., Am J Respir Crit Care Med. 2011 Oct 15;184(8):928-38. Epub 2011 Jul 28.
13. Nuclear factor erythroid 2-like 2 (Nrf2) expression in end-stage liver disease. Kurzawski M, etal., Environ Toxicol Pharmacol. 2012 Jul;34(1):87-95. Epub 2012 Mar 11.
14. Cell-specific elevation of NRF2 and sulfiredoxin-1 as markers of oxidative stress in the lungs of idiopathic pulmonary fibrosis and non-specific interstitial pneumonia. Mazur W, etal., APMIS. 2010 Sep 1;118(9):703-12.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1. Nguyen T, etal., J Biol Chem. 2005 Sep 16;280(37):32485-92. Epub 2005 Jul 6.
18. Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound. Ohnuma T, etal., Toxicol Appl Pharmacol. 2010 Apr 1;244(1):27-36. Epub 2009 Dec 21.
19. Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis. Okada K, etal., J Gastroenterol. 2012 Aug;47(8):924-35. Epub 2012 Feb 28.
20. Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. Osburn WO, etal., Toxicol Sci. 2008 Jul;104(1):218-27. Epub 2008 Apr 15.
21. Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling. Palsamy P and Subramanian S, Biochim Biophys Acta. 2011 Jul;1812(7):719-31. Epub 2011 Mar 23.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
26. The Nrf2-Keap1 cellular defense pathway and heat shock protein 70 (Hsp70) response. Role in protection against oxidative stress in early neonatal unilateral ureteral obstruction (UUO). Rinaldi Tosi ME, etal., Cell Stress Chaperones. 2011 Jan;16(1):57-68. Epub 2010 Aug 24.
27. Ebselen, a seleno-organic antioxidant, as an electrophile. Sakurai T, etal., Chem Res Toxicol. 2006 Sep;19(9):1196-204.
28. Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis. Sarlette A, etal., J Neuropathol Exp Neurol. 2008 Nov;67(11):1055-62.
29. Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Shibata T, etal., Gastroenterology. 2008 Oct;135(4):1358-1368, 1368.e1-4. Epub 2008 Jul 3.
30. Expression of Keap1-Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion. Tanaka N, etal., Brain Res. 2011 Jan 25;1370:246-53. Epub 2010 Nov 11.
31. Keap1 in adhesion complexes. Velichkova M and Hasson T, Cell Motil Cytoskeleton. 2003 Oct;56(2):109-19.
32. Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioning. Videla LA, etal., ScientificWorldJournal. 2012;2012:301494. Epub 2011 Dec 20.
33. Alterations in tumor biomarker GSTP gene methylation patterns induced by prenatal exposure to PFOS. Wan YJ, etal., Toxicology. 2010 Jul-Aug;274(1-3):57-64. Epub 2010 May 26.
34. Baicalein Protects against 6-OHDA-Induced Neurotoxicity through Activation of Keap1/Nrf2/HO-1 and Involving PKCalpha and PI3K/AKT Signaling Pathways. Zhang Z, etal., J Agric Food Chem. 2012 Aug 9.
35. Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy. Zhong Q, etal., Invest Ophthalmol Vis Sci. 2013 Jun 6;54(6):3941-8. doi: 10.1167/iovs.13-11598.
Additional References at PubMed
PMID:9798653   PMID:11921171   PMID:12682069   PMID:14517290   PMID:14764898   PMID:15087497   PMID:15166316   PMID:15282312   PMID:15367669   PMID:15601839   PMID:15983046   PMID:16581765  
PMID:17015834   PMID:17468336   PMID:17982879   PMID:19424503   PMID:20133743   PMID:20173742   PMID:20421418   PMID:20452972   PMID:21703357   PMID:24211725   PMID:24796746   PMID:24796753  
PMID:25049078   PMID:25301875   PMID:25598205   PMID:26655811   PMID:27223823   PMID:27472294   PMID:27815660   PMID:28145852   PMID:29119264   PMID:29845199   PMID:30071128   PMID:30119254  
PMID:31273531   PMID:31355603   PMID:31432116   PMID:31563143   PMID:32590729   PMID:32894623   PMID:33760324   PMID:33777321   PMID:33811899   PMID:34185425   PMID:34278476   PMID:35026282  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2819,768,375 - 19,777,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,768,375 - 19,777,862 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,787,814 - 23,797,272 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,085,659 - 22,095,117 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,998,059 - 20,007,547 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,250,518 - 22,259,868 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,250,518 - 22,259,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,305,765 - 22,315,026 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,259,178 - 20,266,351 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,259,177 - 20,266,352 (-)NCBI
Celera821,161,976 - 21,171,435 (-)NCBICelera
Cytogenetic Map8q13NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381910,486,125 - 10,503,356 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,486,125 - 10,503,558 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,596,801 - 10,614,032 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,457,796 - 10,475,054 (-)NCBINCBI36Build 36hg18NCBI36
Celera1910,491,509 - 10,508,764 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,176,101 - 10,192,927 (-)NCBIHuRef
CHM1_11910,597,575 - 10,614,823 (-)NCBICHM1_1
T2T-CHM13v2.01910,612,569 - 10,629,791 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39921,141,026 - 21,150,628 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,141,026 - 21,150,657 (-)EnsemblGRCm39 Ensembl
GRCm38921,229,730 - 21,239,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,229,730 - 21,239,361 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,034,174 - 21,043,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,980,469 - 20,989,215 (-)NCBIMGSCv36mm8
Celera918,498,845 - 18,508,447 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.74NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554951,704,695 - 1,711,290 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,704,695 - 1,711,339 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11914,402,746 - 14,420,092 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,037,544 - 10,055,091 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,701,298 - 10,717,664 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,701,303 - 10,717,604 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12050,651,070 - 50,661,178 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,650,711 - 50,658,496 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,523,052 - 50,533,206 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,174,558 - 51,182,077 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,164,570 - 51,185,490 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,380,711 - 50,390,863 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,808,833 - 50,818,993 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,049,891 - 51,060,051 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118209,560,465 - 209,569,647 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659782,340 - 793,688 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936659785,059 - 793,775 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl269,276,336 - 69,294,382 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,280,940 - 69,290,267 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,634,153 - 69,643,610 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.169,515,789 - 9,526,699 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,515,416 - 9,522,797 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,471,467 - 10,484,386 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248282,580,861 - 2,595,275 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,580,812 - 2,595,023 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Keap1
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:64
Interacting mature miRNAs:77
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,768,815 - 19,769,017 (+)MAPPERmRatBN7.2
Rnor_6.0822,250,959 - 22,251,160NCBIRnor6.0
Rnor_5.0822,306,206 - 22,306,407UniSTSRnor5.0
RGSC_v3.4820,258,900 - 20,259,101UniSTSRGSC3.4
Celera821,162,417 - 21,162,618UniSTS
RH 3.4 Map8178.1UniSTS
Cytogenetic Map8q13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,776,593 - 19,776,733 (+)MAPPERmRatBN7.2
Rnor_6.0822,258,734 - 22,258,873NCBIRnor6.0
Rnor_5.0822,313,981 - 22,314,120UniSTSRnor5.0
RGSC_v3.4820,266,678 - 20,266,817UniSTSRGSC3.4
Celera821,170,167 - 21,170,306UniSTS
RH 3.4 Map8205.19UniSTS
Cytogenetic Map8q13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,769,609 - 19,769,792 (+)MAPPERmRatBN7.2
Rnor_6.0822,251,753 - 22,251,935NCBIRnor6.0
Rnor_5.0822,307,000 - 22,307,182UniSTSRnor5.0
RGSC_v3.4820,259,694 - 20,259,876UniSTSRGSC3.4
Celera821,163,211 - 21,163,393UniSTS
Cytogenetic Map8q13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,772,493 - 19,772,668 (+)MAPPERmRatBN7.2
Rnor_6.0822,254,636 - 22,254,810NCBIRnor6.0
Rnor_5.0822,309,883 - 22,310,057UniSTSRnor5.0
RGSC_v3.4820,262,578 - 20,262,752UniSTSRGSC3.4
Celera821,166,069 - 21,166,243UniSTS
Cytogenetic Map8q13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,768,411 - 19,768,587 (+)MAPPERmRatBN7.2
Rnor_6.0822,250,555 - 22,250,730NCBIRnor6.0
Rnor_5.0822,305,802 - 22,305,977UniSTSRnor5.0
RGSC_v3.4820,258,496 - 20,258,671UniSTSRGSC3.4
Celera821,162,013 - 21,162,188UniSTS
Cytogenetic Map8q13UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 40 57 41 19 41 8 11 74 35 41 11 8
Low 3
Below cutoff


RefSeq Acc Id: ENSRNOT00000028360   ⟹   ENSRNOP00000028360
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,768,375 - 19,777,862 (-)Ensembl
Rnor_6.0 Ensembl822,250,518 - 22,259,779 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101216   ⟹   ENSRNOP00000081740
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,768,692 - 19,777,333 (-)Ensembl
RefSeq Acc Id: NM_057152   ⟹   NP_476493
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,768,375 - 19,777,862 (-)NCBI
Rnor_6.0822,250,518 - 22,259,779 (-)NCBI
Rnor_5.0822,305,765 - 22,315,026 (-)NCBI
RGSC_v3.4820,259,178 - 20,266,351 (-)RGD
Celera821,161,976 - 21,171,435 (-)NCBI
RefSeq Acc Id: XM_006242591   ⟹   XP_006242653
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,768,694 - 19,777,726 (-)NCBI
Rnor_6.0822,250,521 - 22,259,868 (-)NCBI
Rnor_5.0822,305,765 - 22,315,026 (-)NCBI
RefSeq Acc Id: XM_039080715   ⟹   XP_038936643
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,768,694 - 19,777,444 (-)NCBI
RefSeq Acc Id: NP_476493   ⟸   NM_057152
- UniProtKB: G3V8U2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242653   ⟸   XM_006242591
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZVM9 (UniProtKB/TrEMBL),   A6JNQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028360   ⟸   ENSRNOT00000028360
RefSeq Acc Id: XP_038936643   ⟸   XM_039080715
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZVM9 (UniProtKB/TrEMBL),   A6JNQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081740   ⟸   ENSRNOT00000101216
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P57790-F1-model_v2 AlphaFold P57790 1-624 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621619 AgrOrtholog
BioCyc Gene G2FUF-31432 BioCyc
Ensembl Genes ENSRNOG00000020878 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028360 ENTREZGENE
  ENSRNOP00000028360.3 UniProtKB/TrEMBL
  ENSRNOP00000081740.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028360 ENTREZGENE
  ENSRNOT00000028360.5 UniProtKB/TrEMBL
  ENSRNOT00000101216.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KEAP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KEAP1_BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117519 UniProtKB/TrEMBL
  PTHR24412:SF162 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Keap1 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q9ERI3 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Keap1  Kelch-like ECH-associated protein 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Keap1  Kelch-like ECH-associated protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs releases Nrf2 following administration of antioxidants and xenobiotics 727319
gene_process involved in repression of Antioxidant response element (ARE)-mediated NQO1 gene expression 727319