Stat2 (signal transducer and activator of transcription 2) - Rat Genome Database

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Gene: Stat2 (signal transducer and activator of transcription 2) Rattus norvegicus
Analyze
Symbol: Stat2
Name: signal transducer and activator of transcription 2
RGD ID: 1311649
Description: Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and ubiquitin-like protein ligase binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; defense response to symbiont; and negative regulation of type I interferon-mediated signaling pathway. Predicted to be located in cytosol and plasma membrane. Predicted to be part of ISGF3 complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Zika fever; immunodeficiency 44; and neutropenia. Orthologous to human STAT2 (signal transducer and activator of transcription 2); PARTICIPATES IN interleukin-27 signaling pathway; Jak-Stat signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC288774
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,287,025 - 1,302,858 (+)NCBIGRCr8
mRatBN7.27702,565 - 718,349 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7702,495 - 718,967 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,458,867 - 3,474,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,334,848 - 5,350,643 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,637,673 - 5,653,273 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,691,064 - 2,707,530 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,691,369 - 2,707,741 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,669,952 - 2,685,673 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,564,385 - 1,580,652 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,564,384 - 1,580,651 (+)NCBI
Celera7578,845 - 593,799 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-naphthylamine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-tert-Octylphenol  (ISO)
aconitine  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amiodarone  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
busulfan  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
cerium  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clopidogrel  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
GW 4064  (ISO)
hydroxytyrosol  (ISO)
inulin  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
oxaliplatin  (EXP)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
PRIM-O-GLUCOSYLCIMIFUGIN  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO)
ISGF3 complex  (IBA,ISO)
nucleus  (IBA,ISO)
plasma membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse STAT2 restricts early dengue virus replication. Ashour J, etal., Cell Host Microbe. 2010 Nov 18;8(5):410-21. doi: 10.1016/j.chom.2010.10.007.
2. Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection. Elsaesser HJ, etal., Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5420-5429. doi: 10.1073/pnas.1913776117. Epub 2020 Feb 24.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection. Gopal R, etal., Front Immunol. 2018 Sep 25;9:2151. doi: 10.3389/fimmu.2018.02151. eCollection 2018.
6. An Immunocompetent Mouse Model of Zika Virus Infection. Gorman MJ, etal., Cell Host Microbe. 2018 May 9;23(5):672-685.e6. doi: 10.1016/j.chom.2018.04.003.
7. Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling. Hahm B, etal., Immunity. 2005 Feb;22(2):247-57. doi: 10.1016/j.immuni.2005.01.005.
8. Signaling through the JAK/STAT pathway, recent advances and future challenges. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
9. STAT2-Dependent Immune Responses Ensure Host Survival despite the Presence of a Potent Viral Antagonist. Le-Trilling VTK, etal., J Virol. 2018 Jun 29;92(14). pii: JVI.00296-18. doi: 10.1128/JVI.00296-18. Print 2018 Jul 15.
10. IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus. Li W, etal., J Virol. 2014 Jul;88(13):7578-88. doi: 10.1128/JVI.03117-13. Epub 2014 Apr 23.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism. Miorin L, etal., J Virol. 2019 Jun 28;93(14). pii: JVI.00151-19. doi: 10.1128/JVI.00151-19. Print 2019 Jul 15.
13. The JAK-STAT signaling pathway: input and output integration. Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor. Perry ST, etal., PLoS Pathog. 2011 Feb;7(2):e1001297. doi: 10.1371/journal.ppat.1001297. Epub 2011 Feb 17.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes. Song H, etal., J Immunol. 2019 Apr 15;202(8):2266-2275. doi: 10.4049/jimmunol.1800848. Epub 2019 Mar 6.
23. Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion. Sun SL, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1097-101.
24. Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness. Sung PS, etal., Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10443-8. doi: 10.1073/pnas.1513341112. Epub 2015 Jul 27.
25. A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses. Tripathi S, etal., PLoS Pathog. 2017 Mar 9;13(3):e1006258. doi: 10.1371/journal.ppat.1006258. eCollection 2017 Mar.
26. Association of genetic polymorphisms with interferon-induced haematologic adverse effects in chronic hepatitis C patients. Wada M, etal., J Viral Hepat. 2009 Jun;16(6):388-96. doi: 10.1111/j.1365-2893.2009.01095.x. Epub 2009 Feb 5.
27. A virus-induced conformational switch of STAT1-STAT2 dimers boosts antiviral defenses. Wang Y, etal., Cell Res. 2021 Feb;31(2):206-218. doi: 10.1038/s41422-020-0386-6. Epub 2020 Aug 5.
28. Species-Specific Pathogenicity of Severe Fever with Thrombocytopenia Syndrome Virus Is Determined by Anti-STAT2 Activity of NSs. Yoshikawa R, etal., J Virol. 2019 May 1;93(10). pii: JVI.02226-18. doi: 10.1128/JVI.02226-18. Print 2019 May 15.
Additional References at PubMed
PMID:8605877   PMID:12477932   PMID:12634107   PMID:19609277   PMID:23391734   PMID:24598055   PMID:26122121   PMID:27782195   PMID:31505169   PMID:36762436  


Genomics

Comparative Map Data
Stat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,287,025 - 1,302,858 (+)NCBIGRCr8
mRatBN7.27702,565 - 718,349 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7702,495 - 718,967 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,458,867 - 3,474,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,334,848 - 5,350,643 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,637,673 - 5,653,273 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,691,064 - 2,707,530 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,691,369 - 2,707,741 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,669,952 - 2,685,673 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,564,385 - 1,580,652 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,564,384 - 1,580,651 (+)NCBI
Celera7578,845 - 593,799 (+)NCBICelera
Cytogenetic Map7q11NCBI
STAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,341,597 - 56,360,107 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,341,597 - 56,360,203 (-)EnsemblGRCh38hg38GRCh38
GRCh371256,735,381 - 56,753,891 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,021,648 - 55,040,176 (-)NCBINCBI36Build 36hg18NCBI36
Build 341255,021,650 - 55,040,176NCBI
Celera1256,388,733 - 56,407,397 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,774,045 - 53,793,077 (-)NCBIHuRef
CHM1_11256,702,765 - 56,721,407 (-)NCBICHM1_1
T2T-CHM13v2.01256,309,243 - 56,327,794 (-)NCBIT2T-CHM13v2.0
Stat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,106,367 - 128,128,722 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,106,428 - 128,128,718 (+)EnsemblGRCm39 Ensembl
GRCm3810128,270,498 - 128,292,853 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,270,559 - 128,292,849 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,707,632 - 127,729,905 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,673,525 - 127,695,798 (+)NCBIMGSCv36mm8
Celera10130,656,386 - 130,681,169 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.5NCBI
Stat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,952,738 - 3,970,668 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,953,019 - 3,973,151 (-)NCBIChiLan1.0ChiLan1.0
STAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,972,152 - 37,994,084 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,968,913 - 37,990,850 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,555,523 - 32,574,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,808,586 - 32,827,732 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,808,586 - 32,827,732 (+)Ensemblpanpan1.1panPan2
STAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110641,543 - 660,882 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10642,718 - 658,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10704,962 - 724,101 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010650,365 - 669,707 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10649,947 - 669,646 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110627,617 - 646,943 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010870,771 - 890,099 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010994,493 - 1,013,823 (-)NCBIUU_Cfam_GSD_1.0
Stat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,106,734 - 58,122,062 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646748,727 - 761,287 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646747,178 - 763,449 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,733,035 - 21,751,354 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,733,030 - 21,748,960 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,280,591 - 23,294,360 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,297,890 - 52,316,089 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,297,543 - 52,316,105 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,669,493 - 193,688,727 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,648,020 - 11,660,216 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,645,851 - 11,662,812 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stat2
110 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:270
Count of miRNA genes:156
Interacting mature miRNAs:182
Transcripts:ENSRNOT00000049536
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
RH131097  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27718,069 - 718,253 (+)MAPPERmRatBN7.2
Rnor_6.072,706,872 - 2,707,055NCBIRnor6.0
Rnor_5.072,685,392 - 2,685,575UniSTSRnor5.0
RGSC_v3.471,580,373 - 1,580,556UniSTSRGSC3.4
Celera7593,520 - 593,703UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000049536   ⟹   ENSRNOP00000046028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7702,495 - 718,967 (+)Ensembl
Rnor_6.0 Ensembl72,691,369 - 2,707,150 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088201   ⟹   ENSRNOP00000075125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7702,525 - 718,967 (+)Ensembl
Rnor_6.0 Ensembl72,694,440 - 2,707,741 (+)Ensembl
RefSeq Acc Id: NM_001011905   ⟹   NP_001011905
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,287,090 - 1,302,858 (+)NCBI
mRatBN7.27702,565 - 718,349 (+)NCBI
Rnor_6.072,691,369 - 2,707,151 (+)NCBI
Rnor_5.072,669,952 - 2,685,673 (+)NCBI
RGSC_v3.471,564,385 - 1,580,652 (+)RGD
Celera7578,845 - 593,799 (+)RGD
Sequence:
RefSeq Acc Id: XM_063263089   ⟹   XP_063119159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,287,031 - 1,302,858 (+)NCBI
RefSeq Acc Id: XM_063263090   ⟹   XP_063119160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,287,031 - 1,302,858 (+)NCBI
RefSeq Acc Id: XM_063263091   ⟹   XP_063119161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,287,025 - 1,302,858 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001011905 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119159 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119160 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119161 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83867 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046028.4
  ENSRNOP00000075125.2
RefSeq Acc Id: NP_001011905   ⟸   NM_001011905
- UniProtKB: Q5XI26 (UniProtKB/TrEMBL),   F7EYG9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046028   ⟸   ENSRNOT00000049536
Ensembl Acc Id: ENSRNOP00000075125   ⟸   ENSRNOT00000088201
RefSeq Acc Id: XP_063119161   ⟸   XM_063263091
- Peptide Label: isoform X3
- UniProtKB: F7EYG9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119159   ⟸   XM_063263089
- Peptide Label: isoform X1
- UniProtKB: F7EYG9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119160   ⟸   XM_063263090
- Peptide Label: isoform X2
- UniProtKB: F7EYG9 (UniProtKB/TrEMBL)
Protein Domains
SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI26-F1-model_v2 AlphaFold Q5XI26 1-842 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694931
Promoter ID:EPDNEW_R5456
Type:initiation region
Name:Stat2_1
Description:signal transducer and activator of transcription 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,691,351 - 2,691,411EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311649 AgrOrtholog
BioCyc Gene G2FUF-35380 BioCyc
Ensembl Genes ENSRNOG00000031081 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049536.5 UniProtKB/TrEMBL
  ENSRNOT00000088201.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127907 IMAGE-MGC_LOAD
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAT2_C UniProtKB/TrEMBL
  STAT2_SH2 UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/TrEMBL
  STAT_TF_core UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/TrEMBL
  STAT_TF_DNA-bd_sub UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/TrEMBL
KEGG Report rno:288774 UniProtKB/TrEMBL
MGC_CLONE MGC:95122 IMAGE-MGC_LOAD
NCBI Gene 288774 ENTREZGENE
PANTHER SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2 UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  STAT2_C UniProtKB/TrEMBL
  STAT_alpha UniProtKB/TrEMBL
  STAT_bind UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
PhenoGen Stat2 PhenoGen
PROSITE SH2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031081 RatGTEx
SMART SH2 UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
Superfamily-SCOP P53_like_DNA_bnd UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
UniProt A0A0G2K9T9_RAT UniProtKB/TrEMBL
  F7EYG9 ENTREZGENE, UniProtKB/TrEMBL
  Q5XI26 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Stat2  signal transducer and activator of transcription 2  Stat2_predicted  signal transducer and activator of transcription 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Stat2_predicted  signal transducer and activator of transcription 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED