P4hb (prolyl 4-hydroxylase subunit beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: P4hb (prolyl 4-hydroxylase subunit beta) Rattus norvegicus
Analyze
Symbol: P4hb
Name: prolyl 4-hydroxylase subunit beta
RGD ID: 3244
Description: Enables enzyme binding activity and protein disulfide isomerase activity. Predicted to be involved in several processes, including positive regulation of substrate adhesion-dependent cell spreading; positive regulation of viral entry into host cell; and protein maturation. Predicted to act upstream of with a positive effect on endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within cellular response to interleukin-7 and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum-Golgi intermediate compartment; and lamellipodium. Predicted to be part of endoplasmic reticulum chaperone complex and procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum lumen and external side of plasma membrane. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-nicotine; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cellular thyroid hormone-binding protein; PDI; PDIR; prolyl 4-hydroxylase, beta polypeptide; protein disulfide isomerase; protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide); protein disulfide-isomerase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,335,300 - 106,346,911 (-)NCBIGRCr8
mRatBN7.210105,836,972 - 105,848,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,836,982 - 105,848,500 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,941,098 - 110,952,604 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,404,126 - 110,415,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,757,420 - 105,769,031 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,736,459 - 109,748,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,736,458 - 109,747,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,329,596 - 109,341,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,950,221 - 109,961,716 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,964,724 - 109,976,220 (-)NCBI
Celera10104,380,384 - 104,391,995 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dichlorophenol  (EXP)
2,6-dimethoxyphenol  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
4-octylphenol  (EXP)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
Brodifacoum  (EXP)
bromobenzene  (EXP)
bucladesine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
furfural  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
indinavir  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-serine  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
medroxyprogesterone acetate  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
motexafin gadolinium  (ISO)
N-nitrosomorpholine  (EXP)
N-Phenylmaleimide  (ISO)
nafenopin  (EXP)
naphthalene  (ISO)
nicotine  (EXP)
obeticholic acid  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (EXP)
perfluorododecanoic acid  (EXP)
phenobarbital  (ISO)
phenylarsonous acid  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (EXP)
Propiverine  (EXP)
quercetin  (ISO)
rifampicin  (ISO)
S-nitrosoglutathione  (EXP)
sarin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toxoflavin  (ISO)
triadimefon  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nucleotide sequence of rat liver iodothyronine 5'-monodeiodinase (5' MD): its identity with the protein disulfide isomerase. Boado RJ, etal., Biochem Biophys Res Commun 1988 Sep 30;155(3):1297-304.
2. Enzyme binding-inhibiting assay for iodothyronine 5'-monodeiodinase (5'-MD) and its application to isolation of complementary deoxyribonucleic acid clones for the 5'-MD in rat liver. Boado RJ, etal., Endocrinology 1988 Sep;123(3):1264-73.
3. SOD1 aggregation in astrocytes following ischemia/reperfusion injury: a role of NO-mediated S-nitrosylation of protein disulfide isomerase (PDI). Chen X, etal., J Neuroinflammation. 2012 Oct 12;9:237. doi: 10.1186/1742-2094-9-237.
4. Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin. Edman JC, etal., Nature 1985 Sep 19-25;317(6034):267-70.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons. Levy E, etal., J Biol Chem. 2002 May 10;277(19):16470-7. Epub 2002 Feb 5.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:2757644   PMID:7753822   PMID:8251535   PMID:8366073   PMID:9493907   PMID:9806833   PMID:12095988   PMID:12475965   PMID:14622145   PMID:15225124   PMID:15308636   PMID:15489334  
PMID:15720785   PMID:15767459   PMID:15767678   PMID:16677074   PMID:17928132   PMID:18094359   PMID:18515855   PMID:19199708   PMID:20855262   PMID:21423176   PMID:21670307   PMID:22505424  
PMID:22658674   PMID:22681889   PMID:23152784   PMID:23475612   PMID:23979707   PMID:24333444   PMID:24415753   PMID:28198441   PMID:29476059   PMID:29581031   PMID:35352799  


Genomics

Comparative Map Data
P4hb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,335,300 - 106,346,911 (-)NCBIGRCr8
mRatBN7.210105,836,972 - 105,848,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,836,982 - 105,848,500 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,941,098 - 110,952,604 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,404,126 - 110,415,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,757,420 - 105,769,031 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,736,459 - 109,748,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,736,458 - 109,747,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,329,596 - 109,341,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,950,221 - 109,961,716 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,964,724 - 109,976,220 (-)NCBI
Celera10104,380,384 - 104,391,995 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
P4HB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,843,166 - 81,860,535 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,843,159 - 81,860,856 (-)EnsemblGRCh38hg38GRCh38
GRCh371779,801,042 - 79,818,411 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,394,323 - 77,411,833 (-)NCBINCBI36Build 36hg18NCBI36
Celera1776,404,498 - 76,422,010 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,202,821 - 75,220,332 (-)NCBIHuRef
CHM1_11779,887,239 - 79,904,780 (-)NCBICHM1_1
T2T-CHM13v2.01782,710,331 - 82,727,700 (-)NCBIT2T-CHM13v2.0
P4hb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,451,124 - 120,464,079 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,451,124 - 120,464,079 (-)EnsemblGRCm39 Ensembl
GRCm3811120,560,298 - 120,573,253 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,560,298 - 120,573,253 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,421,618 - 120,434,250 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,376,394 - 120,389,026 (-)NCBIMGSCv36mm8
Celera11132,295,664 - 132,308,296 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.27NCBI
P4hb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,307,932 - 1,324,027 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,307,932 - 1,322,011 (+)NCBIChiLan1.0ChiLan1.0
P4HB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,378,767 - 98,396,916 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,279,545 - 103,297,401 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,248,252 - 76,266,152 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11781,950,826 - 81,968,329 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1781,950,422 - 81,968,109 (-)Ensemblpanpan1.1panPan2
P4HB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19427,827 - 436,880 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9427,830 - 436,064 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,029,990 - 1,039,034 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,021,195 - 1,030,242 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,021,122 - 1,030,242 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,046,356 - 1,055,402 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,172,930 - 1,181,988 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,251,854 - 1,260,908 (+)NCBIUU_Cfam_GSD_1.0
P4hb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,032,744 - 1,043,760 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,367,816 - 5,379,252 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,368,199 - 5,379,215 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P4HB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,121,824 - 1,131,289 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,121,816 - 1,131,291 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
P4HB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,718,743 - 73,733,488 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,718,656 - 73,733,892 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,170,359 - 45,185,570 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P4hb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,699,161 - 10,712,896 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,700,301 - 10,712,889 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P4hb
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:192
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000054958
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat

Markers in Region
RH129632  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,837,024 - 105,837,226 (+)MAPPERmRatBN7.2
Rnor_6.010109,736,512 - 109,736,713NCBIRnor6.0
Rnor_5.010109,329,641 - 109,329,842UniSTSRnor5.0
RGSC_v3.410109,950,266 - 109,950,467UniSTSRGSC3.4
Celera10104,380,437 - 104,380,638UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC131537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB583787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM060266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM067812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000054958   ⟹   ENSRNOP00000051841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,836,982 - 105,848,500 (-)Ensembl
Rnor_6.0 Ensembl10109,736,458 - 109,747,987 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100112   ⟹   ENSRNOP00000086980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,836,982 - 105,848,434 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106240   ⟹   ENSRNOP00000084686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,836,982 - 105,848,261 (-)Ensembl
RefSeq Acc Id: NM_012998   ⟹   NP_037130
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,335,300 - 106,346,911 (-)NCBI
mRatBN7.210105,836,972 - 105,848,583 (-)NCBI
Rnor_6.010109,736,459 - 109,748,070 (-)NCBI
Rnor_5.010109,329,596 - 109,341,091 (-)NCBI
RGSC_v3.410109,950,221 - 109,961,716 (-)RGD
Celera10104,380,384 - 104,391,995 (-)NCBI
Sequence:
RefSeq Acc Id: NP_037130   ⟸   NM_012998
- Peptide Label: precursor
- UniProtKB: P13700 (UniProtKB/Swiss-Prot),   P04785 (UniProtKB/Swiss-Prot),   A6HLE8 (UniProtKB/TrEMBL),   A0A8I6A1R9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051841   ⟸   ENSRNOT00000054958
Ensembl Acc Id: ENSRNOP00000086980   ⟸   ENSRNOT00000100112
Ensembl Acc Id: ENSRNOP00000084686   ⟸   ENSRNOT00000106240
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04785-F1-model_v2 AlphaFold P04785 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697964
Promoter ID:EPDNEW_R8488
Type:initiation region
Name:P4hb_1
Description:prolyl 4-hydroxylase subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010109,747,987 - 109,748,047EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3244 AgrOrtholog
BioCyc Gene G2FUF-22409 BioCyc
Ensembl Genes ENSRNOG00000036689 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055032801 UniProtKB/Swiss-Prot
  ENSRNOG00060030940 UniProtKB/Swiss-Prot
  ENSRNOG00065003976 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000054958.3 UniProtKB/Swiss-Prot
  ENSRNOT00000100112.1 UniProtKB/TrEMBL
  ENSRNOT00000106240.1 UniProtKB/TrEMBL
  ENSRNOT00055056725 UniProtKB/Swiss-Prot
  ENSRNOT00060053755 UniProtKB/Swiss-Prot
  ENSRNOT00065005811 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623688 IMAGE-MGC_LOAD
InterPro Disulphide_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_disulphide_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25506 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72525 IMAGE-MGC_LOAD
NCBI Gene 25506 ENTREZGENE
PANTHER PROTEIN DISULFIDE ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN DISULFIDE-ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen P4hb PhenoGen
PRINTS THIOREDOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ER_TARGET UniProtKB/Swiss-Prot
  THIOREDOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036689 RatGTEx
  ENSRNOG00055032801 RatGTEx
  ENSRNOG00060030940 RatGTEx
  ENSRNOG00065003976 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A1R9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7J4_RAT UniProtKB/TrEMBL
  A6HLE8 ENTREZGENE, UniProtKB/TrEMBL
  A6HLE9_RAT UniProtKB/TrEMBL
  P04785 ENTREZGENE
  P13700 ENTREZGENE
  PDIA1_RAT UniProtKB/Swiss-Prot
UniProt Secondary P13700 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 P4hb  prolyl 4-hydroxylase subunit beta  P4hb  prolyl 4-hydroxylase, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 P4hb  Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 633506