P4hb (prolyl 4-hydroxylase subunit beta) - Rat Genome Database

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Gene: P4hb (prolyl 4-hydroxylase subunit beta) Rattus norvegicus
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Symbol: P4hb
Name: prolyl 4-hydroxylase subunit beta
RGD ID: 3244
Description: Enables enzyme binding activity and protein disulfide isomerase activity. Predicted to be involved in several processes, including positive regulation of substrate adhesion-dependent cell spreading; positive regulation of viral entry into host cell; and protein maturation. Predicted to act upstream of with a positive effect on endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within cellular response to interleukin-7 and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum-Golgi intermediate compartment; and lamellipodium. Predicted to be part of endoplasmic reticulum chaperone complex and procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum lumen and external side of plasma membrane. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-nicotine; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cellular thyroid hormone-binding protein; PDI; PDIR; prolyl 4-hydroxylase, beta polypeptide; protein disulfide isomerase; protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide); protein disulfide-isomerase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,335,300 - 106,346,911 (-)NCBIGRCr8
mRatBN7.210105,836,972 - 105,848,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,836,982 - 105,848,500 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,941,098 - 110,952,604 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,404,126 - 110,415,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,757,420 - 105,769,031 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,736,459 - 109,748,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,736,458 - 109,747,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,329,596 - 109,341,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,950,221 - 109,961,716 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,964,724 - 109,976,220 (-)NCBI
Celera10104,380,384 - 104,391,995 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
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Evidence
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Reference
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Original Reference(s)
P4hbRatCole-Carpenter syndrome  ISOP4HB (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:28492532
P4hbRatCole-Carpenter Syndrome 1  ISOP4HB (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25683117 more ...
P4hbRatgenetic disease  ISOP4HB (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
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Original Reference(s)
P4hbRatChemical and Drug Induced Liver Injury  ISOP4HB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25231249
P4hbRatCole-Carpenter syndrome  ISOP4HB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
P4hbRatMyocardial Ischemia  ISOP4HB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
P4hbRatosteoporosis  ISOP4HB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18924182
P4hbRatProstatic Neoplasms  ISOP4HB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17013881
P4hbRatspinocerebellar ataxia type 17  ISOP4HB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24413982
Object Symbol
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Original Reference(s)
P4hbRatCole-Carpenter Syndrome 1  ISOP4HB (Homo sapiens)7240710 OMIM 

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Original Reference(s)
P4hbRat(+)-catechin multiple interactionsISOP4HB (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of P4HB mRNACTDPMID:24763279
P4hbRat(-)-epigallocatechin 3-gallate increases expressionISOP4HB (Homo sapiens)6480464epigallocatechin gallate results in increased expression of P4HB proteinCTDPMID:31195006
P4hbRat(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of P4HB proteinCTDPMID:28681937
P4hbRat1,2-dimethylhydrazine multiple interactionsISOP4hb (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of P4HB mRNACTDPMID:22206623
P4hbRat1,3-dinitrobenzene increases metabolic processingEXP 64804643-dinitrobenzene results in increased metabolism of P4HB proteinCTDPMID:21402099
P4hbRat1-chloro-2,4-dinitrobenzene affects bindingISOP4HB (Homo sapiens)6480464Dinitrochlorobenzene binds to P4HB proteinCTDPMID:32991956
P4hbRat17alpha-ethynylestradiol affects expressionISOP4hb (Mus musculus)6480464Ethinyl Estradiol affects the expression of P4HB mRNACTDPMID:17555576
P4hbRat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of P4HB mRNACTDPMID:17108234
P4hbRat17alpha-ethynylestradiol increases expressionISOP4hb (Mus musculus)6480464Ethinyl Estradiol results in increased expression of P4HB mRNACTDPMID:17942748
P4hbRat17alpha-ethynylestradiol multiple interactionsISOP4hb (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of P4HB mRNACTDPMID:17942748
P4hbRat17beta-estradiol multiple interactionsEXP 6480464bisphenol A inhibits the reaction [Estradiol binds to P4HB protein]CTDPMID:16543366
P4hbRat17beta-estradiol multiple interactionsISOP4HB (Homo sapiens)6480464[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of P4HB mRNACTDPMID:20823114
P4hbRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOP4hb (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of P4HB mRNACTDPMID:17942748
P4hbRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of P4HB mRNACTDPMID:34747641
P4hbRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOP4hb (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of P4HB mRNACTDPMID:21570461
P4hbRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of P4HB mRNACTDPMID:18796159 and PMID:33387578
P4hbRat2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expressionEXP 64804642 more ...CTDPMID:19954255
P4hbRat2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expressionEXP 64804642 more ...CTDPMID:19954255
P4hbRat2,4-dichlorophenol multiple interactionsEXP 64804642 more ...CTDPMID:16617682
P4hbRat2,6-dimethoxyphenol multiple interactionsISOP4HB (Homo sapiens)6480464[pyrogallol 1 more ...CTDPMID:38598786

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Biological Process
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P4hbRatcellular response to hypoxia involved_inISOP4HB (Homo sapiens)1624291 PMID:12095988RGDPMID:12095988
P4hbRatcellular response to hypoxia involved_inIEAUniProtKB:P07237 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatcellular response to interleukin-7 acts_upstream_of_or_withinIEAUniProtKB:P09103 and ensembl:ENSMUSP000000261221600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatcellular response to interleukin-7 acts_upstream_of_or_withinISOP4hb (Mus musculus)1624291 PMID:29581031RGDPMID:29581031
P4hbRatendoplasmic reticulum to Golgi vesicle-mediated transport acts_upstream_of_positive_effectISOP4hb (Mus musculus)1624291MGI:5504624 PMID:31184304RGDPMID:31184304
P4hbRatendoplasmic reticulum to Golgi vesicle-mediated transport acts_upstream_of_positive_effectIEAUniProtKB:P09103 and ensembl:ENSMUSP000000261221600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatinsulin processing involved_inIEAUniProtKB:P09103 and ensembl:ENSMUSP000000261221600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatinsulin processing involved_inISOP4hb (Mus musculus)1624291MGI:5504624 PMID:31184304RGDPMID:31184304
P4hbRatpeptidyl-proline hydroxylation to 4-hydroxy-L-proline acts_upstream_of_or_withinISOP4HB (Homo sapiens)1624291 PMID:7753822RGDPMID:7753822
P4hbRatpositive regulation of cell adhesion involved_inISOP4HB (Homo sapiens)1624291 PMID:24415753RGDPMID:24415753
P4hbRatpositive regulation of cell adhesion involved_inIEAUniProtKB:P07237 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatpositive regulation of substrate adhesion-dependent cell spreading involved_inISOP4HB (Homo sapiens)1624291 PMID:24415753RGDPMID:24415753
P4hbRatpositive regulation of substrate adhesion-dependent cell spreading involved_inIEAUniProtKB:P07237 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatpositive regulation of T cell migration involved_inIEAUniProtKB:P07237 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatpositive regulation of T cell migration involved_inISOP4HB (Homo sapiens)1624291 PMID:21670307RGDPMID:21670307
P4hbRatpositive regulation of viral entry into host cell involved_inISOP4HB (Homo sapiens)1624291 PMID:21670307RGDPMID:21670307
P4hbRatpositive regulation of viral entry into host cell involved_inIEAUniProtKB:P07237 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatprotein folding involved_inIBAPANTHER:PTN000432607 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
P4hbRatprotein folding in endoplasmic reticulum involved_inISOP4HB (Homo sapiens)1624291 PMID:21091435RGDPMID:21091435
P4hbRatprotein folding in endoplasmic reticulum involved_inIEAUniProtKB:P07237 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
P4hbRatcytoskeleton located_inISOP4HB (Homo sapiens)1624291 PMID:24415753RGDPMID:24415753
P4hbRatcytoskeleton located_inIEAUniProtKB:P07237 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatcytosol located_inISOP4HB (Homo sapiens)1624291 PMID:24415753RGDPMID:24415753
P4hbRatcytosol located_inIEAUniProtKB:P07237 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatendoplasmic reticulum is_active_inISOP4HB (Homo sapiens)1624291 PMID:32149426RGDPMID:32149426
P4hbRatendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
P4hbRatendoplasmic reticulum located_inIEAUniProtKB-SubCell:SL-00951600115GO_REF:0000044UniProtGO_REF:0000044
P4hbRatendoplasmic reticulum located_inIEAUniProtKB:A0A024R8S5 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatendoplasmic reticulum located_inIEAUniProtKB:P09103 and ensembl:ENSMUSP000000261221600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatendoplasmic reticulum located_inISOP4hb (Mus musculus)1624291 PMID:14622145 more ...RGDPMID:14622145 more ...
P4hbRatendoplasmic reticulum located_inIEAUniProtKB:P07237 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatendoplasmic reticulum is_active_inIBAFB:FBgn0286818 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
P4hbRatendoplasmic reticulum located_inISSUniProtKB:P072371600115GO_REF:0000024UniProtGO_REF:0000024
P4hbRatendoplasmic reticulum located_inISOP4HB (Homo sapiens)1624291 PMID:12095988 more ...RGDGO_REF:0000052 more ...
P4hbRatendoplasmic reticulum chaperone complex part_ofISOP4hb (Mus musculus)1624291 PMID:12475965RGDPMID:12475965
P4hbRatendoplasmic reticulum chaperone complex part_ofIEAUniProtKB:P09103 and ensembl:ENSMUSP000000261221600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatendoplasmic reticulum lumen located_inIEAUniProtKB-SubCell:SL-00961600115GO_REF:0000044UniProtGO_REF:0000044
P4hbRatendoplasmic reticulum lumen is_active_inISOP4hb (Mus musculus)1624291MGI:5504624 PMID:31184304RGDPMID:31184304
P4hbRatendoplasmic reticulum lumen is_active_inIEAUniProtKB:P09103 and ensembl:ENSMUSP000000261221600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatendoplasmic reticulum-Golgi intermediate compartment located_inISOP4HB (Homo sapiens)1624291 PMID:15308636RGDPMID:15308636
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Molecular Function
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Original Reference(s)
P4hbRatactin binding enablesISOP4HB (Homo sapiens)1624291UniProtKB:P60709 and PMID:24415753RGDPMID:24415753
P4hbRatactin binding enablesIEAUniProtKB:P07237 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatenzyme binding  IPISod1 (Rattus norvegicus)8655994 RGD 
P4hbRatintegrin binding enablesISOP4hb (Mus musculus)1624291UniProtKB:O54890 and PMID:21670307RGDPMID:21670307
P4hbRatintegrin binding enablesIEAUniProtKB:P07237 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatintegrin binding enablesIEAUniProtKB:P09103 and ensembl:ENSMUSP000000261221600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatintegrin binding enablesISOP4HB (Homo sapiens)1624291UniProtKB:P05106 and PMID:21670307RGDPMID:21670307
P4hbRatisomerase activity enablesIEAUniProtKB-KW:KW-04131600115GO_REF:0000043UniProtGO_REF:0000043
P4hbRatprocollagen-proline 4-dioxygenase activity contributes_toISOP4HB (Homo sapiens)1624291 PMID:7753822RGDPMID:7753822
P4hbRatprocollagen-proline 4-dioxygenase activity contributes_toIEAUniProtKB:P07237 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatprotein binding enablesISOP4hb (Mus musculus)1624291UniProtKB:B5TVM2 more ...RGDPMID:21670307 and PMID:33863978
P4hbRatprotein binding enablesISOP4HB (Homo sapiens)1624291UniProtKB:O00182 more ...RGDPMID:12095988 more ...
P4hbRatprotein disulfide isomerase activity enablesISOP4HB (Homo sapiens)1624291 PMID:15225124 more ...RGDPMID:15225124 more ...
P4hbRatprotein disulfide isomerase activity  IMP 633506 RGD 
P4hbRatprotein disulfide isomerase activity enablesIEAUniProtKB:P07237 and ensembl:ENSP000003278011600115GO_REF:0000107EnsemblGO_REF:0000107
P4hbRatprotein disulfide isomerase activity enablesIBAMGI:104864 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
P4hbRatprotein disulfide isomerase activity enablesIEAEC:5.3.4.11600115GO_REF:0000003UniProtGO_REF:0000003
P4hbRatprotein disulfide isomerase activity enablesIEAInterPro:IPR0057881600115GO_REF:0000002InterProGO_REF:0000002
P4hbRatprotein disulfide isomerase activity enablesIEAInterPro:IPR005788 and InterPro:IPR0057921600115GO_REF:0000002InterProGO_REF:0000002
P4hbRatprotein heterodimerization activity enablesISOP4HB (Homo sapiens)1624291 PMID:23475612RGDPMID:23475612
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Imported Annotations - KEGG (archival)

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Original Reference(s)
P4hbRatEndoplasmic Reticulum-associated degradation pathway  IEA 6907045 KEGGrno:04141

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#
Reference Title
Reference Citation
1. Nucleotide sequence of rat liver iodothyronine 5'-monodeiodinase (5' MD): its identity with the protein disulfide isomerase. Boado RJ, etal., Biochem Biophys Res Commun 1988 Sep 30;155(3):1297-304.
2. Enzyme binding-inhibiting assay for iodothyronine 5'-monodeiodinase (5'-MD) and its application to isolation of complementary deoxyribonucleic acid clones for the 5'-MD in rat liver. Boado RJ, etal., Endocrinology 1988 Sep;123(3):1264-73.
3. SOD1 aggregation in astrocytes following ischemia/reperfusion injury: a role of NO-mediated S-nitrosylation of protein disulfide isomerase (PDI). Chen X, etal., J Neuroinflammation. 2012 Oct 12;9:237. doi: 10.1186/1742-2094-9-237.
4. Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin. Edman JC, etal., Nature 1985 Sep 19-25;317(6034):267-70.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons. Levy E, etal., J Biol Chem. 2002 May 10;277(19):16470-7. Epub 2002 Feb 5.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
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PMID:2757644   PMID:7753822   PMID:8251535   PMID:8366073   PMID:9493907   PMID:9806833   PMID:12095988   PMID:12475965   PMID:14622145   PMID:15225124   PMID:15308636   PMID:15489334  
PMID:15720785   PMID:15767459   PMID:15767678   PMID:16677074   PMID:17928132   PMID:18094359   PMID:18515855   PMID:19199708   PMID:20855262   PMID:21423176   PMID:21670307   PMID:22505424  
PMID:22658674   PMID:22681889   PMID:23152784   PMID:23475612   PMID:23979707   PMID:24333444   PMID:24415753   PMID:28198441   PMID:29476059   PMID:29581031   PMID:35352799  



P4hb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,335,300 - 106,346,911 (-)NCBIGRCr8
mRatBN7.210105,836,972 - 105,848,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,836,982 - 105,848,500 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,941,098 - 110,952,604 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,404,126 - 110,415,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,757,420 - 105,769,031 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,736,459 - 109,748,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,736,458 - 109,747,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,329,596 - 109,341,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,950,221 - 109,961,716 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,964,724 - 109,976,220 (-)NCBI
Celera10104,380,384 - 104,391,995 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
P4HB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,843,166 - 81,860,535 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,843,159 - 81,860,856 (-)EnsemblGRCh38hg38GRCh38
GRCh371779,801,042 - 79,818,411 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,394,323 - 77,411,833 (-)NCBINCBI36Build 36hg18NCBI36
Celera1776,404,498 - 76,422,010 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,202,821 - 75,220,332 (-)NCBIHuRef
CHM1_11779,887,239 - 79,904,780 (-)NCBICHM1_1
T2T-CHM13v2.01782,710,331 - 82,727,700 (-)NCBIT2T-CHM13v2.0
P4hb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,451,124 - 120,464,079 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,451,124 - 120,464,079 (-)EnsemblGRCm39 Ensembl
GRCm3811120,560,298 - 120,573,253 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,560,298 - 120,573,253 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,421,618 - 120,434,250 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,376,394 - 120,389,026 (-)NCBIMGSCv36mm8
Celera11132,295,664 - 132,308,296 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.27NCBI
P4hb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,307,932 - 1,324,027 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,307,932 - 1,322,011 (+)NCBIChiLan1.0ChiLan1.0
P4HB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,378,767 - 98,396,916 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,279,545 - 103,297,401 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,248,252 - 76,266,152 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11781,950,826 - 81,968,329 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1781,950,422 - 81,968,109 (-)Ensemblpanpan1.1panPan2
P4HB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19427,827 - 436,880 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9427,830 - 436,064 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,029,990 - 1,039,034 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,021,195 - 1,030,242 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,021,122 - 1,030,242 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,046,356 - 1,055,402 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,172,930 - 1,181,988 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,251,854 - 1,260,908 (+)NCBIUU_Cfam_GSD_1.0
P4hb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,032,744 - 1,043,760 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,367,816 - 5,379,252 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,368,199 - 5,379,215 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P4HB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,121,824 - 1,131,289 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,121,816 - 1,131,291 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
P4HB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,718,743 - 73,733,488 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,718,656 - 73,733,892 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,170,359 - 45,185,570 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P4hb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,699,161 - 10,712,896 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,700,301 - 10,712,889 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in P4hb
28 total Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
10 109339931 109339932 G T snv ZF (KyushuU) View more Information

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:192
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000054958
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 40 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat

1 to 10 of 40 rows
RH129632  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,837,024 - 105,837,226 (+)MAPPERmRatBN7.2
Rnor_6.010109,736,512 - 109,736,713NCBIRnor6.0
Rnor_5.010109,329,641 - 109,329,842UniSTSRnor5.0
RGSC_v3.410109,950,266 - 109,950,467UniSTSRGSC3.4
Celera10104,380,437 - 104,380,638UniSTS
Cytogenetic Map10q32.3UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 17 of 17 rows
RefSeq Transcripts NM_012998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC131537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB583787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM060266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM067812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSRNOT00000054958   ⟹   ENSRNOP00000051841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,836,982 - 105,848,500 (-)Ensembl
Rnor_6.0 Ensembl10109,736,458 - 109,747,987 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100112   ⟹   ENSRNOP00000086980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,836,982 - 105,848,434 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106240   ⟹   ENSRNOP00000084686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,836,982 - 105,848,261 (-)Ensembl
RefSeq Acc Id: NM_012998   ⟹   NP_037130
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,335,300 - 106,346,911 (-)NCBI
mRatBN7.210105,836,972 - 105,848,583 (-)NCBI
Rnor_6.010109,736,459 - 109,748,070 (-)NCBI
Rnor_5.010109,329,596 - 109,341,091 (-)NCBI
RGSC_v3.410109,950,221 - 109,961,716 (-)RGD
Celera10104,380,384 - 104,391,995 (-)NCBI
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_037130 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40619 (Get FASTA)   NCBI Sequence Viewer  
  AAA40620 (Get FASTA)   NCBI Sequence Viewer  
  AAH61857 (Get FASTA)   NCBI Sequence Viewer  
  CAA26675 (Get FASTA)   NCBI Sequence Viewer  
  EDM06853 (Get FASTA)   NCBI Sequence Viewer  
  EDM06854 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051841
  ENSRNOP00000051841.1
GenBank Protein P04785 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_037130   ⟸   NM_012998
- Peptide Label: precursor
- UniProtKB: P13700 (UniProtKB/Swiss-Prot),   P04785 (UniProtKB/Swiss-Prot),   A6HLE8 (UniProtKB/TrEMBL),   A0A8I6A1R9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051841   ⟸   ENSRNOT00000054958
Ensembl Acc Id: ENSRNOP00000086980   ⟸   ENSRNOT00000100112
Ensembl Acc Id: ENSRNOP00000084686   ⟸   ENSRNOT00000106240
Thioredoxin

Name Modeler Protein Id AA Range Protein Structure
AF-P04785-F1-model_v2 AlphaFold P04785 1-509 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697964
Promoter ID:EPDNEW_R8488
Type:initiation region
Name:P4hb_1
Description:prolyl 4-hydroxylase subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010109,747,987 - 109,748,047EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-22409 BioCyc
Ensembl Genes ENSRNOG00000036689 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000054958 ENTREZGENE
  ENSRNOT00000054958.3 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623688 IMAGE-MGC_LOAD
InterPro Disulphide_isomerase UniProtKB/Swiss-Prot
  Prot_disulphide_isomerase UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
  Thioredoxin_CS UniProtKB/Swiss-Prot
  Thioredoxin_domain UniProtKB/Swiss-Prot
KEGG Report rno:25506 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72525 IMAGE-MGC_LOAD
NCBI Gene 25506 ENTREZGENE
PANTHER PROTEIN DISULFIDE ISOMERASE UniProtKB/Swiss-Prot
  PROTEIN DISULFIDE-ISOMERASE UniProtKB/Swiss-Prot
Pfam Thioredoxin UniProtKB/Swiss-Prot
  Thioredoxin_6 UniProtKB/Swiss-Prot
PhenoGen P4hb PhenoGen
PRINTS THIOREDOXIN UniProtKB/Swiss-Prot
PROSITE ER_TARGET UniProtKB/Swiss-Prot
  THIOREDOXIN_1 UniProtKB/Swiss-Prot
  THIOREDOXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000036689 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A0A8I6A1R9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7J4_RAT UniProtKB/TrEMBL
  A6HLE8 ENTREZGENE, UniProtKB/TrEMBL
  A6HLE9_RAT UniProtKB/TrEMBL
  P04785 ENTREZGENE
  P13700 ENTREZGENE
  PDIA1_RAT UniProtKB/Swiss-Prot
UniProt Secondary P13700 UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 P4hb  prolyl 4-hydroxylase subunit beta  P4hb  prolyl 4-hydroxylase, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 P4hb  Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide)      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression expressed in liver 633506