Agtr2 (angiotensin II receptor, type 2) - Rat Genome Database
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Gene: Agtr2 (angiotensin II receptor, type 2) Rattus norvegicus
Analyze
Symbol: Agtr2
Name: angiotensin II receptor, type 2
RGD ID: 2072
Description: Exhibits transcription factor binding activity. Involved in several processes, including aldosterone secretion; animal organ development; and regulation of secretion. Localizes to perinuclear region of cytoplasm and plasma membrane. Used to study chronic kidney disease; congenital diaphragmatic hernia; glomerulonephritis (multiple); hypertension (multiple); and meconium aspiration syndrome. Biomarker of several diseases, including asthma; congestive heart failure; glomerulosclerosis (multiple); hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2); PARTICIPATES IN angiotensin III signaling pathway via AT2 receptor; angiotensin II signaling pathway via AT2 receptor; G protein mediated signaling pathway via Galphai family; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: angiotensin II type 2 receptor; angiotensin II type-2 receptor; Angiotensin receptor 2; AT2; AT2-R; AT2R; AT2R; type-2 angiotensin II receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X119,389,480 - 119,393,845 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX119,390,013 - 119,393,842 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X119,534,483 - 119,538,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX111,375,374 - 111,376,465 (+)NCBICelera
Cytogenetic MapXq34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(R)-noradrenaline  (ISO)
(S)-nicotine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
aldosterone  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
angiotensin II  (EXP)
benzalkonium chloride  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (EXP)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP)
CGP-42112A  (EXP,ISO)
cholesterol  (EXP)
cilazapril monohydrate  (EXP)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
curcumin  (EXP)
dexamethasone  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (EXP)
edaravone  (EXP)
enalapril  (EXP)
entinostat  (ISO)
esculetin  (EXP)
ethanol  (EXP)
folic acid  (ISO)
fructose  (EXP)
genistein  (EXP)
glycidol  (EXP)
GW 3965  (EXP)
hydrogen peroxide  (ISO)
Ile(5)-angiotensin II  (EXP)
lipopolysaccharide  (EXP)
lithium chloride  (EXP)
losartan  (EXP,ISO)
Methylthiouracil  (EXP)
mevinphos  (EXP)
mifepristone  (EXP)
Nandrolone decanoate  (EXP)
nicotine  (EXP)
nitric oxide  (EXP)
nitrofen  (EXP)
p-menthan-3-ol  (ISO)
paraquat  (ISO)
PD123319  (EXP,ISO)
peroxynitrous acid  (EXP)
phenylephrine  (EXP,ISO)
picrotoxin  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP)
potassium bromate  (ISO)
reserpine  (EXP)
rotenone  (ISO)
sodium chloride  (EXP)
spironolactone  (EXP)
streptozocin  (EXP,ISO)
taurine  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aldosterone secretion  (IMP)
angiotensin-activated signaling pathway  (IEA)
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure  (ISO)
brain renin-angiotensin system  (ISO)
cell growth involved in cardiac muscle cell development  (IMP)
cell surface receptor signaling pathway  (ISO)
cellular response to dexamethasone stimulus  (IDA)
cellular sodium ion homeostasis  (IMP)
cerebellar cortex development  (IMP)
dopamine biosynthetic process  (IMP)
exploration behavior  (ISO)
G protein-coupled receptor signaling pathway  (IBA)
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  (ISO)
inflammatory response  (IBA,IDA,ISO)
intracellular signal transduction  (ISO)
kidney development  (IEP)
kidney morphogenesis  (IMP)
negative regulation of fibroblast proliferation  (IMP)
negative regulation of heart rate  (ISO)
negative regulation of icosanoid secretion  (IMP)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (ISO)
negative regulation of norepinephrine secretion  (IDA)
neuron differentiation  (TAS)
obsolete positive regulation of blood vessel diameter  (IMP)
positive regulation of branching involved in ureteric bud morphogenesis  (IMP,ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytokine production  (IMP)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of metanephric glomerulus development  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phosphoprotein phosphatase activity  (ISO)
positive regulation of renal sodium excretion  (IMP)
positive regulation of transcription, DNA-templated  (ISO)
regulation of metanephros size  (ISO)
regulation of protein import into nucleus  (IDA)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
renin-angiotensin regulation of aldosterone production  (IMP)
response to organonitrogen compound  (IEP)
vasodilation  (ISO)

Cellular Component

Molecular Function

References

References - curated
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6. Bonnet F, etal., J Hypertens. 2002 Aug;20(8):1615-24.
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21. Gendron L, etal., J Mol Endocrinol 2003 Dec;31(3):359-72.
22. Ghosh S, etal., Am J Med Sci. 2002 Dec;324(6):296-304.
23. GOA data from the GO Consortium
24. Goto M, etal., Hypertens Res. 2002 Jan;25(1):125-33.
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47. MGD data from the GO Consortium
48. Mii A, etal., Lab Invest. 2009 Feb;89(2):164-77. Epub 2009 Jan 12.
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50. Moulder JE, etal., Radiat Res. 2004 Mar;161(3):312-7.
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53. Nap A, etal., J Renin Angiotensin Aldosterone Syst 2003 Jun;4(2):100-5.
54. NCBI rat LocusLink and RefSeq merged data July 26, 2002
55. Nishimura H, etal., Mol Cell 1999 Jan;3(1):1-10.
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57. OMIM Disease Annotation Pipeline
58. Padia SH and Carey RM, Pflugers Arch. 2013 Jan;465(1):99-110. doi: 10.1007/s00424-012-1146-3. Epub 2012 Sep 5.
59. Padia SH, etal., Hypertension. 2006 Mar;47(3):537-44. Epub 2005 Dec 27.
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62. Pipeline to import KEGG annotations from KEGG into RGD
63. Reaux A, etal., Trends Endocrinol Metab. 2001 May-Jun;12(4):157-62.
64. RGD automated data pipeline
65. RGD automated import pipeline for gene-chemical interactions
66. Rigoli L, etal., Pediatr Res. 2004 Dec;56(6):988-93. Epub 2004 Oct 6.
67. Sabuhi R, etal., Am J Physiol Renal Physiol. 2011 Mar;300(3):F700-6. Epub 2011 Jan 5.
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Additional References at PubMed
PMID:7599191   PMID:7713098   PMID:8227010   PMID:8227011   PMID:9310306   PMID:9449684   PMID:9878677   PMID:10406457   PMID:10425188   PMID:11068047   PMID:11973418   PMID:12198247  
PMID:12203396   PMID:12420045   PMID:12452333   PMID:12468569   PMID:12477932   PMID:12482596   PMID:12573806   PMID:12609817   PMID:12694402   PMID:12828922   PMID:14684844   PMID:14718351  
PMID:15111328   PMID:15117835   PMID:15153556   PMID:15166182   PMID:15194486   PMID:15226636   PMID:15298543   PMID:15308873   PMID:15367388   PMID:15509535   PMID:15534073   PMID:15544836  
PMID:15572519   PMID:15578192   PMID:15615839   PMID:15746093   PMID:15838360   PMID:16043661   PMID:16122703   PMID:16204414   PMID:16286564   PMID:16330679   PMID:16380081   PMID:16380464  
PMID:16493576   PMID:16603705   PMID:16618840   PMID:16636899   PMID:16690714   PMID:16934905   PMID:17000928   PMID:17043228   PMID:17082724   PMID:17116755   PMID:17159079   PMID:17206447  
PMID:17237611   PMID:17291529   PMID:17485601   PMID:17525253   PMID:17540701   PMID:17656330   PMID:17670863   PMID:17766473   PMID:17880376   PMID:17884764   PMID:17950540   PMID:18006431  
PMID:18028779   PMID:18086951   PMID:18158338   PMID:18208547   PMID:18403896   PMID:18420945   PMID:18607644   PMID:18609298   PMID:18680145   PMID:18926066   PMID:18957383   PMID:18986337  
PMID:19114640   PMID:19151255   PMID:19298848   PMID:19353416   PMID:19379780   PMID:19404405   PMID:19429393   PMID:19513542   PMID:19590192   PMID:19591228   PMID:19808775   PMID:19879325  
PMID:19887855   PMID:19955853   PMID:20440098   PMID:20463030   PMID:20606474   PMID:20663845   PMID:20807798   PMID:20870653   PMID:20964730   PMID:21084406   PMID:21146214   PMID:21189402  
PMID:21288138   PMID:21303953   PMID:21468559   PMID:21484513   PMID:21752621   PMID:21896931   PMID:21967903   PMID:22120166   PMID:22129514   PMID:22287496   PMID:22318954   PMID:22378773  
PMID:22424324   PMID:22504846   PMID:22832514   PMID:22860435   PMID:22911895   PMID:22936038   PMID:23132538   PMID:23149621   PMID:23255326   PMID:23383303   PMID:23489258   PMID:23754618  
PMID:23807455   PMID:23823602   PMID:23871345   PMID:23978469   PMID:24085035   PMID:24464860   PMID:24819472   PMID:24958505   PMID:24971613   PMID:25100281   PMID:25119338   PMID:25170617  
PMID:25238020   PMID:25365520   PMID:25430897   PMID:25562714   PMID:25655919   PMID:25770092   PMID:26137805   PMID:27469059   PMID:27693081   PMID:27763643   PMID:27765882   PMID:27825832  
PMID:27923787   PMID:28160390   PMID:28161727   PMID:28438644   PMID:28695320   PMID:29140411   PMID:29186390   PMID:29289466   PMID:29393347   PMID:30058175   PMID:30190172   PMID:30221707  


Genomics

Comparative Map Data
Agtr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X119,389,480 - 119,393,845 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX119,390,013 - 119,393,842 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X119,534,483 - 119,538,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX111,375,374 - 111,376,465 (+)NCBICelera
Cytogenetic MapXq34NCBI
AGTR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX116,170,744 - 116,174,974 (+)EnsemblGRCh38hg38GRCh38
GRCh38X116,170,744 - 116,174,974 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X115,301,958 - 115,306,225 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X115,215,986 - 115,220,253 (+)NCBINCBI36hg18NCBI36
Build 34X115,113,884 - 115,117,702NCBI
CeleraX115,832,555 - 115,836,822 (-)NCBI
Cytogenetic MapXq23NCBI
HuRefX104,838,955 - 104,843,260 (+)NCBIHuRef
CHM1_1X115,212,791 - 115,217,059 (+)NCBICHM1_1
Agtr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X21,350,863 - 21,355,072 (+)NCBIGRCm39mm39
GRCm38X21,484,624 - 21,488,833 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX21,484,544 - 21,489,164 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X21,061,752 - 21,065,957 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X20,641,585 - 20,646,123 (+)NCBImm8
CeleraX19,607,387 - 19,611,593 (+)NCBICelera
Cytogenetic MapXA2NCBI
cM MapX16.71NCBI
Agtr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555343,653,157 - 3,654,248 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555343,653,112 - 3,654,248 (-)NCBIChiLan1.0ChiLan1.0
AGTR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X115,670,022 - 115,674,287 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX115,671,594 - 115,672,685 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X105,252,903 - 105,257,171 (+)NCBIMhudiblu_PPA_v0panPan3
AGTR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX88,705,765 - 88,706,853 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X88,703,551 - 88,708,451 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Agtr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647913,252,678 - 13,255,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGTR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX95,269,300 - 95,270,388 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X95,267,709 - 95,272,237 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X109,822,530 - 109,826,739 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGTR2
(Chlorocebus sabaeus - African green monkey)		 No map positions available.
Agtr2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624967327,627 - 332,000 (-)NCBI

Position Markers
DXWox27  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X119,403,504 - 119,403,637NCBIRnor6.0
Rnor_5.0X119,548,326 - 119,548,459UniSTSRnor5.0
CeleraX111,387,746 - 111,387,873UniSTS
Cytogenetic MapXq34UniSTS
DXMgh7  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X119,394,326 - 119,394,543NCBIRnor6.0
Rnor_6.01239,282,339 - 39,282,571NCBIRnor6.0
Rnor_5.01241,171,094 - 41,171,326UniSTSRnor5.0
Rnor_5.0X119,539,148 - 119,539,365UniSTSRnor5.0
RGSC_v3.41234,918,461 - 34,918,693UniSTSRGSC3.4
CeleraX111,378,557 - 111,378,785UniSTS
Celera1235,496,132 - 35,496,364UniSTS
Cytogenetic MapXq34UniSTS
Cytogenetic Map12q16UniSTS
SHRSP x BN MapX33.1599UniSTS
SHRSP x BN MapX33.1599RGD
FHH x ACI MapX34.6RGD
AW107640  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X119,393,367 - 119,393,453NCBIRnor6.0
Rnor_5.0X119,538,189 - 119,538,275UniSTSRnor5.0
CeleraX111,377,598 - 111,377,684UniSTS
Cytogenetic MapXq34UniSTS
RH139933  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X119,393,313 - 119,393,513NCBIRnor6.0
Rnor_5.0X119,538,135 - 119,538,335UniSTSRnor5.0
CeleraX111,377,544 - 111,377,744UniSTS
Cytogenetic MapXq34UniSTS
RH 3.4 Map11474.2UniSTS
PMC153509P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X119,391,632 - 119,391,913NCBIRnor6.0
Rnor_5.0X119,536,454 - 119,536,735UniSTSRnor5.0
CeleraX111,375,863 - 111,376,144UniSTS
Cytogenetic MapXq34UniSTS
Agtr2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X119,392,102 - 119,392,182NCBIRnor6.0
Rnor_5.0X119,536,924 - 119,537,004UniSTSRnor5.0
CeleraX111,376,333 - 111,376,413UniSTS
Cytogenetic MapXq34UniSTS
UniSTS:496533  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X119,391,207 - 119,392,168NCBIRnor6.0
Rnor_5.0X119,536,029 - 119,536,990UniSTSRnor5.0
CeleraX111,375,438 - 111,376,399UniSTS
Cytogenetic MapXq34UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X15688119127888215Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X44320616158345622Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX44557974120045269Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X70352120127888215Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X82930791127930791Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X101333032146333032Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX107886746152409805Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X110957467155957467Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X110957467155957467Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118715462159970021Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:500
Count of miRNA genes:264
Interacting mature miRNAs:323
Transcripts:ENSRNOT00000074269
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 8 1 1 18 25 1
Low 13 2 4 3 3 62 4 9 4 3
Below cutoff 3 6 25 19 10 19 3 3 10 6 4 7 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000074269   ⟹   ENSRNOP00000064709
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX119,390,013 - 119,393,842 (+)Ensembl
RefSeq Acc Id: NM_012494   ⟹   NP_036626
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X119,391,143 - 119,392,234 (+)NCBI
Rnor_5.0X119,534,483 - 119,538,667 (+)NCBI
CeleraX111,375,374 - 111,376,465 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257432   ⟹   XP_006257494
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X119,389,480 - 119,393,845 (+)NCBI
Rnor_5.0X119,534,483 - 119,538,667 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036626   ⟸   NM_012494
- UniProtKB: P35351 (UniProtKB/Swiss-Prot),   B1WBL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257494   ⟸   XM_006257432
- Peptide Label: isoform X1
- UniProtKB: P35351 (UniProtKB/Swiss-Prot),   B1WBL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064709   ⟸   ENSRNOT00000074269
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
AT2 I-TASSER model P35351 1-365 view protein structure  

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2072 AgrOrtholog
Ensembl Genes ENSRNOG00000050006 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000064709 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074269 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9102491 IMAGE-MGC_LOAD
InterPro ATII_AT2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATII_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24182 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187209 IMAGE-MGC_LOAD
NCBI Gene 24182 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AGTR2 RGD
PhenoGen Agtr2 PhenoGen
PRINTS ANGIOTENSINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANGIOTENSN2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.162367 ENTREZGENE
UniProt AGTR2_RAT UniProtKB/Swiss-Prot
  B1WBL8 ENTREZGENE, UniProtKB/TrEMBL
  P35351 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Agtr2  angiotensin II receptor, type 2    Angiotensin receptor 2  Name updated 629478 APPROVED
2002-06-10 Agtr2  Angiotensin receptor 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains an immunoreceptor tyrosine-based inhibitory (ITIM)-like motif (VIYPFL) in the cytoplasmic loop domain 625596
gene_expression expressed at high levels during the later stage of fetal development and in the neonate, but declines rapidly after birth 70604
gene_expression abundant in model of retinopathy of prematurity 1298608
gene_expression expressed in muscular and thin arterioles 1298648
gene_expression expressed throughout the rat kidney 1357917
gene_function binds to angiotensin II to facilitate arteriole vascular tone 1298648
gene_mutations_overexpression overexpression inhibits Agtr1 expression in vascular smooth muscle cells (VSMCs) 70604
gene_pathway retinal angiogenesis actions may converge on VEGF- and angiopoietin-dependent pathways 1298608
gene_process regulates growth and metabolism in vascular smooth muscle cells 70604
gene_process regulates growth and metabolism in vascular smooth muscle cells 625596
gene_process plays a role in regulating SHP-1 activity when constitutively associated with Gs and SHP-1 625596
gene_process exerts antiproliferative effect in endothelial and vascular smooth muscle cells 1298575
gene_process plays a role in pressure natriuresis 1298575
gene_process does not play a role in angiotensin I-mediated sympathetic neurotransmission by angiotensin II molecule 1298649
gene_process induces vasodilation 1298648
gene_product belongs to the family of seven-transmembrane G protein-coupled receptors 70604