Agtr2 (angiotensin II receptor, type 2) - Rat Genome Database

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Gene: Agtr2 (angiotensin II receptor, type 2) Rattus norvegicus
Analyze
Symbol: Agtr2
Name: angiotensin II receptor, type 2
RGD ID: 2072
Description: Enables angiotensin type II receptor activity. Involved in several processes, including cellular response to dexamethasone stimulus; positive regulation of branching involved in ureteric bud morphogenesis; and regulation of secretion. Located in perinuclear region of cytoplasm. Used to study chronic kidney disease; congenital diaphragmatic hernia; glomerulonephritis (multiple); hypertension (multiple); and meconium aspiration syndrome. Biomarker of several diseases, including asthma; congestive heart failure; glomerulosclerosis (multiple); hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2); PARTICIPATES IN angiotensin III signaling pathway via AT2 receptor; angiotensin II signaling pathway via AT2 receptor; G protein mediated signaling pathway via Galphai family; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: angiotensin II type 2 receptor; angiotensin II type-2 receptor; Angiotensin receptor 2; AT2; AT2 receptor; AT2-R; AT2R; AT2R; type-2 angiotensin II receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X112,119,673 - 112,124,060 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX112,120,228 - 112,124,057 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX114,138,672 - 114,139,763 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X117,629,475 - 117,630,566 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X115,194,251 - 115,195,342 (+)NCBIRnor_WKY
Rnor_6.0X119,389,480 - 119,393,845 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX119,390,013 - 119,393,842 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X119,534,483 - 119,538,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX111,375,374 - 111,376,465 (+)NCBICelera
Cytogenetic MapXq34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(R)-noradrenaline  (ISO)
(S)-nicotine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
angiotensin II  (EXP)
benzalkonium chloride  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (EXP)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP)
CGP-42112A  (EXP,ISO)
cholesterol  (EXP)
cilazapril monohydrate  (EXP)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
curcumin  (EXP)
D-glucose  (ISO)
dexamethasone  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (EXP,ISO)
dopaminechrome (enol form)  (EXP)
doxorubicin  (EXP)
edaravone  (EXP)
enalapril  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
esculetin  (EXP)
ethanol  (EXP)
folic acid  (ISO)
fructose  (EXP)
genistein  (EXP)
glucose  (ISO)
glycidol  (EXP)
GW 3965  (EXP)
hydrogen peroxide  (ISO)
Ile(5)-angiotensin II  (EXP)
lipopolysaccharide  (EXP)
lithium chloride  (EXP)
losartan  (EXP,ISO)
Methylthiouracil  (EXP)
mevinphos  (EXP)
mifepristone  (EXP)
Nandrolone decanoate  (EXP)
nicotine  (EXP)
nitric oxide  (EXP)
nitrofen  (EXP)
p-menthan-3-ol  (ISO)
paraquat  (ISO)
PD123319  (EXP,ISO)
peroxynitrous acid  (EXP)
phenylephrine  (EXP,ISO)
picrotoxin  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP)
potassium bromate  (ISO)
reserpine  (EXP)
rotenone  (ISO)
sodium chloride  (EXP)
spironolactone  (EXP)
streptozocin  (EXP,ISO)
taurine  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiotensin-activated signaling pathway  (IEA)
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure  (ISO)
brain renin-angiotensin system  (ISO)
cell growth involved in cardiac muscle cell development  (IMP)
cell surface receptor signaling pathway  (ISO)
cellular response to dexamethasone stimulus  (IDA)
cerebellar cortex development  (IMP)
dopamine biosynthetic process  (IMP)
exploration behavior  (ISO)
G protein-coupled receptor signaling pathway  (IBA)
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  (ISO)
inflammatory response  (IBA,ISO)
intracellular signal transduction  (ISO)
intracellular sodium ion homeostasis  (IMP)
kidney development  (IEP)
kidney morphogenesis  (IMP)
negative regulation of fibroblast proliferation  (IMP)
negative regulation of heart rate  (ISO)
negative regulation of icosanoid secretion  (IMP)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (ISO)
negative regulation of norepinephrine secretion  (IDA)
neuron apoptotic process  (ISO)
neuron differentiation  (TAS)
positive regulation of branching involved in ureteric bud morphogenesis  (IMP,ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytokine production  (IMP)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of metanephric glomerulus development  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phosphoprotein phosphatase activity  (ISO)
regulation of metanephros size  (ISO)
regulation of protein import into nucleus  (IDA)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
renin-angiotensin regulation of aldosterone production  (IMP)
response to organonitrogen compound  (IEP)
vasodilation  (IMP,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization. Abadir PM, etal., Hypertension. 2006 Aug;48(2):316-22. Epub 2006 Jun 5.
2. Regulation of renal 12(S)-hydroxyeicosatetraenoic acid in diabetes by angiotensin AT1 and AT2 receptors. Abdel-Rahman EM, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1473-8. Epub 2008 Sep 17.
3. Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis. Arumugam S, etal., Toxicology. 2012 Jan 27;291(1-3):139-45. doi: 10.1016/j.tox.2011.11.008. Epub 2011 Nov 23.
4. Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice. Benndorf RA, etal., Kidney Int. 2009 May;75(10):1039-49. Epub 2009 Feb 11.
5. Differential responses to salt supplementation in adult male and female rat adrenal glands following intrauterine growth restriction. Bibeau K, etal., J Endocrinol. 2011 Apr;209(1):85-94. Epub 2011 Feb 8.
6. Renal expression of angiotensin receptors in long-term diabetes and the effects of angiotensin type 1 receptor blockade. Bonnet F, etal., J Hypertens. 2002 Aug;20(8):1615-24.
7. Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution. Bose KS and Sarma RH, Biochem Biophys Res Commun 1975 Oct 27;66(4):1173-9.
8. Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. Cao Z, etal., J Am Soc Nephrol. 2002 Jul;13(7):1773-87.
9. Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy. Chan LY, etal., J Am Soc Nephrol. 2005 Aug;16(8):2306-17. Epub 2005 Jun 1.
10. Upregulation of angiotensin II receptors in reflux nephropathy. Chertin B, etal., J Pediatr Surg. 2002 Feb;37(2):251-5.
11. Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea. da Silva AQ, etal., Brain Res. 2011 Jan 12;1368:231-8. Epub 2010 Oct 30.
12. International union of pharmacology. XXIII. The angiotensin II receptors. de Gasparo M, etal., Pharmacol Rev. 2000 Sep;52(3):415-72.
13. Angiotensin-2 receptors (AT1-R and AT2-R), new prognostic factors for renal clear-cell carcinoma? Dolley-Hitze T, etal., Br J Cancer. 2010 Nov 23;103(11):1698-705.
14. Angiotensin II, via AT1 and AT2 receptors and NF-kappaB pathway, regulates the inflammatory response in unilateral ureteral obstruction. Esteban V, etal., J Am Soc Nephrol. 2004 Jun;15(6):1514-29.
15. Gbeta gamma -independent constitutive association of Galpha s with SHP-1 and angiotensin II receptor AT2 is essential in AT2-mediated ITIM-independent activation of SHP-1. Feng YH, etal., Proc Natl Acad Sci U S A 2002 Sep 17;99(19):12049-54.
16. Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor. Flores-Munoz M, etal., Hypertension. 2012 Feb;59(2):300-7. Epub 2011 Dec 19.
17. Angiotensin1-9 antagonises pro-hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor. Flores-Munoz M, etal., J Physiol. 2011 Feb 15;589(Pt 4):939-51. Epub 2010 Dec 20.
18. Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla: potential mechanism for sympathetic overactivity in heart failure. Gao L, etal., Hypertension. 2008 Oct;52(4):708-14. Epub 2008 Sep 2.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage. Gelosa P, etal., J Hypertens. 2009 Dec;27(12):2444-51.
21. The angiotensin type 2 receptor of angiotensin II and neuronal differentiation: from observations to mechanisms. Gendron L, etal., J Mol Endocrinol 2003 Dec;31(3):359-72.
22. The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury. Ghosh S, etal., Am J Med Sci. 2002 Dec;324(6):296-304.
23. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
24. Expression and role of angiotensin II type 2 receptor in the kidney and mesangial cells of spontaneously hypertensive rats. Goto M, etal., Hypertens Res. 2002 Jan;25(1):125-33.
25. Implication of genetic variations in congenital obstructive nephropathy. Hahn H, etal., Pediatr Nephrol. 2005 Nov;20(11):1541-4. Epub 2005 Aug 25.
26. Candesartan cilexetil improves angiotensin II type 2 receptor-mediated neurite outgrowth via the PI3K-Akt pathway in fructose-induced insulin-resistant rats. Hashikawa-Hobara N, etal., Diabetes. 2012 Apr;61(4):925-32. Epub 2012 Feb 22.
27. Angiotensin receptor subtypes in thin and muscular juxtamedullary efferent arterioles of rat kidney. Helou CM, etal., Am J Physiol Renal Physiol 2003 Sep;285(3):F507-14. Epub 2003 May 6.
28. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Ichiki T, etal., Nature 1995 Oct 26;377(6551):748-50.
29. Angiotensin II AT(1) and AT(2) receptors contribute to maintain basal adrenomedullary norepinephrine synthesis and tyrosine hydroxylase transcription. Jezova M, etal., Endocrinology 2003 May;144(5):2092-101.
30. Angiotensin II type 2 receptor gene transfer downregulates angiotensin II type 1a receptor in vascular smooth muscle cells. Jin XQ, etal., Hypertension 2002 May;39(5):1021-7.
31. Cardiovascular and renal function of angiotensin II type-2 receptors. Johren O, etal., Cardiovasc Res. 2004 Jun 1;62(3):460-7.
32. Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. Kambayashi Y, etal., J Biol Chem. 1993 Nov 25;268(33):24543-6.
33. Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis. Kim HJ, etal., J Pharmacol Exp Ther. 2011 Feb 25.
34. Mechanism of Ang II involvement in activation of NF-kappaB through phosphorylation of p65 during aging. Kim JM, etal., Age (Dordr). 2011 Feb 12.
35. Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene. Koike G, etal., Hypertension 1995 Dec;26(6 Pt 1):998-1002.
36. Evidence for a functional role of angiotensin II type 2 receptor in the cardiac hypertrophic process in vivo in the rat heart. Lako-Futo Z, etal., Circulation. 2003 Nov 11;108(19):2414-22. Epub 2003 Oct 20.
37. Association of angiotensin converting enzyme and angiotensin type 2 receptor gene polymorphisms with renal damage in posterior urethral valves. Laksmi NK, etal., J Pediatr Urol. 2010 Dec;6(6):560-6. Epub 2010 Feb 10.
38. Regulation and expression of a renin-angiotensin system in human pancreas and pancreatic endocrine tumours. Lam KY and Leung PS, Eur J Endocrinol. 2002 Apr;146(4):567-72.
39. The involvement of angiotensin type 1 and type 2 receptors in estrogen-induced cell proliferation and vascular endothelial growth factor expression in the rat anterior pituitary. Lawnicka H, etal., ScientificWorldJournal. 2012;2012:358102. Epub 2012 Apr 26.
40. Upregulation of AT2 receptor and iNOS impairs angiotensin II-induced contraction without endothelium influence in young normotensive diabetic rats. Lee JH, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R144-54. Epub 2008 May 7.
41. Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo. Lee S, etal., Exp Transl Stroke Med. 2012 Aug 24;4(1):16.
42. Taurine may prevent diabetic rats from developing cardiomyopathy also by downregulating angiotensin II type2 receptor expression. Li C, etal., Cardiovasc Drugs Ther. 2005 Mar;19(2):105-12.
43. Hypoxic preconditioning induces an AT2-R/VEGFR-2(Flk-1) interaction in the neonatal brain microvasculature for neuroprotection. Lopez-Aguilera F, etal., Neuroscience. 2012 Aug 2;216:1-9. Epub 2012 May 6.
44. Angiotensin II receptor blockade inhibits pneumocyte apoptosis in experimental meconium aspiration. Lukkarinen H, etal., Pediatr Res. 2004 Feb;55(2):326-33. Epub 2003 Nov 6.
45. Angiotensin AT(2) receptor stimulation inhibits early renal inflammation in renovascular hypertension. Matavelli LC, etal., Hypertension. 2011 Feb;57(2):308-13. Epub 2010 Dec 28.
46. Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke. McCarthy CA, etal., Stroke. 2009 Apr;40(4):1482-9. Epub 2009 Feb 26.
47. Direct angiotensin II type 2 receptor stimulation decreases dopamine synthesis in the rat striatum. Mertens B, etal., Neuropharmacology. 2010 Jun;58(7):1038-44. Epub 2010 Jan 26.
48. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
49. Angiotensin II receptor blockade inhibits acute glomerular injuries with the alteration of receptor expression. Mii A, etal., Lab Invest. 2009 Feb;89(2):164-77. Epub 2009 Jan 12.
50. Distribution of angiotensin AT1 and AT2 receptor subtypes in the rat kidney. Miyata N, etal., Am J Physiol 1999 Sep;277(3 Pt 2):F437-46.
51. Impact of angiotensin II type 2 receptor blockade on experimental radiation nephropathy. Moulder JE, etal., Radiat Res. 2004 Mar;161(3):312-7.
52. Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis. Naito T, etal., Am J Physiol Renal Physiol. 2010 Mar;298(3):F683-91. Epub 2009 Dec 30.
53. Overview of in vivo xenotransplantation studies: prospects for the future. Najarian JS Transplant Proc. 1992 Apr;24(2):733-8.
54. No involvement of the AT2-receptor in angiotensin II-enhanced sympathetic transmission in vitro. Nap A, etal., J Renin Angiotensin Aldosterone Syst 2003 Jun;4(2):100-5.
55. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
56. Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Nishimura H, etal., Mol Cell 1999 Jan;3(1):1-10.
57. Local fetal lung renin-angiotensin system as a target to treat congenital diaphragmatic hernia. Nogueira-Silva C, etal., Mol Med. 2012 Mar 27;18(1):231-43. doi: 10.2119/molmed.2011.00210.
58. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
59. AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function. Padia SH and Carey RM, Pflugers Arch. 2013 Jan;465(1):99-110. doi: 10.1007/s00424-012-1146-3. Epub 2012 Sep 5.
60. Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat. Padia SH, etal., Hypertension. 2006 Mar;47(3):537-44. Epub 2005 Dec 27.
61. Angiotensin II type 2 receptors and nitric oxide sustain oxygenation in the clipped kidney of early Goldblatt hypertensive rats. Palm F, etal., Hypertension. 2008 Feb;51(2):345-51. Epub 2007 Dec 24.
62. Genetic variation and activity of the renin-angiotensin system and severe hypoglycemia in type 1 diabetes. Pedersen-Bjergaard U, etal., Am J Med. 2008 Mar;121(3):246.e1-8.
63. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
64. Angiotensin III: a central regulator of vasopressin release and blood pressure. Reaux A, etal., Trends Endocrinol Metab. 2001 May-Jun;12(4):157-62.
65. GOA pipeline RGD automated data pipeline
66. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
67. Angiotensin-converting enzyme and angiotensin type 2 receptor gene genotype distributions in Italian children with congenital uropathies. Rigoli L, etal., Pediatr Res. 2004 Dec;56(6):988-93. Epub 2004 Oct 6.
68. Role of the angiotensin II AT2 receptor in inflammation and oxidative stress: opposing effects in lean and obese Zucker rats. Sabuhi R, etal., Am J Physiol Renal Physiol. 2011 Mar;300(3):F700-6. Epub 2011 Jan 5.
69. The renin-angiotensin system contributes to renal fibrosis through regulation of fibrocytes. Sakai N, etal., J Hypertens. 2008 Apr;26(4):780-90.
70. Inhibition of Angiotensin II receptors during pregnancy induces malformations in developing rat kidney. Sanchez SI, etal., Eur J Pharmacol. 2008 Jun 24;588(1):114-23. Epub 2008 Apr 9.
71. Prenatal blockade of Ang II receptors affects neonatal rat hindbrain structure and receptor localization. Sanchez SI, etal., Exp Neurol. 2009 Dec;220(2):246-54. Epub 2009 Aug 13.
72. Retinal angiogenesis is mediated by an interaction between the angiotensin type 2 receptor, VEGF, and angiopoietin. Sarlos S, etal., Am J Pathol 2003 Sep;163(3):879-87.
73. Angiotensin II type 2 receptor-mediated inhibition of norepinephrine release in isolated rat hearts. Sasaoka T, etal., J Cardiovasc Pharmacol. 2008 Aug;52(2):176-83.
74. A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. Senbonmatsu T, etal., EMBO J. 2003 Dec 15;22(24):6471-82.
75. Chronic angiotensin (1-7) injection accelerates STZ-induced diabetic renal injury. Shao Y, etal., Acta Pharmacol Sin. 2008 Jul;29(7):829-37.
76. Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies. Singh RR, etal., Am J Physiol Renal Physiol. 2007 Aug;293(2):F548-54. Epub 2007 May 30.
77. Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor. Sourris KC, etal., Diabetologia. 2010 Nov;53(11):2442-51. Epub 2010 Jul 15.
78. Angiotensin II type 1 receptor blockade restores angiotensin-(1-7)-induced coronary vasodilation in hypertrophic rat hearts. Souza AP, etal., Clin Sci (Lond). 2013 Nov;125(9):449-59. doi: 10.1042/CS20120519.
79. Angiotensin-(1-7) inhibits vascular calcification in rats. Sui YB, etal., Peptides. 2013 Apr;42:25-34. doi: 10.1016/j.peptides.2012.12.023. Epub 2013 Jan 3.
80. Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression. Tsutsumi Y, etal., Circ Res. 1998 Nov 16;83(10):1035-46.
81. Blood pressure and renal hemodynamic responses to acute angiotensin II infusion are enhanced in a female mouse model of systemic lupus erythematosus. Venegas-Pont M, etal., Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1286-92. Epub 2011 Sep 7.
82. AGTR2 mutations in X-linked mental retardation. Vervoort VS, etal., Science 2002 Jun 28;296(5577):2401-3.
83. Effect of valsartan on the expression of angiotensin II receptors in the lung of chronic antigen exposure rats. Wang T, etal., Chin Med J (Engl). 2008 Nov 20;121(22):2312-9.
84. Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice. Waseda Y, etal., Respir Res. 2008 May 23;9:43.
85. Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20. Wolf G, etal., Lab Invest 2002 Oct;82(10):1305-17.
86. Time-dependent expression of renal vaso-regulatory molecules in LPS-induced endotoxemia in rat. Yamaguchi N, etal., Peptides. 2006 Sep;27(9):2258-70. Epub 2006 May 24.
87. Angiotensin II type 2 receptor gene is not responsible for familial vesicoureteral reflux. Yoneda A, etal., J Urol. 2002 Sep;168(3):1138-41.
88. Association of angiotensin II type 2 receptor gene A1818T polymorphism with progression of immunoglobulin A nephropathy in Korean patients. Yoon HJ, etal., J Korean Med Sci. 2009 Jan;24 Suppl:S38-43. Epub 2009 Jan 28.
89. Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance. Yvan-Charvet L, etal., Diabetes. 2005 Apr;54(4):991-9.
90. [Angiotensin II type 2 receptors participate in the regulation of inflammatory cytokine secretion in adult rat hypertrophied cardiomyocytes]. Zhou J, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Nov;28(11):1971-3.
91. Regulation of angiotensin-(1-7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure. Zong WN, etal., Acta Pharmacol Sin. 2011 Nov;32(11):1345-50. doi: 10.1038/aps.2011.96. Epub 2011 Oct 3.
Additional References at PubMed
PMID:7599191   PMID:7713098   PMID:8227010   PMID:9310306   PMID:9449684   PMID:9878677   PMID:10406457   PMID:10425188   PMID:11068047   PMID:11973418   PMID:12198247   PMID:12203396  
PMID:12420045   PMID:12452333   PMID:12468569   PMID:12477932   PMID:12482596   PMID:12573806   PMID:12609817   PMID:12694402   PMID:12828922   PMID:14684844   PMID:14718351   PMID:15111328  
PMID:15117835   PMID:15153556   PMID:15166182   PMID:15194486   PMID:15226636   PMID:15298543   PMID:15308873   PMID:15367388   PMID:15509535   PMID:15534073   PMID:15544836   PMID:15572519  
PMID:15578192   PMID:15615839   PMID:15746093   PMID:15838360   PMID:16043661   PMID:16122703   PMID:16204414   PMID:16286564   PMID:16330679   PMID:16380081   PMID:16380464   PMID:16493576  
PMID:16603705   PMID:16618840   PMID:16636899   PMID:16690714   PMID:16934905   PMID:17000928   PMID:17043228   PMID:17082724   PMID:17116755   PMID:17159079   PMID:17206447   PMID:17237611  
PMID:17291529   PMID:17485601   PMID:17525253   PMID:17540701   PMID:17656330   PMID:17670863   PMID:17766473   PMID:17880376   PMID:17884764   PMID:17950540   PMID:18006431   PMID:18028779  
PMID:18086951   PMID:18158338   PMID:18208547   PMID:18403896   PMID:18420945   PMID:18607644   PMID:18609298   PMID:18680145   PMID:18926066   PMID:18957383   PMID:18986337   PMID:19114640  
PMID:19151255   PMID:19298848   PMID:19353416   PMID:19379780   PMID:19404405   PMID:19429393   PMID:19513542   PMID:19590192   PMID:19591228   PMID:19808775   PMID:19879325   PMID:19887855  
PMID:19955853   PMID:20440098   PMID:20463030   PMID:20606474   PMID:20663845   PMID:20807798   PMID:20870653   PMID:20964730   PMID:21084406   PMID:21146214   PMID:21189402   PMID:21288138  
PMID:21303953   PMID:21468559   PMID:21484513   PMID:21752621   PMID:21896931   PMID:21967903   PMID:22120166   PMID:22129514   PMID:22287496   PMID:22318954   PMID:22378773   PMID:22424324  
PMID:22504846   PMID:22832514   PMID:22860435   PMID:22911895   PMID:22936038   PMID:23132538   PMID:23149621   PMID:23255326   PMID:23383303   PMID:23489258   PMID:23754618   PMID:23807455  
PMID:23823602   PMID:23871345   PMID:23978469   PMID:24085035   PMID:24464860   PMID:24819472   PMID:24958505   PMID:24971613   PMID:25100281   PMID:25119338   PMID:25170617   PMID:25238020  
PMID:25365520   PMID:25430897   PMID:25562714   PMID:25655919   PMID:25770092   PMID:26137805   PMID:27469059   PMID:27693081   PMID:27763643   PMID:27765882   PMID:27825832   PMID:27923787  
PMID:28160390   PMID:28161727   PMID:28438644   PMID:28695320   PMID:29140411   PMID:29186390   PMID:29289466   PMID:29393347   PMID:30058175   PMID:30190172   PMID:30221707   PMID:32565336  
PMID:32979558   PMID:33739377   PMID:33970125   PMID:34828323   PMID:35373008   PMID:36397318   PMID:36922642  


Genomics

Comparative Map Data
Agtr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X112,119,673 - 112,124,060 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX112,120,228 - 112,124,057 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX114,138,672 - 114,139,763 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X117,629,475 - 117,630,566 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X115,194,251 - 115,195,342 (+)NCBIRnor_WKY
Rnor_6.0X119,389,480 - 119,393,845 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX119,390,013 - 119,393,842 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X119,534,483 - 119,538,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX111,375,374 - 111,376,465 (+)NCBICelera
Cytogenetic MapXq34NCBI
AGTR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X116,170,744 - 116,174,974 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX116,170,744 - 116,174,974 (+)EnsemblGRCh38hg38GRCh38
GRCh37X115,301,997 - 115,306,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X115,215,986 - 115,220,253 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X115,113,884 - 115,117,702NCBI
CeleraX115,832,555 - 115,836,822 (-)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX104,838,955 - 104,843,260 (+)NCBIHuRef
CHM1_1X115,212,791 - 115,217,059 (+)NCBICHM1_1
T2T-CHM13v2.0X114,580,328 - 114,584,558 (+)NCBIT2T-CHM13v2.0
Agtr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X21,350,863 - 21,355,072 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX21,350,783 - 21,355,403 (+)EnsemblGRCm39 Ensembl
GRCm38X21,484,624 - 21,488,833 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX21,484,544 - 21,489,164 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X21,061,752 - 21,065,957 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,641,585 - 20,646,123 (+)NCBIMGSCv36mm8
CeleraX19,607,387 - 19,611,593 (+)NCBICelera
Cytogenetic MapXA2NCBI
cM MapX16.71NCBI
Agtr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555343,653,157 - 3,654,248 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555343,653,112 - 3,654,248 (-)NCBIChiLan1.0ChiLan1.0
AGTR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X115,607,378 - 115,608,469 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X105,252,903 - 105,257,171 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X115,670,022 - 115,674,287 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX115,671,594 - 115,672,685 (+)Ensemblpanpan1.1panPan2
AGTR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X88,703,551 - 88,708,451 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX88,705,765 - 88,706,853 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX74,841,362 - 74,845,718 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X90,431,596 - 90,435,944 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX90,433,258 - 90,434,346 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X87,892,846 - 87,897,203 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X89,651,006 - 89,655,363 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X89,385,692 - 89,390,050 (+)NCBIUU_Cfam_GSD_1.0
Agtr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X87,731,904 - 87,736,189 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647913,252,678 - 13,255,570 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647913,252,678 - 13,255,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGTR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX95,269,300 - 95,270,388 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X95,267,709 - 95,272,237 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X109,822,530 - 109,826,739 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGTR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606528,955,602 - 28,958,335 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agtr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624967329,284 - 330,372 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624967327,627 - 332,000 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Agtr2
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:500
Count of miRNA genes:264
Interacting mature miRNAs:323
Transcripts:ENSRNOT00000074269
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat

Markers in Region
DXWox27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X112,133,718 - 112,133,852 (+)MAPPERmRatBN7.2
Rnor_6.0X119,403,504 - 119,403,637NCBIRnor6.0
Rnor_5.0X119,548,326 - 119,548,459UniSTSRnor5.0
CeleraX111,387,746 - 111,387,873UniSTS
Cytogenetic MapXq34UniSTS
DXMgh7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X112,124,540 - 112,124,758 (+)MAPPERmRatBN7.2
mRatBN7.21233,819,167 - 33,819,400 (+)MAPPERmRatBN7.2
Rnor_6.01239,282,339 - 39,282,571NCBIRnor6.0
Rnor_6.0X119,394,326 - 119,394,543NCBIRnor6.0
Rnor_5.01241,171,094 - 41,171,326UniSTSRnor5.0
Rnor_5.0X119,539,148 - 119,539,365UniSTSRnor5.0
RGSC_v3.41234,918,461 - 34,918,693UniSTSRGSC3.4
Celera1235,496,132 - 35,496,364UniSTS
CeleraX111,378,557 - 111,378,785UniSTS
SHRSP x BN MapX33.1599RGD
SHRSP x BN MapX33.1599UniSTS
FHH x ACI MapX34.6RGD
Cytogenetic MapXq34UniSTS
Cytogenetic Map12q16UniSTS
AW107640  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X112,123,581 - 112,123,668 (+)MAPPERmRatBN7.2
Rnor_6.0X119,393,367 - 119,393,453NCBIRnor6.0
Rnor_5.0X119,538,189 - 119,538,275UniSTSRnor5.0
CeleraX111,377,598 - 111,377,684UniSTS
Cytogenetic MapXq34UniSTS
RH139933  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X112,123,527 - 112,123,728 (+)MAPPERmRatBN7.2
Rnor_6.0X119,393,313 - 119,393,513NCBIRnor6.0
Rnor_5.0X119,538,135 - 119,538,335UniSTSRnor5.0
CeleraX111,377,544 - 111,377,744UniSTS
RH 3.4 Map11474.2UniSTS
Cytogenetic MapXq34UniSTS
PMC153509P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X112,121,846 - 112,122,128 (+)MAPPERmRatBN7.2
Rnor_6.0X119,391,632 - 119,391,913NCBIRnor6.0
Rnor_5.0X119,536,454 - 119,536,735UniSTSRnor5.0
CeleraX111,375,863 - 111,376,144UniSTS
Cytogenetic MapXq34UniSTS
Agtr2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X112,122,316 - 112,122,397 (+)MAPPERmRatBN7.2
Rnor_6.0X119,392,102 - 119,392,182NCBIRnor6.0
Rnor_5.0X119,536,924 - 119,537,004UniSTSRnor5.0
CeleraX111,376,333 - 111,376,413UniSTS
Cytogenetic MapXq34UniSTS
UniSTS:496533  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X112,121,421 - 112,122,383 (+)MAPPERmRatBN7.2
Rnor_6.0X119,391,207 - 119,392,168NCBIRnor6.0
Rnor_5.0X119,536,029 - 119,536,990UniSTSRnor5.0
CeleraX111,375,438 - 111,376,399UniSTS
Cytogenetic MapXq34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 8 1 1 18 25 1
Low 13 2 4 3 3 62 4 9 4 3
Below cutoff 3 6 25 19 10 19 3 3 10 6 4 7 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000074269   ⟹   ENSRNOP00000064709
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX112,120,228 - 112,124,057 (+)Ensembl
Rnor_6.0 EnsemblX119,390,013 - 119,393,842 (+)Ensembl
RefSeq Acc Id: NM_012494   ⟹   NP_036626
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X112,121,358 - 112,122,449 (+)NCBI
Rnor_6.0X119,391,143 - 119,392,234 (+)NCBI
Rnor_5.0X119,534,483 - 119,538,667 (+)NCBI
CeleraX111,375,374 - 111,376,465 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257432   ⟹   XP_006257494
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X112,119,673 - 112,124,060 (+)NCBI
Rnor_6.0X119,389,480 - 119,393,845 (+)NCBI
Rnor_5.0X119,534,483 - 119,538,667 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036626   ⟸   NM_012494
- UniProtKB: P35351 (UniProtKB/Swiss-Prot),   B1WBL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257494   ⟸   XM_006257432
- Peptide Label: isoform X1
- UniProtKB: P35351 (UniProtKB/Swiss-Prot),   B1WBL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064709   ⟸   ENSRNOT00000074269
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35351-F1-model_v2 AlphaFold P35351 1-363 view protein structure
AT2 I-TASSER model P35351 1-365 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2072 AgrOrtholog
BioCyc Gene G2FUF-1363 BioCyc
Ensembl Genes ENSRNOG00000050006 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000064709 ENTREZGENE
  ENSRNOP00000064709.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074269 ENTREZGENE
  ENSRNOT00000074269.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9102491 IMAGE-MGC_LOAD
InterPro ATII_AT2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATII_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24182 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187209 IMAGE-MGC_LOAD
NCBI Gene 24182 ENTREZGENE
PANTHER CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RELAXIN FAMILY PEPTIDE RECEPTOR 3.3A1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AGTR2 RGD
PhenoGen Agtr2 PhenoGen
PRINTS ANGIOTENSINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANGIOTENSN2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AGTR2_RAT UniProtKB/Swiss-Prot
  B1WBL8 ENTREZGENE, UniProtKB/TrEMBL
  P35351 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Agtr2  angiotensin II receptor, type 2    Angiotensin receptor 2  Name updated 629478 APPROVED
2002-06-10 Agtr2  Angiotensin receptor 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains an immunoreceptor tyrosine-based inhibitory (ITIM)-like motif (VIYPFL) in the cytoplasmic loop domain 625596
gene_expression expressed at high levels during the later stage of fetal development and in the neonate, but declines rapidly after birth 70604
gene_expression abundant in model of retinopathy of prematurity 1298608
gene_expression expressed in muscular and thin arterioles 1298648
gene_expression expressed throughout the rat kidney 1357917
gene_function binds to angiotensin II to facilitate arteriole vascular tone 1298648
gene_mutations_overexpression overexpression inhibits Agtr1 expression in vascular smooth muscle cells (VSMCs) 70604
gene_pathway retinal angiogenesis actions may converge on VEGF- and angiopoietin-dependent pathways 1298608
gene_process regulates growth and metabolism in vascular smooth muscle cells 70604
gene_process regulates growth and metabolism in vascular smooth muscle cells 625596
gene_process plays a role in regulating SHP-1 activity when constitutively associated with Gs and SHP-1 625596
gene_process exerts antiproliferative effect in endothelial and vascular smooth muscle cells 1298575
gene_process plays a role in pressure natriuresis 1298575
gene_process does not play a role in angiotensin I-mediated sympathetic neurotransmission by angiotensin II molecule 1298649
gene_process induces vasodilation 1298648
gene_product belongs to the family of seven-transmembrane G protein-coupled receptors 70604