Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent, 1B) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent, 1B) Rattus norvegicus
Analyze
Symbol: Ppm1b
Name: protein phosphatase, Mg2+/Mn2+ dependent, 1B
RGD ID: 3374
Description: Predicted to have protein serine/threonine phosphatase activity. Predicted to be involved in several processes, including cellular protein modification process; negative regulation of interferon-beta production; and regulation of signal transduction. Predicted to localize to cytosol; membrane; and nucleolus. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: PP2C-beta; Pp2c2; protein phosphatase 1B; protein phosphatase 1B, magnesium dependent, beta isoform; protein phosphatase 2C isoform beta; Protein phosphatase type 1B (formely 2C) Mg-dependent beta isoform; Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.068,219,385 - 8,280,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,218,696 - 8,280,124 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.068,151,741 - 8,212,739 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,319,544 - 8,373,795 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.168,319,543 - 8,373,795 (+)NCBI
Celera69,370,886 - 9,431,637 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
acetazolamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
glafenine  (EXP)
haloperidol  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
methapyrilene  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (ISO)
paracetamol  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
propiconazole  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IEA,ISO,ISS)
membrane  (IEA,ISO,ISS)
nucleolus  (ISO)
nucleus  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1312947   PMID:7532404   PMID:8889548   PMID:12477932   PMID:18930133   PMID:20801214   PMID:22750291   PMID:23088624  


Genomics

Comparative Map Data
Ppm1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.068,219,385 - 8,280,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,218,696 - 8,280,124 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.068,151,741 - 8,212,739 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,319,544 - 8,373,795 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.168,319,543 - 8,373,795 (+)NCBI
Celera69,370,886 - 9,431,637 (-)NCBICelera
Cytogenetic Map6q12NCBI
PPM1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl244,167,969 - 44,244,384 (+)EnsemblGRCh38hg38GRCh38
GRCh38244,168,853 - 44,247,330 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37244,395,984 - 44,471,570 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36244,249,504 - 44,315,246 (+)NCBINCBI36hg18NCBI36
Build 34244,307,666 - 44,370,261NCBI
Celera244,234,958 - 44,300,689 (+)NCBI
Cytogenetic Map2p21NCBI
HuRef244,132,461 - 44,198,020 (+)NCBIHuRef
CHM1_1244,325,361 - 44,391,185 (+)NCBICHM1_1
Ppm1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391785,264,169 - 85,331,420 (+)NCBIGRCm39mm39
GRCm381784,956,741 - 85,023,992 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1784,956,741 - 85,023,991 (+)EnsemblGRCm38mm10GRCm38
MGSCv371785,356,081 - 85,423,332 (+)NCBIGRCm37mm9NCBIm37
MGSCv361784,866,341 - 84,925,447 (+)NCBImm8
Celera1789,319,953 - 89,386,219 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.13NCBI
Ppm1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544111,276,525 - 11,338,586 (+)NCBIChiLan1.0ChiLan1.0
PPM1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A45,230,001 - 45,262,587 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02A44,254,168 - 44,325,132 (+)NCBIMhudiblu_PPA_v0panPan3
PPM1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1046,590,079 - 46,665,866 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11046,590,110 - 46,680,792 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ppm1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365087,732,724 - 7,804,964 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPM1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1396,237,660 - 96,317,278 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,392,133 - 102,472,029 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPM1B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11463,003,885 - 63,093,584 (-)NCBI
Ppm1b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473825,657,084 - 25,738,913 (+)NCBI

Position Markers
BE112607  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.068,220,324 - 8,220,483NCBIRnor6.0
Rnor_5.068,152,936 - 8,153,095UniSTSRnor5.0
RGSC_v3.468,319,625 - 8,319,784UniSTSRGSC3.4
Celera69,430,539 - 9,430,698UniSTS
Cytogenetic Map6q12UniSTS
RH141215  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.068,272,867 - 8,273,071NCBIRnor6.0
Rnor_5.068,205,479 - 8,205,683UniSTSRnor5.0
RGSC_v3.468,373,116 - 8,373,320UniSTSRGSC3.4
Celera69,377,939 - 9,378,143UniSTS
Cytogenetic Map6q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6123620518Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6125048718Rat
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6135623029Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6135623029Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6135623029Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6135623029Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6135623029Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6141917988Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6142388212Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6142388212Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142388212Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6142388212Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6142388212Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6143665660Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6143665660Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6143665660Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6144015370Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6144570292Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6175623393Rat
8693645Alc31Alcohol consumption QTL 313.70.038drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)613505323600274Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6112039328706721Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112039346120393Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)6112039375023446Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)6616172276002731Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6616172276002731Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)67009971115379601Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6808322221515439Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6808322221515439Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:115
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000040509, ENSRNOT00000048656
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAHX01041627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01041628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ780970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV110469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM042005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM075941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM104054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM108050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM141620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN800175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S90449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000040509   ⟹   ENSRNOP00000041472
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl68,219,385 - 8,280,124 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000048656   ⟹   ENSRNOP00000048342
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl68,220,228 - 8,273,549 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079279   ⟹   ENSRNOP00000074301
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl68,220,228 - 8,271,054 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083470   ⟹   ENSRNOP00000074150
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl68,218,696 - 8,270,293 (+)Ensembl
RefSeq Acc Id: NM_001270619   ⟹   NP_001257548
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.068,220,228 - 8,271,055 (+)NCBI
Rnor_5.068,151,741 - 8,212,739 (+)NCBI
Celera69,379,955 - 9,430,794 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270620   ⟹   NP_001257549
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.068,219,385 - 8,280,124 (+)NCBI
Rnor_5.068,151,741 - 8,212,739 (+)NCBI
Celera69,370,886 - 9,431,637 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033096   ⟹   NP_149087
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.068,220,228 - 8,273,549 (+)NCBI
Rnor_5.068,151,741 - 8,212,739 (+)NCBI
RGSC_v3.468,319,544 - 8,373,795 (+)RGD
Celera69,377,461 - 9,430,794 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764454   ⟹   XP_008762676
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.068,220,233 - 8,280,127 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594035   ⟹   XP_017449524
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.068,220,233 - 8,280,127 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594036   ⟹   XP_017449525
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.068,220,233 - 8,279,501 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_149087   ⟸   NM_033096
- Peptide Label: isoform 1
- UniProtKB: P35815 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257549   ⟸   NM_001270620
- Peptide Label: isoform 3
- UniProtKB: Q642F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257548   ⟸   NM_001270619
- Peptide Label: isoform 2
- UniProtKB: Q99ND8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762676   ⟸   XM_008764454
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017449524   ⟸   XM_017594035
- Peptide Label: isoform X1
- UniProtKB: Q642F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449525   ⟸   XM_017594036
- Peptide Label: isoform X1
- UniProtKB: Q642F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074301   ⟸   ENSRNOT00000079279
RefSeq Acc Id: ENSRNOP00000048342   ⟸   ENSRNOT00000048656
RefSeq Acc Id: ENSRNOP00000074150   ⟸   ENSRNOT00000083470
RefSeq Acc Id: ENSRNOP00000041472   ⟸   ENSRNOT00000040509
Protein Domains
PPM-type phosphatase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694378
Promoter ID:EPDNEW_R4903
Type:multiple initiation site
Name:Ppm1b_1
Description:protein phosphatase, Mg2+/Mn2+ dependent, 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.068,220,226 - 8,220,286EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3374 AgrOrtholog
Ensembl Genes ENSRNOG00000030667 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000041472 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000048342 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074150 UniProtKB/TrEMBL
  ENSRNOP00000074301 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040509 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000048656 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000079279 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000083470 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599216 IMAGE-MGC_LOAD
  IMAGE:7113731 IMAGE-MGC_LOAD
InterPro PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24667 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72371 IMAGE-MGC_LOAD
  MGC:93319 IMAGE-MGC_LOAD
NCBI Gene 24667 ENTREZGENE
PANTHER PTHR13832 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppm1b PhenoGen
PROSITE PPM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PP2Cc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81601 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.4143 ENTREZGENE
UniProt A0A0G2K7C6_RAT UniProtKB/TrEMBL
  P35815 ENTREZGENE, UniProtKB/Swiss-Prot
  Q642F2 ENTREZGENE, UniProtKB/TrEMBL
  Q99ND8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D3ZLY2 UniProtKB/TrEMBL
  Q546R0 UniProtKB/Swiss-Prot
  Q64046 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-03 Ppm1b  protein phosphatase, Mg2+/Mn2+ dependent, 1B  Ppm1b  protein phosphatase 1B, magnesium dependent, beta isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ppm1b  Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform      Symbol and Name status set to approved 70586 APPROVED