Pnpla8 (patatin-like phospholipase domain containing 8) - Rat Genome Database

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Gene: Pnpla8 (patatin-like phospholipase domain containing 8) Rattus norvegicus
Analyze
Symbol: Pnpla8
Name: patatin-like phospholipase domain containing 8
RGD ID: 1311444
Description: Predicted to enable calcium-independent phospholipase A2 activity. Predicted to be involved in several processes, including arachidonic acid secretion; glycerophospholipid metabolic process; and unsaturated fatty acid metabolic process. Predicted to be located in mitochondrion and peroxisomal membrane. Predicted to be active in membrane. Orthologous to human PNPLA8 (patatin like phospholipase domain containing 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium-independent phospholipase A2-gamma; intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; LOC314075; patatin-like phospholipase domain-containing protein 8; RGD1311444; similar to intracellular membrane-associated calcium-independent phospholipase A2 gamma
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8667,056,783 - 67,118,714 (+)NCBIGRCr8
mRatBN7.2661,329,810 - 61,391,736 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl661,329,810 - 61,391,734 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx661,665,649 - 61,727,585 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0661,980,640 - 62,042,576 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0661,453,124 - 61,515,027 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0664,224,870 - 64,288,465 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl664,224,861 - 64,286,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0673,814,201 - 73,876,147 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4663,644,462 - 63,676,544 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1663,674,719 - 63,707,771 (+)NCBI
Celera660,325,313 - 60,388,908 (+)NCBICelera
Cytogenetic Map6q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
DDT  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gallic acid  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloroethene  (ISO)
thiram  (ISO)
tributylstannane  (EXP)
Triptolide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10744668   PMID:10833412   PMID:15695510   PMID:15908428   PMID:17213206  


Genomics

Comparative Map Data
Pnpla8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8667,056,783 - 67,118,714 (+)NCBIGRCr8
mRatBN7.2661,329,810 - 61,391,736 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl661,329,810 - 61,391,734 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx661,665,649 - 61,727,585 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0661,980,640 - 62,042,576 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0661,453,124 - 61,515,027 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0664,224,870 - 64,288,465 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl664,224,861 - 64,286,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0673,814,201 - 73,876,147 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4663,644,462 - 63,676,544 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1663,674,719 - 63,707,771 (+)NCBI
Celera660,325,313 - 60,388,908 (+)NCBICelera
Cytogenetic Map6q21NCBI
PNPLA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387108,470,417 - 108,528,178 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7108,470,417 - 108,569,666 (-)EnsemblGRCh38hg38GRCh38
GRCh377108,110,861 - 108,168,622 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367107,899,305 - 107,953,874 (-)NCBINCBI36Build 36hg18NCBI36
Celera7102,925,427 - 102,979,992 (-)NCBICelera
Cytogenetic Map7q31.1NCBI
HuRef7102,479,082 - 102,536,797 (-)NCBIHuRef
CHM1_17108,044,179 - 108,101,909 (-)NCBICHM1_1
T2T-CHM13v2.07109,795,069 - 109,852,801 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27107,478,078 - 107,535,820 (-)NCBI
Pnpla8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391244,315,916 - 44,362,718 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1244,268,153 - 44,369,315 (+)EnsemblGRCm39 Ensembl
GRCm381244,269,132 - 44,315,936 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1244,221,370 - 44,322,532 (+)EnsemblGRCm38mm10GRCm38
MGSCv371245,370,141 - 45,414,424 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361245,139,472 - 45,182,573 (+)NCBIMGSCv36mm8
Celera1245,626,908 - 45,667,980 (+)NCBICelera
Cytogenetic Map12B2NCBI
cM Map1220.71NCBI
Pnpla8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541012,711,082 - 12,753,433 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541012,715,072 - 12,753,433 (-)NCBIChiLan1.0ChiLan1.0
PNPLA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26145,320,226 - 145,365,332 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17193,590,196 - 193,681,667 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07100,456,096 - 100,511,836 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17113,176,014 - 113,230,799 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7113,177,202 - 113,230,799 (-)Ensemblpanpan1.1panPan2
PNPLA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11812,134,921 - 12,181,496 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1812,141,830 - 12,179,974 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1811,779,378 - 11,825,993 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01812,406,088 - 12,453,716 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1812,406,080 - 12,454,928 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11812,223,261 - 12,270,831 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01812,143,880 - 12,191,247 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01812,371,185 - 12,418,564 (+)NCBIUU_Cfam_GSD_1.0
Pnpla8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511868,318,956 - 68,348,464 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366531,470,299 - 1,499,900 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366531,470,314 - 1,499,813 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9108,269,830 - 108,320,267 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19108,271,343 - 108,320,574 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29119,139,826 - 119,157,430 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PNPLA8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12177,385,923 - 77,437,894 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2177,385,537 - 77,437,860 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604226,424,768 - 26,477,705 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnpla8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473921,260,117 - 21,289,195 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473921,252,812 - 21,305,118 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pnpla8
189 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:664
Count of miRNA genes:302
Interacting mature miRNAs:381
Transcripts:ENSRNOT00000047296
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat

Markers in Region
D6Rat204  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2661,362,473 - 61,362,692 (+)MAPPERmRatBN7.2
Rnor_6.0664,257,523 - 64,257,741NCBIRnor6.0
Rnor_5.0673,846,885 - 73,847,103UniSTSRnor5.0
RGSC_v3.4663,677,094 - 63,677,311RGDRGSC3.4
RGSC_v3.4663,677,095 - 63,677,313UniSTSRGSC3.4
RGSC_v3.1663,680,220 - 63,680,437RGD
Celera660,357,966 - 60,358,184UniSTS
SHRSP x BN Map643.1999RGD
SHRSP x BN Map643.1999UniSTS
Cytogenetic Map6q21UniSTS
RH129565  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2661,391,520 - 61,391,701 (+)MAPPERmRatBN7.2
Rnor_6.0664,286,570 - 64,286,750NCBIRnor6.0
Rnor_5.0673,875,932 - 73,876,112UniSTSRnor5.0
RGSC_v3.4663,706,142 - 63,706,322UniSTSRGSC3.4
Celera660,387,013 - 60,387,193UniSTS
RH 3.4 Map6449.9UniSTS
Cytogenetic Map6q21UniSTS
RH142249  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2661,357,002 - 61,357,182 (+)MAPPERmRatBN7.2
Rnor_6.0664,252,053 - 64,252,232NCBIRnor6.0
Rnor_5.0673,841,415 - 73,841,594UniSTSRnor5.0
RGSC_v3.4663,671,625 - 63,671,804UniSTSRGSC3.4
Celera660,352,496 - 60,352,675UniSTS
RH 3.4 Map6449.5UniSTS
Cytogenetic Map6q21UniSTS
AI454558  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2661,331,024 - 61,331,227 (+)MAPPERmRatBN7.2
Rnor_6.0664,226,076 - 64,226,278NCBIRnor6.0
Rnor_5.0673,815,438 - 73,815,640UniSTSRnor5.0
RGSC_v3.4663,645,648 - 63,645,850UniSTSRGSC3.4
Celera660,326,519 - 60,326,721UniSTS
RH 3.4 Map6447.1UniSTS
Cytogenetic Map6q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 8 10 74 35 41 11 8
Low 1 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000047296   ⟹   ENSRNOP00000049214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl661,329,810 - 61,391,734 (+)Ensembl
Rnor_6.0 Ensembl664,252,020 - 64,286,785 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082105   ⟹   ENSRNOP00000073644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl661,329,810 - 61,361,641 (+)Ensembl
Rnor_6.0 Ensembl664,252,111 - 64,284,768 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093159   ⟹   ENSRNOP00000076225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl661,329,810 - 61,391,734 (+)Ensembl
Rnor_6.0 Ensembl664,224,861 - 64,252,776 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl664,252,715 - 64,253,371 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl664,224,971 - 64,256,899 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093664   ⟹   ENSRNOP00000076306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl664,224,970 - 64,252,503 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093700   ⟹   ENSRNOP00000076265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl664,252,970 - 64,256,898 (+)Ensembl
RefSeq Acc Id: NM_001108020   ⟹   NP_001101490
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8667,056,790 - 67,118,714 (+)NCBI
mRatBN7.2661,329,810 - 61,391,736 (+)NCBI
RefSeq Acc Id: XM_063261901   ⟹   XP_063117971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8667,057,015 - 67,118,714 (+)NCBI
RefSeq Acc Id: XM_063261902   ⟹   XP_063117972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8667,056,783 - 67,118,714 (+)NCBI
RefSeq Acc Id: XM_063261903   ⟹   XP_063117973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8667,056,785 - 67,118,714 (+)NCBI
RefSeq Acc Id: ENSRNOP00000073644   ⟸   ENSRNOT00000082105
RefSeq Acc Id: ENSRNOP00000076265   ⟸   ENSRNOT00000093700
RefSeq Acc Id: ENSRNOP00000076306   ⟸   ENSRNOT00000093664
RefSeq Acc Id: ENSRNOP00000076225   ⟸   ENSRNOT00000093159
RefSeq Acc Id: ENSRNOP00000049214   ⟸   ENSRNOT00000047296
RefSeq Acc Id: NP_001101490   ⟸   NM_001108020
- UniProtKB: D3ZRC4 (UniProtKB/Swiss-Prot),   A0A1W2Q6C9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117972   ⟸   XM_063261902
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063117973   ⟸   XM_063261903
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063117971   ⟸   XM_063261901
- Peptide Label: isoform X1
- UniProtKB: D3ZRC4 (UniProtKB/Swiss-Prot),   A0A1W2Q6C9 (UniProtKB/TrEMBL)
Protein Domains
PNPLA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRC4-F1-model_v2 AlphaFold D3ZRC4 1-776 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694579
Promoter ID:EPDNEW_R5101
Type:initiation region
Name:Pnpla8_1
Description:patatin-like phospholipase domain containing 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0664,224,890 - 64,224,950EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311444 AgrOrtholog
BioCyc Gene G2FUF-37690 BioCyc
Ensembl Genes ENSRNOG00000039091 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065009530 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047296 ENTREZGENE
  ENSRNOT00000047296.7 UniProtKB/Swiss-Prot
  ENSRNOT00000082105.2 UniProtKB/TrEMBL
  ENSRNOT00000093159.2 UniProtKB/TrEMBL
  ENSRNOT00065015254 UniProtKB/Swiss-Prot
Gene3D-CATH Cytosolic phospholipase A2 catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPLipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PNPLA8-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PNPLA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 314075 ENTREZGENE
PANTHER CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA UniProtKB/Swiss-Prot
  CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA UniProtKB/Swiss-Prot
  CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA UniProtKB/TrEMBL
  CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA UniProtKB/TrEMBL
Pfam Patatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pnpla8 PhenoGen
PROSITE PNPLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039091 RatGTEx
  ENSRNOG00065009530 RatGTEx
Superfamily-SCOP SSF52151 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K621_RAT UniProtKB/TrEMBL
  A0A1W2Q6C9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRC4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-27 Pnpla8  patatin-like phospholipase domain containing 8  RGD1311444_predicted  similar to intracellular membrane-associated calcium-independent phospholipase A2 gamma (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1311444_predicted  similar to intracellular membrane-associated calcium-independent phospholipase A2 gamma (predicted)  LOC314075_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314075_predicted  similar to intracellular membrane-associated calcium-independent phospholipase A2 gamma (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL