Dbi (diazepam binding inhibitor) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Dbi (diazepam binding inhibitor) Rattus norvegicus
Analyze
Symbol: Dbi
Name: diazepam binding inhibitor
RGD ID: 2490
Description: Enables benzodiazepine receptor binding activity and fatty-acyl-CoA binding activity. Involved in several processes, including conditioned place preference; positive regulation of release of sequestered calcium ion into cytosol; and regulation of lipid metabolic process. Acts upstream of or within regulation of GABAergic synaptic transmission. Located in contractile muscle fiber; extracellular space; and synaptic vesicle. Biomarker of morphine dependence. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human DBI (diazepam binding inhibitor, acyl-CoA binding protein); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ACBP; Acoabp3; acyl-CoA-binding protein; Diazepam binding inhibitor (GABA receptor modulator acyl-Coenxyme A binding protein); diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein); Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenxyme A binding protein); diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein); diazepam binding inhibitor-like; endozepine; Ep; GABA receptor modulator; LOC100365425; LOC679040; LRRGT00046; octadecaneuropeptide; Odn; RNACOABP3; triakontatetraneuropeptide; Ttn
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Dbi-ps3  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81333,794,231 - 33,802,632 (-)NCBIGRCr8
mRatBN7.21331,241,466 - 31,249,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1331,206,988 - 31,268,693 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1333,810,529 - 33,818,913 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01335,098,375 - 35,106,759 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01332,372,805 - 32,381,190 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01336,147,667 - 36,156,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1336,117,119 - 36,174,908 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01341,225,978 - 41,283,627 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,125,562 - 31,133,906 (-)NCBICelera
Cytogenetic Map13q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dichlorobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bezafibrate  (ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bleomycin A2  (EXP)
Brodifacoum  (EXP)
buspirone  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
difenoconazole  (ISO)
diisononyl phthalate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenofibrate  (ISO)
finasteride  (EXP)
flumazenil  (ISO)
flunitrazepam  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hydralazine  (ISO)
indometacin  (EXP)
inulin  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
maneb  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylazoxymethanol  (ISO)
morphine  (EXP)
myristoyl-CoA  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
nifedipine  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorodecanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
procymidone  (EXP)
progesterone  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The interaction of acyl-CoA with acyl-CoA binding protein and carnitine palmitoyltransferase I. Abo-Hashema KA, etal., Int J Biochem Cell Biol. 2001 Aug;33(8):807-15.
2. Ontogeny of diazepam binding inhibitor/acyl-CoA binding protein mRNA and peripheral benzodiazepine receptor mRNA expression in the rat. Burgi B, etal., J Neuroendocrinol. 1999 Feb;11(2):85-100.
3. Dietary n-3 polyunsaturated fatty acids increase T-lymphocyte phospholipid mass and acyl-CoA binding protein expression. Collison LW, etal., Lipids. 2005 Jan;40(1):81-7.
4. Subcellular location and neuronal release of diazepam binding inhibitor. Ferrarese C, etal., J Neurochem. 1987 Apr;48(4):1093-102.
5. Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain. Ferrero P, etal., Proc Natl Acad Sci U S A. 1986 Feb;83(3):827-31.
6. Acyl-CoA binding protein expression is fiber type- specific and elevated in muscles from the obese insulin-resistant Zucker rat. Franch J, etal., Diabetes. 2002 Feb;51(2):449-54.
7. The triakontatetraneuropeptide (TTN) stimulates thymidine incorporation in rat astrocytes through peripheral-type benzodiazepine receptors. Gandolfo P, etal., J Neurochem. 2000 Aug;75(2):701-7.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Molecular biology of diazepam binding inhibitor. Gray PW Neuropharmacology 1987 Jul;26(7B):863-5.
11. Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors. Guidotti A, etal., Proc Natl Acad Sci U S A. 1983 Jun;80(11):3531-5.
12. Psychological stress, but not physical stress, causes increase in diazepam binding inhibitor (DBI) mRNA expression in mouse brains. Katsura M, etal., Brain Res Mol Brain Res 2002 Jul 15;104(1):103-9.
13. Functional involvement of benzodiazepine receptors in ethanol-induced increases of diazepam binding inhibitor (DBI) and its mRNA in the mouse brain. Katsura M, etal., Brain Res Mol Brain Res. 1998 Feb;54(1):124-32. doi: 10.1016/s0169-328x(97)00330-6.
14. Withdrawal from nicotine facilitates diazepam binding inhibitor mRNA expression in mouse cerebral cortex. Katsura M, etal., Brain Res Mol Brain Res. 2001 Dec 30;97(2):194-8. doi: 10.1016/s0169-328x(01)00310-2.
15. Cloning and tissue-specific functional characterization of the promoter of the rat diazepam binding inhibitor, a peptide with multiple biological actions. Kolmer M, etal., Proc Natl Acad Sci U S A 1993 Sep 15;90(18):8439-43.
16. Structure of the rat gene encoding the multifunctional acyl-CoA-binding protein: conservation of intron 1 sequences in rodents and man. Addendum. Kroll JB, etal., Gene 1996 Sep 16;173(2):239-40.
17. [Relationship between GSK-3 beta -50T/C and DBI +529A/T polymorphisms in Japanese alcoholics]. Kurihara K, etal., Nihon Arukoru Yakubutsu Igakkai Zasshi. 2010 Oct;45(5):430-6.
18. Structure-activity relationships of a series of analogues of the octadecaneuropeptide ODN on calcium mobilization in rat astrocytes. Leprince J, etal., J Med Chem. 1998 Nov 5;41(23):4433-8.
19. Diazepam-binding inhibitor mediates feedback regulation of pancreatic secretion and postprandial release of cholecystokinin. Li Y, etal., J Clin Invest. 2000 Feb;105(3):351-9.
20. Conditioned place preference associates with the mRNA expression of diazepam binding inhibitor in brain regions of the addicted rat during withdrawal. Liu X, etal., Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):47-54. doi: 10.1016/j.molbrainres.2005.02.021. Epub 2005 Apr 1.
21. Acyl-CoA-binding protein/diazepam-binding inhibitor gene and pseudogenes. A typical housekeeping gene family. Mandrup S, etal., J Mol Biol 1992 Dec 5;228(3):1011-22.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Putative diazepam binding inhibitor peptide: cDNA clones from rat. Mocchetti I, etal., Proc Natl Acad Sci U S A 1986 Oct;83(19):7221-5.
24. L-type high voltage-gated calcium channels cause an increase in diazepam binding inhibitor mRNA expression after sustained exposure to ethanol in mouse cerebral cortical neurons. Mohri Y, etal., Brain Res Mol Brain Res. 2003 May 12;113(1-2):52-6. doi: 10.1016/s0169-328x(03)00089-5.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Physical and functional interaction of Acyl-CoA-binding protein with hepatocyte nuclear factor-4 alpha. Petrescu AD, etal., J Biol Chem. 2003 Dec 19;278(51):51813-24. Epub 2003 Oct 6.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Identification of a novel phosphorylation site of acyl-CoA binding protein (ACBP) in nodularin-induced apoptotic hepatocytes. Solstad T, etal., Exp Cell Res. 2008 Jun 10;314(10):2141-9. Epub 2008 Mar 30.
31. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
32. Beta-amyloid peptide stimulates endozepine release in cultured rat astrocytes through activation of N-formyl peptide receptors. Tokay T, etal., Glia. 2008 Oct;56(13):1380-9.
33. The relationship between alcoholism and DBI gene polymorphism in Japanese--genotyping of the +529A/T in DBI gene polymorphism based on PCR. Waga C, etal., Nihon Arukoru Yakubutsu Igakkai Zasshi. 2007 Dec;42(6):629-34.
34. Overexpression of acyl-coA binding protein and its effects on the flux of free fatty acids in McA-RH 7777 cells. Yang Y, etal., Lipids. 2001 Jun;36(6):595-600.
35. Relationship between alcohol dependence and the DBI rs2276596 (C/A) polymorphism in Japanese. Yoshihara E, etal., Nihon Arukoru Yakubutsu Igakkai Zasshi. 2014 Feb;49(1):39-44.
Additional References at PubMed
PMID:2769267   PMID:2803267   PMID:12477932   PMID:14651853   PMID:15489334   PMID:15611101   PMID:16411019   PMID:16902415   PMID:17150371   PMID:18157544   PMID:20458337   PMID:21079819  
PMID:21698759   PMID:22871113   PMID:23160530   PMID:23376485   PMID:23533145   PMID:28698967   PMID:39056770  


Genomics

Comparative Map Data
Dbi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81333,794,231 - 33,802,632 (-)NCBIGRCr8
mRatBN7.21331,241,466 - 31,249,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1331,206,988 - 31,268,693 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1333,810,529 - 33,818,913 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01335,098,375 - 35,106,759 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01332,372,805 - 32,381,190 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01336,147,667 - 36,156,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1336,117,119 - 36,174,908 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01341,225,978 - 41,283,627 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,125,562 - 31,133,906 (-)NCBICelera
Cytogenetic Map13q11NCBI
DBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382119,366,977 - 119,372,543 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2119,366,924 - 119,372,550 (+)EnsemblGRCh38hg38GRCh38
GRCh372120,124,553 - 120,130,119 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362119,840,974 - 119,846,592 (+)NCBINCBI36Build 36hg18NCBI36
Build 342119,840,889 - 119,846,350NCBI
Celera2113,450,643 - 113,456,260 (+)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2112,449,577 - 112,455,194 (+)NCBIHuRef
CHM1_12120,128,008 - 120,133,626 (+)NCBICHM1_1
T2T-CHM13v2.02119,800,515 - 119,806,082 (+)NCBIT2T-CHM13v2.0
Dbi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,041,010 - 120,048,826 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,041,010 - 120,048,808 (-)EnsemblGRCm39 Ensembl
GRCm381120,113,280 - 120,121,096 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,113,280 - 120,121,078 (-)EnsemblGRCm38mm10GRCm38
MGSCv371122,009,857 - 122,017,673 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361121,940,826 - 121,948,625 (-)NCBIMGSCv36mm8
Celera1122,773,452 - 122,781,226 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.65NCBI
Dbi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545910,342,251 - 10,347,733 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545910,342,528 - 10,347,700 (-)NCBIChiLan1.0ChiLan1.0
DBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21321,375,396 - 21,381,007 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B21,390,369 - 21,395,980 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B6,309,048 - 6,314,660 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B119,887,596 - 119,893,214 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B119,887,728 - 119,892,986 (+)Ensemblpanpan1.1panPan2
DBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11930,640,429 - 30,645,704 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1930,640,429 - 30,646,405 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1930,905,296 - 30,910,550 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01932,024,656 - 32,029,915 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1932,024,656 - 32,029,921 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11930,711,432 - 30,716,683 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01930,877,551 - 30,882,803 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01932,064,483 - 32,069,735 (-)NCBIUU_Cfam_GSD_1.0
Dbi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530390,631,489 - 90,636,553 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646950,980,595 - 50,986,506 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646950,981,198 - 50,986,224 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DBI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1524,895,522 - 24,906,372 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11524,895,575 - 24,900,710 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,578,170 - 28,583,311 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11010,956,529 - 10,962,135 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606111,725,241 - 11,730,866 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dbi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473225,764,260 - 25,769,419 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473225,764,260 - 25,769,453 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dbi
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:210
Count of miRNA genes:164
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000072295, ENSRNOT00000074685
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat

Markers in Region
D13Wox14  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81333,794,093 - 33,794,292 (+)Marker Load Pipeline
mRatBN7.21331,241,328 - 31,241,527 (+)MAPPERmRatBN7.2
Rnor_6.01336,147,530 - 36,147,728NCBIRnor6.0
Rnor_5.01341,256,237 - 41,256,435UniSTSRnor5.0
Celera1331,125,419 - 31,125,623UniSTS
Cytogenetic Map13q13UniSTS
D13Mgh13  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81333,794,096 - 33,794,229 (+)Marker Load Pipeline
mRatBN7.21331,241,331 - 31,241,464 (+)MAPPERmRatBN7.2
Rnor_6.01336,147,533 - 36,147,665NCBIRnor6.0
Rnor_5.01341,256,240 - 41,256,372UniSTSRnor5.0
Celera1331,125,422 - 31,125,560UniSTS
Cytogenetic Map13q13UniSTS
D13Arb18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21331,250,431 - 31,250,591 (+)MAPPERmRatBN7.2
Rnor_6.01336,156,655 - 36,156,814NCBIRnor6.0
Rnor_5.01341,265,373 - 41,265,532UniSTSRnor5.0
Celera1331,134,485 - 31,134,644UniSTS
Cytogenetic Map13q11UniSTS
Cytogenetic Map13q13UniSTS
RH138332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21331,250,527 - 31,250,689 (+)MAPPERmRatBN7.2
Rnor_6.01336,156,751 - 36,156,912NCBIRnor6.0
Rnor_5.01341,265,469 - 41,265,630UniSTSRnor5.0
Celera1331,134,581 - 31,134,742UniSTS
Cytogenetic Map13q11UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH000634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY383701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC084717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M20268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X96560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z11991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z11992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z21846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000072295   ⟹   ENSRNOP00000066874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1331,207,078 - 31,268,693 (-)Ensembl
Rnor_6.0 Ensembl1336,117,119 - 36,174,908 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074685   ⟹   ENSRNOP00000067623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1331,241,464 - 31,248,897 (-)Ensembl
Rnor_6.0 Ensembl1336,147,668 - 36,156,076 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113849   ⟹   ENSRNOP00000080590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1331,241,464 - 31,249,697 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115051   ⟹   ENSRNOP00000092993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1331,206,988 - 31,258,920 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117885   ⟹   ENSRNOP00000089774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1331,243,918 - 31,249,853 (-)Ensembl
RefSeq Acc Id: NM_031853   ⟹   NP_114054
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81333,794,231 - 33,802,618 (-)NCBI
mRatBN7.21331,241,466 - 31,249,853 (-)NCBI
Rnor_6.01336,147,667 - 36,156,076 (-)NCBI
Rnor_5.01341,225,978 - 41,283,627 (-)NCBI
Celera1331,125,562 - 31,133,906 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272038   ⟹   XP_063128108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81333,794,231 - 33,802,632 (-)NCBI
RefSeq Acc Id: NP_114054   ⟸   NM_031853
- UniProtKB: Q2V4X5 (UniProtKB/Swiss-Prot),   Q63160 (UniProtKB/Swiss-Prot),   P11030 (UniProtKB/Swiss-Prot),   A6K7Y8 (UniProtKB/TrEMBL),   A0A8L2QZ93 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066874   ⟸   ENSRNOT00000072295
Ensembl Acc Id: ENSRNOP00000067623   ⟸   ENSRNOT00000074685
Ensembl Acc Id: ENSRNOP00000092993   ⟸   ENSRNOT00000115051
Ensembl Acc Id: ENSRNOP00000089774   ⟸   ENSRNOT00000117885
Ensembl Acc Id: ENSRNOP00000080590   ⟸   ENSRNOT00000113849
RefSeq Acc Id: XP_063128108   ⟸   XM_063272038
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A9F5 (UniProtKB/TrEMBL)
Protein Domains
ACB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11030-F1-model_v2 AlphaFold P11030 1-87 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698769
Promoter ID:EPDNEW_R9292
Type:multiple initiation site
Name:Dbi_1
Description:diazepam binding inhibitor, acyl-CoA binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01336,156,024 - 36,156,084EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2490 AgrOrtholog
BioCyc Gene G2FUF-18508 BioCyc
Ensembl Genes ENSRNOG00000046889 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072295.4 UniProtKB/TrEMBL
  ENSRNOT00000074685.3 UniProtKB/TrEMBL
  ENSRNOT00000113849.1 UniProtKB/TrEMBL
  ENSRNOT00000115051.1 UniProtKB/TrEMBL
  ENSRNOT00000117885 ENTREZGENE
  ENSRNOT00000117885.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7310272 IMAGE-MGC_LOAD
InterPro Acyl-CoA-binding_prot_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA-binding_protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA-binding_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25045 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105272 IMAGE-MGC_LOAD
NCBI Gene 25045 ENTREZGENE
PANTHER ACYL-COA-BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACYL-COA-BINDING PROTEIN, ACBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ACBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DBI RGD
PhenoGen Dbi PhenoGen
PRINTS ACOABINDINGP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ACB_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046889 RatGTEx
Superfamily-SCOP SSF47027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZTD4_RAT UniProtKB/TrEMBL
  A0A8I6A9F5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFN5_RAT UniProtKB/TrEMBL
  A0A8L2QZ93 ENTREZGENE, UniProtKB/TrEMBL
  A6K7Y8 ENTREZGENE, UniProtKB/TrEMBL
  ACBP_RAT UniProtKB/Swiss-Prot
  M0RBE1_RAT UniProtKB/TrEMBL
  P11030 ENTREZGENE
  Q2V4X5 ENTREZGENE
  Q63160 ENTREZGENE
  Q6TXF3_RAT UniProtKB/TrEMBL
UniProt Secondary Q2V4X5 UniProtKB/Swiss-Prot
  Q63160 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-08 Dbi  diazepam binding inhibitor  Dbi  diazepam binding inhibitor, acyl-CoA binding protein  Name changed 629549 APPROVED
2016-06-01 Dbi  diazepam binding inhibitor, acyl-CoA binding protein  Dbi  diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-29 Dbi  diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)  LOC100365425  diazepam binding inhibitor-like  Data merged from RGD:2319055 737654 PROVISIONAL
2013-03-29 Dbi  diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)  LOC679040  similar to Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP)  Data merged from RGD:1593084 737654 PROVISIONAL
2011-08-02 Dbi  diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)  Dbi  diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100365425  diazepam binding inhibitor-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-25 Dbi  diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)  Dbi  diazepam binding inhibitor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC679040  similar to Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Dbi  diazepam binding inhibitor      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA level high in brain regions, testes, kidney, liver, and heart 727651
gene_function binds medium- and long-chain acyl-CoA esters and may function as their intracellular carriers; displaces diazepam from the benzodiazepine recognition site located on the GABA type a receptor  
gene_process induces medium-chain acyl-CoA ester synthesis  
gene_protein 87 amino acids 727651