(+)-butaclamol decreases activity ISO RGD:732101 6480464 Butaclamol results in decreased activity of KCNH2 protein CTD PMID:28551711 (-)-lobeline decreases activity ISO RGD:732101 6480464 Lobeline results in decreased activity of KCNH2 protein CTD PMID:28551711 (R,R,R)-alpha-tocopherol multiple interactions ISO RGD:732101 6480464 alpha-Tocopherol inhibits the reaction [Glucose results in decreased activity of KCNH2 protein] CTD PMID:12531891 (S)-duloxetine hydrochloride decreases activity ISO RGD:732101 6480464 Duloxetine Hydrochloride results in decreased activity of KCNH2 protein CTD PMID:28551711 (S)-naringenin multiple interactions ISO RGD:732101 6480464 Amiodarone promotes the reaction [naringenin results in decreased activity of KCNH2 protein] more ... CTD PMID:18057881 (S)-naringenin decreases activity ISO RGD:732101 6480464 naringenin results in decreased activity of KCNH2 protein CTD PMID:18057881 (S)-nicotine increases expression ISO RGD:732102 6480464 Nicotine results in increased expression of KCNH2 mRNA CTD PMID:17997037 (Z)-chlorprothixene decreases activity ISO RGD:732101 6480464 Chlorprothixene results in decreased activity of KCNH2 protein CTD PMID:28551711 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactions ISO RGD:732101 6480464 [o, p'-DDT results in decreased activity of KCNH2 protein] which results in decreased import of Thallium CTD PMID:21362439 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases activity ISO RGD:732101 6480464 o, p'-DDT results in decreased activity of KCNH2 protein CTD PMID:21362439 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine decreases activity ISO RGD:732101 6480464 Hexetidine results in decreased activity of KCNH2 protein CTD PMID:28551711 1,3-diphenylguanidine multiple interactions ISO RGD:732101 6480464 [diphenylguanidine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium CTD PMID:21362439 1,3-diphenylguanidine decreases activity ISO RGD:732101 6480464 diphenylguanidine results in decreased activity of KCNH2 protein CTD PMID:21362439 1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethyl-2-butanol decreases activity ISO RGD:732101 6480464 clobutinol results in decreased activity of KCNH2 protein CTD PMID:19034038 , PMID:28551711 1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-2-phenothiazinyl]ethanone decreases activity ISO RGD:732101 6480464 piperacetazine results in decreased activity of KCNH2 protein CTD PMID:28551711 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine decreases activity ISO RGD:732101 6480464 cloperastine results in decreased activity of KCNH2 protein CTD PMID:28551711 1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester decreases activity ISO RGD:732101 6480464 carbetapentane results in decreased activity of KCNH2 protein CTD PMID:19034038 10H-phenothiazine decreases activity ISO RGD:732101 6480464 phenothiazine results in decreased activity of KCNH2 protein CTD PMID:28551711 17alpha-ethynylestradiol affects expression ISO RGD:732102 6480464 Ethinyl Estradiol affects the expression of KCNH2 mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:732102 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KCNH2 mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of KCNH2 mRNA CTD PMID:17557909 17alpha-ethynylestradiol increases expression ISO RGD:732102 6480464 Ethinyl Estradiol results in increased expression of KCNH2 mRNA CTD PMID:17942748 2,2-diphenylacetic acid (1-ethyl-3-piperidinyl) ester decreases activity ISO RGD:732101 6480464 piperidolate results in decreased activity of KCNH2 protein CTD PMID:28551711 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732102 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KCNH2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of KCNH2 mRNA CTD PMID:32109520 , PMID:33387578 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions ISO RGD:732101 6480464 [Verapamil results in decreased activity of KCNH2 protein] which results in decreased import of Thallium, Verapamil inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 more ... 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile decreases activity ISO RGD:732101 6480464 Verapamil results in decreased activity of KCNH2 protein CTD PMID:15671647 more ... 2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine decreases activity ISO RGD:732101 6480464 dimethisoquin results in decreased activity of KCNH2 protein CTD PMID:28551711 2-[2-(diethylamino)ethylamino]-2-phenylacetic acid 3-methylbutyl ester decreases activity ISO RGD:732101 6480464 camylofine results in decreased activity of KCNH2 protein CTD PMID:28551711 2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol decreases activity ISO RGD:732101 6480464 Flupenthixol results in decreased activity of KCNH2 protein CTD PMID:28551711 2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide decreases activity ISO RGD:732101 6480464 Lidoflazine results in decreased activity of KCNH2 protein CTD PMID:16278312 , PMID:28551711 2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide multiple interactions ISO RGD:732101 6480464 Lidoflazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 2-deoxy-D-glucose multiple interactions ISO RGD:732101 6480464 [Deoxyglucose co-treated with Glucose deficiency] results in decreased activity of KCNH2 protein more ... CTD PMID:12531891 2-deoxy-D-glucose decreases activity ISO RGD:732101 6480464 Deoxyglucose results in decreased activity of KCNH2 protein CTD PMID:12531891 2-hydroxy-2,2-diphenylacetic acid 2-(diethylamino)ethyl ester decreases activity ISO RGD:732101 6480464 Benactyzine results in decreased activity of KCNH2 protein CTD PMID:28551711 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester decreases activity ISO RGD:732101 6480464 homosalate results in decreased activity of KCNH2 protein CTD PMID:28551711 3,3',4,4',5-pentachlorobiphenyl affects activity ISO RGD:732101 6480464 3 more ... CTD PMID:22676973 3,3',5,5'-tetrabromobisphenol A decreases expression ISO RGD:732102 6480464 tetrabromobisphenol A results in decreased expression of KCNH2 mRNA CTD PMID:25172293 3,3-diphenyl-N-(1-phenylethyl)-1-propanamine decreases activity ISO RGD:732101 6480464 Fendiline results in decreased activity of KCNH2 protein CTD PMID:28551711 3,4-dimethoxybenzoic acid 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl ester decreases activity ISO RGD:732101 6480464 mebeverine results in decreased activity of KCNH2 protein CTD PMID:28551711 3,6-diaminoacridine decreases activity ISO RGD:732101 6480464 Proflavine results in decreased activity of KCNH2 protein CTD PMID:28551711 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1H-benzimidazol-2-one decreases activity ISO RGD:732101 6480464 Benperidol results in decreased activity of KCNH2 protein CTD PMID:28551711 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:732101 6480464 [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium] CTD PMID:19419905 4,4'-diaminodiphenylmethane decreases expression ISO RGD:732102 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of KCNH2 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol decreases methylation ISO RGD:732102 6480464 bis(4-hydroxyphenyl)sulfone results in decreased methylation of KCNH2 exon CTD PMID:33297965 4,4'-sulfonyldiphenol multiple interactions ISO RGD:732101 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Fulvestrant] results in decreased methylation of KCNH2 gene CTD PMID:31601247 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol multiple interactions ISO RGD:732101 6480464 SM 21 promotes the reaction [ifenprodil results in decreased activity of KCNH2 protein] CTD PMID:17460149 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol decreases activity ISO RGD:732101 6480464 ifenprodil results in decreased activity of KCNH2 protein CTD PMID:17460149 , PMID:28551711 4-amino-5-chloro-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide decreases activity ISO RGD:732101 6480464 clebopride results in decreased activity of KCNH2 protein CTD PMID:28551711 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide multiple interactions ISO RGD:732101 6480464 beta-Cyclodextrins analog inhibits the reaction [Cisapride results in decreased activity of KCNH2 protein] more ... CTD PMID:11005845 more ... 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide affects binding ISO RGD:732101 6480464 Cisapride binds to KCNH2 protein CTD PMID:18701618 , PMID:19260734 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide affects localization ISO RGD:732101 6480464 Cisapride affects the localization of KCNH2 protein mutant form CTD PMID:10531299 , PMID:11741928 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide decreases activity ISO RGD:732101 6480464 Cisapride results in decreased activity of KCNH2 protein CTD PMID:11741928 more ... 4-aminopyridine decreases activity ISO RGD:732101 6480464 4-Aminopyridine results in decreased activity of KCNH2 protein CTD PMID:19915712 4-hydroxyphenyl retinamide decreases expression ISO RGD:732102 6480464 Fenretinide results in decreased expression of KCNH2 mRNA CTD PMID:28973697 4-hydroxyphenyl retinamide increases expression ISO RGD:732102 6480464 Fenretinide results in increased expression of KCNH2 mRNA CTD PMID:28973697 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole decreases activity ISO RGD:732101 6480464 Triclabendazole results in decreased activity of KCNH2 protein CTD PMID:28551711 7H-xanthine multiple interactions ISO RGD:732101 6480464 [Xanthine co-treated with XDH protein] results in decreased activity of KCNH2 protein CTD PMID:12531891 , PMID:14973143 9H-xanthine multiple interactions ISO RGD:732101 6480464 [Xanthine co-treated with XDH protein] results in decreased activity of KCNH2 protein CTD PMID:12531891 , PMID:14973143 [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol multiple interactions ISO RGD:732101 6480464 Mefloquine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol decreases activity ISO RGD:732101 6480464 Mefloquine results in decreased activity of KCNH2 protein CTD PMID:28551711 acetylmethadol multiple interactions ISO RGD:732101 6480464 Methadyl Acetate inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 aflatoxin B1 decreases methylation ISO RGD:732101 6480464 Aflatoxin B1 results in decreased methylation of KCNH2 intron CTD PMID:30157460 Aflatoxin B2 alpha increases methylation ISO RGD:732101 6480464 aflatoxin B2 results in increased methylation of KCNH2 intron, aflatoxin B2 results in increased methylation of KCNH2 polyA tail CTD PMID:30157460 ajmaline decreases activity ISO RGD:732101 6480464 Ajmaline results in decreased activity of KCNH2 protein CTD PMID:15599706 , PMID:24052561 aldehydo-D-glucose multiple interactions ISO RGD:732101 6480464 [Deoxyglucose co-treated with Glucose deficiency] results in decreased activity of KCNH2 protein more ... CTD PMID:12531891 aldehydo-D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of KCNH2 protein CTD PMID:31729781 aldehydo-D-glucose decreases activity ISO RGD:732101 6480464 Glucose deficiency results in decreased activity of KCNH2 protein, Glucose results in decreased activity of KCNH2 protein CTD PMID:12531891 all-trans-retinoic acid decreases expression ISO RGD:732101 6480464 Tretinoin results in decreased expression of KCNH2 mRNA CTD PMID:15894607 , PMID:23830798 alpidem decreases activity ISO RGD:732101 6480464 alpidem results in decreased activity of KCNH2 protein CTD PMID:24052561 alverine decreases activity ISO RGD:732101 6480464 alverine results in decreased activity of KCNH2 protein CTD PMID:28551711 amantadine decreases activity ISO RGD:732101 6480464 Amantadine results in decreased activity of KCNH2 protein CTD PMID:21158687 amiodarone multiple interactions ISO RGD:732101 6480464 Amiodarone binds to and results in decreased activity of KCNH2 protein more ... CTD PMID:15272206 more ... amiodarone decreases activity ISO RGD:732101 6480464 Amiodarone results in decreased activity of KCNH2 protein CTD PMID:10208308 more ... amiodarone affects activity ISO RGD:732101 6480464 Amiodarone affects the activity of KCNH2 protein CTD PMID:22020101 amitriptyline multiple interactions ISO RGD:732101 6480464 Amitriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 , PMID:21158687 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of KCNH2 mRNA CTD PMID:16483693 Ammothamnine multiple interactions ISO RGD:732101 6480464 oxymatrine inhibits the reaction [arsenic trioxide results in decreased localization of KCNH2 protein] CTD PMID:23103450 Ammothamnine increases expression ISO RGD:732101 6480464 oxymatrine results in increased expression of KCNH2 protein CTD PMID:23103450 amorolfine decreases activity ISO RGD:732101 6480464 amorolfine results in decreased activity of KCNH2 protein CTD PMID:28551711 amperozide multiple interactions ISO RGD:732101 6480464 amperozide inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of KCNH2 mRNA CTD PMID:30779732 amsacrine multiple interactions ISO RGD:732101 6480464 Amsacrine binds to and results in decreased activity of KCNH2 protein CTD PMID:15148258 aprindine decreases activity ISO RGD:732101 6480464 Aprindine results in decreased activity of KCNH2 protein CTD PMID:28551711 aripiprazole multiple interactions ISO RGD:732101 6480464 Aripiprazole inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 aripiprazole decreases activity ISO RGD:732101 6480464 Aripiprazole results in decreased activity of KCNH2 protein CTD PMID:28551711 aristolochic acid A increases expression ISO RGD:732101 6480464 aristolochic acid I results in increased expression of KCNH2 mRNA CTD PMID:33212167 Arkin (TN) decreases activity ISO RGD:732101 6480464 vesnarinone results in decreased activity of KCNH2 protein CTD PMID:12695533 , PMID:17146843 Arkin (TN) affects response to substance ISO RGD:732101 6480464 KCNH2 gene SNP affects the susceptibility to vesnarinone CTD PMID:12695533 arsane affects expression ISO RGD:732101 6480464 Arsenic affects the expression of KCNH2 mRNA CTD PMID:18414638 arsenic atom affects expression ISO RGD:732101 6480464 Arsenic affects the expression of KCNH2 mRNA CTD PMID:18414638 arsenous acid decreases expression ISO RGD:732101 6480464 Arsenic Trioxide results in decreased expression of KCNH2 protein CTD PMID:22977528 arsenous acid multiple interactions ISO RGD:732101 6480464 Arsenic Trioxide affects the expression of and results in increased activity of KCNH2 protein more ... CTD PMID:23103450 more ... arsenous acid increases expression ISO RGD:732101 6480464 Arsenic Trioxide results in increased expression of KCNH2 mRNA CTD PMID:15070760 arsenous acid increases degradation ISO RGD:732101 6480464 Arsenic Trioxide results in increased degradation of KCNH2 protein CTD PMID:28521025 arsenous acid decreases activity ISO RGD:732101 6480464 Arsenic Trioxide results in decreased activity of KCNH2 protein CTD PMID:25107562 arsenous acid decreases localization ISO RGD:732101 6480464 Arsenic Trioxide results in decreased localization of KCNH2 protein CTD PMID:15213294 , PMID:23103450 astemizole decreases activity ISO RGD:732101 6480464 Astemizole results in decreased activity of KCNH2 protein CTD PMID:10422790 more ... astemizole affects binding ISO RGD:732101 6480464 Astemizole binds to KCNH2 gene polymorphism, Astemizole binds to KCNH2 protein CTD PMID:15272206 more ... astemizole affects localization ISO RGD:732101 6480464 Astemizole affects the localization of KCNH2 protein mutant form CTD PMID:10531299 , PMID:11741928 astemizole decreases activity EXP 6480464 Astemizole results in decreased activity of KCNH2 protein CTD PMID:11040061 astemizole decreases activity ISO RGD:732102 6480464 Astemizole results in decreased activity of KCNH2 protein CTD PMID:16723379 astemizole multiple interactions ISO RGD:732101 6480464 Astemizole binds to and results in decreased activity of KCNH2 protein more ... CTD PMID:10376921 more ... atorvastatin calcium multiple interactions EXP 6480464 Berberine promotes the reaction [Atorvastatin results in decreased activity of KCNH2 protein] CTD PMID:30086269 atorvastatin calcium decreases activity EXP 6480464 Atorvastatin results in decreased activity of KCNH2 protein CTD PMID:30086269 ATP decreases activity ISO RGD:732101 6480464 Adenosine Triphosphate deficiency results in decreased activity of KCNH2 protein CTD PMID:12531891 atrazine increases expression ISO RGD:732101 6480464 Atrazine results in increased expression of KCNH2 mRNA CTD PMID:22378314 azaperone decreases activity ISO RGD:732101 6480464 Azaperone results in decreased activity of KCNH2 protein CTD PMID:28551711 Azaspiracid multiple interactions ISO RGD:732101 6480464 azaspiracid binds to and results in decreased activity of KCNH2 protein CTD PMID:22856456 azelastine decreases activity ISO RGD:732101 6480464 azelastine results in decreased activity of KCNH2 protein CTD PMID:28551711 Azimilide decreases activity ISO RGD:732101 6480464 azimilide results in decreased activity of KCNH2 protein CTD PMID:15821840 more ... Azimilide multiple interactions ISO RGD:732101 6480464 Acids inhibits the reaction [azimilide results in decreased activity of KCNH2 protein] more ... CTD PMID:15821840 more ... Balofloxacin affects binding ISO RGD:732101 6480464 balofloxacin binds to KCNH2 protein CTD PMID:34058295 benzalkonium chloride decreases activity ISO RGD:732101 6480464 Benzalkonium Compounds results in decreased activity of KCNH2 protein CTD PMID:24052561 benzatropine decreases activity ISO RGD:732101 6480464 Benztropine results in decreased activity of KCNH2 protein CTD PMID:28551711 benzethonium chloride decreases activity ISO RGD:732101 6480464 Benzethonium results in decreased activity of KCNH2 protein CTD PMID:21362439 more ... benzethonium chloride multiple interactions ISO RGD:732101 6480464 [Benzethonium results in decreased activity of KCNH2 protein] which results in decreased import of Thallium CTD PMID:21362439 benzo[a]pyrene decreases methylation ISO RGD:732101 6480464 Benzo(a)pyrene results in decreased methylation of KCNH2 3' UTR, Benzo(a)pyrene results in decreased methylation of KCNH2 exon CTD PMID:27901495 benzo[a]pyrene affects methylation ISO RGD:732101 6480464 Benzo(a)pyrene affects the methylation of KCNH2 intron, Benzo(a)pyrene affects the methylation of KCNH2 polyA tail CTD PMID:30157460 benzo[a]pyrene increases methylation ISO RGD:732101 6480464 Benzo(a)pyrene results in increased methylation of KCNH2 promoter CTD PMID:27901495 benzo[e]pyrene increases methylation ISO RGD:732101 6480464 benzo(e)pyrene results in increased methylation of KCNH2 intron CTD PMID:30157460 benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester decreases activity ISO RGD:732101 6480464 benfluorex results in decreased activity of KCNH2 protein CTD PMID:28551711 benzydamine decreases activity ISO RGD:732101 6480464 Benzydamine results in decreased activity of KCNH2 protein CTD PMID:28551711 bepridil multiple interactions ISO RGD:732101 6480464 Bepridil binds to and results in decreased activity of KCNH2 protein, Bepridil inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:15272206 , PMID:21158687 bepridil decreases activity ISO RGD:732101 6480464 Bepridil results in decreased activity of KCNH2 protein CTD PMID:15671647 , PMID:24052561 berberine multiple interactions EXP 6480464 Berberine promotes the reaction [Atorvastatin results in decreased activity of KCNH2 protein], Berberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein] CTD PMID:30086269 berberine decreases activity EXP 6480464 Berberine results in decreased activity of KCNH2 protein CTD PMID:30086269 betahistine decreases activity ISO RGD:732101 6480464 Betahistine results in decreased activity of KCNH2 protein CTD PMID:28551711 bis(2-chloroethyl) sulfide affects expression EXP 6480464 Mustard Gas affects the expression of KCNH2 mRNA CTD PMID:15651846 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of KCNH2 mRNA CTD PMID:25181051 , PMID:33296240 bisphenol A decreases methylation ISO RGD:732101 6480464 bisphenol A results in decreased methylation of KCNH2 gene CTD PMID:31601247 bopindolol decreases activity ISO RGD:732101 6480464 bopindolol results in decreased activity of KCNH2 protein CTD PMID:28551711 brefeldin A multiple interactions ISO RGD:732101 6480464 Brefeldin A promotes the reaction [vandetanib results in decreased expression of KCNH2 protein modified form] CTD PMID:35680041 brefeldin A decreases expression ISO RGD:732101 6480464 Brefeldin A results in decreased expression of KCNH2 protein modified form CTD PMID:35680041 bromhexine decreases activity ISO RGD:732101 6480464 Bromhexine results in decreased activity of KCNH2 protein CTD PMID:28551711 Bromocyclen decreases activity ISO RGD:732101 6480464 bromocyclen results in decreased activity of KCNH2 protein CTD PMID:28551711 Bromperidol decreases activity ISO RGD:732101 6480464 bromperidol results in decreased activity of KCNH2 protein CTD PMID:28551711 brompheniramine decreases activity ISO RGD:732101 6480464 Brompheniramine results in decreased activity of KCNH2 protein CTD PMID:17010640 , PMID:17516459 buclizine decreases activity ISO RGD:732101 6480464 buclizine results in decreased activity of KCNH2 protein CTD PMID:28551711 buta-1,3-diene decreases expression ISO RGD:732102 6480464 1, 3-butadiene results in decreased expression of KCNH2 mRNA CTD PMID:29038090 butanal increases expression ISO RGD:732101 6480464 butyraldehyde results in increased expression of KCNH2 mRNA CTD PMID:26079696 butoconazole decreases activity ISO RGD:732101 6480464 butoconazole results in decreased activity of KCNH2 protein CTD PMID:28551711 C3-thiacarbocyanine cation decreases activity ISO RGD:732101 6480464 Dithiazanine results in decreased activity of KCNH2 protein CTD PMID:28551711 cadmium dichloride increases methylation EXP 6480464 Cadmium Chloride results in increased methylation of KCNH2 promoter CTD PMID:22457795 calcitriol increases expression ISO RGD:732101 6480464 Calcitriol results in increased expression of KCNH2 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:732101 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of KCNH2 mRNA CTD PMID:21592394 calcium atom multiple interactions EXP 6480464 Nimodipine inhibits the reaction [KCNH2 protein affects the abundance of Calcium] CTD PMID:11040061 calcium(0) multiple interactions EXP 6480464 Nimodipine inhibits the reaction [KCNH2 protein affects the abundance of Calcium] CTD PMID:11040061 carbachol affects response to substance ISO RGD:732101 6480464 KCNH2 protein mutant form affects the susceptibility to Carbachol CTD PMID:29574456 carbinoxamine decreases activity ISO RGD:732101 6480464 carbinoxamine results in decreased activity of KCNH2 protein CTD PMID:28551711 carmustine decreases expression ISO RGD:732101 6480464 Carmustine results in decreased expression of KCNH2 mRNA CTD PMID:15980968 carvedilol decreases activity ISO RGD:732101 6480464 carvedilol results in decreased activity of KCNH2 protein CTD PMID:11164846 , PMID:16314852 carvedilol affects activity ISO RGD:732101 6480464 carvedilol affects the activity of KCNH2 protein CTD PMID:22020101 casticin decreases expression ISO RGD:732102 6480464 casticin results in decreased expression of KCNH2 mRNA CTD PMID:28444820 cefotetan decreases activity ISO RGD:732101 6480464 Cefotetan results in decreased activity of KCNH2 protein CTD PMID:28551711 cepharanthine decreases activity ISO RGD:732101 6480464 cepharanthine results in decreased activity of KCNH2 protein CTD PMID:28551711 cetalkonium chloride decreases activity ISO RGD:732101 6480464 cetalkonium chloride results in decreased activity of KCNH2 protein CTD PMID:28551711 CGP 52608 multiple interactions ISO RGD:732101 6480464 CGP 52608 promotes the reaction [RORA protein binds to KCNH2 gene] CTD PMID:28238834 chloramine T multiple interactions ISO RGD:732101 6480464 chloramine-T results in increased oxidation of and results in decreased activity of KCNH2 protein CTD PMID:17624316 chlordecone increases expression ISO RGD:732102 6480464 Chlordecone results in increased expression of KCNH2 mRNA CTD PMID:29980752 chlorobutanol multiple interactions ISO RGD:732101 6480464 Chlorobutanol binds to and results in decreased activity of KCNH2 protein more ... CTD PMID:14527710 , PMID:20071423 chlorobutanol decreases activity ISO RGD:732101 6480464 Chlorobutanol results in decreased activity of KCNH2 protein CTD PMID:14527710 chloroform decreases activity ISO RGD:732101 6480464 Chloroform results in decreased activity of KCNH2 protein CTD PMID:22024336 chlorphenamine decreases activity ISO RGD:732101 6480464 Chlorpheniramine results in decreased activity of KCNH2 protein CTD PMID:19885040 chlorphenamine affects activity ISO RGD:732101 6480464 Chlorpheniramine affects the activity of KCNH2 protein CTD PMID:16278312 chlorphenamine multiple interactions ISO RGD:732101 6480464 Chlorpheniramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 chlorpromazine multiple interactions ISO RGD:732101 6480464 Chlorpromazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 chlorpromazine decreases activity ISO RGD:732101 6480464 Chlorpromazine results in decreased activity of KCNH2 protein CTD PMID:15071359 , PMID:24052561 cholesterol decreases localization EXP 6480464 Cholesterol results in decreased localization of KCNH2 protein CTD PMID:21525004 cibenzoline decreases activity ISO RGD:732101 6480464 cifenline results in decreased activity of KCNH2 protein CTD PMID:24052561 ciclopirox multiple interactions ISO RGD:732101 6480464 ciclopirox inhibits the reaction [Terfenadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]], ciclopirox promotes the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 cinacalcet decreases activity ISO RGD:732101 6480464 Cinacalcet results in decreased activity of KCNH2 protein CTD PMID:28551711 cinchocaine decreases activity ISO RGD:732101 6480464 Dibucaine results in decreased activity of KCNH2 protein CTD PMID:28551711 cinchonine decreases activity ISO RGD:732101 6480464 cinchonine results in decreased activity of KCNH2 protein CTD PMID:28551711 ciprofloxacin affects binding ISO RGD:732101 6480464 Ciprofloxacin binds to KCNH2 protein CTD PMID:34058295 cisapride affects localization ISO RGD:732101 6480464 Cisapride affects the localization of KCNH2 protein mutant form CTD PMID:10531299 , PMID:11741928 cisapride decreases activity ISO RGD:732101 6480464 Cisapride results in decreased activity of KCNH2 protein CTD PMID:11741928 more ... cisapride affects binding ISO RGD:732101 6480464 Cisapride binds to KCNH2 protein CTD PMID:18701618 , PMID:19260734 cisapride multiple interactions ISO RGD:732101 6480464 beta-Cyclodextrins analog inhibits the reaction [Cisapride results in decreased activity of KCNH2 protein] more ... CTD PMID:11005845 more ... cisplatin increases expression ISO RGD:732101 6480464 Cisplatin results in increased expression of KCNH2 CTD PMID:22020779 cisplatin decreases expression ISO RGD:732101 6480464 Cisplatin results in decreased expression of KCNH2 mRNA CTD PMID:27594783 cisplatin increases response to substance ISO RGD:732101 6480464 KCNH2 results in increased susceptibility to Cisplatin CTD PMID:22020779 clarithromycin multiple interactions ISO RGD:732101 6480464 [KCNE2 protein mutant form binds to KCNH2 protein] which results in increased susceptibility to Clarithromycin CTD PMID:10219239 clarithromycin decreases activity ISO RGD:732101 6480464 Clarithromycin results in decreased activity of KCNH2 protein CTD PMID:24052561 clemastine decreases activity ISO RGD:732101 6480464 Clemastine results in decreased activity of KCNH2 protein CTD PMID:28551711 clofazimine decreases activity ISO RGD:732101 6480464 Clofazimine results in decreased activity of KCNH2 protein CTD PMID:28551711 clofedanol decreases activity ISO RGD:732101 6480464 clofedanol results in decreased activity of KCNH2 protein CTD PMID:28551711 clomipramine multiple interactions ISO RGD:732101 6480464 Clomipramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 clopenthixol decreases activity ISO RGD:732101 6480464 Clopenthixol results in decreased activity of KCNH2 protein CTD PMID:28551711 clorotepine decreases activity ISO RGD:732101 6480464 octoclothepine results in decreased activity of KCNH2 protein CTD PMID:28551711 Clotiapine decreases activity ISO RGD:732101 6480464 clothiapine results in decreased activity of KCNH2 protein CTD PMID:28551711 clotrimazole decreases activity ISO RGD:732101 6480464 Clotrimazole results in decreased activity of KCNH2 protein CTD PMID:28551711 clozapine multiple interactions ISO RGD:732101 6480464 Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 cobalt dichloride decreases expression ISO RGD:732101 6480464 cobaltous chloride results in decreased expression of KCNH2 mRNA CTD PMID:22941251 codeine decreases activity ISO RGD:732101 6480464 Codeine results in decreased activity of KCNH2 protein CTD PMID:19034038 colforsin daropate hydrochloride multiple interactions ISO RGD:732101 6480464 [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium] CTD PMID:19419905 copper atom increases expression EXP 6480464 Copper results in increased expression of KCNH2 mRNA CTD PMID:30556269 copper(0) increases expression EXP 6480464 Copper results in increased expression of KCNH2 mRNA CTD PMID:30556269 corticosterone increases expression EXP 6480464 Corticosterone results in increased expression of KCNH2 mRNA CTD PMID:18835572 crizotinib decreases activity ISO RGD:732101 6480464 crizotinib results in decreased activity of KCNH2 protein CTD PMID:23707608 crystal violet decreases activity ISO RGD:732101 6480464 Gentian Violet results in decreased activity of KCNH2 protein CTD PMID:28551711 curcumin decreases activity ISO RGD:732101 6480464 Curcumin results in decreased activity of KCNH2 protein CTD PMID:28551711 cyamemazine decreases activity ISO RGD:732101 6480464 cyamemazine metabolite results in decreased activity of KCNH2 protein, cyamemazine results in decreased activity of KCNH2 protein CTD PMID:16494862 , PMID:18957172 cyclosporin A decreases methylation ISO RGD:732101 6480464 Cyclosporine results in decreased methylation of KCNH2 promoter CTD PMID:27989131 D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of KCNH2 protein CTD PMID:31729781 D-glucose multiple interactions ISO RGD:732101 6480464 [Deoxyglucose co-treated with Glucose deficiency] results in decreased activity of KCNH2 protein more ... CTD PMID:12531891 D-glucose decreases activity ISO RGD:732101 6480464 Glucose deficiency results in decreased activity of KCNH2 protein, Glucose results in decreased activity of KCNH2 protein CTD PMID:12531891 Danofloxacin affects binding ISO RGD:732101 6480464 danofloxacin binds to KCNH2 protein CTD PMID:34058295 dantrolene decreases activity ISO RGD:732101 6480464 Dantrolene results in decreased activity of KCNH2 protein CTD PMID:24052561 darifenacin decreases activity ISO RGD:732101 6480464 darifenacin results in decreased activity of KCNH2 protein CTD PMID:28551711 daunorubicin decreases expression ISO RGD:732101 6480464 Daunorubicin results in decreased expression of KCNH2 mRNA CTD PMID:26537877 , PMID:28940058 DDT decreases activity ISO RGD:732101 6480464 DDT results in decreased activity of KCNH2 protein CTD PMID:28551711 denopamine decreases activity ISO RGD:732101 6480464 denopamine results in decreased activity of KCNH2 protein CTD PMID:28551711 deptropine decreases activity ISO RGD:732101 6480464 dibenzheptropine results in decreased activity of KCNH2 protein CTD PMID:28551711 desipramine decreases activity ISO RGD:732101 6480464 Desipramine results in decreased activity of KCNH2 protein CTD PMID:20211602 , PMID:24052561 desloratadine multiple interactions ISO RGD:732101 6480464 [desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein more ... CTD PMID:29143966 desloratadine decreases activity ISO RGD:732101 6480464 desloratadine results in decreased activity of KCNH2 protein CTD PMID:28551711 , PMID:29143966 desmethylastemizole multiple interactions ISO RGD:732101 6480464 desmethylastemizole binds to and results in decreased activity of KCNH2 protein CTD PMID:10376921 dexbrompheniramine decreases activity ISO RGD:732101 6480464 dexbrompheniramine results in decreased activity of KCNH2 protein CTD PMID:28551711 dexetimide decreases activity ISO RGD:732101 6480464 Dexetimide results in decreased activity of KCNH2 protein CTD PMID:28551711 dextran sulfate multiple interactions ISO RGD:732102 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of KCNH2 mRNA CTD PMID:29950665 dextromethorphan decreases activity ISO RGD:732101 6480464 Dextromethorphan results in decreased activity of KCNH2 protein CTD PMID:19034038 diallyl trisulfide multiple interactions ISO RGD:732101 6480464 diallyl trisulfide results in decreased expression of and results in decreased activity of KCNH2 protein CTD PMID:24504171 diallyl trisulfide decreases activity ISO RGD:732101 6480464 diallyl trisulfide results in decreased activity of KCNH2 protein CTD PMID:23272117 diarsenic trioxide increases expression ISO RGD:732101 6480464 Arsenic Trioxide results in increased expression of KCNH2 mRNA CTD PMID:15070760 diarsenic trioxide multiple interactions ISO RGD:732101 6480464 Arsenic Trioxide affects the expression of and results in increased activity of KCNH2 protein more ... CTD PMID:23103450 more ... diarsenic trioxide decreases localization ISO RGD:732101 6480464 Arsenic Trioxide results in decreased localization of KCNH2 protein CTD PMID:15213294 , PMID:23103450 diarsenic trioxide increases degradation ISO RGD:732101 6480464 Arsenic Trioxide results in increased degradation of KCNH2 protein CTD PMID:28521025 diarsenic trioxide decreases activity ISO RGD:732101 6480464 Arsenic Trioxide results in decreased activity of KCNH2 protein CTD PMID:25107562 diarsenic trioxide decreases expression ISO RGD:732101 6480464 Arsenic Trioxide results in decreased expression of KCNH2 protein CTD PMID:22977528 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of KCNH2 mRNA CTD PMID:21266533 Didecyldimethylammonium decreases activity ISO RGD:732101 6480464 didecyldimethylammonium results in decreased activity of KCNH2 protein CTD PMID:21362439 , PMID:28551711 Didecyldimethylammonium multiple interactions ISO RGD:732101 6480464 [didecyldimethylammonium results in decreased activity of KCNH2 protein] which results in decreased import of Thallium CTD PMID:21362439 difloxacin affects binding ISO RGD:732101 6480464 difloxacin binds to KCNH2 protein CTD PMID:34058295 digoxin multiple interactions ISO RGD:732101 6480464 Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein] more ... CTD PMID:19139152 digoxin affects response to substance ISO RGD:732101 6480464 KCNH2 gene affects the susceptibility to Digoxin CTD PMID:19139152 digoxin decreases expression ISO RGD:732101 6480464 Digoxin results in decreased expression of KCNH2 protein modified form CTD PMID:19139152 digoxin decreases activity ISO RGD:732101 6480464 Digoxin results in decreased activity of KCNH2 protein CTD PMID:19139152 dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium decreases activity ISO RGD:732101 6480464 Benzethonium results in decreased activity of KCNH2 protein CTD PMID:21362439 more ... dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium multiple interactions ISO RGD:732101 6480464 [Benzethonium results in decreased activity of KCNH2 protein] which results in decreased import of Thallium CTD PMID:21362439 dioxygen multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of KCNH2 mRNA CTD PMID:33729688 diphenylpyraline decreases activity ISO RGD:732101 6480464 diphenylpyraline results in decreased activity of KCNH2 protein CTD PMID:28551711 dipyridamole decreases activity ISO RGD:732101 6480464 Dipyridamole results in decreased activity of KCNH2 protein CTD PMID:17146843 disopyramide decreases activity ISO RGD:732101 6480464 Disopyramide results in decreased activity of KCNH2 protein CTD PMID:18724381 , PMID:28551711 disopyramide multiple interactions ISO RGD:732101 6480464 Disopyramide binds to and results in decreased activity of KCNH2 protein CTD PMID:15272206 dithiazanine decreases activity ISO RGD:732101 6480464 Dithiazanine results in decreased activity of KCNH2 protein CTD PMID:28551711 dobutamine decreases activity ISO RGD:732101 6480464 Dobutamine results in decreased activity of KCNH2 protein CTD PMID:24052561 dofetilide multiple interactions ISO RGD:732101 6480464 [Terfenadine co-treated with dofetilide] binds to and results in decreased activity of KCNH2 protein more ... CTD PMID:10828461 more ... dofetilide affects binding ISO RGD:732101 6480464 dofetilide binds to KCNH2 protein CTD PMID:15272206 more ... dofetilide decreases activity ISO RGD:732101 6480464 dofetilide results in decreased activity of KCNH2 protein CTD PMID:10828461 more ... dolasetron decreases activity ISO RGD:732101 6480464 dolasetron results in decreased activity of KCNH2 protein CTD PMID:28551711 Domiphen bromide decreases activity ISO RGD:732101 6480464 domiphen results in decreased activity of KCNH2 protein CTD PMID:21362439 , PMID:28551711 Domiphen bromide multiple interactions ISO RGD:732101 6480464 [domiphen results in decreased activity of KCNH2 protein] which results in decreased import of Thallium CTD PMID:21362439 domperidone decreases activity ISO RGD:732101 6480464 Domperidone results in decreased activity of KCNH2 protein CTD PMID:15640612 , PMID:28551711 domperidone multiple interactions ISO RGD:732101 6480464 Domperidone inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 domperidone affects response to substance ISO RGD:732101 6480464 KCNH2 gene SNP affects the susceptibility to Domperidone CTD PMID:21063774 doxepin multiple interactions ISO RGD:732101 6480464 Doxepin inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 doxorubicin multiple interactions ISO RGD:732101 6480464 Erythromycin affects the reaction [KCNH2 protein results in decreased susceptibility to Doxorubicin] CTD PMID:16086867 doxorubicin decreases expression ISO RGD:732101 6480464 Doxorubicin results in decreased expression of KCNH2 mRNA CTD PMID:26537877 more ... doxorubicin decreases response to substance ISO RGD:732101 6480464 KCNH2 protein results in decreased susceptibility to Doxorubicin CTD PMID:16086867 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of KCNH2 mRNA CTD PMID:19915844 dronedarone decreases activity ISO RGD:732101 6480464 dronedarone results in decreased activity of KCNH2 protein CTD PMID:15618689 dronedarone multiple interactions ISO RGD:732101 6480464 Potassium inhibits the reaction [dronedarone results in decreased activity of KCNH2 protein] CTD PMID:15618689 droperidol decreases activity ISO RGD:732101 6480464 Droperidol results in decreased activity of KCNH2 protein CTD PMID:16757186 , PMID:28551711 droperidol multiple interactions ISO RGD:732101 6480464 Droperidol inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 dutasteride decreases activity ISO RGD:732101 6480464 Dutasteride results in decreased activity of KCNH2 protein CTD PMID:28551711 dyclonine decreases activity ISO RGD:732101 6480464 dyclonine results in decreased activity of KCNH2 protein CTD PMID:28551711 E-4031 multiple interactions ISO RGD:732101 6480464 [KCNE2 protein binds to KCNH2 protein] which results in increased susceptibility to E 4031 more ... CTD PMID:10219239 more ... E-4031 decreases activity ISO RGD:732101 6480464 E 4031 results in decreased activity of KCNH2 protein CTD PMID:11741928 more ... E-4031 affects localization ISO RGD:732101 6480464 E 4031 affects the localization of KCNH2 protein mutant form CTD PMID:11741928 E-4031 multiple interactions EXP 6480464 E 4031 inhibits the reaction [Progesterone results in decreased localization of KCNH2 protein] CTD PMID:21525004 E-4031 increases activity ISO RGD:732101 6480464 E 4031 results in increased activity of KCNH2 protein mutant form CTD PMID:10531299 E-4031 affects binding ISO RGD:732101 6480464 E 4031 binds to KCNH2 protein CTD PMID:19260734 Ebastine decreases activity ISO RGD:732101 6480464 ebastine results in decreased activity of KCNH2 protein CTD PMID:28551711 Eburnamonine decreases activity ISO RGD:732101 6480464 eburnamonine results in decreased activity of KCNH2 protein CTD PMID:28551711 econazole decreases activity ISO RGD:732101 6480464 Econazole results in decreased activity of KCNH2 protein CTD PMID:21362439 econazole multiple interactions ISO RGD:732101 6480464 [Econazole results in decreased activity of KCNH2 protein] which results in decreased import of Thallium CTD PMID:21362439 eletriptan decreases activity ISO RGD:732101 6480464 eletriptan results in decreased activity of KCNH2 protein CTD PMID:28551711 eliprodil multiple interactions ISO RGD:732101 6480464 eliprodil inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 emedastine decreases activity ISO RGD:732101 6480464 emedastine results in decreased activity of KCNH2 protein CTD PMID:28551711 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of KCNH2 mRNA CTD PMID:29391264 enoxacin affects binding ISO RGD:732101 6480464 Enoxacin binds to KCNH2 protein CTD PMID:34058295 enrofloxacin affects binding ISO RGD:732101 6480464 Enrofloxacin binds to KCNH2 protein CTD PMID:34058295 epinastine decreases activity ISO RGD:732101 6480464 epinastine results in decreased activity of KCNH2 protein CTD PMID:28551711 erlotinib hydrochloride affects activity ISO RGD:732101 6480464 Erlotinib Hydrochloride affects the activity of KCNH2 protein CTD PMID:23707608 erlotinib hydrochloride decreases activity ISO RGD:732101 6480464 Erlotinib Hydrochloride results in decreased activity of KCNH2 protein CTD PMID:35680041 erythromycin A affects binding ISO RGD:732101 6480464 Erythromycin binds to KCNH2 protein CTD PMID:18701618 erythromycin A decreases activity ISO RGD:732101 6480464 Erythromycin results in decreased activity of KCNH2 protein CTD PMID:24052561 erythromycin A multiple interactions ISO RGD:732101 6480464 Erythromycin affects the reaction [KCNH2 protein results in decreased susceptibility to Doxorubicin], Erythromycin binds to and results in decreased activity of KCNH2 protein CTD PMID:15272206 , PMID:16086867 ethanol affects splicing ISO RGD:732102 6480464 Ethanol affects the splicing of KCNH2 mRNA CTD PMID:30319688 ezogabine affects activity ISO RGD:732101 6480464 ezogabine affects the activity of KCNH2 protein CTD PMID:28641963 Febantel decreases activity ISO RGD:732101 6480464 febantel results in decreased activity of KCNH2 protein CTD PMID:28551711 fenoverine decreases activity ISO RGD:732101 6480464 fenoverine results in decreased activity of KCNH2 protein CTD PMID:28551711 fentanyl decreases activity ISO RGD:732101 6480464 Fentanyl results in decreased activity of KCNH2 protein CTD PMID:28551711 Fexofenadine hydrochloride multiple interactions ISO RGD:732101 6480464 E 4031 inhibits the reaction [fexofenadine results in increased activity of KCNH2 protein mutant form], fexofenadine inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein] CTD PMID:12070109 , PMID:28521025 Fexofenadine hydrochloride increases activity ISO RGD:732101 6480464 fexofenadine results in increased activity of KCNH2 protein mutant form CTD PMID:12070109 fingolimod hydrochloride decreases activity ISO RGD:732101 6480464 Fingolimod Hydrochloride results in decreased activity of KCNH2 protein CTD PMID:25223691 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of KCNH2 mRNA CTD PMID:18035473 flecainide multiple interactions ISO RGD:732101 6480464 Flecainide binds to and results in decreased activity of KCNH2 protein CTD PMID:15272206 flecainide decreases activity ISO RGD:732101 6480464 Flecainide results in decreased activity of KCNH2 protein CTD PMID:24052561 fleroxacin affects binding ISO RGD:732101 6480464 Fleroxacin binds to KCNH2 protein CTD PMID:34058295 flufenamic acid multiple interactions ISO RGD:732101 6480464 E 4031 inhibits the reaction [Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]], Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium] CTD PMID:12359267 fluorescein (lactone form) decreases activity ISO RGD:732101 6480464 Fluorescein results in decreased activity of KCNH2 protein CTD PMID:28551711 fluoxetine multiple interactions ISO RGD:732101 6480464 Fluoxetine binds to and results in decreased activity of KCNH2 protein more ... CTD PMID:11805215 more ... fluoxetine decreases expression ISO RGD:732101 6480464 Fluoxetine results in decreased expression of KCNH2 protein modified form CTD PMID:35680041 fluoxetine decreases activity ISO RGD:732101 6480464 Fluoxetine results in decreased activity of KCNH2 protein CTD PMID:16967046 , PMID:24052561 fluoxetine affects response to substance ISO RGD:732101 6480464 KCNH2 protein affects the susceptibility to Fluoxetine CTD PMID:16967046 fluoxetine affects localization ISO RGD:732101 6480464 Fluoxetine affects the localization of KCNH2 protein CTD PMID:16967046 flupenthixol decreases activity ISO RGD:732101 6480464 Flupenthixol results in decreased activity of KCNH2 protein CTD PMID:28551711 flurazepam decreases activity ISO RGD:732101 6480464 Flurazepam results in decreased activity of KCNH2 protein CTD PMID:28551711 fluvoxamine multiple interactions ISO RGD:732101 6480464 [Terfenadine co-treated with Fluvoxamine] binds to and results in decreased activity of KCNH2 protein more ... CTD PMID:20071423 , PMID:21158687 fluvoxamine decreases activity ISO RGD:732101 6480464 Fluvoxamine results in decreased activity of KCNH2 protein CTD PMID:24052561 fomocaine decreases activity ISO RGD:732101 6480464 fomocain results in decreased activity of KCNH2 protein CTD PMID:28551711 formoterol fumarate decreases activity ISO RGD:732101 6480464 Formoterol Fumarate results in decreased activity of KCNH2 protein CTD PMID:28551711 fulvestrant multiple interactions ISO RGD:732101 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Fulvestrant] results in decreased methylation of KCNH2 gene CTD PMID:31601247 gabapentin decreases activity ISO RGD:732101 6480464 gabapentin results in decreased activity of KCNH2 protein CTD PMID:15716081 gatifloxacin multiple interactions ISO RGD:732101 6480464 [Gatifloxacin binds to and results in decreased activity of KCNH2 protein] which results in decreased export of Potassium, Gatifloxacin binds to and results in decreased activity of KCNH2 protein CTD PMID:34058295 geldanamycin affects localization ISO RGD:732101 6480464 geldanamycin affects the localization of KCNH2 protein CTD PMID:12775586 geldanamycin decreases activity ISO RGD:732101 6480464 geldanamycin results in decreased activity of KCNH2 protein CTD PMID:12775586 , PMID:24052561 geldanamycin increases degradation ISO RGD:732101 6480464 geldanamycin results in increased degradation of KCNH2 protein CTD PMID:12775586 geldanamycin multiple interactions ISO RGD:732101 6480464 geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein] CTD PMID:12775586 geldanamycin decreases expression ISO RGD:732101 6480464 geldanamycin results in decreased expression of KCNH2 protein modified form CTD PMID:12775586 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of KCNH2 mRNA CTD PMID:33387578 ginsenoside Rb1 affects activity ISO RGD:732101 6480464 ginsenoside Rb1 affects the activity of KCNH2 protein CTD PMID:15842772 ginsenoside Rf affects activity ISO RGD:732101 6480464 ginsenoside Rf affects the activity of KCNH2 protein CTD PMID:15842772 ginsenoside Rg1 affects activity ISO RGD:732101 6480464 ginsenoside Rg1 affects the activity of KCNH2 protein CTD PMID:15842772 glucose decreases activity ISO RGD:732101 6480464 Glucose deficiency results in decreased activity of KCNH2 protein, Glucose results in decreased activity of KCNH2 protein CTD PMID:12531891 glucose decreases expression EXP 6480464 Glucose results in decreased expression of KCNH2 protein CTD PMID:31729781 glucose multiple interactions ISO RGD:732101 6480464 [Deoxyglucose co-treated with Glucose deficiency] results in decreased activity of KCNH2 protein more ... CTD PMID:12531891 glyburide decreases activity ISO RGD:732101 6480464 Glyburide results in decreased activity of KCNH2 protein CTD PMID:24052561 Grepafloxacin decreases activity ISO RGD:732101 6480464 grepafloxacin results in decreased activity of KCNH2 protein CTD PMID:21158687 Halofantrine decreases activity ISO RGD:732101 6480464 halofantrine results in decreased activity of KCNH2 protein CTD PMID:28551711 haloperidol multiple interactions ISO RGD:732101 6480464 Haloperidol inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 , PMID:21158687 haloperidol decreases activity ISO RGD:732101 6480464 Haloperidol results in decreased activity of KCNH2 protein CTD PMID:15671647 more ... hydrogen peroxide multiple interactions ISO RGD:732101 6480464 Hydrogen Peroxide inhibits the reaction [Astemizole results in decreased activity of KCNH2 protein mutant form] more ... CTD PMID:10828461 hydroxychloroquine multiple interactions ISO RGD:732101 6480464 [Hydroxychloroquine binds to and results in decreased activity of KCNH2 protein] which results in decreased export of Potassium, Hydroxychloroquine binds to and results in decreased activity of KCNH2 protein CTD PMID:34058295 hydroxyzine decreases activity ISO RGD:732101 6480464 Hydroxyzine results in decreased activity of KCNH2 protein CTD PMID:19057127 ibogaine decreases activity ISO RGD:732101 6480464 Ibogaine results in decreased activity of KCNH2 protein CTD PMID:23707769 , PMID:24307198 ICI 118551 decreases activity ISO RGD:732101 6480464 ICI 118551 results in decreased activity of KCNH2 protein CTD PMID:16314852 ICI 118551 multiple interactions ISO RGD:732101 6480464 ICI 118551 results in decreased activity of [KCNH2 protein binds to KCNH2 protein] CTD PMID:15679475 idarubicin decreases activity ISO RGD:732101 6480464 Idarubicin results in decreased activity of KCNH2 protein CTD PMID:24052561 imipramine multiple interactions ISO RGD:732101 6480464 Imipramine binds to and results in decreased activity of KCNH2 protein, Imipramine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:15272206 more ... imipramine decreases activity ISO RGD:732101 6480464 Imipramine results in decreased activity of KCNH2 protein CTD PMID:24052561 imipramine decreases localization EXP 6480464 Imipramine results in decreased localization of KCNH2 protein CTD PMID:21525004 ipriflavone decreases activity ISO RGD:732101 6480464 ipriflavone results in decreased activity of KCNH2 protein CTD PMID:28551711 isoconazole decreases activity ISO RGD:732101 6480464 isoconazole results in decreased activity of KCNH2 protein CTD PMID:28551711 ivabradine decreases activity ISO RGD:732101 6480464 ivabradine results in decreased activity of KCNH2 protein CTD PMID:28551711 ketoconazole affects activity ISO RGD:732101 6480464 Ketoconazole affects the activity of KCNH2 protein mutant form CTD PMID:17965736 ketoconazole decreases response to substance ISO RGD:732101 6480464 KCNH2 protein mutant form results in decreased susceptibility to Ketoconazole CTD PMID:16542653 ketoconazole multiple interactions ISO RGD:732101 6480464 [Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein more ... CTD PMID:15272206 more ... ketoconazole decreases activity ISO RGD:732101 6480464 Ketoconazole results in decreased activity of KCNH2, Ketoconazole results in decreased activity of KCNH2 protein CTD PMID:16542653 more ... ketoconazole affects localization ISO RGD:732101 6480464 Ketoconazole affects the localization of KCNH2, Ketoconazole affects the localization of KCNH2 protein mutant form CTD PMID:17965736 lamotrigine decreases activity ISO RGD:732101 6480464 lamotrigine results in decreased activity of KCNH2 protein CTD PMID:15716081 lidocaine decreases activity ISO RGD:732101 6480464 Lidocaine results in decreased activity of KCNH2 protein CTD PMID:24052561 Liranaftate decreases activity ISO RGD:732101 6480464 liranaftate results in decreased activity of KCNH2 protein CTD PMID:28551711 lofepramine decreases activity ISO RGD:732101 6480464 Lofepramine results in decreased activity of KCNH2 protein CTD PMID:28551711 lomefloxacin affects binding ISO RGD:732101 6480464 lomefloxacin binds to KCNH2 protein CTD PMID:34058295 loratadine affects activity ISO RGD:732101 6480464 Loratadine affects the activity of KCNH2 protein CTD PMID:16278312 loratadine multiple interactions ISO RGD:732101 6480464 [desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein more ... CTD PMID:11705456 more ... loratadine decreases activity ISO RGD:732101 6480464 Loratadine results in decreased activity of KCNH2 protein CTD PMID:10604956 , PMID:29143966 lovastatin affects activity ISO RGD:732101 6480464 Lovastatin affects the activity of KCNH2 protein CTD PMID:16278312 loxapine decreases activity ISO RGD:732101 6480464 Loxapine results in decreased activity of KCNH2 protein CTD PMID:28551711 lubeluzole multiple interactions ISO RGD:732101 6480464 lubeluzole binds to and results in decreased activity of KCNH2 protein CTD PMID:29550817 malachite green cation decreases activity ISO RGD:732101 6480464 malachite green results in decreased activity of KCNH2 protein CTD PMID:21362439 malachite green cation multiple interactions ISO RGD:732101 6480464 [malachite green results in decreased activity of KCNH2 protein] which results in decreased import of Thallium CTD PMID:21362439 manidipine decreases activity ISO RGD:732101 6480464 manidipine results in decreased activity of KCNH2 protein CTD PMID:28551711 Maprotiline multiple interactions ISO RGD:732101 6480464 Maprotiline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 Mebhydrolin napadisilate decreases activity ISO RGD:732101 6480464 diazoline results in decreased activity of KCNH2 protein CTD PMID:28551711 mefloquine multiple interactions ISO RGD:732101 6480464 Mefloquine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 mefloquine decreases activity ISO RGD:732101 6480464 Mefloquine results in decreased activity of KCNH2 protein CTD PMID:28551711 mepyramine multiple interactions ISO RGD:732101 6480464 Pyrilamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 mepyramine affects activity ISO RGD:732101 6480464 Pyrilamine affects the activity of KCNH2 protein CTD PMID:16278312 mercury atom increases expression ISO RGD:732101 6480464 Mercury results in increased expression of KCNH2 mRNA CTD PMID:16823088 mercury(0) increases expression ISO RGD:732101 6480464 Mercury results in increased expression of KCNH2 mRNA CTD PMID:16823088 mesoridazine decreases activity ISO RGD:732101 6480464 Mesoridazine results in decreased activity of KCNH2 protein CTD PMID:17042915 methadone multiple interactions ISO RGD:732101 6480464 Chlorobutanol promotes the reaction [Methadone results in decreased activity of KCNH2 protein] CTD PMID:14527710 methadone decreases activity ISO RGD:732101 6480464 Methadone results in decreased activity of KCNH2 protein CTD PMID:14527710 methapyrilene increases methylation ISO RGD:732101 6480464 Methapyrilene results in increased methylation of KCNH2 intron CTD PMID:30157460 methdilazine decreases activity ISO RGD:732101 6480464 methdilazine results in decreased activity of KCNH2 protein CTD PMID:28551711 methiothepin decreases activity ISO RGD:732101 6480464 Methiothepin results in decreased activity of KCNH2 protein CTD PMID:28551711 methylmercury chloride decreases expression ISO RGD:732101 6480464 methylmercuric chloride results in decreased expression of KCNH2 mRNA CTD PMID:28001369 methylseleninic acid increases expression ISO RGD:732101 6480464 methylselenic acid results in increased expression of KCNH2 mRNA CTD PMID:18548127 metixene decreases activity ISO RGD:732101 6480464 methixene results in decreased activity of KCNH2 protein CTD PMID:28551711 metoclopramide decreases activity ISO RGD:732101 6480464 Metoclopramide results in decreased activity of KCNH2 protein CTD PMID:15640612 metoprolol multiple interactions ISO RGD:732101 6480464 Metoprolol results in decreased activity of [KCNH2 protein binds to KCNH2 protein] CTD PMID:15679475 metoprolol decreases activity ISO RGD:732101 6480464 Metoprolol results in decreased activity of KCNH2 protein CTD PMID:16314852 mexiletine decreases activity ISO RGD:732101 6480464 Mexiletine results in decreased activity of KCNH2 protein CTD PMID:24052561 Mibefradil multiple interactions ISO RGD:732101 6480464 Mibefradil inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 Mibefradil decreases activity ISO RGD:732101 6480464 Mibefradil results in decreased activity of KCNH2 protein CTD PMID:28551711 miconazole decreases activity ISO RGD:732101 6480464 Miconazole results in decreased activity of KCNH2 protein CTD PMID:28551711 mitoxantrone decreases expression ISO RGD:732101 6480464 Mitoxantrone results in decreased expression of KCNH2 mRNA CTD PMID:26537877 , PMID:28940058 Mitragynine decreases expression ISO RGD:732101 6480464 mitragynine results in decreased expression of KCNH2 protein CTD PMID:27260674 Mitragynine multiple interactions ISO RGD:732101 6480464 mitragynine binds to and results in decreased activity of KCNH2 protein CTD PMID:27260674 Mizolastine decreases activity ISO RGD:732101 6480464 mizolastine results in decreased activity of KCNH2 protein CTD PMID:11082114 , PMID:28551711 moxifloxacin decreases activity ISO RGD:732101 6480464 moxifloxacin results in decreased activity of KCNH2 protein CTD PMID:24052561 , PMID:27553911 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO RGD:732101 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [TGFB1 protein results in decreased expression of KCNH2 protein] CTD PMID:22853924 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:732101 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein] CTD PMID:28521025 N-methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine decreases activity ISO RGD:732101 6480464 bifemelane results in decreased activity of KCNH2 protein CTD PMID:28551711 nadifloxacin affects binding ISO RGD:732101 6480464 nadifloxacin binds to KCNH2 protein CTD PMID:34058295 naftifine decreases activity ISO RGD:732101 6480464 naftifine results in decreased activity of KCNH2 protein CTD PMID:28551711 nefazodone decreases activity ISO RGD:732101 6480464 nefazodone results in decreased activity of KCNH2 protein CTD PMID:24052561 , PMID:28551711 nefazodone affects activity ISO RGD:732101 6480464 nefazodone affects the activity of KCNH2 protein CTD PMID:26821276 nefazodone multiple interactions ISO RGD:732101 6480464 nefazodone binds to and results in decreased activity of KCNH2 protein CTD PMID:24374264 , PMID:26821276 nicotine increases expression ISO RGD:732102 6480464 Nicotine results in increased expression of KCNH2 mRNA CTD PMID:17997037 Nifekalant decreases activity ISO RGD:732101 6480464 nifekalant results in decreased activity of KCNH2 protein CTD PMID:28551711 Nifekalant affects activity ISO RGD:732101 6480464 nifekalant affects the activity of KCNH2 protein CTD PMID:22020101 Niflumic acid multiple interactions ISO RGD:732101 6480464 E 4031 inhibits the reaction [Niflumic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]], Niflumic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium] CTD PMID:12359267 Niguldipine decreases activity ISO RGD:732101 6480464 niguldipine results in decreased activity of KCNH2 protein CTD PMID:28551711 nilotinib decreases activity ISO RGD:732101 6480464 nilotinib results in decreased activity of KCNH2 protein CTD PMID:23707608 nilotinib decreases expression ISO RGD:732101 6480464 nilotinib results in decreased expression of KCNH2 protein modified form CTD PMID:35680041 nilotinib multiple interactions ISO RGD:732101 6480464 N-butanoylsphingosine inhibits the reaction [nilotinib results in decreased expression of KCNH2 protein modified form], nilotinib results in decreased expression of and results in decreased activity of KCNH2 protein CTD PMID:35680041 nimesulide decreases activity ISO RGD:732101 6480464 nimesulide results in decreased activity of KCNH2 protein CTD PMID:24052561 nimodipine multiple interactions EXP 6480464 Nimodipine inhibits the reaction [KCNH2 protein affects the abundance of Calcium] CTD PMID:11040061 Nitrovin decreases activity ISO RGD:732101 6480464 Nitrovin results in decreased activity of KCNH2 protein CTD PMID:28551711 norfloxacin affects binding ISO RGD:732101 6480464 Norfloxacin binds to KCNH2 protein CTD PMID:34058295 Norfluoxetine decreases activity ISO RGD:732101 6480464 norfluoxetine results in decreased activity of KCNH2 protein CTD PMID:16967046 Norfluoxetine affects response to substance ISO RGD:732101 6480464 KCNH2 protein affects the susceptibility to norfluoxetine CTD PMID:16967046 Norfluoxetine affects localization ISO RGD:732101 6480464 norfluoxetine affects the localization of KCNH2 protein CTD PMID:16967046 nortriptyline multiple interactions ISO RGD:732101 6480464 Nortriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 ofloxacin affects binding ISO RGD:732101 6480464 Ofloxacin binds to KCNH2 protein CTD PMID:34058295 olanzapine decreases activity ISO RGD:732101 6480464 olanzapine results in decreased activity of KCNH2 protein CTD PMID:16494862 olanzapine multiple interactions ISO RGD:732101 6480464 olanzapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 oligomycin B decreases activity ISO RGD:732101 6480464 oligomycin B results in decreased activity of KCNH2 protein CTD PMID:24052561 Orbifloxacin affects binding ISO RGD:732101 6480464 orbifloxacin binds to KCNH2 protein CTD PMID:34058295 ouabain decreases expression ISO RGD:732101 6480464 Ouabain results in decreased expression of KCNH2 protein modified form CTD PMID:19139152 ouabain multiple interactions ISO RGD:732101 6480464 Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 ouabain decreases activity ISO RGD:732101 6480464 Ouabain results in decreased activity of KCNH2 protein CTD PMID:21158687 oxeladin decreases activity ISO RGD:732101 6480464 oxeladin results in decreased activity of KCNH2 protein CTD PMID:28551711 oxiconazole decreases activity ISO RGD:732101 6480464 oxiconazole results in decreased activity of KCNH2 protein CTD PMID:28551711 oxybuprocaine decreases activity ISO RGD:732101 6480464 benoxinate results in decreased activity of KCNH2 protein CTD PMID:28551711 Oxyphencyclimine decreases activity ISO RGD:732101 6480464 oxyphencyclimine results in decreased activity of KCNH2 protein CTD PMID:28551711 paliperidone palmitate decreases activity ISO RGD:732101 6480464 Paliperidone Palmitate results in decreased activity of KCNH2 protein CTD PMID:21394035 palonosetron decreases activity ISO RGD:732101 6480464 palonosetron results in decreased activity of KCNH2 protein CTD PMID:28551711 Panaxadiol affects activity ISO RGD:732101 6480464 panaxadiol affects the activity of KCNH2 protein CTD PMID:15842772 Panaxatriol affects activity ISO RGD:732101 6480464 panaxatriol affects the activity of KCNH2 protein CTD PMID:15842772 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of KCNH2 mRNA CTD PMID:33387578 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of KCNH2 mRNA CTD PMID:32680482 parathiazine decreases activity ISO RGD:732101 6480464 pyrathiazine results in decreased activity of KCNH2 protein CTD PMID:28551711 pecazine decreases activity ISO RGD:732101 6480464 mepazine results in decreased activity of KCNH2 protein CTD PMID:28551711 pefloxacin affects binding ISO RGD:732101 6480464 Pefloxacin binds to KCNH2 protein CTD PMID:34058295 pentamidine multiple interactions ISO RGD:732101 6480464 Pentamidine affects the localization of and affects the activity of KCNH2 protein more ... CTD PMID:15340016 more ... pentamidine decreases activity ISO RGD:732101 6480464 Pentamidine results in decreased activity of KCNH2 protein CTD PMID:21158687 pentanal increases expression ISO RGD:732101 6480464 pentanal results in increased expression of KCNH2 mRNA CTD PMID:26079696 pentobarbital decreases activity ISO RGD:732101 6480464 Pentobarbital results in decreased activity of KCNH2 protein CTD PMID:11862331 perhexiline affects binding ISO RGD:732101 6480464 Perhexiline binds to KCNH2 protein CTD PMID:18701618 periciazine decreases activity ISO RGD:732101 6480464 periciazine results in decreased activity of KCNH2 protein CTD PMID:28551711 perphenazine multiple interactions ISO RGD:732101 6480464 Perphenazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 perphenazine decreases activity ISO RGD:732101 6480464 Perphenazine results in decreased activity of KCNH2 protein CTD PMID:28551711 phentolamine multiple interactions ISO RGD:732101 6480464 Phentolamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 phentolamine decreases activity ISO RGD:732101 6480464 Phentolamine results in decreased activity of KCNH2 protein CTD PMID:24052561 phenylephrine multiple interactions ISO RGD:732101 6480464 Phenylephrine affects the reaction [KCNH2 protein results in increased transport of Potassium] CTD PMID:19419905 phenytoin decreases activity ISO RGD:732101 6480464 Phenytoin results in decreased activity of KCNH2 protein CTD PMID:21158687 pimobendan decreases activity ISO RGD:732101 6480464 pimobendan results in decreased activity of KCNH2 protein CTD PMID:24052561 pimozide multiple interactions ISO RGD:732101 6480464 Pimozide inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 , PMID:21158687 pimozide decreases activity ISO RGD:732101 6480464 Pimozide results in decreased activity of KCNH2 protein CTD PMID:15671647 , PMID:24052561 pizotifen decreases activity ISO RGD:732101 6480464 Pizotyline results in decreased activity of KCNH2 protein CTD PMID:28551711 potassium atom multiple interactions ISO RGD:732101 6480464 [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium] more ... CTD PMID:11805215 more ... potassium atom increases transport ISO RGD:732101 6480464 KCNH2 protein results in increased transport of Potassium CTD PMID:11805215 more ... potassium atom affects folding ISO RGD:732101 6480464 Potassium deficiency affects the folding of KCNH2 protein CTD PMID:19139152 Prenylamine decreases activity ISO RGD:732101 6480464 Prenylamine results in decreased activity of KCNH2 protein CTD PMID:16278312 pridinol decreases activity ISO RGD:732101 6480464 pridinol results in decreased activity of KCNH2 protein CTD PMID:28551711 probucol decreases activity ISO RGD:732101 6480464 Probucol results in decreased activity of KCNH2 protein SNP CTD PMID:15043509 procainamide multiple interactions ISO RGD:732101 6480464 Procainamide binds to and results in decreased activity of KCNH2 protein CTD PMID:15272206 profenamine decreases activity ISO RGD:732101 6480464 profenamine results in decreased activity of KCNH2 protein CTD PMID:28551711 progesterone multiple interactions EXP 6480464 2-Hydroxypropyl-beta-cyclodextrin inhibits the reaction [Progesterone results in decreased localization of KCNH2 protein] more ... CTD PMID:21525004 promazine decreases activity ISO RGD:732101 6480464 Promazine results in decreased activity of KCNH2 protein CTD PMID:28551711 propafenone multiple interactions ISO RGD:732101 6480464 Propafenone analog binds to and results in decreased activity of KCNH2 protein more ... CTD PMID:21158687 , PMID:21175572 propafenone decreases activity ISO RGD:732101 6480464 Propafenone results in decreased activity of KCNH2 protein CTD PMID:18724381 , PMID:24052561 propafenone affects activity ISO RGD:732101 6480464 Propafenone affects the activity of KCNH2 protein CTD PMID:16278312 propanal increases expression ISO RGD:732101 6480464 propionaldehyde results in increased expression of KCNH2 mRNA CTD PMID:26079696 propranolol multiple interactions ISO RGD:732101 6480464 Propranolol results in decreased activity of [KCNH2 protein binds to KCNE2 protein], Propranolol results in decreased activity of [KCNH2 protein binds to KCNH2 protein] CTD PMID:15679475 propranolol decreases activity ISO RGD:732101 6480464 Propranolol results in decreased activity of KCNH2 protein CTD PMID:16314852 pyridine affects binding ISO RGD:732101 6480464 pyridine analog binds to KCNH2 protein CTD PMID:17768047 pyruvic acid multiple interactions ISO RGD:732101 6480464 Pyruvic Acid inhibits the reaction [[Deoxyglucose co-treated with Glucose deficiency] results in decreased activity of KCNH2 protein] CTD PMID:12531891 pyrvinium decreases activity ISO RGD:732101 6480464 pyrvinium results in decreased activity of KCNH2 protein CTD PMID:28551711 quetiapine fumarate decreases activity ISO RGD:732101 6480464 Quetiapine Fumarate results in decreased activity of KCNH2 protein CTD PMID:28551711 quetiapine fumarate multiple interactions ISO RGD:732101 6480464 Quetiapine Fumarate inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 quifenadine decreases activity ISO RGD:732101 6480464 quifenadine results in decreased activity of KCNH2 protein CTD PMID:28551711 quinacrine decreases activity ISO RGD:732101 6480464 Quinacrine results in decreased activity of KCNH2 protein CTD PMID:28551711 quinidine multiple interactions ISO RGD:732101 6480464 [Quinidine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium more ... CTD PMID:15821840 more ... quinidine decreases activity ISO RGD:732101 6480464 Quinidine results in decreased activity of KCNH2 protein CTD PMID:11741928 more ... quinidine affects activity ISO RGD:732101 6480464 Quinidine affects the activity of KCNH2 protein CTD PMID:22020101 quinidine affects binding ISO RGD:732101 6480464 Quinidine binds to KCNH2 protein CTD PMID:18701618 quinidine affects localization ISO RGD:732101 6480464 Quinidine affects the localization of KCNH2 protein mutant form CTD PMID:11741928 quinidine affects response to substance ISO RGD:732101 6480464 KCNH2 gene SNP affects the susceptibility to Quinidine CTD PMID:12695533 quinidine decreases response to substance ISO RGD:732101 6480464 KCNH2 gene mutant form results in decreased susceptibility to Quinidine CTD PMID:15673388 quinine affects response to substance ISO RGD:732101 6480464 KCNH2 gene SNP affects the susceptibility to Quinine CTD PMID:12695533 quinine decreases activity ISO RGD:732101 6480464 Quinine results in decreased activity of KCNH2 protein CTD PMID:12695533 , PMID:28551711 ractopamine decreases activity ISO RGD:732101 6480464 ractopamine results in decreased activity of KCNH2 protein CTD PMID:28551711 radicicol decreases activity ISO RGD:732101 6480464 monorden results in decreased activity of KCNH2 protein CTD PMID:12775586 radicicol decreases expression ISO RGD:732101 6480464 monorden results in decreased expression of KCNH2 protein modified form CTD PMID:12775586 ranolazine decreases activity ISO RGD:732101 6480464 Ranolazine results in decreased activity of KCNH2 protein CTD PMID:24052561 ranolazine multiple interactions ISO RGD:732101 6480464 Ranolazine inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein] CTD PMID:28521025 reactive oxygen species multiple interactions ISO RGD:732101 6480464 [iron(III)-ascorbic acid complex results in increased abundance of Reactive Oxygen Species] affects the reaction [KCNH2 protein affects the transport of Potassium], [iron(III)-ascorbic acid complex results in increased abundance of Reactive Oxygen Species] which affects the activity of KCNH2 protein CTD PMID:9326673 rescinnamine decreases activity ISO RGD:732101 6480464 rescinnamine results in decreased activity of KCNH2 protein CTD PMID:28551711 reserpine decreases activity ISO RGD:732101 6480464 Reserpine results in decreased activity of KCNH2 protein CTD PMID:21362439 , PMID:28551711 reserpine multiple interactions ISO RGD:732101 6480464 [Reserpine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium CTD PMID:21362439 resveratrol multiple interactions ISO RGD:732101 6480464 resveratrol inhibits the reaction [arsenic trioxide results in decreased activity of KCNH2 protein] CTD PMID:25107562 risperidone multiple interactions ISO RGD:732101 6480464 Risperidone inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 ritanserin multiple interactions ISO RGD:732101 6480464 Ritanserin inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 rolipram decreases activity ISO RGD:732101 6480464 Rolipram results in decreased activity of KCNH2 protein CTD PMID:17146843 rose bengal decreases activity ISO RGD:732101 6480464 Rose Bengal results in decreased activity of KCNH2 protein CTD PMID:28551711 rosuvastatin calcium decreases activity ISO RGD:732101 6480464 Rosuvastatin Calcium results in decreased activity of KCNH2 protein CTD PMID:28551711 rotenone decreases activity ISO RGD:732101 6480464 Rotenone results in decreased activity of KCNH2 protein CTD PMID:24052561 rotenone multiple interactions EXP 6480464 [3-bromo-2-oxopropionic acid co-treated with Rotenone] results in decreased expression of KCNH2 protein CTD PMID:31585160 rotigotine decreases activity ISO RGD:732101 6480464 rotigotine results in decreased activity of KCNH2 protein CTD PMID:28551711 rubidium atom multiple interactions ISO RGD:732101 6480464 Rubidium inhibits the reaction [Gramicidin results in decreased expression of KCNH2 protein modified form] CTD PMID:19139152 Salmeterol xinafoate decreases activity ISO RGD:732101 6480464 Salmeterol Xinafoate results in decreased activity of KCNH2 protein CTD PMID:28551711 sertaconazole decreases activity ISO RGD:732101 6480464 sertaconazole results in decreased activity of KCNH2 protein CTD PMID:28551711 sertindole multiple interactions ISO RGD:732101 6480464 sertindole inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 sertindole decreases activity ISO RGD:732101 6480464 sertindole results in decreased activity of KCNH2 protein CTD PMID:16278312 , PMID:24052561 sertraline decreases activity ISO RGD:732101 6480464 Sertraline results in decreased activity of KCNH2 protein CTD PMID:28551711 simvastatin decreases localization EXP 6480464 Simvastatin results in decreased localization of KCNH2 protein CTD PMID:21525004 simvastatin decreases activity EXP 6480464 Simvastatin results in decreased activity of KCNH2 protein CTD PMID:30086269 simvastatin multiple interactions EXP 6480464 Berberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein] CTD PMID:30086269 sodium arsenite affects methylation ISO RGD:732101 6480464 sodium arsenite affects the methylation of KCNH2 gene CTD PMID:28589171 sodium atom multiple interactions ISO RGD:732101 6480464 Sodium deficiency inhibits the reaction [Digoxin results in decreased expression of KCNH2 protein] CTD PMID:19139152 sodium cyanide multiple interactions ISO RGD:732101 6480464 Sodium Cyanide inhibits the reaction [Glucose results in decreased activity of KCNH2 protein] CTD PMID:12531891 sorafenib decreases activity ISO RGD:732101 6480464 sorafenib results in decreased activity of KCNH2 protein CTD PMID:28551711 sotalol decreases response to substance ISO RGD:732101 6480464 KCNH2 gene mutant form results in decreased susceptibility to Sotalol CTD PMID:15673388 sotalol decreases activity ISO RGD:732101 6480464 Sotalol results in decreased activity of KCNH2 protein CTD PMID:16757186 more ... sotalol multiple interactions ISO RGD:732101 6480464 Potassium inhibits the reaction [Sotalol results in decreased activity of KCNH2 protein] CTD PMID:16960444 sotalol affects binding ISO RGD:732101 6480464 Sotalol analog binds to KCNH2 protein CTD PMID:18701618 strychnine decreases activity ISO RGD:732101 6480464 Strychnine results in decreased activity of KCNH2 protein CTD PMID:28551711 sulforaphane increases expression ISO RGD:732102 6480464 sulforaphane results in increased expression of KCNH2 mRNA CTD PMID:30529165 sunitinib decreases activity ISO RGD:732101 6480464 sunitinib results in decreased activity of KCNH2 protein CTD PMID:21906609 more ... Syrosingopine decreases activity ISO RGD:732101 6480464 syrosingopine results in decreased activity of KCNH2 protein CTD PMID:28551711 tacrine decreases activity ISO RGD:732101 6480464 Tacrine results in decreased activity of KCNH2 protein CTD PMID:24052561 tamoxifen multiple interactions ISO RGD:732101 6480464 [Tamoxifen results in decreased activity of KCNH2 protein] which results in decreased import of Thallium more ... CTD PMID:15272206 more ... tamoxifen decreases activity ISO RGD:732101 6480464 Tamoxifen results in decreased activity of KCNH2 protein CTD PMID:21362439 , PMID:28551711 tamoxifen affects expression ISO RGD:732102 6480464 Tamoxifen affects the expression of KCNH2 mRNA CTD PMID:17555576 tazarotene decreases activity ISO RGD:732101 6480464 tazarotene results in decreased activity of KCNH2 protein CTD PMID:28551711 terbinafine decreases activity ISO RGD:732101 6480464 terbinafine results in decreased activity of KCNH2 protein CTD PMID:28551711 terconazole decreases activity ISO RGD:732101 6480464 terconazole results in decreased activity of KCNH2 protein CTD PMID:28551711 Terfenadine multiple interactions ISO RGD:732101 6480464 2-(4-(2-(3 more ... CTD PMID:10828461 more ... Terfenadine affects binding ISO RGD:732101 6480464 Terfenadine binds to KCNH2 protein CTD PMID:18701618 , PMID:19260734 Terfenadine decreases activity ISO RGD:732101 6480464 Terfenadine results in decreased activity of KCNH2 protein CTD PMID:10422790 more ... terodiline multiple interactions ISO RGD:732101 6480464 terodiline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 testosterone increases expression ISO RGD:732101 6480464 Testosterone results in increased expression of KCNH2 mRNA CTD PMID:21592394 testosterone multiple interactions ISO RGD:732101 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of KCNH2 mRNA CTD PMID:21592394 tetramethrin decreases activity ISO RGD:732101 6480464 tetramethrin results in decreased activity of KCNH2 protein CTD PMID:28551711 thallium increases transport ISO RGD:732101 6480464 KCNH2 protein results in increased transport of Thallium, KCNH2 results in increased transport of Thallium CTD PMID:19583963 , PMID:21158687 thallium multiple interactions ISO RGD:732101 6480464 2-(4-(2-(3 more ... CTD PMID:19583963 more ... thallium increases import ISO RGD:732101 6480464 KCNH2 protein results in increased import of Thallium CTD PMID:21158688 thioridazine multiple interactions ISO RGD:732101 6480464 Thioridazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 thioridazine decreases activity ISO RGD:732101 6480464 Thioridazine results in decreased activity of KCNH2 protein CTD PMID:15671647 more ... tiamulin decreases activity ISO RGD:732101 6480464 tiamulin results in decreased activity of KCNH2 protein CTD PMID:28551711 tifenamil decreases activity ISO RGD:732101 6480464 thiphenamil results in decreased activity of KCNH2 protein CTD PMID:28551711 tipepidine decreases activity ISO RGD:732101 6480464 tipepidine results in decreased activity of KCNH2 protein CTD PMID:28551711 tiquizium bromide decreases activity ISO RGD:732101 6480464 thiaton results in decreased activity of KCNH2 protein CTD PMID:28551711 titanium dioxide multiple interactions ISO RGD:732102 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of KCNH2 mRNA CTD PMID:29950665 tolcapone decreases activity ISO RGD:732101 6480464 tolcapone results in decreased activity of KCNH2 protein CTD PMID:24052561 topiramate decreases activity ISO RGD:732101 6480464 topiramate results in decreased activity of KCNH2 protein CTD PMID:15716081 toremifene decreases activity ISO RGD:732101 6480464 Toremifene results in decreased activity of KCNH2 protein CTD PMID:28551711 trazodone decreases activity ISO RGD:732101 6480464 Trazodone results in decreased activity of KCNH2 protein CTD PMID:15740727 , PMID:28551711 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of KCNH2 mRNA CTD PMID:33387578 trichostatin A decreases expression ISO RGD:732101 6480464 trichostatin A results in decreased expression of KCNH2 mRNA CTD PMID:24935251 trifluoperazine multiple interactions ISO RGD:732101 6480464 Trifluoperazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 trifluperidol multiple interactions ISO RGD:732101 6480464 Trifluperidol inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 triflupromazine decreases activity ISO RGD:732101 6480464 Triflupromazine results in decreased activity of KCNH2 protein CTD PMID:28551711 Tripelennamine decreases activity ISO RGD:732101 6480464 Tripelennamine results in decreased activity of KCNH2 protein CTD PMID:28551711 triprolidine decreases activity ISO RGD:732101 6480464 Triprolidine results in decreased activity of KCNH2 protein CTD PMID:28551711 triptonide increases expression ISO RGD:732102 6480464 triptonide results in increased expression of KCNH2 mRNA CTD PMID:33045310 Triton X-100 decreases activity ISO RGD:732101 6480464 Octoxynol results in decreased activity of KCNH2 protein CTD PMID:24052561 Valnemulin decreases activity ISO RGD:732101 6480464 valnemulin results in decreased activity of KCNH2 protein CTD PMID:28551711 valproic acid increases methylation ISO RGD:732101 6480464 Valproic Acid results in increased methylation of KCNH2 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:732101 6480464 Valproic Acid affects the expression of KCNH2 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:732101 6480464 Valproic Acid results in increased expression of KCNH2 mRNA CTD PMID:23179753 , PMID:29154799 vandetanib affects binding ISO RGD:732101 6480464 vandetanib binds to KCNH2 protein CTD PMID:29630634 vandetanib decreases expression ISO RGD:732101 6480464 vandetanib results in decreased expression of KCNH2 protein modified form CTD PMID:35680041 vandetanib multiple interactions ISO RGD:732101 6480464 Brefeldin A promotes the reaction [vandetanib results in decreased expression of KCNH2 protein modified form] more ... CTD PMID:35680041 vanoxerine dihydrochloride multiple interactions ISO RGD:732101 6480464 vanoxerine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 venlafaxine hydrochloride decreases activity ISO RGD:732101 6480464 Venlafaxine Hydrochloride results in decreased activity of KCNH2 protein CTD PMID:21158687 verapamil multiple interactions ISO RGD:732101 6480464 [Verapamil results in decreased activity of KCNH2 protein] which results in decreased import of Thallium, Verapamil inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 more ... verapamil decreases activity ISO RGD:732101 6480464 Verapamil results in decreased activity of KCNH2 protein CTD PMID:15671647 more ... vincamine decreases activity ISO RGD:732101 6480464 Vincamine results in decreased activity of KCNH2 protein CTD PMID:28551711 Vinpocetine multiple interactions ISO RGD:732101 6480464 vinpocetine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 Vinpocetine decreases activity ISO RGD:732101 6480464 vinpocetine results in decreased activity of KCNH2 protein CTD PMID:17146843 vitamin E multiple interactions ISO RGD:732101 6480464 Vitamin E inhibits the reaction [TNF protein results in decreased activity of KCNH2 protein] CTD PMID:14973143 vitamin E increases expression ISO RGD:732101 6480464 Vitamin E results in increased expression of KCNH2 mRNA CTD PMID:19244175 xaliproden decreases activity ISO RGD:732101 6480464 xaliproden results in decreased activity of KCNH2 protein CTD PMID:28551711 zimeldine decreases activity ISO RGD:732101 6480464 Zimeldine results in decreased activity of KCNH2 protein CTD PMID:24052561 zinc pyrithione decreases activity ISO RGD:732101 6480464 pyrithione zinc results in decreased activity of KCNH2 protein CTD PMID:28551711 ziprasidone decreases activity ISO RGD:732101 6480464 ziprasidone results in decreased activity of KCNH2 protein CTD PMID:28551711