Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:5138
Term: fluvoxamine
Definition: A 5-methoxyvalerophenone O-(2-aminoethyl)oxime that has formula C15H21F3N2O2.
Chemical ID: MESH:D016666
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2decreases activityISORGD:7321016480464CTDFluvoxamine results in decreased activity of KCNH2 protein

PMID:24052561
Kcnh2multiple interactionsISORGD:7321016480464CTD[Terfenadine co-treated with Fluvoxamine] binds to and results in decreased activity of KCNH2 protein, Fluvoxamine binds to and results in decreased activity of KCNH2 protein, Fluvoxamine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

PMID:20071423, PMID:21158687
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.