Ramp1 (receptor activity modifying protein 1)

Gene: Ramp1 (receptor activity modifying protein 1) Rattus norvegicus

Analyze

Symbol:

Ramp1

Name:

receptor activity modifying protein 1

RGD ID:

61870

Description:

Enables coreceptor activity. Involved in receptor internalization. Located in extracellular space. Is active in glutamatergic synapse and synaptic membrane. Orthologous to human RAMP1 (receptor activity modifying protein 1); INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

receptor (calcitonin) activity modifying protein 1; receptor (G protein-coupled) activity modifying protein 1; receptor activity-modifying protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	99,213,031 - 99,263,696 (+)	NCBI		GRCr8
mRatBN7.2	9	91,765,481 - 91,816,152 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	91,781,285 - 91,816,151 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	100,192,341 - 100,242,910 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	105,328,109 - 105,378,678 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	103,693,378 - 103,742,967 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	98,313,632 - 98,364,206 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	98,313,632 - 98,364,205 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	97,995,669 - 98,041,719 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	90,402,493 - 90,450,038 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	90,607,261 - 90,654,807 (+)	NCBI
Celera	9	89,308,226 - 89,359,459 (+)	NCBI		Celera
Cytogenetic Map	9	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bethlem Myopathy 1A (ISO)

chromosome 2q37 deletion syndrome (ISO)

D-2-hydroxyglutaric aciduria 1 (ISO)

Experimental Liver Cirrhosis (ISO)

hereditary spastic paraplegia 30 (ISO)

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (EXP)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-nitropyrene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

arsane (EXP,ISO)

arsenic atom (EXP,ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (EXP,ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calciol (EXP)

calcitriol (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

choline (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (EXP)

curcumin (ISO)

cyclophosphamide (ISO)

cytarabine (ISO)

deoxynivalenol (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

dibutyl phthalate (EXP,ISO)

dimethylarsinic acid (EXP)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

folic acid (ISO)

fonofos (ISO)

gentamycin (EXP)

glyphosate (EXP)

indometacin (ISO)

inulin (ISO)

irinotecan (EXP)

isoprenaline (EXP,ISO)

ketamine (EXP)

L-methionine (ISO)

menadione (ISO)

methapyrilene (ISO)

methotrexate (ISO)

Muraglitazar (EXP)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

nickel sulfate (ISO)

nicotine (EXP)

nitric oxide (EXP)

nitrofen (EXP)

ozone (ISO)

paclitaxel (ISO)

parathion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenethyl caffeate (EXP)

phenylephrine (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (EXP,ISO)

quercetin (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium atom (EXP)

sunitinib (ISO)

T-2 toxin (ISO)

tacrolimus hydrate (ISO)

tamoxifen (ISO)

temozolomide (ISO)

terbufos (ISO)

Tesaglitazar (EXP)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

titanium dioxide (ISO)

tremolite asbestos (ISO)

triclosan (ISO)

triphenyl phosphate (EXP)

tungsten (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA,ISO)

amylin receptor signaling pathway (IEA,ISO)

angiogenesis (IEA,ISO)

calcitonin gene-related peptide receptor signaling pathway (IEA,ISO)

calcium ion transport (IBA,IEA,ISO)

cellular response to hormone stimulus (IBA)

G protein-coupled receptor signaling pathway (IBA,ISO)

intracellular protein transport (IEA)

positive regulation of protein binding (IDA)

positive regulation of protein glycosylation (IEA,ISO)

protein localization to plasma membrane (IBA,IEA,ISO)

protein transport (IBA,ISO)

receptor internalization (IBA,IDA,IEA,ISO)

regulation of G protein-coupled receptor signaling pathway (IEA)

Cellular Component

cell surface (IBA,IEA,ISO)

CGRP receptor complex (IEA,ISO)

extracellular space (IDA)

glutamatergic synapse (IDA)

membrane (IEA)

plasma membrane (ISO)

receptor complex (IBA,ISO)

synaptic membrane (IDA)

Molecular Function

amylin receptor activity (IEA,ISO)

calcitonin gene-related peptide binding (IEA,ISO)

calcitonin gene-related peptide receptor activity (IEA,ISO)

coreceptor activity (IBA,IDA,IEA,IMP,ISO)

G protein-coupled receptor binding (NAS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking.	Bomberger JM, etal., J Biol Chem. 2005 Mar 11;280(10):9297-307. Epub 2004 Dec 21.
2.	Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure.	Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists.	Mallee JJ, etal., J Biol Chem 2002 Apr 19;277(16):14294-8. Epub 2002 Feb 14.
6.	Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors.	Marvizón JC, etal., Neuroscience. 2007 Aug 10;148(1):250-65. doi: 10.1016/j.neuroscience.2007.05.036. Epub 2007 Jul 5.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy.	Nagae T, etal., Biochem Biophys Res Commun 2000 Apr 2;270(1):89-93.
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat.	Oliver KR, etal., Eur J Neurosci 2001 Aug;14(4):618-28.
11.	mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung.	Qing X, etal., Am J Physiol Lung Cell Mol Physiol 2001 Mar;280(3):L547-54.
12.	GOA pipeline	RGD automated data pipeline
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Antiapoptotic effect of calcitonin gene-related peptide on oxidative stress-induced injury in H9c2 cardiomyocytes via the RAMP1/CRLR complex.	Sueur S, etal., J Mol Cell Cardiol. 2005 Dec;39(6):955-63. Epub 2005 Oct 19.
15.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16.	Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro.	Tomoda Y, etal., Cardiovasc Res 2001 Mar;49(4):721-30.

Additional References at PubMed

PMID:1299114	PMID:1299115	PMID:9620797	PMID:10854696	PMID:10882736	PMID:11804624	PMID:12626334	PMID:12801991	PMID:12837925	PMID:14715154	PMID:14722252	PMID:15193773
PMID:15643132	PMID:16458982	PMID:16713642	PMID:17310067	PMID:18039931	PMID:18186028	PMID:18241048	PMID:18434369	PMID:18599553	PMID:18655130	PMID:20596610	PMID:21034462
PMID:21040789	PMID:22038237	PMID:22208649	PMID:22500019	PMID:26927337

Genomics

Comparative Map Data

Ramp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	99,213,031 - 99,263,696 (+)	NCBI		GRCr8
mRatBN7.2	9	91,765,481 - 91,816,152 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	91,781,285 - 91,816,151 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	100,192,341 - 100,242,910 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	105,328,109 - 105,378,678 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	103,693,378 - 103,742,967 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	98,313,632 - 98,364,206 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	98,313,632 - 98,364,205 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	97,995,669 - 98,041,719 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	90,402,493 - 90,450,038 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	90,607,261 - 90,654,807 (+)	NCBI
Celera	9	89,308,226 - 89,359,459 (+)	NCBI		Celera
Cytogenetic Map	9	q36	NCBI

RAMP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	237,858,880 - 237,912,106 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	237,858,893 - 237,912,106 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	238,768,266 - 238,820,748 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	238,432,926 - 238,485,495 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	238,550,286 - 238,602,746	NCBI
Celera	2	232,481,221 - 232,533,800 (+)	NCBI		Celera
Cytogenetic Map	2	q37.3	NCBI
HuRef	2	230,560,137 - 230,612,778 (+)	NCBI		HuRef
CHM1_1	2	238,773,978 - 238,826,564 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	238,348,771 - 238,402,144 (+)	NCBI		T2T-CHM13v2.0

Ramp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	91,107,544 - 91,152,918 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	91,107,544 - 91,152,918 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	91,179,822 - 91,225,196 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	91,179,822 - 91,225,196 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	93,076,399 - 93,121,773 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	93,010,447 - 93,054,085 (+)	NCBI		MGSCv36	mm8
Celera	1	94,117,772 - 94,162,742 (+)	NCBI		Celera
Cytogenetic Map	1	D	NCBI
cM Map	1	46.08	NCBI

Ramp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955542	2,530,349 - 2,564,072 (-)	NCBI	ChiLan1.0	ChiLan1.0

RAMP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	140,492,353 - 140,558,565 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	140,507,320 - 140,573,532 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	125,092,164 - 125,144,032 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	243,942,771 - 243,995,221 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	243,942,771 - 243,995,221 (+)	Ensembl	panpan1.1		panPan2

RAMP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	48,431,136 - 48,466,070 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	48,437,919 - 48,466,070 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	48,924,771 - 48,962,496 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	48,813,868 - 48,851,604 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	48,813,905 - 48,851,525 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	48,689,424 - 48,727,160 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	48,477,911 - 48,515,642 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	48,710,077 - 48,748,033 (+)	NCBI		UU_Cfam_GSD_1.0

Ramp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	190,399,529 - 190,436,574 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936525	503,070 - 540,281 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936525	503,119 - 540,159 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAMP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	137,490,356 - 137,535,553 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	137,490,440 - 137,535,555 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	151,914,286 - 151,944,914 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAMP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	123,873,597 - 123,931,215 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	123,873,351 - 123,931,248 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	75,479,406 - 75,535,761 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ramp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624847	3,169,360 - 3,202,389 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624847	3,169,339 - 3,202,393 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ramp1
246 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	132
Count of miRNA genes:	107
Interacting mature miRNAs:	110
Transcripts:	ENSRNOT00000027012
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	48598251	93598251	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	58163035	100929646	Rat
731171	Glom6	Glomerulus QTL 6	2.8	0.0003	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	9	64573531	109573531	Rat
724547	Cm21	Cardiac mass QTL 21	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	9	79271511	102910209	Rat
61385	Edpm9	Estrogen-dependent pituitary mass QTL 9	3.43	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	63869687	108869687	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	56771635	101771635	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	62072275	96470995	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	61381434	104821652	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	75712843	111552878	Rat
4889852	Pur26	Proteinuria QTL 26	15	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	77813894	101597663	Rat
7794784	Mcs31	Mammary carcinoma susceptibility QTL 31	2.98		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	9	77813894	111552878	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	62072275	96470995	Rat
4889943	Bss90	Bone structure and strength QTL 90	4.1		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	9	86369631	92058970	Rat

Markers in Region

RH137956

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	91,776,803 - 91,776,946 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	99,520,938 - 99,521,080	NCBI	Rnor6.0
Rnor_6.0	9	98,324,875 - 98,325,017	NCBI	Rnor6.0
Rnor_5.0	9	98,006,912 - 98,007,054	UniSTS	Rnor5.0
Rnor_5.0	9	99,190,621 - 99,190,763	UniSTS	Rnor5.0
RGSC_v3.4	9	90,413,736 - 90,413,878	UniSTS	RGSC3.4
Celera	9	89,319,465 - 89,319,607	UniSTS
Cytogenetic Map	9	q36	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	16	28	18	19	18	8	10	31		23	11	8
Low		27	29	23		23		1	23	34	18
Below cutoff									20	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006245473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006245474	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084148	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB028933	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB030942	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB042887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC115196	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF181550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027012 ⟹ ENSRNOP00000027012

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	91,785,098 - 91,816,151 (+)	Ensembl
Rnor_6.0 Ensembl	9	98,313,632 - 98,364,205 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095283 ⟹ ENSRNOP00000083989

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	91,781,285 - 91,816,151 (+)	Ensembl

RefSeq Acc Id:

NM_031645 ⟹ NP_113833

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	99,213,116 - 99,263,696 (+)	NCBI
mRatBN7.2	9	91,765,561 - 91,816,151 (+)	NCBI
Rnor_6.0	9	98,313,632 - 98,364,205 (+)	NCBI
Rnor_5.0	9	97,995,669 - 98,041,719 (+)	NCBI
RGSC_v3.4	9	90,402,493 - 90,450,038 (+)	RGD
Celera	9	89,308,226 - 89,359,459 (+)	RGD

Sequence:

show sequence

AGCTCGGCAAGGCGCAGGGACGGCGGGGCTCTGCTTGCCATGGCCCCCGGCCTGCGGGGCCTCC
CGCGGCGCGGCCTCTGGCTGCTGCTGGCTCATCATCTCTTCATGGTCACTGCCTGCCGGGACCC
TGACTATGGTACTCTCATCCAGGAGCTGTGTCTCAGCCGCTTCAAAGAGGACATGGAGACCATA
GGGAAGACTCTGTGGTGTGACTGGGGAAAGACCATAGGGAGCTATGGGGAGCTCACTCACTGCA
CCAAACTCGTGGCAAACAAGATTGGCTGTTTCTGGCCCAATCCGGAAGTGGACAAGTTCTTCAT
TGCTGTCCACCACCGCTACTTCAGCAAGTGCCCAGTCTCGGGCAGGGCCCTGCGGGACCCTCCC
AACAGCATCCTCTGCCCTTTCATTGTGCTCCCCATTACGGTCACACTGCTCATGACTGCCCTGG
TGGTCTGGAGGAGCAAGCGCACAGAGGGCATCGTGTAGGTGTCCCAGGTGATGGGGGATTGGGG
AACCATGGGCCTGGCCCAGCAACAGCATCAGGGACAGACCCCACATTGCATCCTGCTCTAGCCT
AGTTAGCACAGGATTTGAAAGCAGATCTGCATTACACTAAACCTGCCCCAGCCAGAGGCTTCTA
ACAGGGGAGCAGGGACCTGCCTCTGTTTACCTCTGAAAGAGCGCTAAGCGCCAGGTCTCTGGTA
TACTTCATCACCACCATCATGTGGGCATTCCGACCTCTGAGGAAGACTGCACAGATGTGTTTGT
GGATGCATAGTTTGTGATTAAACGAGCGTTCTTAAACTTGAA

hide sequence

RefSeq Acc Id:

XM_017596613 ⟹ XP_017452102

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	99,214,018 - 99,263,692 (+)	NCBI
mRatBN7.2	9	91,766,463 - 91,816,152 (+)	NCBI
Rnor_6.0	9	98,313,729 - 98,364,206 (+)	NCBI

Sequence:

show sequence

AGCCCGGGCTGCAGCGAAGGTGGTGACCTAGGGCCGGGAGGGCAACACCTGAACGCACCTTACT
CAGGGCATGGGTTCCGGCAGGACAGCAGAGTGGTGATAGAGGGGGCTGCACCACCTTCCGCTGC
CACGGAGACAAGGTGGCTTGGGCGCATCACCCAGCTGGCCATCCGAAGGCATCAGCAACTTTTG
ATCATACAACGGGCATCTTGCTTGTCAGGAGGGATGGGGAAGCCGGGATCCCCTGCCTGCACTT
CAGTTCTCCAAACCGATACAAGCTCTCTGAGCCAGAGGCAGTTTACAGATGTGCAGTCTTCAAC
CAGAGCCACAGCTTAGGGATCTCGACACTAACTACAACTGGAAACCTACAGCAGTTGCTTTTCG
AGACCGTTATTATCACGGGGATTTTGTGGTTGGCTTGTTAACTTGGCACTTGTTGCTAATAAAT
ATCAGAGGTGGCAGACTTGCTGGGTTTTTGCCTTAGATTGATCAGAAACTGTAGCCCAGAGTGA
CCAACAAGAACAACCCAACCCATCTCAGTTCCCTTGTCTGTAATGCGCTCAAAATTCGGTCAGG
ACCCTGGACTGCCATACCTGTTGGACAAAACGGCAGGCACACAGCTACATCTTCACGAAAGCAA
ACAAAGAGTCGGTCCAGTGTCCCTGGAAAGGCCTGTGGCTTAATGGTTCTTGTGGTCTTTCCCC
AAACCCATGGTGTTGGTCAGAGGCACCCACTACACAGGCTCTAGTGCTGGTGAAGGTTGGCCCC
TGGTGCTGTTTATAGCTAAGGCAGCAGCTTGGGGCAGTGTAGCGAGTCCGCGGTGACTGGGCAG
GAACAGCACTGGAGACCTTCCATTTGCCGGGCAGATCTCCCCTGTGTGTAGTCCTTGCCGAGGA
GTGCCAGCTCATCATCTCTTCATGGTCACTGCCTGCCGGGACCCTGACTATGGTACTCTCATCC
AGGAGCTGTGTCTCAGCCGCTTCAAAGAGGACATGGAGACCATAGGGAAGACTCTGTGGTGTGA
CTGGGGAAAGACCATAGGGAGCTATGGGGAGCTCACTCACTGCACCAAACTCGTGGCAAACAAG
ATTGGCTGTTTCTGGCCCAATCCGGAAGTGGACAAGTTCTTCATTGCTGTCCACCACCGCTACT
TCAGCAAGTGCCCAGTCTCGGGCAGGGCCCTGCGGGACCCTCCCAACAGCATCCTCTGCCCTTT
CATTGTGCTCCCCATTACGGTCACACTGCTCATGACTGCCCTGGTGGTCTGGAGGAGCAAGCGC
ACAGAGGGCATCGTGTAGGTGTCCCAGGTGATGGGGGATTGGGGAACCATGGGCCTGGCCCAGC
AACAGCATCAGGGACAGACCCCACATTGCATCCTGCTCTAGCCTAGTTAGCACAGGATTTGAAA
GCAGATCTGCATTACACTAAACCTGCCCCAGCCAGAGGCTTCTAACAGGGGAGCAGGGACCTGC
CTCTGTTTACCTCTGAAAGAGCGCTAAGCGCCAGGTCTCTGGTATACTTCATCACCACCATCAT
GTGGGCATTCCGACCTCTGAGGAAGACTGCACAGATGTGTTTGTGGATGCATAGTTTGTGATTA
AACGAGCGTTCTTAAACTTGG

hide sequence

RefSeq Acc Id:

XM_039084148 ⟹ XP_038940076

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	99,213,031 - 99,263,256 (+)	NCBI
mRatBN7.2	9	91,765,481 - 91,815,705 (+)	NCBI

RefSeq Acc Id:

XM_063267661 ⟹ XP_063123731

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	99,213,031 - 99,241,541 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_113833	(Get FASTA)	NCBI Sequence Viewer
	XP_017452102	(Get FASTA)	NCBI Sequence Viewer
	XP_038940076	(Get FASTA)	NCBI Sequence Viewer
	XP_063123731	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG09434	(Get FASTA)	NCBI Sequence Viewer
	BAA79194	(Get FASTA)	NCBI Sequence Viewer
	BAA94425	(Get FASTA)	NCBI Sequence Viewer
	BAB03504	(Get FASTA)	NCBI Sequence Viewer
	EDL92038	(Get FASTA)	NCBI Sequence Viewer
	EDL92039	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027012.3
	ENSRNOP00000083989.1
	ENSRNOP00065028570
GenBank Protein	Q9JJ74	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_113833 ⟸ NM_031645
- Peptide Label:	precursor
- UniProtKB:	Q9JJ74 (UniProtKB/Swiss-Prot), A6JQP8 (UniProtKB/TrEMBL), Q9JMD9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAPGLRGLPRRGLWLLLAHHLFMVTACRDPDYGTLIQELCLSRFKEDMETIGKTLWCDWGKTIG SYGELTHCTKLVANKIGCFWPNPEVDKFFIAVHHRYFSKCPVSGRALRDPPNSILCPFIVLPIT VTLLMTALVVWRSKRTEGIV hide sequence

RefSeq Acc Id:	XP_017452102 ⟸ XM_017596613
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2QEF6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVTACRDPDYGTLIQELCLSRFKEDMETIGKTLWCDWGKTIGSYGELTHCTKLVANKIGCFWPN PEVDKFFIAVHHRYFSKCPVSGRALRDPPNSILCPFIVLPITVTLLMTALVVWRSKRTEGIV hide sequence

Ensembl Acc Id:

ENSRNOP00000027012 ⟸ ENSRNOT00000027012

RefSeq Acc Id:	XP_038940076 ⟸ XM_039084148
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000083989 ⟸ ENSRNOT00000095283

RefSeq Acc Id:	XP_063123731 ⟸ XM_063267661
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JJ74-F1-model_v2	AlphaFold	Q9JJ74	1-148	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696855

Promoter ID:

EPDNEW_R7380

Type:

initiation region

Name:

Ramp1_1

Description:

receptor activity modifying protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	98,313,621 - 98,313,681	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61870	AgrOrtholog
BioCyc Gene	G2FUF-26728	BioCyc
Ensembl Genes	ENSRNOG00000019926	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00065020874	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000027012.3	UniProtKB/TrEMBL
	ENSRNOT00000095283.1	UniProtKB/TrEMBL
	ENSRNOT00065035465	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.150.510	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	RAMP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RAMP_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:58965	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	58965	ENTREZGENE
PANTHER	PTHR14076	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RECEPTOR ACTIVITY-MODIFYING PROTEIN 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	RAMP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ramp1	PhenoGen
PROSITE	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019926	RatGTEx
	ENSRNOG00065020874	RatGTEx
TIGR	TC205211
UniProt	A0A8I5ZXU4_RAT	UniProtKB/TrEMBL
	A0A8L2QEF6	ENTREZGENE, UniProtKB/TrEMBL
	A6JQP8	ENTREZGENE, UniProtKB/TrEMBL
	A6JQP9_RAT	UniProtKB/TrEMBL
	Q9JJ74	ENTREZGENE
	Q9JMD9	ENTREZGENE, UniProtKB/TrEMBL
	Q9WVQ4_RAT	UniProtKB/TrEMBL
	RAMP1_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-14	Ramp1	receptor activity modifying protein 1	Ramp1	receptor (G protein-coupled) activity modifying protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Ramp1	receptor (G protein-coupled) activity modifying protein 1	Ramp1	receptor (calcitonin) activity modifying protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Ramp1	receptor (calcitonin) activity modifying protein 1			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	may play a role in chronic heart failure	625420
gene_expression	mRNA and protein expressed in both atria and ventricles with a 3-fold increase in expression in chronic heart failure models	625420
gene_function	transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determine its glycosylation state	61729
gene_function	transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determine its glycosylation state	68902
gene_physical_interaction	forms a complex with calcitonin receptor-like receptor (CRLR) to form functional calcitonin gene-related peptide (CGRP) receptor	625420
gene_process	mediates increased lipid synthesis, triglyceride accumulation, mesangial expansion, glomerulosclerosis, and proteinuria by increasing the expression of transforming growth factor and vascular endothelial growth factor	625420

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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