Lig4 (DNA ligase 4) - Rat Genome Database

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Gene: Lig4 (DNA ligase 4) Rattus norvegicus
Analyze
Symbol: Lig4
Name: DNA ligase 4
RGD ID: 1304639
Description: Enables ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Involved in DNA ligation and cellular response to lithium ion. Predicted to be located in condensed chromosome and nucleoplasm. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including DNA ligase IV deficiency; colorectal cancer; multiple myeloma; pancreatic cancer; and prostate cancer. Orthologous to human LIG4 (DNA ligase 4); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA ligase (ATP) 4; ligase IV, DNA, ATP-dependent; LOC290907
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81686,220,345 - 86,228,930 (+)NCBIGRCr8
mRatBN7.21679,518,393 - 79,526,956 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1679,518,312 - 79,527,040 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1684,798,850 - 84,805,611 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01688,251,496 - 88,258,257 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01683,493,568 - 83,499,498 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01685,331,771 - 85,339,496 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1685,331,866 - 85,337,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01684,770,824 - 84,778,539 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41684,881,880 - 84,888,448 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11684,871,561 - 84,874,322 (+)NCBI
Celera1677,305,627 - 77,312,388 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-quinic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
barium sulfate  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
biphenyl-4-amine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bortezomib  (ISO)
carbon nanotube  (ISO)
ceric oxide  (EXP)
chlordecone  (ISO)
chromium(6+)  (ISO)
clorgyline  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
fenfluramine  (ISO)
fonofos  (ISO)
gallic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lithium chloride  (EXP)
methylmercury chloride  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
ochratoxin A  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
succimer  (ISO)
terbufos  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer. Damaraju S, etal., Clin Cancer Res. 2006 Apr 15;12(8):2545-54.
2. Ligase-4 Deficiency Causes Distinctive Immune Abnormalities in Asymptomatic Individuals. Felgentreff K, etal., J Clin Immunol. 2016 May;36(4):341-53. doi: 10.1007/s10875-016-0266-5. Epub 2016 Apr 11.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer. Kuhmann C, etal., Hum Mol Genet. 2014 Apr 15;23(8):2043-54. doi: 10.1093/hmg/ddt599. Epub 2013 Nov 26.
6. DNA repair gene polymorphisms and risk of pancreatic cancer. Li D, etal., Clin Cancer Res. 2009 Jan 15;15(2):740-6.
7. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Lieber MR Annu Rev Biochem. 2010;79:181-211. doi: 10.1146/annurev.biochem.052308.093131.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks. Nagaki S, etal., Biochem Biophys Res Commun. 1998 May 8;246(1):137-41.
10. Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. Nijnik A, etal., J Clin Invest. 2009 Jun;119(6):1696-705. doi: 10.1172/JCI32743. Epub 2009 May 18.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination. Roddam PL, etal., J Med Genet. 2002 Dec;39(12):900-5.
17. Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Rucci F, etal., Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3024-9. doi: 10.1073/pnas.0914865107. Epub 2010 Feb 1.
18. Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility. Zhao P, etal., BMC Cancer. 2013 May 10;13:234. doi: 10.1186/1471-2407-13-234.
19. Lithium chloride protects retinal neurocytes from nutrient deprivation by promoting DNA non-homologous end-joining. Zhuang J, etal., Biochem Biophys Res Commun. 2009 Mar 13;380(3):650-4. Epub 2009 Jan 31.
Additional References at PubMed
PMID:8798671   PMID:9242410   PMID:9809069   PMID:9823897   PMID:9875844   PMID:9889105   PMID:10716994   PMID:10823907   PMID:10911993   PMID:11248063   PMID:11779495   PMID:12361565  
PMID:12517771   PMID:12531011   PMID:12589063   PMID:15175260   PMID:15194694   PMID:15968270   PMID:16777961   PMID:17554302   PMID:17713479   PMID:19589734   PMID:20383123   PMID:21390131  
PMID:22192310   PMID:23275564   PMID:24837021   PMID:25941166   PMID:29463814  


Genomics

Comparative Map Data
Lig4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81686,220,345 - 86,228,930 (+)NCBIGRCr8
mRatBN7.21679,518,393 - 79,526,956 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1679,518,312 - 79,527,040 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1684,798,850 - 84,805,611 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01688,251,496 - 88,258,257 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01683,493,568 - 83,499,498 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01685,331,771 - 85,339,496 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1685,331,866 - 85,337,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01684,770,824 - 84,778,539 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41684,881,880 - 84,888,448 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11684,871,561 - 84,874,322 (+)NCBI
Celera1677,305,627 - 77,312,388 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
LIG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813108,207,442 - 108,218,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13108,207,439 - 108,218,368 (-)EnsemblGRCh38hg38GRCh38
GRCh3713108,859,790 - 108,870,697 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613107,657,791 - 107,668,717 (-)NCBINCBI36Build 36hg18NCBI36
Build 3413107,657,791 - 107,665,883NCBI
Celera1389,704,529 - 89,715,460 (-)NCBICelera
Cytogenetic Map13q33.3NCBI
HuRef1389,450,570 - 89,461,621 (-)NCBIHuRef
CHM1_113108,828,932 - 108,839,838 (-)NCBICHM1_1
T2T-CHM13v2.013107,433,544 - 107,444,540 (-)NCBIT2T-CHM13v2.0
Lig4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39810,020,020 - 10,027,680 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl810,019,049 - 10,027,686 (-)EnsemblGRCm39 Ensembl
GRCm3889,970,020 - 9,977,680 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl89,969,049 - 9,977,686 (-)EnsemblGRCm38mm10GRCm38
MGSCv3789,970,020 - 9,976,323 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3689,969,992 - 9,976,295 (-)NCBIMGSCv36mm8
Celera810,145,430 - 10,151,733 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map84.52NCBI
Lig4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554043,606,077 - 3,615,193 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554043,606,077 - 3,615,193 (+)NCBIChiLan1.0ChiLan1.0
LIG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214109,694,060 - 109,705,357 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113108,374,564 - 108,385,554 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01389,336,434 - 89,347,418 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113108,474,718 - 108,485,421 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13108,475,820 - 108,478,555 (-)Ensemblpanpan1.1panPan2
LIG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12256,980,333 - 56,987,636 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2256,980,622 - 56,983,357 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2256,752,066 - 56,759,380 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02257,500,830 - 57,508,151 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2257,500,745 - 57,510,390 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12257,101,978 - 57,109,289 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02257,090,156 - 57,097,580 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02257,127,280 - 57,134,599 (-)NCBIUU_Cfam_GSD_1.0
Lig4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945192,083,762 - 192,090,382 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364723,861,866 - 3,867,933 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364723,861,833 - 3,867,943 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1175,537,036 - 75,547,716 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11175,537,027 - 75,547,711 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,953,056 - 82,962,185 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1386,576,200 - 86,587,097 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl386,577,304 - 86,580,039 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604643,235,759 - 43,246,667 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lig4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247933,699,506 - 3,706,073 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247933,699,394 - 3,706,591 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lig4
157 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:25
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000019615
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 30 28 16 19 16 73 30 35 11
Low 1 13 29 25 25 8 11 1 5 6 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000019615   ⟹   ENSRNOP00000019615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1679,518,399 - 79,527,040 (+)Ensembl
Rnor_6.0 Ensembl1685,331,866 - 85,337,769 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097537   ⟹   ENSRNOP00000095406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1679,518,312 - 79,527,040 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101750   ⟹   ENSRNOP00000093705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1679,518,462 - 79,527,040 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106603   ⟹   ENSRNOP00000092486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1679,518,451 - 79,527,040 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111224   ⟹   ENSRNOP00000078250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1679,518,412 - 79,527,040 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111250   ⟹   ENSRNOP00000079496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1679,518,423 - 79,527,040 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112670   ⟹   ENSRNOP00000077244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1679,518,420 - 79,527,040 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116261   ⟹   ENSRNOP00000076669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1679,521,846 - 79,527,040 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116266   ⟹   ENSRNOP00000091637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1679,521,699 - 79,527,040 (+)Ensembl
RefSeq Acc Id: NM_001106095   ⟹   NP_001099565
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81686,220,442 - 86,227,203 (+)NCBI
mRatBN7.21679,518,468 - 79,525,229 (+)NCBI
Rnor_6.01685,331,866 - 85,337,769 (+)NCBI
Rnor_5.01684,770,824 - 84,778,539 (+)NCBI
RGSC_v3.41684,881,880 - 84,888,448 (+)RGD
Celera1677,305,627 - 77,312,388 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253477   ⟹   XP_006253539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81686,220,345 - 86,228,930 (+)NCBI
mRatBN7.21679,518,393 - 79,526,956 (+)NCBI
Rnor_6.01685,331,771 - 85,339,496 (+)NCBI
Rnor_5.01684,770,824 - 84,778,539 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001099565   ⟸   NM_001106095
- UniProtKB: D4A0U6 (UniProtKB/TrEMBL),   A6IWS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253539   ⟸   XM_006253477
- Peptide Label: isoform X1
- UniProtKB: D4A0U6 (UniProtKB/TrEMBL),   A6IWS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019615   ⟸   ENSRNOT00000019615
RefSeq Acc Id: ENSRNOP00000092486   ⟸   ENSRNOT00000106603
RefSeq Acc Id: ENSRNOP00000076669   ⟸   ENSRNOT00000116261
RefSeq Acc Id: ENSRNOP00000095406   ⟸   ENSRNOT00000097537
RefSeq Acc Id: ENSRNOP00000091637   ⟸   ENSRNOT00000116266
RefSeq Acc Id: ENSRNOP00000093705   ⟸   ENSRNOT00000101750
RefSeq Acc Id: ENSRNOP00000079496   ⟸   ENSRNOT00000111250
RefSeq Acc Id: ENSRNOP00000078250   ⟸   ENSRNOT00000111224
RefSeq Acc Id: ENSRNOP00000077244   ⟸   ENSRNOT00000112670
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A0U6-F1-model_v2 AlphaFold D4A0U6 1-911 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700249
Promoter ID:EPDNEW_R10772
Type:initiation region
Name:Lig4_1
Description:DNA ligase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01685,331,847 - 85,331,907EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304639 AgrOrtholog
BioCyc Gene G2FUF-10614 BioCyc
Ensembl Genes ENSRNOG00000014605 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019615.6 UniProtKB/TrEMBL
  ENSRNOT00000097537.1 UniProtKB/TrEMBL
  ENSRNOT00000101750.1 UniProtKB/TrEMBL
  ENSRNOT00000106603.1 UniProtKB/TrEMBL
  ENSRNOT00000111224.1 UniProtKB/TrEMBL
  ENSRNOT00000111250.1 UniProtKB/TrEMBL
  ENSRNOT00000112670.1 UniProtKB/TrEMBL
  ENSRNOT00000116261.1 UniProtKB/TrEMBL
  ENSRNOT00000116266.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3260.10 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
  3.40.50.10190 UniProtKB/TrEMBL
  6.10.250.520 UniProtKB/TrEMBL
  DNA ligase/mRNA capping enzyme UniProtKB/TrEMBL
InterPro Adenylation_DNA_ligase_IV UniProtKB/TrEMBL
  BRCT UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
  DNA_ligase UniProtKB/TrEMBL
  DNA_ligase_A_C UniProtKB/TrEMBL
  DNA_ligase_A_M UniProtKB/TrEMBL
  DNA_ligase_A_N UniProtKB/TrEMBL
  DNA_ligase_CS UniProtKB/TrEMBL
  DNA_ligase_IV UniProtKB/TrEMBL
  DNA_ligase_N_sf UniProtKB/TrEMBL
  LIG4 UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
KEGG Report rno:290907 UniProtKB/TrEMBL
NCBI Gene 290907 ENTREZGENE
PANTHER DNA LIGASE 4 UniProtKB/TrEMBL
  PTHR45997 UniProtKB/TrEMBL
Pfam BRCT UniProtKB/TrEMBL
  DNA_ligase_A_C UniProtKB/TrEMBL
  DNA_ligase_A_M UniProtKB/TrEMBL
  DNA_ligase_A_N UniProtKB/TrEMBL
  DNA_ligase_IV UniProtKB/TrEMBL
PhenoGen Lig4 PhenoGen
PROSITE BRCT UniProtKB/TrEMBL
  DNA_LIGASE_A1 UniProtKB/TrEMBL
  DNA_LIGASE_A2 UniProtKB/TrEMBL
  DNA_LIGASE_A3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014605 RatGTEx
SMART BRCT UniProtKB/TrEMBL
Superfamily-SCOP BRCT UniProtKB/TrEMBL
  DNA ligase/mRNA capping enzyme, catalytic domain UniProtKB/TrEMBL
  Nucleic_acid_OB UniProtKB/TrEMBL
  SSF117018 UniProtKB/TrEMBL
UniProt A6IWS2 ENTREZGENE, UniProtKB/TrEMBL
  D4A0U6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Lig4  DNA ligase 4  Lig4  ligase IV, DNA, ATP-dependent  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Lig4  ligase IV, DNA, ATP-dependent   Lig4_predicted  ligase IV, DNA, ATP-dependent (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lig4_predicted  ligase IV, DNA, ATP-dependent (predicted)      Symbol and Name status set to approved 70820 APPROVED