Gene: Agtr2 (angiotensin II receptor, type 2) Rattus norvegicus
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Symbol:
Agtr2
Name:
angiotensin II receptor, type 2
Description:
Exhibits transcription factor binding activity. Involved in several processes, including aldosterone secretion; animal organ development; and regulation of secretion. Localizes to the perinuclear region of cytoplasm and plasma membrane. Used to study chronic kidney disease; congenital diaphragmatic hernia; glomerulonephritis (multiple); hypertension (multiple); and meconium aspiration syndrome. Biomarker of several diseases, including asthma; congestive heart failure; glomerulosclerosis (multiple); hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal failure; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2); PARTICIPATES IN angiotensin III signaling pathway via AT2 receptor; angiotensin II signaling pathway via AT2 receptor; G protein mediated signaling pathway via Galphai family; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 3',5'-cyclic GMP.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
angiotensin II type 2 receptor; angiotensin II type-2 receptor; Angiotensin receptor 2; AT2; AT2-R; AT2R; AT2 R; type-2 angiotensin II receptor
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
AGTR2 (angiotensin II receptor type 2) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):
Agtr2 (angiotensin II receptor, type 2) HGNC
NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Agtr2 (angiotensin II receptor type 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
AGTR2 (angiotensin II receptor type 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
AGTR2 (angiotensin II receptor type 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Agtr2 (angiotensin II receptor type 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
AGTR2 (angiotensin II receptor type 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Agtr2 (angiotensin II receptor, type 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
AGTR2 (angiotensin II receptor type 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
agtr2 (angiotensin II receptor, type 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 119,389,480 - 119,393,845 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 119,390,013 - 119,393,842 (+) Ensembl Rnor_5.0 X 119,534,483 - 119,538,667 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 Celera X 111,375,374 - 111,376,465 (+) NCBI Celera Cytogenetic Map X q34 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
AIDS-Associated Nephropathy ISO RGD:10126 1303381 RGD asthma IEP 5147457 mRNA, protein:increased expression:lung RGD chronic kidney disease IMP 6903863 RGD congenital diaphragmatic hernia IMP 6903875 RGD congestive heart failure IEP 6903846 RGD congestive heart failure IEP 8549482 mRNA, protein:decreased expression:heart RGD Diabetes Mellitus, Experimental IEP 6903861 mRNA, protein:decreased expression:kidney RGD Diabetic Nephropathies IEP 6903847 associated with Diabetes Mellitus, Experimental, mRNA:decreased expression:kidney RGD dilated cardiomyopathy ISO RGD:619558 6903900 mRNA, protein:increased expression:heart left ventricle RGD dilated cardiomyopathy IEP 8549486 protein:increased expression:heart RGD end stage renal failure ISO RGD:10126 6903843 RGD end stage renal failure ISO RGD:619558 6903283 associated with Vesico-Ureteral Reflux, DNA:SNP: :-1332A>G (human) RGD Endotoxemia IEP 6903849 protein:decreased expression:kidney RGD Fetal Growth Retardation IEP 5129179 RGD Fibrosis IMP 6903874 associated with Hypertension RGD Fibrosis ISO RGD:10126 6903848 associated with Ureteral Obstruction RGD focal segmental glomerulosclerosis IEP 5129175 protein:increased expression:kidney cortex RGD glomerulonephritis IMP 6903845 RGD glomerulosclerosis IMP 6903284 associated with Kidney Failure, Chronic RGD glomerulosclerosis ISO RGD:10126 6903882 RGD glomerulosclerosis IEP 6903859 mRNA:increased expression:kidney RGD hypertension IEP 6903865 mRNA, protein:decreased expression:kidney RGD hypertension IMP 6903372 RGD hypertension IMP 5129169 associated with Sleep Apnea Syndromes RGD hypoglycemia ISO RGD:619558 2313551 associated with Diabetes Mellitus, Insulin-Dependent, DNA:polymorphism: :1675G>A (human) RGD Hypoxia-Ischemia, Brain IMP 6903872 RGD IgA glomerulonephritis disease_progression ISO RGD:619558 6903844 DNA:polymorphism: :1818A>T (human) RGD IgA glomerulonephritis ISO RGD:619558 6903851 protein:increased expression:kidney tubule RGD Inflammation ISO RGD:10126 6903855 associated with Ureteral Obstruction RGD Insulin Resistance IEP 6903873 protein:increased expression:dorsal root ganglion, neuron RGD intellectual disability ISO RGD:619558 1300276 RGD meconium aspiration syndrome treatment IMP 11039054 RGD obesity ISO RGD:10126 2313554 RGD pancreatic cancer ISO RGD:619558 2325641 mRNA:increased expression:pancreas RGD pulmonary fibrosis ISO RGD:10126 5147454 RGD Radiation Injuries, Experimental IMP 6903857 RGD renal cell carcinoma disease_progression ISO RGD:619558 6903280 protein:increased expression:kidney RGD renovascular hypertension IMP 6903868 RGD renovascular hypertension IDA 6903867 RGD Reperfusion Injury IDA 6903870 RGD Stroke IMP 6903905 RGD systemic lupus erythematosus ISO RGD:10126 6892717 RGD type 2 diabetes mellitus IEP 2313550 mRNA, protein:increased expression:aorta RGD Urogenital Abnormalities ISO RGD:619558 6903850 DNA:transition:intron RGD Urogenital Abnormalities ISO RGD:619558 6903853 DNA:transition:intron:-1332A>G (human) RGD vesicoureteral reflux ISO RGD:619558 6903866 RGD vesicoureteral reflux no_association ISO RGD:619558 6903860 DNA:transition:intron:-1332A>G (human) RGD vesicoureteral reflux ISO RGD:619558 6903853 DNA:transition:intron:-1332A>G (human) RGD
Imported Annotations - ClinVar
autistic disorder ISO RGD:619558 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 Mental Retardation, X-Linked 88 ISO RGD:619558 8554872 ClinVar Annotator: match by term: X-Linked Mental Retardation 88 ClinVar PMID:12089445 more ... syndromic X-linked intellectual disability Lubs type ISO RGD:619558 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868
Imported Annotations - CTD
Diabetic Cardiomyopathies ISO RGD:619558 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15587404 , PMID:16025228 hypertension ISO RGD:619558 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15710752 invasive lobular carcinoma ISO RGD:619558 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8389152 Left Ventricular Hypertrophy ISO RGD:619558 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20467270 Mammary Neoplasms, Experimental ISO RGD:619558 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8389152 Mental Retardation, X-Linked ISO RGD:619558 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12089445 Neoplasm Metastasis ISO RGD:619558 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18059164 ovarian cyst ISO RGD:619558 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21239663 Stomach Neoplasms ISO RGD:619558 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18059164 Vascular System Injuries ISO RGD:619558 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16982965
(R)-noradrenaline affects response to substance ISO RGD:10126 6480464 AGTR2 protein affects the susceptibility to Norepinephrine CTD PMID:11714657 (S)-nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of AGTR2 mRNA, Nicotine results in decreased expression of AGTR2 protein CTD PMID:19429393 (S)-nicotine affects expression EXP 6480464 Nicotine affects the expression of AGTR2 protein CTD PMID:22691361 17alpha-ethynylestradiol multiple interactions ISO RGD:10126 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AGTR2 mRNA CTD PMID:17942748 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of AGTR2 mRNA, Estradiol results in increased expression of AGTR2 protein CTD PMID:18388195 17beta-estradiol increases expression ISO RGD:10126 6480464 Estradiol results in increased expression of AGTR2 mRNA CTD PMID:19484750 17beta-estradiol multiple interactions EXP 6480464 [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Estradiol CTD PMID:18388195 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10126 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AGTR2 mRNA CTD PMID:17942748 3',5'-cyclic GMP multiple interactions EXP 6480464 [PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP] CTD PMID:16982965 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine multiple interactions EXP 6480464 [Puromycin Aminonucleoside co-treated with Cholesterol] results in increased expression of AGTR2 mRNA CTD PMID:12495295 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression EXP 6480464 Puromycin Aminonucleoside results in increased expression of AGTR2 mRNA CTD PMID:12495295 4,4'-sulfonyldiphenol increases expression ISO RGD:10126 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of AGTR2 mRNA CTD PMID:30951980 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile increases expression EXP 6480464 Fadrozole results in increased expression of AGTR2 protein CTD PMID:18586661 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of AGTR2 mRNA CTD PMID:24780913 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expression ISO RGD:10126 6480464 Uric Acid results in increased expression of AGTR2 mRNA CTD PMID:30710622 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO RGD:10126 6480464 APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR2 mRNA] CTD PMID:30710622 aldosterone increases expression EXP 6480464 Aldosterone results in increased expression of AGTR2 mRNA CTD PMID:15809360 amlodipine decreases expression EXP 6480464 Amlodipine results in decreased expression of AGTR2 mRNA CTD PMID:18403896 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of AGTR2 mRNA CTD PMID:16483693 angiotensin II increases expression EXP 6480464 Angiotensin II results in increased expression of AGTR2 mRNA, Angiotensin II results in increased expression of AGTR2 protein CTD PMID:12969123 benzalkonium chloride multiple interactions ISO RGD:10126 6480464 [IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of AGTR2 mRNA CTD PMID:30171875 bisphenol A multiple interactions ISO RGD:10126 6480464 [potassium bromate co-treated with bisphenol A] affects the expression of AGTR2 mRNA, [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AGTR2 mRNA] CTD PMID:27082013 bisphenol A increases expression ISO RGD:10126 6480464 bisphenol A results in increased expression of AGTR2 mRNA CTD PMID:30951980 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Genistein] results in increased methylation of AGTR2 gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of AGTR2 mRNA CTD PMID:25181051 bisphenol F increases expression ISO RGD:10126 6480464 bisphenol F results in increased expression of AGTR2 mRNA CTD PMID:30951980 caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of AGTR2 mRNA, Caffeine results in decreased expression of AGTR2 protein CTD PMID:25986755 , PMID:30423288 candesartan multiple interactions ISO RGD:619558 6480464 [PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein] CTD PMID:18551021 candesartan decreases expression EXP 6480464 candesartan results in decreased expression of AGTR2 mRNA CTD PMID:18796534 Candesartan cilexetil increases expression EXP 6480464 candesartan cilexetil results in increased expression of AGTR2 protein CTD PMID:22120037 cholesterol multiple interactions EXP 6480464 [Cholesterol co-treated with Methylthiouracil] results in increased expression of AGTR2 mRNA more ... CTD PMID:12495295 , PMID:21269478 cilazapril monohydrate multiple interactions EXP 6480464 [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA], Cilazapril inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA] CTD PMID:15331931 clofibrate increases expression ISO RGD:10126 6480464 Clofibrate results in increased expression of AGTR2 mRNA CTD PMID:17585979 cobalt dichloride increases expression ISO RGD:10126 6480464 cobaltous chloride results in increased expression of AGTR2 mRNA CTD PMID:25511041 copper atom decreases expression EXP 6480464 Copper results in decreased expression of AGTR2 mRNA CTD PMID:30556269 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of AGTR2 mRNA CTD PMID:30556269 copper(II) sulfate affects expression ISO RGD:619558 6480464 Copper Sulfate affects the expression of AGTR2 mRNA CTD PMID:19549813 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of AGTR2 mRNA CTD PMID:30423288 corticosterone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Corticosterone results in increased expression of AGTR2 mRNA] CTD PMID:30423288 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of AGTR2 mRNA, Dexamethasone results in decreased expression of AGTR2 protein CTD PMID:30359671 dexamethasone multiple interactions EXP 6480464 AGTR2 protein inhibits the reaction [Dexamethasone results in decreased expression of GDNF mRNA] more ... CTD PMID:30359671 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of AGTR2 mRNA, Diethylstilbestrol results in increased expression of AGTR2 protein CTD PMID:14722030 dioxygen increases expression ISO RGD:10126 6480464 Oxygen deficiency results in increased expression of AGTR2 mRNA CTD PMID:16769992 dioxygen affects expression ISO RGD:10126 6480464 Oxygen deficiency affects the expression of AGTR2 protein CTD PMID:25511041 dioxygen multiple interactions ISO RGD:10126 6480464 Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of AGTR2 protein] CTD PMID:25511041 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of AGTR2 mRNA, Oxygen deficiency results in increased expression of AGTR2 protein CTD PMID:19118600 doxorubicin multiple interactions EXP 6480464 [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA] more ... CTD PMID:15331931 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of AGTR2 mRNA CTD PMID:15331931 edaravone multiple interactions EXP 6480464 Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR2 mRNA] CTD PMID:19118600 enalapril increases expression EXP 6480464 Enalapril results in increased expression of AGTR2 mRNA CTD PMID:18765277 enalapril decreases expression EXP 6480464 Enalapril results in decreased expression of AGTR2 mRNA CTD PMID:18403896 , PMID:9740612 entinostat decreases expression ISO RGD:619558 6480464 entinostat results in decreased expression of AGTR2 mRNA CTD PMID:27188386 esculetin multiple interactions EXP 6480464 esculetin inhibits the reaction [Dietary Fats results in increased expression of AGTR2 mRNA], esculetin promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR2 mRNA] CTD PMID:28946194 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of AGTR2 mRNA, Ethanol results in decreased expression of AGTR2 protein CTD PMID:29548890 folic acid increases expression ISO RGD:10126 6480464 Folic Acid results in increased expression of AGTR2 mRNA, Folic Acid results in increased expression of AGTR2 protein CTD PMID:12969123 fructose multiple interactions EXP 6480464 APLN protein modified form inhibits the reaction [Fructose results in increased expression of AGTR2 mRNA] CTD PMID:30710622 fructose increases expression EXP 6480464 Fructose results in increased expression of AGTR2 mRNA CTD PMID:30710622 genistein multiple interactions EXP 6480464 [bisphenol A co-treated with Genistein] results in increased methylation of AGTR2 gene CTD PMID:28505145 glycidol decreases expression EXP 6480464 glycidol results in decreased expression of AGTR2 mRNA CTD PMID:24395379 GW 3965 affects expression EXP 6480464 GW 3965 affects the expression of AGTR2 mRNA CTD PMID:17420776 hydrogen peroxide increases expression ISO RGD:10126 6480464 Hydrogen Peroxide results in increased expression of AGTR2 mRNA CTD PMID:30710622 Ile(5)-angiotensin II increases expression EXP 6480464 Angiotensin II results in increased expression of AGTR2 mRNA, Angiotensin II results in increased expression of AGTR2 protein CTD PMID:12969123 lipopolysaccharide multiple interactions EXP 6480464 AGTR2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] more ... CTD PMID:19118600 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of AGTR2 mRNA CTD PMID:19118600 losartan multiple interactions EXP 6480464 [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA] more ... CTD PMID:11967826 , PMID:15331931 losartan multiple interactions ISO RGD:10126 6480464 Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of AGTR2 protein] CTD PMID:25511041 losartan increases expression EXP 6480464 Losartan results in increased expression of AGTR2 protein CTD PMID:18300857 losartan decreases expression EXP 6480464 Losartan results in decreased expression of AGTR2 mRNA CTD PMID:9336375 Methylthiouracil multiple interactions EXP 6480464 [Cholesterol co-treated with Methylthiouracil] results in increased expression of AGTR2 mRNA more ... CTD PMID:21269478 mevinphos multiple interactions EXP 6480464 [Mevinphos results in increased activity of AGTR2 protein] which results in increased abundance of Peroxynitrous Acid CTD PMID:23824088 mevinphos increases expression EXP 6480464 Mevinphos results in increased expression of AGTR2 mRNA, Mevinphos results in increased expression of AGTR2 protein CTD PMID:23824088 mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Corticosterone results in increased expression of AGTR2 mRNA], Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of AGTR2 mRNA] CTD PMID:30359671 , PMID:30423288 Nandrolone decanoate increases expression EXP 6480464 nandrolone decanoate results in increased expression of AGTR2 mRNA CTD PMID:17906098 nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of AGTR2 mRNA, Nicotine results in decreased expression of AGTR2 protein CTD PMID:19429393 nicotine affects expression EXP 6480464 Nicotine affects the expression of AGTR2 protein CTD PMID:22691361 nitric oxide affects response to substance EXP 6480464 AGTR2 protein affects the susceptibility to Nitric Oxide CTD PMID:9374809 nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of AGTR2 mRNA CTD PMID:15578192 , PMID:16292651 p-menthan-3-ol decreases expression ISO RGD:619558 6480464 Menthol results in decreased expression of AGTR2 mRNA CTD PMID:26760959 paraquat decreases expression ISO RGD:619558 6480464 Paraquat results in decreased expression of AGTR2 mRNA CTD PMID:20035857 PD123319 multiple interactions ISO RGD:619558 6480464 [PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein], PD 123319 binds to and results in decreased activity of AGTR2 protein CTD PMID:15807884 , PMID:18551021 PD123319 multiple interactions ISO RGD:10126 6480464 PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]], PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]] CTD PMID:25446015 PD123319 decreases activity EXP 6480464 PD 123319 results in decreased activity of AGTR2 protein CTD PMID:11509473 , PMID:18388195 PD123319 increases expression EXP 6480464 PD 123319 results in increased expression of AGTR2 mRNA, PD 123319 results in increased expression of AGTR2 protein CTD PMID:11893553 PD123319 decreases expression EXP 6480464 PD 123319 results in decreased expression of AGTR2 mRNA CTD PMID:9336375 , PMID:9740612 PD123319 multiple interactions EXP 6480464 [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine more ... CTD PMID:16982965 more ... peroxynitrous acid multiple interactions EXP 6480464 [Mevinphos results in increased activity of AGTR2 protein] which results in increased abundance of Peroxynitrous Acid CTD PMID:23824088 phenylephrine multiple interactions EXP 6480464 [CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine, [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine CTD PMID:19151255 phenylephrine affects response to substance ISO RGD:10126 6480464 AGTR2 protein affects the susceptibility to Phenylephrine CTD PMID:11714657 picrotoxin decreases expression EXP 6480464 Picrotoxin results in decreased expression of AGTR2 mRNA CTD PMID:15170462 pioglitazone multiple interactions ISO RGD:10126 6480464 [ANGPT2 protein binds to and results in increased activity of AGTR2 protein] promotes the reaction [pioglitazone binds to and results in increased activity of PPARG protein], [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of AGTR2 mRNA CTD PMID:15992368 , PMID:27935865 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of AGTR2 mRNA, pirinixic acid results in increased expression of AGTR2 protein CTD PMID:12832660 , PMID:18300857 potassium bromate multiple interactions ISO RGD:10126 6480464 [potassium bromate co-treated with bisphenol A] affects the expression of AGTR2 mRNA, [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AGTR2 mRNA] CTD PMID:27082013 reserpine increases expression EXP 6480464 Reserpine results in increased expression of AGTR2 mRNA, Reserpine results in increased expression of AGTR2 protein CTD PMID:20964730 rotenone multiple interactions ISO RGD:10126 6480464 [AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein more ... CTD PMID:25446015 rotenone increases expression ISO RGD:10126 6480464 Rotenone results in increased expression of AGTR2 mRNA, Rotenone results in increased expression of AGTR2 protein CTD PMID:25446015 , PMID:29665408 sodium chloride decreases expression EXP 6480464 Sodium Chloride results in decreased expression of AGTR2 mRNA, Sodium Chloride results in decreased expression of AGTR2 protein CTD PMID:15809360 sodium chloride multiple interactions EXP 6480464 AGTR2 protein inhibits the reaction [Sodium Chloride results in increased activity of AGT protein] CTD PMID:15809360 spironolactone increases expression EXP 6480464 Spironolactone results in increased expression of AGTR2 protein CTD PMID:18586661 streptozocin increases expression ISO RGD:10126 6480464 Streptozocin results in increased expression of AGTR2 mRNA, Streptozocin results in increased expression of AGTR2 protein CTD PMID:17724226 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of AGTR2 mRNA, Streptozocin results in increased expression of AGTR2 protein CTD PMID:15587404 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR2 mRNA more ... CTD PMID:15587404 , PMID:28946194 taurine decreases expression EXP 6480464 Taurine results in decreased expression of AGTR2 protein CTD PMID:16025228 testosterone affects expression EXP 6480464 Testosterone affects the expression of AGTR2 mRNA CTD PMID:17237611 tetrachloromethane multiple interactions ISO RGD:10126 6480464 AGTR2 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA], AGTR2 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] CTD PMID:16774739 tetrachloromethane increases response to substance ISO RGD:10126 6480464 AGTR2 gene mutant form results in increased susceptibility to Carbon Tetrachloride CTD PMID:16774739 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of AGTR2 mRNA CTD PMID:12832660 tetrathiomolybdate(2-) decreases expression ISO RGD:619558 6480464 tetrathiomolybdate analog results in decreased expression of AGTR2 mRNA CTD PMID:19323979 tributylstannane decreases expression ISO RGD:10126 6480464 tributyltin results in decreased expression of AGTR2 protein CTD PMID:30172001 trichloroethene decreases expression ISO RGD:10126 6480464 Trichloroethylene results in decreased expression of AGTR2 mRNA CTD PMID:15363585 triclosan increases expression ISO RGD:619558 6480464 Triclosan results in increased expression of AGTR2 mRNA CTD PMID:30510588 valproic acid decreases methylation ISO RGD:619558 6480464 Valproic Acid results in decreased methylation of AGTR2 gene CTD PMID:29154799 valproic acid increases expression ISO RGD:10126 6480464 Valproic Acid results in increased expression of AGTR2 mRNA CTD PMID:24896083 valsartan affects response to substance ISO RGD:10126 6480464 AGTR2 affects the susceptibility to Valsartan CTD PMID:12215461 valsartan increases expression EXP 6480464 Valsartan results in increased expression of AGTR2 protein CTD PMID:16982965 valsartan decreases expression EXP 6480464 Valsartan results in decreased expression of AGTR2 mRNA CTD PMID:18403896 valsartan multiple interactions EXP 6480464 [PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP] more ... CTD PMID:11403356 , PMID:16982965 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of AGTR2 mRNA CTD PMID:20566332 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of AGTR2 mRNA CTD PMID:20566332 XL147 multiple interactions ISO RGD:10126 6480464 [N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of AGTR2 mRNA CTD PMID:27935865
Gene-Chemical Interaction Annotations
