Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent, 1B) - Rat Genome Database

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Gene: Ppm1b (protein phosphatase, Mg2+/Mn2+ dependent, 1B) Rattus norvegicus
Analyze
Symbol: Ppm1b
Name: protein phosphatase, Mg2+/Mn2+ dependent, 1B
RGD ID: 3374
Description: Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in several processes, including negative regulation of interferon-beta production; negative regulation of intracellular signal transduction; and protein modification process. Predicted to be located in membrane and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; aconitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PP2C-beta; Pp2c2; protein phosphatase 1B; protein phosphatase 1B, magnesium dependent, beta isoform; protein phosphatase 2C isoform beta; Protein phosphatase type 1B (formely 2C) Mg-dependent beta isoform; Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.269,646,695 - 9,707,471 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl69,655,765 - 9,707,974 (-)Ensembl
Rnor_6.068,219,385 - 8,280,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,218,696 - 8,280,124 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.068,151,741 - 8,212,739 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,319,544 - 8,373,795 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.168,319,543 - 8,373,795 (+)NCBI
Celera69,370,886 - 9,431,637 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
acetazolamide  (ISO)
aconitine  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
haloperidol  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
methapyrilene  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IEA,ISO,ISS)
membrane  (IEA,ISO,ISS)
nucleolus  (ISO)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Differentiation-dependent enhanced expression of protein phosphatase 2Cbeta in germ cells of mouse seminiferous tubules. Kato S, etal., FEBS Lett 1996 Nov 4;396(2-3):293-7.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The mouse protein phosphatase 2Cbeta (Ppm1b) gene maps to the distal part of mouse chromosome 17. Watanabe T, etal., Genomics 1996 Apr 1;33(1):147-9.
Additional References at PubMed
PMID:1312947   PMID:7532404   PMID:8889548   PMID:12477932   PMID:18930133   PMID:20801214   PMID:22750291   PMID:23088624  


Genomics

Comparative Map Data
Ppm1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.269,646,695 - 9,707,471 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl69,655,765 - 9,707,974 (-)Ensembl
Rnor_6.068,219,385 - 8,280,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,218,696 - 8,280,124 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.068,151,741 - 8,212,739 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,319,544 - 8,373,795 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.168,319,543 - 8,373,795 (+)NCBI
Celera69,370,886 - 9,431,637 (-)NCBICelera
Cytogenetic Map6q12NCBI
PPM1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38244,168,875 - 44,246,928 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl244,167,969 - 44,244,384 (+)EnsemblGRCh38hg38GRCh38
GRCh37244,396,014 - 44,461,785 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36244,249,504 - 44,315,246 (+)NCBINCBI36hg18NCBI36
Build 34244,307,666 - 44,370,261NCBI
Celera244,234,958 - 44,300,689 (+)NCBI
Cytogenetic Map2p21NCBI
HuRef244,132,461 - 44,198,020 (+)NCBIHuRef
CHM1_1244,325,419 - 44,391,185 (+)NCBICHM1_1
T2T-CHM13v2.0244,174,224 - 44,239,988 (+)NCBI
Ppm1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391785,264,169 - 85,331,420 (+)NCBIGRCm39mm39
GRCm39 Ensembl1785,264,169 - 85,331,419 (+)Ensembl
GRCm381784,956,741 - 85,023,992 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1784,956,741 - 85,023,991 (+)EnsemblGRCm38mm10GRCm38
MGSCv371785,356,081 - 85,423,332 (+)NCBIGRCm37mm9NCBIm37
MGSCv361784,866,341 - 84,925,447 (+)NCBImm8
Celera1789,319,953 - 89,386,219 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.13NCBI
Ppm1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544111,276,525 - 11,352,095 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544111,276,525 - 11,338,586 (+)NCBIChiLan1.0ChiLan1.0
PPM1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A45,230,001 - 45,262,587 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A45,230,001 - 45,262,587 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A44,254,168 - 44,325,132 (+)NCBIMhudiblu_PPA_v0panPan3
PPM1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,590,110 - 46,680,792 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,590,079 - 46,665,866 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1046,450,255 - 46,538,849 (+)NCBI
ROS_Cfam_1.01047,467,776 - 47,557,210 (+)NCBI
ROS_Cfam_1.0 Ensembl1047,468,700 - 47,547,566 (+)Ensembl
UMICH_Zoey_3.11047,175,538 - 47,264,123 (+)NCBI
UNSW_CanFamBas_1.01047,466,410 - 47,555,184 (+)NCBI
UU_Cfam_GSD_1.01047,649,226 - 47,737,813 (+)NCBI
Ppm1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629236,292,532 - 36,376,368 (-)NCBI
SpeTri2.0NW_0049365087,732,724 - 7,804,964 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPM1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,221,873 - 96,317,247 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1396,237,660 - 96,317,278 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,392,133 - 102,472,029 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPM1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11463,003,885 - 63,093,584 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1463,016,553 - 63,093,592 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604548,789,555 - 48,865,251 (+)NCBIVero_WHO_p1.0
Ppm1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473825,656,755 - 25,723,236 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473825,657,084 - 25,738,913 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
BE112607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.269,706,372 - 9,706,532 (-)MAPPERmRatBN7.2
Rnor_6.068,220,324 - 8,220,483NCBIRnor6.0
Rnor_5.068,152,936 - 8,153,095UniSTSRnor5.0
RGSC_v3.468,319,625 - 8,319,784UniSTSRGSC3.4
Celera69,430,539 - 9,430,698UniSTS
Cytogenetic Map6q12UniSTS
RH141215  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.269,653,748 - 9,653,953 (-)MAPPERmRatBN7.2
Rnor_6.068,272,867 - 8,273,071NCBIRnor6.0
Rnor_5.068,205,479 - 8,205,683UniSTSRnor5.0
RGSC_v3.468,373,116 - 8,373,320UniSTSRGSC3.4
Celera69,377,939 - 9,378,143UniSTS
Cytogenetic Map6q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:115
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000040509, ENSRNOT00000048656
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ780970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV110469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM042005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM075941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM104054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM108050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM141620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN800175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S90449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000040509   ⟹   ENSRNOP00000041472
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl68,219,385 - 8,280,124 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000048656   ⟹   ENSRNOP00000048342
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl68,220,228 - 8,273,549 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079279   ⟹   ENSRNOP00000074301
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl69,655,765 - 9,707,974 (-)Ensembl
Rnor_6.0 Ensembl68,220,228 - 8,271,054 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083470   ⟹   ENSRNOP00000074150
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl69,665,052 - 9,677,022 (-)Ensembl
Rnor_6.0 Ensembl68,218,696 - 8,270,293 (+)Ensembl
RefSeq Acc Id: NM_001270619   ⟹   NP_001257548
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.269,655,765 - 9,706,628 (-)NCBI
Rnor_6.068,220,228 - 8,271,055 (+)NCBI
Rnor_5.068,151,741 - 8,212,739 (+)NCBI
Celera69,379,955 - 9,430,794 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270620   ⟹   NP_001257549
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.269,646,695 - 9,707,471 (-)NCBI
Rnor_6.068,219,385 - 8,280,124 (+)NCBI
Rnor_5.068,151,741 - 8,212,739 (+)NCBI
Celera69,370,886 - 9,431,637 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033096   ⟹   NP_149087
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.269,653,271 - 9,706,628 (-)NCBI
Rnor_6.068,220,228 - 8,273,549 (+)NCBI
Rnor_5.068,151,741 - 8,212,739 (+)NCBI
RGSC_v3.468,319,544 - 8,373,795 (+)RGD
Celera69,377,461 - 9,430,794 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_149087   ⟸   NM_033096
- Peptide Label: isoform 1
- UniProtKB: P35815 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257549   ⟸   NM_001270620
- Peptide Label: isoform 3
- UniProtKB: Q642F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257548   ⟸   NM_001270619
- Peptide Label: isoform 2
- UniProtKB: Q99ND8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074301   ⟸   ENSRNOT00000079279
RefSeq Acc Id: ENSRNOP00000048342   ⟸   ENSRNOT00000048656
RefSeq Acc Id: ENSRNOP00000074150   ⟸   ENSRNOT00000083470
RefSeq Acc Id: ENSRNOP00000041472   ⟸   ENSRNOT00000040509
Protein Domains
PPM-type phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35815-F1-model_v2 AlphaFold P35815 1-390 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694378
Promoter ID:EPDNEW_R4903
Type:multiple initiation site
Name:Ppm1b_1
Description:protein phosphatase, Mg2+/Mn2+ dependent, 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.068,220,226 - 8,220,286EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3374 AgrOrtholog
BioCyc Gene G2FUF-38652 BioCyc
Ensembl Genes ENSRNOG00000030667 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000074150.2 UniProtKB/TrEMBL
  ENSRNOP00000074301.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079279.2 UniProtKB/TrEMBL
  ENSRNOT00000083470.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599216 IMAGE-MGC_LOAD
  IMAGE:7113731 IMAGE-MGC_LOAD
InterPro PP2C_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24667 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72371 IMAGE-MGC_LOAD
  MGC:93319 IMAGE-MGC_LOAD
NCBI Gene 24667 ENTREZGENE
Pfam PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppm1b PhenoGen
PROSITE PPM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PP2Cc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81601 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81606 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K7C6_RAT UniProtKB/TrEMBL
  A0A0G2K7Q5_RAT UniProtKB/TrEMBL
  P35815 ENTREZGENE, UniProtKB/Swiss-Prot
  Q642F2 ENTREZGENE, UniProtKB/TrEMBL
  Q99ND8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D3ZLY2 UniProtKB/TrEMBL
  Q546R0 UniProtKB/Swiss-Prot
  Q64046 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-03 Ppm1b  protein phosphatase, Mg2+/Mn2+ dependent, 1B  Ppm1b  protein phosphatase 1B, magnesium dependent, beta isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ppm1b  Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform      Symbol and Name status set to approved 70586 APPROVED