Ramp1 (receptor activity modifying protein 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ramp1 (receptor activity modifying protein 1) Rattus norvegicus
Analyze
Symbol: Ramp1
Name: receptor activity modifying protein 1
RGD ID: 61870
Description: Enables coreceptor activity. Involved in receptor internalization. Located in extracellular space. Orthologous to human RAMP1 (receptor activity modifying protein 1); INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: receptor (calcitonin) activity modifying protein 1; receptor (G protein-coupled) activity modifying protein 1; receptor activity-modifying protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,213,031 - 99,263,696 (+)NCBIGRCr8
mRatBN7.2991,765,481 - 91,816,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,781,285 - 91,816,151 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,192,341 - 100,242,910 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,328,109 - 105,378,678 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,693,378 - 103,742,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,313,632 - 98,364,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,313,632 - 98,364,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0997,995,669 - 98,041,719 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,402,493 - 90,450,038 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1990,607,261 - 90,654,807 (+)NCBI
Celera989,308,226 - 89,359,459 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cytarabine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
dimethylarsinic acid  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
fonofos  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (EXP)
isoprenaline  (EXP,ISO)
ketamine  (EXP)
L-methionine  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
Muraglitazar  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
nicotine  (EXP)
nitric oxide  (EXP)
nitrofen  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking. Bomberger JM, etal., J Biol Chem. 2005 Mar 11;280(10):9297-307. Epub 2004 Dec 21.
2. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists. Mallee JJ, etal., J Biol Chem 2002 Apr 19;277(16):14294-8. Epub 2002 Feb 14.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy. Nagae T, etal., Biochem Biophys Res Commun 2000 Apr 2;270(1):89-93.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. Oliver KR, etal., Eur J Neurosci 2001 Aug;14(4):618-28.
10. mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Qing X, etal., Am J Physiol Lung Cell Mol Physiol 2001 Mar;280(3):L547-54.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Antiapoptotic effect of calcitonin gene-related peptide on oxidative stress-induced injury in H9c2 cardiomyocytes via the RAMP1/CRLR complex. Sueur S, etal., J Mol Cell Cardiol. 2005 Dec;39(6):955-63. Epub 2005 Oct 19.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro. Tomoda Y, etal., Cardiovasc Res 2001 Mar;49(4):721-30.
Additional References at PubMed
PMID:1299114   PMID:1299115   PMID:9620797   PMID:10854696   PMID:10882736   PMID:11804624   PMID:12626334   PMID:12801991   PMID:12837925   PMID:14715154   PMID:14722252   PMID:15193773  
PMID:15643132   PMID:16458982   PMID:16713642   PMID:17310067   PMID:17614212   PMID:18039931   PMID:18186028   PMID:18241048   PMID:18434369   PMID:18599553   PMID:18655130   PMID:20596610  
PMID:21034462   PMID:21040789   PMID:22038237   PMID:22208649   PMID:22500019   PMID:26927337  


Genomics

Comparative Map Data
Ramp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,213,031 - 99,263,696 (+)NCBIGRCr8
mRatBN7.2991,765,481 - 91,816,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,781,285 - 91,816,151 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,192,341 - 100,242,910 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,328,109 - 105,378,678 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,693,378 - 103,742,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,313,632 - 98,364,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,313,632 - 98,364,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0997,995,669 - 98,041,719 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,402,493 - 90,450,038 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1990,607,261 - 90,654,807 (+)NCBI
Celera989,308,226 - 89,359,459 (+)NCBICelera
Cytogenetic Map9q36NCBI
RAMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,858,880 - 237,912,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,858,893 - 237,912,106 (+)EnsemblGRCh38hg38GRCh38
GRCh372238,768,266 - 238,820,748 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,432,926 - 238,485,495 (+)NCBINCBI36Build 36hg18NCBI36
Build 342238,550,286 - 238,602,746NCBI
Celera2232,481,221 - 232,533,800 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,560,137 - 230,612,778 (+)NCBIHuRef
CHM1_12238,773,978 - 238,826,564 (+)NCBICHM1_1
T2T-CHM13v2.02238,348,771 - 238,402,144 (+)NCBIT2T-CHM13v2.0
Ramp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,107,544 - 91,152,918 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,107,544 - 91,152,918 (+)EnsemblGRCm39 Ensembl
GRCm38191,179,822 - 91,225,196 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,179,822 - 91,225,196 (+)EnsemblGRCm38mm10GRCm38
MGSCv37193,076,399 - 93,121,773 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,010,447 - 93,054,085 (+)NCBIMGSCv36mm8
Celera194,117,772 - 94,162,742 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.08NCBI
Ramp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555422,530,349 - 2,564,072 (-)NCBIChiLan1.0ChiLan1.0
RAMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213140,492,353 - 140,558,565 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B140,507,320 - 140,573,532 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B125,092,164 - 125,144,032 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B243,942,771 - 243,995,221 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B243,942,771 - 243,995,221 (+)Ensemblpanpan1.1panPan2
RAMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12548,431,136 - 48,466,070 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2548,437,919 - 48,466,070 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2548,924,771 - 48,962,496 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02548,813,868 - 48,851,604 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2548,813,905 - 48,851,525 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,689,424 - 48,727,160 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,477,911 - 48,515,642 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,710,077 - 48,748,033 (+)NCBIUU_Cfam_GSD_1.0
Ramp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303190,399,529 - 190,436,574 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525503,070 - 540,281 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936525503,119 - 540,159 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15137,490,356 - 137,535,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115137,490,440 - 137,535,555 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215151,914,286 - 151,944,914 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAMP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110123,873,597 - 123,931,215 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10123,873,351 - 123,931,248 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604075,479,406 - 75,535,761 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ramp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248473,169,360 - 3,202,389 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248473,169,339 - 3,202,393 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ramp1
246 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:107
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000027012
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat

Markers in Region
RH137956  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2991,776,803 - 91,776,946 (+)MAPPERmRatBN7.2
Rnor_6.0999,520,938 - 99,521,080NCBIRnor6.0
Rnor_6.0998,324,875 - 98,325,017NCBIRnor6.0
Rnor_5.0998,006,912 - 98,007,054UniSTSRnor5.0
Rnor_5.0999,190,621 - 99,190,763UniSTSRnor5.0
RGSC_v3.4990,413,736 - 90,413,878UniSTSRGSC3.4
Celera989,319,465 - 89,319,607UniSTS
Cytogenetic Map9q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 16 28 18 19 18 8 10 31 23 11 8
Low 27 29 23 23 1 23 34 18
Below cutoff 20 1

Sequence


RefSeq Acc Id: ENSRNOT00000027012   ⟹   ENSRNOP00000027012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl991,785,098 - 91,816,151 (+)Ensembl
Rnor_6.0 Ensembl998,313,632 - 98,364,205 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095283   ⟹   ENSRNOP00000083989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl991,781,285 - 91,816,151 (+)Ensembl
RefSeq Acc Id: NM_031645   ⟹   NP_113833
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,213,116 - 99,263,696 (+)NCBI
mRatBN7.2991,765,561 - 91,816,151 (+)NCBI
Rnor_6.0998,313,632 - 98,364,205 (+)NCBI
Rnor_5.0997,995,669 - 98,041,719 (+)NCBI
RGSC_v3.4990,402,493 - 90,450,038 (+)RGD
Celera989,308,226 - 89,359,459 (+)RGD
Sequence:
RefSeq Acc Id: XM_017596613   ⟹   XP_017452102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,214,018 - 99,263,692 (+)NCBI
mRatBN7.2991,766,463 - 91,816,152 (+)NCBI
Rnor_6.0998,313,729 - 98,364,206 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084148   ⟹   XP_038940076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,213,031 - 99,263,256 (+)NCBI
mRatBN7.2991,765,481 - 91,815,705 (+)NCBI
RefSeq Acc Id: XM_063267661   ⟹   XP_063123731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,213,031 - 99,241,541 (+)NCBI
RefSeq Acc Id: NP_113833   ⟸   NM_031645
- Peptide Label: precursor
- UniProtKB: Q9JJ74 (UniProtKB/Swiss-Prot),   A6JQP8 (UniProtKB/TrEMBL),   Q9JMD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452102   ⟸   XM_017596613
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QEF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027012   ⟸   ENSRNOT00000027012
RefSeq Acc Id: XP_038940076   ⟸   XM_039084148
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000083989   ⟸   ENSRNOT00000095283
RefSeq Acc Id: XP_063123731   ⟸   XM_063267661
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJ74-F1-model_v2 AlphaFold Q9JJ74 1-148 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696855
Promoter ID:EPDNEW_R7380
Type:initiation region
Name:Ramp1_1
Description:receptor activity modifying protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0998,313,621 - 98,313,681EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61870 AgrOrtholog
BioCyc Gene G2FUF-26728 BioCyc
Ensembl Genes ENSRNOG00000019926 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00065020874 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027012.3 UniProtKB/TrEMBL
  ENSRNOT00000095283.1 UniProtKB/TrEMBL
  ENSRNOT00065035465 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.510 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAMP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58965 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 58965 ENTREZGENE
PANTHER PTHR14076 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ramp1 PhenoGen
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019926 RatGTEx
  ENSRNOG00065020874 RatGTEx
TIGR TC205211
UniProt A0A8I5ZXU4_RAT UniProtKB/TrEMBL
  A0A8L2QEF6 ENTREZGENE, UniProtKB/TrEMBL
  A6JQP8 ENTREZGENE, UniProtKB/TrEMBL
  A6JQP9_RAT UniProtKB/TrEMBL
  Q9JJ74 ENTREZGENE
  Q9JMD9 ENTREZGENE, UniProtKB/TrEMBL
  Q9WVQ4_RAT UniProtKB/TrEMBL
  RAMP1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Ramp1  receptor activity modifying protein 1  Ramp1  receptor (G protein-coupled) activity modifying protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ramp1  receptor (G protein-coupled) activity modifying protein 1  Ramp1  receptor (calcitonin) activity modifying protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ramp1  receptor (calcitonin) activity modifying protein 1       Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in chronic heart failure 625420
gene_expression mRNA and protein expressed in both atria and ventricles with a 3-fold increase in expression in chronic heart failure models 625420
gene_function transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determine its glycosylation state 61729
gene_function transports calcitonin receptor-like receptor (Calcr) to the cell membrane and determine its glycosylation state 68902
gene_physical_interaction forms a complex with calcitonin receptor-like receptor (CRLR) to form functional calcitonin gene-related peptide (CGRP) receptor 625420
gene_process mediates increased lipid synthesis, triglyceride accumulation, mesangial expansion, glomerulosclerosis, and proteinuria by increasing the expression of transforming growth factor and vascular endothelial growth factor 625420