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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tropisetron
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Accession:CHEBI:32269 term browser browse the term
Definition:An indolyl carboxylate ester obtained by formal condensation of the carboxy group of indole-3-carboxylic acid with the hydroxy group of tropine.
Synonyms:exact_synonym: (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylate
 related_synonym: 1alphaH,5alphaH-Tropan-3alpha-yl indole-3-carboxylate;   Formula=C17H20N2O2;   InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+;   InChIKey=ZNRGQMMCGHDTEI-ITGUQSILSA-N;   SMILES=CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12;   tropisetronum
 xref: CAS:89565-68-4;   Drug_Central:2775;   KEGG:C13666;   KEGG:D02130
 xref_mesh: MESH:C045504
 xref: PDBeChem:TKT;   PMID:22905891;   PMID:23135693;   PMID:23415734;   PMID:23440693;   PMID:23515583;   PMID:23717236;   PMID:23727438;   PMID:23774631;   PMID:23868810;   PMID:23896722;   PMID:23937291;   PMID:24226381;   PMID:24374478;   PMID:24389031;   PMID:24455480;   PMID:24461640;   Reaxys:3619989;   Wikipedia:Tropisetron
 cyclic_relationship: is_conjugate_base_of CHEBI:77571


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tropisetron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein] CTD PMID:38513929 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of BAX protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of BAX protein] CTD PMID:38513929 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 protein] CTD PMID:38513929 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp12 caspase 12 multiple interactions EXP Tropisetron inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP12 protein] CTD PMID:26286524 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 ISO
EXP		 Tropisetron results in increased expression of CASP3 protein modified form
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of CASP3 protein]]; methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of CASP3 protein]; Tropisetron inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]
Paclitaxel inhibits the reaction [Tropisetron results in increased expression of CASP3 protein modified form]		 CTD PMID:26286524 PMID:34654991 PMID:36504472 PMID:38513929 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP Tropisetron inhibits the reaction [Hydrogen Peroxide results in increased activity of CAT protein] CTD PMID:26286524 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases expression		 EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CCL3 protein] CTD PMID:23285267 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Cst3 cystatin C multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of CST3 protein] CTD PMID:33387473 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
decreases expression		 EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein] CTD PMID:23285267 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
decreases expression		 EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein] CTD PMID:23285267 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP tropisetron results in increased expression of HMOX1 protein
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased activity of HMOX1 protein]]; SB 203580 inhibits the reaction [Tropisetron results in increased expression of HMOX1 protein]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased activity of HMOX1 protein]; Tropisetron inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]		 CTD PMID:23285267 PMID:26286524 PMID:38513929 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression		 EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein] CTD PMID:23285267 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of IL1B protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of IL1B protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of IL1B protein]		 CTD PMID:24374478 PMID:36504472 PMID:38513929 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP tropisetron inhibits the reaction [Vincristine results in increased expression of IL2 protein] CTD PMID:24374478 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 EXP chromium mesoporphyrin inhibits the reaction [Tropisetron results in decreased expression of IL6 protein]; SB 203580 inhibits the reaction [Tropisetron results in decreased expression of IL6 protein]
tropisetron results in decreased expression of IL6 protein		 CTD PMID:23285267 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of IRAK1 protein] CTD PMID:36504472 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of JAK2 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of JAK2 protein] CTD PMID:38513929 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mir146a microRNA 146a multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of MIR146A mRNA] CTD PMID:36504472 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA] CTD PMID:33387473 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in decreased expression of MMP9 mRNA] CTD PMID:33387473 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity		 EXP
ISO		 chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased activity of MPO protein]; SB 203580 inhibits the reaction [tropisetron results in decreased activity of MPO protein]
tropisetron inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein]		 CTD PMID:23285267 PMID:25837923 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of NFE2L2 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of NFE2L2 protein]; Tropisetron inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 protein] CTD PMID:26286524 PMID:38513929 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 [Paclitaxel co-treated with Tropisetron] results in decreased expression of RELA protein
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of RELA protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of RELA protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of RELA protein]		 CTD PMID:34654991 PMID:36504472 PMID:38513929 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO tropisetron inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA] CTD PMID:33387473 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] CTD PMID:36504472 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 EXP
ISO		 chromium mesoporphyrin inhibits the reaction [Tropisetron results in decreased expression of TNF protein]; methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of TNF protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of TNF protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Tropisetron inhibits the reaction [Vincristine results in increased expression of TNF protein]
tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
tropisetron results in decreased expression of TNF protein		 CTD PMID:23285267 PMID:24374478 PMID:36504472 PMID:38513929 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of TP53 protein] CTD PMID:33387473 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of TRAF6 protein] CTD PMID:36504472 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        immunomodulator 15067
          tropisetron 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heterobicyclic compound 17237
                                      benzopyrrole 9739
                                        indoles 9427
                                          indolyl carboxylic acid 3463
                                            indol-3-yl carboxylic acid 3462
                                              indole-3-carboxylic acid 30
                                                tropisetron 29
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