Kcnh2 (potassium voltage-gated channel subfamily H member 2) - Rat Genome Database

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Gene: Kcnh2 (potassium voltage-gated channel subfamily H member 2) Rattus norvegicus
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Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
RGD ID: 621414
Description: Enables inward rectifier potassium channel activity and scaffold protein binding activity. Involved in central nervous system development; potassium ion transport; and regulation of membrane potential. Located in plasma membrane. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; aldehydo-D-glucose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eag-related protein 1; ERG-1; ERG1; ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related protein 1; potassium channel, voltage gated eag related subfamily H, member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; r-ERG; RERG; voltage-gated potassium channel subunit Kv11.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2410,826,834 - 10,859,009 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,826,928 - 10,859,008 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,973,605 - 16,005,332 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0411,793,792 - 11,825,521 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0410,145,580 - 10,177,308 (+)NCBIRnor_WKY
Rnor_6.047,355,066 - 7,387,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,355,574 - 7,387,253 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,366,726 - 7,398,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,192,644 - 6,224,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,192,643 - 6,224,284 (+)NCBI
Celera46,444,570 - 6,473,521 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-butaclamol  (ISO)
(-)-lobeline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-duloxetine hydrochloride  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
(Z)-chlorprothixene  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine  (ISO)
1,3-diphenylguanidine  (ISO)
1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethyl-2-butanol  (ISO)
1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-2-phenothiazinyl]ethanone  (ISO)
1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine  (ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
10H-phenothiazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2-diphenylacetic acid (1-ethyl-3-piperidinyl) ester  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine  (ISO)
2-[2-(diethylamino)ethylamino]-2-phenylacetic acid 3-methylbutyl ester  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (ISO)
2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxy-2,2-diphenylacetic acid 2-(diethylamino)ethyl ester  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3-diphenyl-N-(1-phenylethyl)-1-propanamine  (ISO)
3,4-dimethoxybenzoic acid 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl ester  (ISO)
3,6-diaminoacridine  (ISO)
3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1H-benzimidazol-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (ISO)
4-amino-5-chloro-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
4-aminopyridine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole  (ISO)
7H-xanthine  (ISO)
9H-xanthine  (ISO)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
acetylmethadol  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ajmaline  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpidem  (ISO)
alverine  (ISO)
amantadine  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amorolfine  (ISO)
amperozide  (ISO)
amphetamine  (EXP)
amsacrine  (ISO)
aprindine  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
Arkin (TN)  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
astemizole  (EXP,ISO)
atorvastatin calcium  (EXP)
ATP  (ISO)
atrazine  (ISO)
azaperone  (ISO)
Azaspiracid  (ISO)
azelastine  (ISO)
Azimilide  (ISO)
Balofloxacin  (ISO)
benzalkonium chloride  (ISO)
benzatropine  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester  (ISO)
benzydamine  (ISO)
bepridil  (ISO)
berberine  (EXP)
betahistine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bopindolol  (ISO)
brefeldin A  (ISO)
bromhexine  (ISO)
Bromocyclen  (ISO)
Bromperidol  (ISO)
brompheniramine  (ISO)
buclizine  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
butoconazole  (ISO)
C3-thiacarbocyanine cation  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbachol  (ISO)
carbinoxamine  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
casticin  (ISO)
cefotetan  (ISO)
cepharanthine  (ISO)
cetalkonium chloride  (ISO)
CGP 52608  (ISO)
chloramine T  (ISO)
chlordecone  (ISO)
chlorobutanol  (ISO)
chloroform  (ISO)
chlorphenamine  (ISO)
chlorpromazine  (ISO)
cholesterol  (EXP)
cibenzoline  (ISO)
ciclopirox  (ISO)
cinacalcet  (ISO)
cinchocaine  (ISO)
cinchonine  (ISO)
ciprofloxacin  (ISO)
cisapride  (ISO)
cisplatin  (ISO)
clarithromycin  (ISO)
clemastine  (ISO)
clofazimine  (ISO)
clofedanol  (ISO)
clomipramine  (ISO)
clopenthixol  (ISO)
clorotepine  (ISO)
Clotiapine  (ISO)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
codeine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
crizotinib  (ISO)
crystal violet  (ISO)
curcumin  (ISO)
cyamemazine  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
Danofloxacin  (ISO)
dantrolene  (ISO)
darifenacin  (ISO)
daunorubicin  (ISO)
DDT  (ISO)
denopamine  (ISO)
deptropine  (ISO)
desipramine  (ISO)
desloratadine  (ISO)
desmethylastemizole  (ISO)
dexbrompheniramine  (ISO)
dexetimide  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
Didecyldimethylammonium  (ISO)
difloxacin  (ISO)
digoxin  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dioxygen  (EXP)
diphenylpyraline  (ISO)
dipyridamole  (ISO)
disopyramide  (ISO)
dithiazanine  (ISO)
dobutamine  (ISO)
dofetilide  (ISO)
dolasetron  (ISO)
Domiphen bromide  (ISO)
domperidone  (ISO)
doxepin  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
droperidol  (ISO)
dutasteride  (ISO)
dyclonine  (ISO)
E-4031  (EXP,ISO)
Ebastine  (ISO)
Eburnamonine  (ISO)
econazole  (ISO)
eletriptan  (ISO)
eliprodil  (ISO)
emedastine  (ISO)
endosulfan  (EXP)
enoxacin  (ISO)
enrofloxacin  (ISO)
epinastine  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (ISO)
ethanol  (ISO)
ezogabine  (ISO)
Febantel  (ISO)
fenoverine  (ISO)
fentanyl  (ISO)
Fexofenadine hydrochloride  (ISO)
fingolimod hydrochloride  (ISO)
flavonoids  (EXP)
flecainide  (ISO)
fleroxacin  (ISO)
flufenamic acid  (ISO)
fluorescein (lactone form)  (ISO)
fluoxetine  (ISO)
flupenthixol  (ISO)
flurazepam  (ISO)
fluvoxamine  (ISO)
fomocaine  (ISO)
formoterol fumarate  (ISO)
fulvestrant  (ISO)
gabapentin  (ISO)
gatifloxacin  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
ginsenoside Rb1  (ISO)
ginsenoside Rf  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glyburide  (ISO)
Grepafloxacin  (ISO)
Halofantrine  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
hydroxyzine  (ISO)
ibogaine  (ISO)
ICI 118551  (ISO)
idarubicin  (ISO)
imipramine  (EXP,ISO)
ipriflavone  (ISO)
isoconazole  (ISO)
ivabradine  (ISO)
ketoconazole  (ISO)
lamotrigine  (ISO)
lidocaine  (ISO)
Liranaftate  (ISO)
lofepramine  (ISO)
lomefloxacin  (ISO)
loratadine  (ISO)
lovastatin  (ISO)
loxapine  (ISO)
lubeluzole  (ISO)
malachite green cation  (ISO)
manidipine  (ISO)
Maprotiline  (ISO)
Mebhydrolin napadisilate  (ISO)
mefloquine  (ISO)
mepyramine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mesoridazine  (ISO)
methadone  (ISO)
methapyrilene  (ISO)
methdilazine  (ISO)
methiothepin  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
metixene  (ISO)
metoclopramide  (ISO)
metoprolol  (ISO)
mexiletine  (ISO)
Mibefradil  (ISO)
miconazole  (ISO)
mitoxantrone  (ISO)
Mitragynine  (ISO)
Mizolastine  (ISO)
moxifloxacin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine  (ISO)
nadifloxacin  (ISO)
naftifine  (ISO)
nefazodone  (ISO)
nicotine  (ISO)
Nifekalant  (ISO)
Niflumic acid  (ISO)
Niguldipine  (ISO)
nilotinib  (ISO)
nimesulide  (ISO)
nimodipine  (EXP)
Nitrovin  (ISO)
norfloxacin  (ISO)
Norfluoxetine  (ISO)
nortriptyline  (ISO)
ofloxacin  (ISO)
olanzapine  (ISO)
oligomycin B  (ISO)
Orbifloxacin  (ISO)
ouabain  (ISO)
oxeladin  (ISO)
oxiconazole  (ISO)
oxybuprocaine  (ISO)
Oxyphencyclimine  (ISO)
paliperidone palmitate  (ISO)
palonosetron  (ISO)
Panaxadiol  (ISO)
Panaxatriol  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
parathiazine  (ISO)
pecazine  (ISO)
pefloxacin  (ISO)
pentamidine  (ISO)
pentanal  (ISO)
pentobarbital  (ISO)
perhexiline  (ISO)
periciazine  (ISO)
perphenazine  (ISO)
phentolamine  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
pimobendan  (ISO)
pimozide  (ISO)
pizotifen  (ISO)
potassium atom  (ISO)
Prenylamine  (ISO)
pridinol  (ISO)
probucol  (ISO)
procainamide  (ISO)
profenamine  (ISO)
progesterone  (EXP)
promazine  (ISO)
propafenone  (ISO)
propanal  (ISO)
propranolol  (ISO)
pyridine  (ISO)
pyruvic acid  (ISO)
pyrvinium  (ISO)
quetiapine fumarate  (ISO)
quifenadine  (ISO)
quinacrine  (ISO)
quinidine  (ISO)
quinine  (ISO)
ractopamine  (ISO)
radicicol  (ISO)
ranolazine  (ISO)
reactive oxygen species  (ISO)
rescinnamine  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
risperidone  (ISO)
ritanserin  (ISO)
rolipram  (ISO)
rose bengal  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
rotigotine  (ISO)
rubidium atom  (ISO)
Salmeterol xinafoate  (ISO)
sertaconazole  (ISO)
sertindole  (ISO)
sertraline  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium cyanide  (ISO)
sorafenib  (ISO)
sotalol  (ISO)
strychnine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Syrosingopine  (ISO)
tacrine  (ISO)
tamoxifen  (ISO)
tazarotene  (ISO)
terbinafine  (ISO)
terconazole  (ISO)
Terfenadine  (ISO)
terodiline  (ISO)
testosterone  (ISO)
tetramethrin  (ISO)
thallium  (ISO)
thioridazine  (ISO)
tiamulin  (ISO)
tifenamil  (ISO)
tipepidine  (ISO)
tiquizium bromide  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
topiramate  (ISO)
toremifene  (ISO)
trazodone  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trifluoperazine  (ISO)
trifluperidol  (ISO)
triflupromazine  (ISO)
Tripelennamine  (ISO)
triprolidine  (ISO)
triptonide  (ISO)
Triton X-100  (ISO)
Valnemulin  (ISO)
valproic acid  (ISO)
vandetanib  (ISO)
vanoxerine dihydrochloride  (ISO)
venlafaxine hydrochloride  (ISO)
verapamil  (ISO)
vincamine  (ISO)
Vinpocetine  (ISO)
vitamin E  (ISO)
xaliproden  (ISO)
zimeldine  (ISO)
zinc pyrithione  (ISO)
ziprasidone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. RERG is a molecular correlate of the inward-rectifying K current in clonal rat pituitary cells. Bauer CK, etal., Receptors Channels 1998;6(1):19-29.
2. Regulation of an ERG K+ current by Src tyrosine kinase. Cayabyab FS and Schlichter LC, J Biol Chem 2002 Apr 19;277(16):13673-81.
3. Expression of the IKr components KCNH2 (rERG) and KCNE2 (rMiRP1) during late rat heart development. Chun KR, etal., Exp Mol Med. 2004 Aug 31;36(4):367-71.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2. Guo J, etal., J Biol Chem. 2012 Sep 28;287(40):33132-41. Epub 2012 Aug 9.
7. Fast erg K+ currents in rat embryonic serotonergic neurones. Hirdes W, etal., J Physiol. 2005 Apr 1;564(Pt 1):33-49. Epub 2005 Jan 27.
8. Short QT syndrome and atrial fibrillation caused by mutation in KCNH2. Hong K, etal., J Cardiovasc Electrophysiol. 2005 Apr;16(4):394-6.
9. The regulation of the cardiac potassium channel (HERG) by caveolin-1. Lin J, etal., Biochem Cell Biol. 2008 Oct;86(5):405-15. doi: 10.1139/o08-118.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Identification of two nervous system-specific members of the erg potassium channel gene family. Shi W, etal., J Neurosci 1997 Dec 15;17(24):9423-32.
19. Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing. Tester DJ, etal., Heart Rhythm. 2005 May;2(5):507-17.
20. Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers. Wimmers S, etal., Pflugers Arch. 2001 Jan;441(4):450-5.
21. Tissue and species distribution of mRNA for the IKr-like K+ channel, erg. Wymore RS, etal., Circ Res 1997 Feb;80(2):261-8.
Additional References at PubMed
PMID:7604285   PMID:7736582   PMID:7889573   PMID:8587608   PMID:8995352   PMID:9351446   PMID:9351462   PMID:10718922   PMID:10843886   PMID:11953308   PMID:14525949   PMID:14668215  
PMID:14670813   PMID:16339175   PMID:17322986   PMID:19913309   PMID:19921238   PMID:20605793   PMID:21063088   PMID:21463633   PMID:21536673   PMID:23589291   PMID:24931372   PMID:25281747  
PMID:27071825   PMID:28280240   PMID:29507111   PMID:29949809   PMID:30544220   PMID:32388931   PMID:32559772   PMID:33263944   PMID:33426760   PMID:35841324  


Genomics

Comparative Map Data
Kcnh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2410,826,834 - 10,859,009 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,826,928 - 10,859,008 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,973,605 - 16,005,332 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0411,793,792 - 11,825,521 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0410,145,580 - 10,177,308 (+)NCBIRnor_WKY
Rnor_6.047,355,066 - 7,387,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,355,574 - 7,387,253 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,366,726 - 7,398,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,192,644 - 6,224,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,192,643 - 6,224,284 (+)NCBI
Celera46,444,570 - 6,473,521 (+)NCBICelera
Cytogenetic Map4q11NCBI
KCNH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387150,944,961 - 150,978,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7150,944,961 - 150,978,321 (-)EnsemblGRCh38hg38GRCh38
GRCh377150,642,049 - 150,675,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,272,982 - 150,305,947 (-)NCBINCBI36Build 36hg18NCBI36
Build 347150,079,696 - 150,090,563NCBI
Celera7145,199,077 - 145,232,050 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,454,320 - 144,487,268 (-)NCBIHuRef
CHM1_17150,650,401 - 150,683,838 (-)NCBICHM1_1
T2T-CHM13v2.07152,117,824 - 152,151,201 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27149,971,333 - 150,004,698 (-)NCBI
Kcnh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,524,583 - 24,556,671 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl524,524,587 - 24,556,602 (-)EnsemblGRCm39 Ensembl
GRCm38524,319,589 - 24,351,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,319,589 - 24,351,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv37523,825,407 - 23,857,422 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36523,829,654 - 23,861,669 (-)NCBIMGSCv36mm8
Celera521,266,318 - 21,295,272 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map510.94NCBI
Kcnh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,391,384 - 5,422,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,391,444 - 5,422,241 (-)NCBIChiLan1.0ChiLan1.0
KCNH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17154,680,927 - 154,713,525 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v07142,528,979 - 142,562,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KCNH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,009,031 - 15,041,786 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,009,031 - 15,041,504 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,617,297 - 15,650,061 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,724,206 - 16,757,289 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1616,724,490 - 16,757,289 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,103,715 - 15,136,482 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,685,081 - 15,717,872 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,735,820 - 15,768,605 (-)NCBIUU_Cfam_GSD_1.0
Kcnh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,491,041 - 6,523,203 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,379,669 - 6,412,390 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365276,380,222 - 6,412,390 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,243,524 - 6,279,111 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,242,826 - 6,279,154 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,719,117 - 6,725,624 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,123,601 - 119,156,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,124,007 - 119,156,794 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607215,095,069 - 15,128,476 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,632,726 - 5,663,771 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248005,633,060 - 5,663,700 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnh2
81 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:165
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000013800
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 38 12 2 6 2 64 14 38
Low 3 5 14 8 13 8 8 11 10 18 3 11 8
Below cutoff 26 26 26 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013800   ⟹   ENSRNOP00000013800
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,826,928 - 10,859,008 (+)Ensembl
Rnor_6.0 Ensembl47,355,574 - 7,387,253 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084826   ⟹   ENSRNOP00000073593
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,849,037 - 10,859,008 (+)Ensembl
Rnor_6.0 Ensembl47,377,563 - 7,387,240 (+)Ensembl
RefSeq Acc Id: NM_053949   ⟹   NP_446401
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,827,369 - 10,859,009 (+)NCBI
Rnor_6.047,355,601 - 7,387,241 (+)NCBI
Rnor_5.047,366,726 - 7,398,606 (+)NCBI
RGSC_v3.446,192,644 - 6,224,285 (+)RGD
Celera46,444,570 - 6,473,521 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235867   ⟹   XP_006235929
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,826,834 - 10,859,008 (+)NCBI
Rnor_6.047,355,066 - 7,387,282 (+)NCBI
Rnor_5.047,366,726 - 7,398,606 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762630   ⟹   XP_008760852
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,848,982 - 10,859,008 (+)NCBI
Rnor_6.047,377,219 - 7,387,282 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039106950   ⟹   XP_038962878
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,845,184 - 10,859,008 (+)NCBI
RefSeq Acc Id: XM_039106951   ⟹   XP_038962879
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2410,826,834 - 10,853,613 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_446401   ⟸   NM_053949
- UniProtKB: O08720 (UniProtKB/Swiss-Prot),   O08962 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006235929   ⟸   XM_006235867
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008760852   ⟸   XM_008762630
- Peptide Label: isoform X3
- UniProtKB: Q6DKY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073593   ⟸   ENSRNOT00000084826
RefSeq Acc Id: ENSRNOP00000013800   ⟸   ENSRNOT00000013800
RefSeq Acc Id: XP_038962879   ⟸   XM_039106951
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038962878   ⟸   XM_039106950
- Peptide Label: isoform X2
Protein Domains
Cyclic nucleotide-binding   PAC   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08962-F1-model_v2 AlphaFold O08962 1-1163 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621414 AgrOrtholog
BioCyc Gene G2FUF-46033 BioCyc
Ensembl Genes ENSRNOG00000009872 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000013800 ENTREZGENE
  ENSRNOP00000013800.3 UniProtKB/TrEMBL
  ENSRNOP00000073593 ENTREZGENE
  ENSRNOP00000073593.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013800 ENTREZGENE
  ENSRNOT00000013800.5 UniProtKB/TrEMBL
  ENSRNOT00000084826 ENTREZGENE
  ENSRNOT00000084826.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-assoc_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117018 UniProtKB/Swiss-Prot
NCBI Gene 117018 ENTREZGENE
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KCNH2 RGD
PhenoGen Kcnh2 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERGCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs sensory_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LN86_RAT UniProtKB/TrEMBL
  KCNH2_RAT UniProtKB/Swiss-Prot
  O08720 ENTREZGENE
  O08962 ENTREZGENE
  Q6DKY7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O08720 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnh2  potassium voltage-gated channel subfamily H member 2  Kcnh2  potassium channel, voltage gated eag related subfamily H, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnh2  potassium channel, voltage gated eag related subfamily H, member 2  Kcnh2  potassium voltage-gated channel, subfamily H (eag-related), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kcnh2  potassium voltage-gated channel, subfamily H (eag-related), member 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kcnh2  potassium voltage-gated channel, subfamily H (eag-related), member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in stomach fundus and antrum, brain, adrenal gland, thymus, retina, and skeletal muscle 625508
gene_function creates a voltage-dependent inward-rectifying K current 729087
gene_homology has 96% amino acid identify to HERG 729087
gene_process currents generated may counteract in the increase of muscle tone resulting in the regulation of the rhythms in stomach smooth muscle contraction 625508
gene_process responsible for the potassium current deactivation by depolarization 625508
gene_product 165-205 kDa protein 625508