RGD Reference Report - Psychological stress, but not physical stress, causes increase in diazepam binding inhibitor (DBI) mRNA expression in mouse brains. - Rat Genome Database

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Psychological stress, but not physical stress, causes increase in diazepam binding inhibitor (DBI) mRNA expression in mouse brains.

Authors: Katsura, M  Mohri, Y  Shuto, K  Tsujimura, A  Ukai, M  Ohkuma, S 
Citation: Katsura M, etal., Brain Res Mol Brain Res 2002 Jul 15;104(1):103-9.
RGD ID: 727672
Pubmed: PMID:12117556   (View Abstract at PubMed)

Effects of conditioned emotional stimuli (CES), which induce psychological stress, on the expression of cerebral diazepam binding inhibitor (DBI) mRNA in mouse were examined using a communication box. Cerebral DBI mRNA expression significantly increased in a time-dependent manner after the application of CES. The maximal enhancement of DBI mRNA expression was observed 2 days after the application of CES, and this increase faded out over 7 days after the treatment. Flunitrazepam (1 mg/kg), an agonist for central benzodiazepine (BZD) receptors, completely abolished the CES-induced elevation of cerebral DBI contents and its mRNA expressions. These results indicate that cerebral DBI is enhanced by psychological stress, which is regulated by central BZD receptors.

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Gene Dbi diazepam binding inhibitor Rattus norvegicus

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