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Gene: Lig4 (DNA ligase 4) Rattus norvegicus
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Symbol: Lig4
Name: DNA ligase 4
Description: Exhibits ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Involved in DNA ligation and cellular response to lithium ion. Localizes to the nucleus. Human ortholog(s) of this gene implicated in several diseases, including DNA ligase IV deficiency; colorectal cancer; multiple myeloma; pancreatic cancer; and prostate cancer. Orthologous to human LIG4 (DNA ligase 4); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DNA ligase (ATP) 4; ligase IV, DNA, ATP-dependent; LOC290907
Orthologs:
Homo sapiens (human) : LIG4 (DNA ligase 4)  HGNC  Alliance
Mus musculus (house mouse) : Lig4 (ligase IV, DNA, ATP-dependent)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lig4 (DNA ligase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : LIG4 (DNA ligase 4)
Canis lupus familiaris (dog) : LIG4 (DNA ligase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lig4 (DNA ligase 4)
Sus scrofa (pig) : LIG4 (DNA ligase 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01685,331,771 - 85,339,496 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1685,331,866 - 85,337,769 (+)Ensembl
Rnor_5.01684,770,824 - 84,778,539 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41684,881,880 - 84,888,448 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11684,871,561 - 84,874,322 (+)NCBI
Celera1677,305,627 - 77,312,388 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Lig4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1304639
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.