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Gene: Kcnh2 (potassium voltage-gated channel, subfamily H (eag-related), member 2) Mus musculus
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Symbol: Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Description: Exhibits inward rectifier potassium channel activity. Involved in potassium ion transmembrane transport; regulation of heart rate by cardiac conduction; and regulation of ventricular cardiac muscle cell membrane repolarization. Localizes to the cytoplasm; nuclear envelope; and plasma membrane. Used to study short QT syndrome. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Is expressed in several structures, including brain; early conceptus; gonad; heart; and retina. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI326795; eag-related protein 1; ERG-1; ERG1; ether a go-go related; ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related protein 1; LQT; Lqt2; M-erg; MERG; Merg1; merg1a; merg1b; potassium voltage-gated channel subfamily H member 2; voltage-gated potassium channel subunit Kv11.1
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38524,319,589 - 24,351,684 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37523,825,407 - 23,857,422 (-)NCBIGRCm37mm9NCBIm37
MGSCv36523,829,654 - 23,861,669 (-)NCBImm8
Celera521,266,318 - 21,295,272 (-)NCBICelera
Cytogenetic Map5 A3NCBI
cM Map510.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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