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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | increases expression | ISO | RGD:1351339 | 6480464 | Nicotine results in increased expression of SPTLC3 mRNA | CTD | PMID:23825647 | 17beta-estradiol 3-benzoate | decreases expression | EXP | | 6480464 | estradiol 3-benzoate results in decreased expression of SPTLC3 mRNA | CTD | PMID:32741896 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | RGD:1320696 | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | RGD:1320696 | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1351339 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SPTLC3 mRNA | CTD | PMID:23152189 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1351339 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SPTLC3 mRNA | CTD | PMID:20106945 more ... | 2-hydroxypropanoic acid | decreases expression | ISO | RGD:1351339 | 6480464 | Lactic Acid results in decreased expression of SPTLC3 mRNA | CTD | PMID:30851411 | 4-hydroxyphenyl retinamide | increases expression | ISO | RGD:1320696 | 6480464 | Fenretinide results in increased expression of SPTLC3 mRNA | CTD | PMID:28973697 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of SPTLC3 mRNA | CTD | PMID:28959563 | aflatoxin B1 | affects expression | ISO | RGD:1351339 | 6480464 | Aflatoxin B1 affects the expression of SPTLC3 protein | CTD | PMID:20106945 | aflatoxin B1 | decreases expression | ISO | RGD:1351339 | 6480464 | Aflatoxin B1 results in decreased expression of SPTLC3 mRNA | CTD | PMID:21632981 more ... | Azaspiracid | decreases expression | ISO | RGD:1351339 | 6480464 | azaspiracid results in decreased expression of SPTLC3 mRNA | CTD | PMID:28939011 | azathioprine | decreases expression | ISO | RGD:1351339 | 6480464 | Azathioprine results in decreased expression of SPTLC3 mRNA | CTD | PMID:22623647 | benzo[a]pyrene | decreases expression | ISO | RGD:1351339 | 6480464 | Benzo(a)pyrene results in decreased expression of SPTLC3 mRNA | CTD | PMID:20106945 more ... | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RGD:1351339 | 6480464 | 7 more ... | CTD | PMID:26238291 | benzo[e]pyrene | decreases methylation | ISO | RGD:1351339 | 6480464 | benzo(e)pyrene results in decreased methylation of SPTLC3 intron | CTD | PMID:30157460 | beta-naphthoflavone | decreases expression | ISO | RGD:1351339 | 6480464 | beta-Naphthoflavone results in decreased expression of SPTLC3 mRNA | CTD | PMID:32858204 | bis(2-ethylhexyl) phthalate | increases expression | ISO | RGD:1351339 | 6480464 | Diethylhexyl Phthalate results in increased expression of SPTLC3 mRNA | CTD | PMID:31163220 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of SPTLC3 mRNA | CTD | PMID:26496021 | bisphenol A | affects expression | ISO | RGD:1351339 | 6480464 | bisphenol A affects the expression of SPTLC3 mRNA | CTD | PMID:30903817 | bisphenol A | increases expression | ISO | RGD:1351339 | 6480464 | bisphenol A results in increased expression of SPTLC3 mRNA | CTD | PMID:27685785 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SPTLC3 mRNA | CTD | PMID:25181051, PMID:34947998 | chlordecone | increases expression | ISO | RGD:1320696 | 6480464 | Chlordecone results in increased expression of SPTLC3 mRNA | CTD | PMID:33711761 | chloroprene | increases expression | ISO | RGD:1320696 | 6480464 | Chloroprene results in increased expression of SPTLC3 mRNA | CTD | PMID:23125180 | copper(II) sulfate | decreases expression | ISO | RGD:1351339 | 6480464 | Copper Sulfate results in decreased expression of SPTLC3 mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:1351339 | 6480464 | Cyclosporine results in decreased expression of SPTLC3 mRNA | CTD | PMID:20106945 more ... | cytarabine | decreases expression | ISO | RGD:1351339 | 6480464 | Cytarabine results in decreased expression of SPTLC3 mRNA | CTD | PMID:21198554 | dorsomorphin | multiple interactions | ISO | RGD:1351339 | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | RGD:1351339 | 6480464 | Doxorubicin results in decreased expression of SPTLC3 mRNA | CTD | PMID:29803840 | formaldehyde | decreases expression | ISO | RGD:1351339 | 6480464 | Formaldehyde results in decreased expression of SPTLC3 mRNA | CTD | PMID:23649840 | formaldehyde | increases expression | ISO | RGD:1351339 | 6480464 | Formaldehyde results in increased expression of SPTLC3 mRNA | CTD | PMID:23649840 | leflunomide | decreases expression | ISO | RGD:1351339 | 6480464 | leflunomide results in decreased expression of SPTLC3 mRNA | CTD | PMID:28988120 | mercury dibromide | increases expression | ISO | RGD:1351339 | 6480464 | mercuric bromide results in increased expression of SPTLC3 mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | RGD:1351339 | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPTLC3 mRNA | CTD | PMID:27188386 | methapyrilene | decreases methylation | ISO | RGD:1351339 | 6480464 | Methapyrilene results in decreased methylation of SPTLC3 intron | CTD | PMID:30157460 | methyl methanesulfonate | decreases expression | ISO | RGD:1351339 | 6480464 | Methyl Methanesulfonate results in decreased expression of SPTLC3 mRNA | CTD | PMID:23649840 | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of SPTLC3 gene | CTD | PMID:33148267 | nickel sulfate | decreases expression | ISO | RGD:1351339 | 6480464 | nickel sulfate results in decreased expression of SPTLC3 mRNA | CTD | PMID:22714537 | nicotine | increases expression | ISO | RGD:1351339 | 6480464 | Nicotine results in increased expression of SPTLC3 mRNA | CTD | PMID:23825647 | paracetamol | decreases expression | ISO | RGD:1351339 | 6480464 | Acetaminophen results in decreased expression of SPTLC3 mRNA | CTD | PMID:21420995, PMID:29067470 | PCB138 | multiple interactions | ISO | RGD:1320696 | 6480464 | [2 more ... | CTD | PMID:25510870 | perfluorononanoic acid | multiple interactions | ISO | RGD:1320696 | 6480464 | [Dietary Fats co-treated with perfluoro-n-nonanoic acid] results in increased expression of SPTLC3 mRNA | CTD | PMID:33483757 | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of SPTLC3 gene | CTD | PMID:33148267 | phenylmercury acetate | increases expression | ISO | RGD:1351339 | 6480464 | Phenylmercuric Acetate results in increased expression of SPTLC3 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | RGD:1351339 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPTLC3 mRNA | CTD | PMID:27188386 | pirinixic acid | multiple interactions | ISO | RGD:1320696 | 6480464 | [pirinixic acid co-treated with PPARA] results in increased expression of SPTLC3 mRNA | CTD | PMID:20813756 | pirinixic acid | increases expression | ISO | RGD:1320696 | 6480464 | pirinixic acid results in increased expression of SPTLC3 mRNA | CTD | PMID:20813756 | potassium chromate | decreases expression | ISO | RGD:1351339 | 6480464 | potassium chromate(VI) results in decreased expression of SPTLC3 mRNA | CTD | PMID:22714537 | quercetin | decreases expression | ISO | RGD:1351339 | 6480464 | Quercetin results in decreased expression of SPTLC3 mRNA | CTD | PMID:21632981 | rac-lactic acid | decreases expression | ISO | RGD:1351339 | 6480464 | Lactic Acid results in decreased expression of SPTLC3 mRNA | CTD | PMID:30851411 | SB 431542 | multiple interactions | ISO | RGD:1351339 | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | RGD:1351339 | 6480464 | Silicon Dioxide analog results in decreased expression of SPTLC3 mRNA | CTD | PMID:25895662 | sulforaphane | decreases expression | ISO | RGD:1351339 | 6480464 | sulforaphane results in decreased expression of SPTLC3 mRNA | CTD | PMID:31838189 | sunitinib | decreases expression | ISO | RGD:1351339 | 6480464 | Sunitinib results in decreased expression of SPTLC3 mRNA | CTD | PMID:31533062 | temozolomide | decreases expression | ISO | RGD:1351339 | 6480464 | Temozolomide results in decreased expression of SPTLC3 mRNA | CTD | PMID:31758290 | testosterone | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Testosterone] results in increased expression of SPTLC3 mRNA | CTD | PMID:26496021 | tetracycline | increases expression | ISO | RGD:1320696 | 6480464 | Tetracycline results in increased expression of SPTLC3 mRNA | CTD | PMID:16917069 | trichostatin A | increases expression | ISO | RGD:1351339 | 6480464 | trichostatin A results in increased expression of SPTLC3 mRNA | CTD | PMID:24935251 | urethane | decreases expression | ISO | RGD:1351339 | 6480464 | Urethane results in decreased expression of SPTLC3 mRNA | CTD | PMID:28818685 | valproic acid | increases expression | ISO | RGD:1351339 | 6480464 | Valproic Acid results in increased expression of SPTLC3 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | RGD:1351339 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPTLC3 mRNA | CTD | PMID:27188386 | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of SPTLC3 gene | CTD | PMID:31682807 | vitamin E | decreases expression | ISO | RGD:1351339 | 6480464 | Vitamin E results in decreased expression of SPTLC3 mRNA | CTD | PMID:19244175 | zoledronic acid | decreases expression | ISO | RGD:1351339 | 6480464 | zoledronic acid results in decreased expression of SPTLC3 mRNA | CTD | PMID:24714768 | |