KCNH2 (potassium voltage-gated channel subfamily H member 2) - Rat Genome Database

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Gene: KCNH2 (potassium voltage-gated channel subfamily H member 2) Chlorocebus sabaeus
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Symbol: KCNH2
Name: potassium voltage-gated channel subfamily H member 2
RGD ID: 18787298
Description: ENCODES a protein that exhibits inward rectifier potassium channel activity (ortholog); monoatomic ion channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN potassium ion transmembrane transport (ortholog); potassium ion transport (ortholog); regulation of heart rate by cardiac conduction (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); atrial fibrillation (ortholog); Brugada syndrome (ortholog); FOUND IN cell surface (inferred); inward rectifier potassium channel complex (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,123,601 - 119,156,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,124,007 - 119,156,794 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607215,095,069 - 15,128,476 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,123,601 - 119,156,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,124,007 - 119,156,794 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607215,095,069 - 15,128,476 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
KCNH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387150,944,961 - 150,978,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7150,944,961 - 150,978,321 (-)EnsemblGRCh38hg38GRCh38
GRCh377150,642,049 - 150,675,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,272,982 - 150,305,947 (-)NCBINCBI36Build 36hg18NCBI36
Build 347150,079,696 - 150,090,563NCBI
Celera7145,199,077 - 145,232,050 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,454,320 - 144,487,268 (-)NCBIHuRef
CHM1_17150,650,401 - 150,683,838 (-)NCBICHM1_1
T2T-CHM13v2.07152,117,824 - 152,151,201 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27149,971,333 - 150,004,698 (-)NCBI
Kcnh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,524,583 - 24,556,671 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl524,524,587 - 24,556,602 (-)EnsemblGRCm39 Ensembl
GRCm38524,319,589 - 24,351,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,319,589 - 24,351,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv37523,825,407 - 23,857,422 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36523,829,654 - 23,861,669 (-)NCBIMGSCv36mm8
Celera521,266,318 - 21,295,272 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map510.94NCBI
Kcnh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,719,357 - 11,751,424 (+)NCBIGRCr8
mRatBN7.2410,826,834 - 10,859,009 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,826,928 - 10,859,008 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,973,605 - 16,005,332 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,793,792 - 11,825,521 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,145,580 - 10,177,308 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,355,066 - 7,387,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,355,574 - 7,387,253 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,366,726 - 7,398,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,192,644 - 6,224,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,192,643 - 6,224,284 (+)NCBI
Celera46,444,570 - 6,473,521 (+)NCBICelera
Cytogenetic Map4q11NCBI
Kcnh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,391,384 - 5,422,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,391,444 - 5,422,241 (-)NCBIChiLan1.0ChiLan1.0
KCNH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,362,612 - 187,395,976 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,372,876 - 39,406,239 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,528,979 - 142,562,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,680,927 - 154,713,525 (-)NCBIpanpan1.1PanPan1.1panPan2
KCNH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,009,031 - 15,041,786 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,009,031 - 15,041,504 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,617,297 - 15,650,061 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,724,206 - 16,757,289 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1616,724,490 - 16,757,289 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,103,715 - 15,136,482 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,685,081 - 15,717,872 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,735,820 - 15,768,605 (-)NCBIUU_Cfam_GSD_1.0
Kcnh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,491,041 - 6,523,203 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,379,669 - 6,412,390 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,380,222 - 6,412,390 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,243,524 - 6,279,111 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,242,826 - 6,279,154 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,719,117 - 6,725,624 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Kcnh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,632,726 - 5,663,771 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248005,633,060 - 5,663,700 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000004823   ⟹   ENSCSAP00000003067
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl21119,124,007 - 119,156,794 (-)Ensembl
RefSeq Acc Id: XM_007983457   ⟹   XP_007981648
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.121119,123,601 - 119,156,985 (-)NCBI
Vero_WHO_p1.0NW_02366607215,095,069 - 15,128,461 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007983458   ⟹   XP_007981649
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.121119,123,907 - 119,154,323 (-)NCBI
Vero_WHO_p1.0NW_02366607215,095,626 - 15,125,626 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007983461   ⟹   XP_007981652
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.121119,123,601 - 119,134,629 (-)NCBI
Vero_WHO_p1.0NW_02366607215,095,069 - 15,106,095 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037990961   ⟹   XP_037846889
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607215,095,626 - 15,128,455 (-)NCBI
RefSeq Acc Id: XM_037990962   ⟹   XP_037846890
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607215,095,626 - 15,126,875 (-)NCBI
RefSeq Acc Id: XM_037990963   ⟹   XP_037846891
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607215,095,626 - 15,128,455 (-)NCBI
RefSeq Acc Id: XM_037990964   ⟹   XP_037846892
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607215,095,626 - 15,128,455 (-)NCBI
RefSeq Acc Id: XM_037990965   ⟹   XP_037846893
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607215,095,626 - 15,128,455 (-)NCBI
RefSeq Acc Id: XM_037990966   ⟹   XP_037846894
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607215,095,626 - 15,128,476 (-)NCBI
RefSeq Acc Id: XM_037990967   ⟹   XP_037846895
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607215,097,550 - 15,128,455 (-)NCBI
RefSeq Acc Id: XP_007981648   ⟸   XM_007983457
- Peptide Label: isoform X5
- UniProtKB: A0A0D9R378 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007981652   ⟸   XM_007983461
- Peptide Label: isoform X10
RefSeq Acc Id: XP_007981649   ⟸   XM_007983458
- Peptide Label: isoform X3
- UniProtKB: A0A0D9R378 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000003067   ⟸   ENSCSAT00000004823
RefSeq Acc Id: XP_037846894   ⟸   XM_037990966
- Peptide Label: isoform X8
- UniProtKB: A0A0D9R378 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037846893   ⟸   XM_037990965
- Peptide Label: isoform X7
- UniProtKB: A0A0D9R378 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037846892   ⟸   XM_037990964
- Peptide Label: isoform X6
- UniProtKB: A0A0D9R378 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037846891   ⟸   XM_037990963
- Peptide Label: isoform X4
- UniProtKB: A0A0D9R378 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037846889   ⟸   XM_037990961
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R378 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037846890   ⟸   XM_037990962
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R378 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037846895   ⟸   XM_037990967
- Peptide Label: isoform X9


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006815 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004823.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1200.260 UniProtKB/TrEMBL
  1.10.287.70 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
  PAS domain UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/TrEMBL
  K_chnl_volt-dep_ERG UniProtKB/TrEMBL
  KCNH_channel UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-assoc_C UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
NCBI Gene KCNH2 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2 UniProtKB/TrEMBL
  VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  PAS_9 UniProtKB/TrEMBL
PRINTS EAGCHANLFMLY UniProtKB/TrEMBL
  ERGCHANNEL UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/TrEMBL
  SSF55785 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A0D9R378 ENTREZGENE, UniProtKB/TrEMBL