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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:7494
Term: nefazodone
Definition: A N-alkylpiperazine that has formula C25H32ClN5O2.
Chemical ID: MESH:C051752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2affects activityISOKCNH2 (Homo sapiens)6480464CTDnefazodone affects the activity of KCNH2 proteinPMID:26821276
Kcnh2decreases activityISOKCNH2 (Homo sapiens)6480464CTDnefazodone results in decreased activity of KCNH2 proteinPMID:24052561 PMID:28551711
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTDnefazodone binds to and results in decreased activity of KCNH2 proteinPMID:24374264 PMID:26821276
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