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Gene: P4hb (prolyl 4-hydroxylase, beta polypeptide) Mus musculus
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Symbol: P4hb
Name: prolyl 4-hydroxylase, beta polypeptide
Description: Exhibits integrin binding activity. Predicted to contribute to procollagen-proline 4-dioxygenase activity. Involved in cellular response to interleukin-7. Localizes to the endoplasmic reticulum chaperone complex and external side of plasma membrane. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Is expressed in several structures, including alimentary system; central nervous system; cranium; heart; and sensory organ. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cellular thyroid hormone-binding protein; endoplasmic reticulum resident protein 59; ER protein 59; ERp59; p55; PDI; Pdia1; prolyl 4-hydroxylase subunit beta; protein disulfide isomerase; protein disulfide-isomerase; Thbp
Orthologs:
Homo sapiens (human) : P4HB (prolyl 4-hydroxylase subunit beta)  HGNC  Alliance
Rattus norvegicus (Norway rat) : P4hb (prolyl 4-hydroxylase subunit beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P4hb (prolyl 4-hydroxylase subunit beta)
Pan paniscus (bonobo/pygmy chimpanzee) : P4HB (prolyl 4-hydroxylase subunit beta)
Canis lupus familiaris (dog) : P4HB (prolyl 4-hydroxylase subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P4hb (prolyl 4-hydroxylase subunit beta)
Sus scrofa (pig) : P4HB (prolyl 4-hydroxylase subunit beta)
Chlorocebus sabaeus (green monkey) : P4HB (prolyl 4-hydroxylase subunit beta)
Heterocephalus glaber (naked mole-rat) : P4hb (prolyl 4-hydroxylase subunit beta)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl11120,560,298 - 120,573,253 (-)Ensembl
GRCm3811120,560,298 - 120,573,253 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711120,421,618 - 120,434,250 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611120,376,394 - 120,389,026 (-)NCBImm8
Celera11132,295,664 - 132,308,296 (-)NCBICelera
Cytogenetic Map11 E2NCBI
cM Map1184.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on P4hb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11046
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.