Kcnh2 (potassium voltage-gated channel subfamily H member 2) - Rat Genome Database

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Gene: Kcnh2 (potassium voltage-gated channel subfamily H member 2) Rattus norvegicus
Analyze
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
RGD ID: 621414
Description: Enables inward rectifier potassium channel activity and scaffold protein binding activity. Involved in central nervous system development; potassium ion transport; and regulation of membrane potential. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; aldehydo-D-glucose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: eag-related protein 1; ERG-1; ERG1; ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related protein 1; potassium channel, voltage gated eag related subfamily H, member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; r-ERG; RERG; voltage-gated potassium channel subunit Kv11.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2410,826,834 - 10,859,009 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl410,826,928 - 10,859,008 (+)Ensembl
Rnor_6.047,355,066 - 7,387,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,355,574 - 7,387,253 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,366,726 - 7,398,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,192,644 - 6,224,285 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.146,192,643 - 6,224,284 (+)NCBI
Celera46,444,570 - 6,473,521 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-butaclamol  (ISO)
(-)-lobeline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-duloxetine hydrochloride  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
(Z)-chlorprothixene  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine  (ISO)
1,3-diphenylguanidine  (ISO)
1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethyl-2-butanol  (ISO)
1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-2-phenothiazinyl]ethanone  (ISO)
1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine  (ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
10H-phenothiazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2-diphenylacetic acid (1-ethyl-3-piperidinyl) ester  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine  (ISO)
2-[2-(diethylamino)ethylamino]-2-phenylacetic acid 3-methylbutyl ester  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (ISO)
2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxy-2,2-diphenylacetic acid 2-(diethylamino)ethyl ester  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3-diphenyl-N-(1-phenylethyl)-1-propanamine  (ISO)
3,4-dimethoxybenzoic acid 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl ester  (ISO)
3,6-diaminoacridine  (ISO)
3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1H-benzimidazol-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (ISO)
4-amino-5-chloro-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
4-aminopyridine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole  (ISO)
7H-xanthine  (ISO)
9H-xanthine  (ISO)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
acetylmethadol  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ajmaline  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpidem  (ISO)
alverine  (ISO)
amantadine  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amorolfine  (ISO)
amperozide  (ISO)
amphetamine  (EXP)
amsacrine  (ISO)
aprindine  (ISO)
aripiprazole  (ISO)
aristolochic acid  (ISO)
Arkin (TN)  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
astemizole  (EXP,ISO)
atorvastatin calcium  (EXP)
ATP  (ISO)
atrazine  (ISO)
azaperone  (ISO)
Azaspiracid  (ISO)
azelastine  (ISO)
Azimilide  (ISO)
Balofloxacin  (ISO)
benzalkonium chloride  (ISO)
benzatropine  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester  (ISO)
benzydamine  (ISO)
bepridil  (ISO)
berberine  (EXP)
betahistine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP)
bopindolol  (ISO)
bromhexine  (ISO)
Bromocyclen  (ISO)
Bromperidol  (ISO)
brompheniramine  (ISO)
buclizine  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
butoconazole  (ISO)
C3-thiacarbocyanine cation  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbachol  (ISO)
carbinoxamine  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
casticin  (ISO)
cefotetan  (ISO)
cepharanthine  (ISO)
cetalkonium chloride  (ISO)
chloramine T  (ISO)
chlordecone  (ISO)
chlorobutanol  (ISO)
chloroform  (ISO)
chlorphenamine  (ISO)
chlorpromazine  (ISO)
cholesterol  (EXP)
cibenzoline  (ISO)
ciclopirox  (ISO)
cinacalcet  (ISO)
cinchocaine  (ISO)
cinchonine  (ISO)
ciprofloxacin  (ISO)
cisapride  (ISO)
cisplatin  (ISO)
clarithromycin  (ISO)
clemastine  (ISO)
clofazimine  (ISO)
clofedanol  (ISO)
clomipramine  (ISO)
clopenthixol  (ISO)
clorotepine  (ISO)
Clotiapine  (ISO)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
codeine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
crizotinib  (ISO)
crystal violet  (ISO)
curcumin  (ISO)
cyamemazine  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
Danofloxacin  (ISO)
dantrolene  (ISO)
darifenacin  (ISO)
daunorubicin  (ISO)
DDT  (ISO)
denopamine  (ISO)
deptropine  (ISO)
desipramine  (ISO)
desloratadine  (ISO)
desmethylastemizole  (ISO)
dexbrompheniramine  (ISO)
dexetimide  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
difloxacin  (ISO)
digoxin  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
diphenylpyraline  (ISO)
dipyridamole  (ISO)
disopyramide  (ISO)
dithiazanine  (ISO)
dobutamine  (ISO)
dofetilide  (ISO)
dolasetron  (ISO)
Domiphen bromide  (ISO)
domperidone  (ISO)
doxepin  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
droperidol  (ISO)
dutasteride  (ISO)
dyclonine  (ISO)
E-4031  (EXP,ISO)
Ebastine  (ISO)
Eburnamonine  (ISO)
econazole  (ISO)
eletriptan  (ISO)
eliprodil  (ISO)
emedastine  (ISO)
endosulfan  (EXP)
enoxacin  (ISO)
enrofloxacin  (ISO)
epinastine  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (ISO)
ethanol  (ISO)
ezogabine  (ISO)
fenoverine  (ISO)
fentanyl  (ISO)
Fexofenadine hydrochloride  (ISO)
fingolimod hydrochloride  (ISO)
flavonoids  (EXP)
flecainide  (ISO)
fleroxacin  (ISO)
flufenamic acid  (ISO)
fluorescein (lactone form)  (ISO)
fluoxetine  (ISO)
flupenthixol  (ISO)
flurazepam  (ISO)
fluvoxamine  (ISO)
fomocaine  (ISO)
formoterol fumarate  (ISO)
gabapentin  (ISO)
gatifloxacin  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
ginsenoside Rb1  (ISO)
ginsenoside Rf  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glyburide  (ISO)
Grepafloxacin  (ISO)
Halofantrine  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
hydroxyzine  (ISO)
ibogaine  (ISO)
ICI 118551  (ISO)
idarubicin  (ISO)
imipramine  (EXP,ISO)
ipriflavone  (ISO)
isoconazole  (ISO)
ivabradine  (ISO)
ketoconazole  (ISO)
lamotrigine  (ISO)
lidocaine  (ISO)
Liranaftate  (ISO)
lofepramine  (ISO)
lomefloxacin  (ISO)
loratadine  (ISO)
lovastatin  (ISO)
loxapine  (ISO)
lubeluzole  (ISO)
malachite green cation  (ISO)
manidipine  (ISO)
Maprotiline  (ISO)
Matrine  (ISO)
Mebhydrolin napadisilate  (ISO)
mefloquine  (ISO)
mepyramine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mesoridazine  (ISO)
methadone  (ISO)
methapyrilene  (ISO)
methdilazine  (ISO)
methiothepin  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
metixene  (ISO)
metoclopramide  (ISO)
metoprolol  (ISO)
mexiletine  (ISO)
Mibefradil  (ISO)
miconazole  (ISO)
mitoxantrone  (ISO)
Mitragynine  (ISO)
Mizolastine  (ISO)
moxifloxacin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine  (ISO)
nadifloxacin  (ISO)
naftifine  (ISO)
nefazodone  (ISO)
nicotine  (ISO)
Nifekalant  (ISO)
Niflumic acid  (ISO)
Niguldipine  (ISO)
nilotinib  (ISO)
nimesulide  (ISO)
nimodipine  (EXP)
Nitrovin  (ISO)
norfloxacin  (ISO)
Norfluoxetine  (ISO)
nortriptyline  (ISO)
ofloxacin  (ISO)
olanzapine  (ISO)
oligomycin B  (ISO)
Orbifloxacin  (ISO)
ouabain  (ISO)
oxeladin  (ISO)
oxiconazole  (ISO)
oxybuprocaine  (ISO)
Oxyphencyclimine  (ISO)
paliperidone palmitate  (ISO)
palonosetron  (ISO)
Panaxatriol  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
parathiazine  (ISO)
pecazine  (ISO)
pefloxacin  (ISO)
pentamidine  (ISO)
pentanal  (ISO)
pentobarbital  (ISO)
perhexiline  (ISO)
periciazine  (ISO)
perphenazine  (ISO)
phentolamine  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
pimobendan  (ISO)
pimozide  (ISO)
pizotifen  (ISO)
potassium atom  (ISO)
Prenylamine  (ISO)
pridinol  (ISO)
probucol  (ISO)
procainamide  (ISO)
profenamine  (ISO)
progesterone  (EXP)
promazine  (ISO)
propafenone  (ISO)
propanal  (ISO)
propranolol  (ISO)
pyridine  (ISO)
pyruvic acid  (ISO)
pyrvinium  (ISO)
quetiapine fumarate  (ISO)
quifenadine  (ISO)
quinacrine  (ISO)
quinidine  (ISO)
quinine  (ISO)
ractopamine  (ISO)
radicicol  (ISO)
ranolazine  (ISO)
reactive oxygen species  (ISO)
rescinnamine  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
risperidone  (ISO)
ritanserin  (ISO)
rolipram  (ISO)
rose bengal  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
rotigotine  (ISO)
rubidium atom  (ISO)
Salmeterol xinafoate  (ISO)
sertaconazole  (ISO)
sertindole  (ISO)
sertraline  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium cyanide  (ISO)
sorafenib  (ISO)
sotalol  (ISO)
strychnine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Syrosingopine  (ISO)
tacrine  (ISO)
tamoxifen  (ISO)
tazarotene  (ISO)
terbinafine  (ISO)
terconazole  (ISO)
Terfenadine  (ISO)
terodiline  (ISO)
testosterone  (ISO)
tetramethrin  (ISO)
thallium  (ISO)
thioridazine  (ISO)
tiamulin  (ISO)
tifenamil  (ISO)
tipepidine  (ISO)
tiquizium bromide  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
topiramate  (ISO)
toremifene  (ISO)
trazodone  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trifluoperazine  (ISO)
trifluperidol  (ISO)
triflupromazine  (ISO)
Tripelennamine  (ISO)
triprolidine  (ISO)
triptonide  (ISO)
Triton X-100  (ISO)
Valnemulin  (ISO)
valproic acid  (ISO)
vandetanib  (ISO)
vanoxerine dihydrochloride  (ISO)
venlafaxine hydrochloride  (ISO)
verapamil  (ISO)
vincamine  (ISO)
Vinpocetine  (ISO)
vitamin E  (ISO)
xaliproden  (ISO)
zimeldine  (ISO)
zinc pyrithione  (ISO)
ziprasidone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

Additional References at PubMed
PMID:7604285   PMID:7736582   PMID:7889573   PMID:8587608   PMID:8995352   PMID:9351446   PMID:9351462   PMID:10718922   PMID:10843886   PMID:11953308   PMID:14525949   PMID:14668215  
PMID:14670813   PMID:16339175   PMID:17322986   PMID:19913309   PMID:19921238   PMID:20605793   PMID:21063088   PMID:21463633   PMID:21536673   PMID:23589291   PMID:24931372   PMID:25281747  
PMID:27071825   PMID:28280240   PMID:29507111   PMID:29949809   PMID:30544220   PMID:32388931   PMID:32559772   PMID:33263944   PMID:33426760