Kcnh2 (potassium voltage-gated channel subfamily H member 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Kcnh2 (potassium voltage-gated channel subfamily H member 2) Chinchilla lanigera
Analyze
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
RGD ID: 8888636
Description: ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); identical protein binding (ortholog); inward rectifier potassium channel activity (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); cellular response to xenobiotic stimulus (ortholog); membrane depolarization during action potential (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); atrial fibrillation (ortholog); Brugada syndrome (ortholog); FOUND IN cell surface (ortholog); inward rectifier potassium channel complex (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium channel, voltage gated eag related subfamily H, member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,391,384 - 5,422,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,391,444 - 5,422,241 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Kcnh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,391,384 - 5,422,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,391,444 - 5,422,241 (-)NCBIChiLan1.0ChiLan1.0
KCNH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387150,944,961 - 150,978,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7150,944,961 - 150,978,321 (-)EnsemblGRCh38hg38GRCh38
GRCh377150,642,049 - 150,675,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,272,982 - 150,305,947 (-)NCBINCBI36Build 36hg18NCBI36
Build 347150,079,696 - 150,090,563NCBI
Celera7145,199,077 - 145,232,050 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,454,320 - 144,487,268 (-)NCBIHuRef
CHM1_17150,650,401 - 150,683,838 (-)NCBICHM1_1
T2T-CHM13v2.07152,117,824 - 152,151,201 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27149,971,333 - 150,004,698 (-)NCBI
Kcnh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,524,583 - 24,556,671 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl524,524,587 - 24,556,602 (-)EnsemblGRCm39 Ensembl
GRCm38524,319,589 - 24,351,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,319,589 - 24,351,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv37523,825,407 - 23,857,422 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36523,829,654 - 23,861,669 (-)NCBIMGSCv36mm8
Celera521,266,318 - 21,295,272 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map510.94NCBI
Kcnh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,719,357 - 11,751,424 (+)NCBIGRCr8
mRatBN7.2410,826,834 - 10,859,009 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,826,928 - 10,859,008 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,973,605 - 16,005,332 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,793,792 - 11,825,521 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,145,580 - 10,177,308 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,355,066 - 7,387,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,355,574 - 7,387,253 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,366,726 - 7,398,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,192,644 - 6,224,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,192,643 - 6,224,284 (+)NCBI
Celera46,444,570 - 6,473,521 (+)NCBICelera
Cytogenetic Map4q11NCBI
KCNH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,362,612 - 187,395,976 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,372,876 - 39,406,239 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,528,979 - 142,562,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,680,927 - 154,713,525 (-)NCBIpanpan1.1PanPan1.1panPan2
KCNH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,009,031 - 15,041,786 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,009,031 - 15,041,504 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,617,297 - 15,650,061 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,724,206 - 16,757,289 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1616,724,490 - 16,757,289 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,103,715 - 15,136,482 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,685,081 - 15,717,872 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,735,820 - 15,768,605 (-)NCBIUU_Cfam_GSD_1.0
Kcnh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,491,041 - 6,523,203 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,379,669 - 6,412,390 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,380,222 - 6,412,390 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,243,524 - 6,279,111 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,242,826 - 6,279,154 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,719,117 - 6,725,624 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,123,601 - 119,156,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,124,007 - 119,156,794 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607215,095,069 - 15,128,476 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,632,726 - 5,663,771 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248005,633,060 - 5,663,700 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000002142   ⟹   ENSCLAP00000002097
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554915,391,384 - 5,422,241 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000002143   ⟹   ENSCLAP00000002098
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554915,391,384 - 5,401,545 (-)Ensembl
RefSeq Acc Id: XM_005404800   ⟹   XP_005404857
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554915,391,444 - 5,422,241 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005404857 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000002097
  ENSCLAP00000002097.1
  ENSCLAP00000002098.1
RefSeq Acc Id: XP_005404857   ⟸   XM_005404800
- UniProtKB: A0A8C2YIY5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000002097   ⟸   ENSCLAT00000002142
Ensembl Acc Id: ENSCLAP00000002098   ⟸   ENSCLAT00000002143
Protein Domains
Cyclic nucleotide-binding   PAC   PAS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001522 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000002142 ENTREZGENE
  ENSCLAT00000002142.1 UniProtKB/TrEMBL
  ENSCLAT00000002143.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1200.260 UniProtKB/TrEMBL
  1.10.287.70 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
  PAS domain UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/TrEMBL
  K_chnl_volt-dep_ERG UniProtKB/TrEMBL
  KCNH_channel UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-assoc_C UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
NCBI Gene Kcnh2 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2 UniProtKB/TrEMBL
  VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  PAS_9 UniProtKB/TrEMBL
PRINTS EAGCHANLFMLY UniProtKB/TrEMBL
  ERGCHANNEL UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/TrEMBL
  SSF55785 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A8C2YIY5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YIY8_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Kcnh2  potassium voltage-gated channel subfamily H member 2    potassium channel, voltage gated eag related subfamily H, member 2  Symbol and/or name change 5135510 APPROVED
2015-08-25 Kcnh2  potassium channel, voltage gated eag related subfamily H, member 2    potassium voltage-gated channel, subfamily H (eag-related), member 2  Symbol and/or name change 5135510 APPROVED