Kmt2c (lysine methyltransferase 2C) - Rat Genome Database

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Pathways
Gene: Kmt2c (lysine methyltransferase 2C) Rattus norvegicus
Analyze
Symbol: Kmt2c
Name: lysine methyltransferase 2C
RGD ID: 1587205
Description: Predicted to enable histone H3K4 methyltransferase activity. Involved in response to electrical stimulus. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Used to study rheumatoid arthritis. Human ortholog(s) of this gene implicated in Kleefstra syndrome 2; carcinoma (multiple); and stomach cancer. Orthologous to human KMT2C (lysine methyltransferase 2C); PARTICIPATES IN DNA modification pathway; histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: histone-lysine N-methyltransferase 2C; LOC502710; lysine (K)-specific methyltransferase 2C; myeloid/lymphoid or mixed-lineage leukemia 3-like; similar to Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.249,620,638 - 9,834,787 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl49,609,627 - 9,833,539 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0482,506 - 109,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.046,083,650 - 6,294,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl46,083,736 - 6,292,516 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.046,104,240 - 6,315,339 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0482,826 - 109,979 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.445,020,018 - 5,239,019 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4484,949 - 698,981 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. SPLUNC1 and MLL3 regulate cancer stem cells in nasopharyngeal carcinoma. Bian S, etal., J BUON. 2019 Jul-Aug;24(4):1700-1705.
2. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
3. H3K4 Methylation Status and Lysine Specific Methyltransferase KMT2C Expression Correlate with Prognosis in Lung Adenocarcinoma. Bosgana P, etal., Curr Mol Pharmacol. 2021;14(6):1028-1036. doi: 10.2174/1874467213999200831130739.
4. MLL3 Inhibits Apoptosis of Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Promotes Secretion of Inflammatory Factors by Activating CCL2 and the NF-κB Pathway. Fan W, etal., Inflammation. 2021 Oct;44(5):1803-1814. doi: 10.1007/s10753-021-01459-2. Epub 2021 Apr 29.
5. Comprehensive analysis of genomic alterations of Chinese hilar cholangiocarcinoma patients. Feng F, etal., Int J Clin Oncol. 2021 Apr;26(4):717-727. doi: 10.1007/s10147-020-01846-z. Epub 2021 Jan 2.
6. Assessment of MLL methyltransferase gene expression in larynx carcinoma. Figueiredo DL, etal., Oncol Rep. 2015 Apr;33(4):2017-22. doi: 10.3892/or.2015.3756. Epub 2015 Jan 28.
7. Genetic landscape of esophageal squamous cell carcinoma. Gao YB, etal., Nat Genet. 2014 Oct;46(10):1097-102. doi: 10.1038/ng.3076. Epub 2014 Aug 24.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma. Ho AS, etal., J Clin Invest. 2019 Oct 1;129(10):4276-4289. doi: 10.1172/JCI128227.
10. Mll3 genetic variants affect risk of gastric cancer in the chinese han population. Li B, etal., Asian Pac J Cancer Prev. 2013;14(7):4239-42. doi: 10.7314/apjcp.2013.14.7.4239.
11. Association of MLL3 expression with prognosis in gastric cancer. Li B, etal., Genet Mol Res. 2014 Sep 12;13(3):7513-8. doi: 10.4238/2014.September.12.18.
12. A missense mutation (S3660L) in MLL3 gene influences risk of gastric cancer. Li B, etal., J BUON. 2014 Apr-Jun;19(2):394-7.
13. ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Long HK, etal., Biochem Soc Trans. 2013 Jun;41(3):727-40. doi: 10.1042/BST20130028.
14. Genomic Analyses for Predictors of Response to Chemoradiation in Stage III Non-Small Cell Lung Cancer. Luo LY, etal., Adv Radiat Oncol. 2020 Nov 14;6(1):100615. doi: 10.1016/j.adro.2020.10.027. eCollection 2021 Jan-Feb.
15. Mutational landscape of aggressive cutaneous squamous cell carcinoma. Pickering CR, etal., Clin Cancer Res. 2014 Oct 10. pii: clincanres.1768.2014.
16. Acute and Chronic Electroconvulsive Seizures (ECS) Differentially Regulate the Expression of Epigenetic Machinery in the Adult Rat Hippocampus. Pusalkar M, etal., Int J Neuropsychopharmacol. 2016 Sep 21;19(9). pii: pyw040. doi: 10.1093/ijnp/pyw040. Print 2016 Sep.
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Shilatifard A Annu Rev Biochem. 2012;81:65-95. doi: 10.1146/annurev-biochem-051710-134100.
21. Deregulated expression of selected histone methylases and demethylases in prostate carcinoma. Vieira FQ, etal., Endocr Relat Cancer. 2013 Dec 16;21(1):51-61. doi: 10.1530/ERC-13-0375. Print 2014 Feb.
22. Comprehensive analysis of age-related somatic mutation profiles in Chinese young lung adenocarcinoma patients. Yang B, etal., Cancer Med. 2019 Apr;8(4):1350-1358. doi: 10.1002/cam4.1839. Epub 2019 Mar 1.
Additional References at PubMed
PMID:17021013   PMID:17500065   PMID:18172164   PMID:22266653   PMID:22658674   PMID:26324722  


Genomics

Comparative Map Data
Kmt2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.249,620,638 - 9,834,787 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl49,609,627 - 9,833,539 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0482,506 - 109,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.046,083,650 - 6,294,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl46,083,736 - 6,292,516 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.046,104,240 - 6,315,339 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0482,826 - 109,979 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.445,020,018 - 5,239,019 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4484,949 - 698,981 (-)NCBICelera
Cytogenetic Map4q11NCBI
KMT2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387152,134,925 - 152,436,003 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7152,134,922 - 152,436,644 (-)EnsemblGRCh38hg38GRCh38
GRCh377151,832,010 - 152,133,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367151,462,943 - 151,764,023 (-)NCBINCBI36Build 36hg18NCBI36
Build 347151,271,503 - 151,570,699NCBI
Celera7146,389,572 - 146,690,258 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7145,643,457 - 145,868,582 (-)NCBIHuRef
CHM1_17151,840,538 - 152,142,092 (-)NCBICHM1_1
T2T-CHM13v2.07153,307,815 - 153,608,900 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27151,159,181 - 151,460,261 (-)NCBI
Kmt2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39525,476,793 - 25,703,853 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl525,476,796 - 25,703,781 (-)EnsemblGRCm39 Ensembl
GRCm38525,271,795 - 25,498,855 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl525,271,798 - 25,498,783 (-)EnsemblGRCm38mm10GRCm38
MGSCv37524,777,612 - 25,004,601 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36524,781,859 - 25,008,848 (-)NCBIMGSCv36mm8
Celera522,207,830 - 22,380,620 (-)NCBICelera
Cytogenetic Map5B1NCBI
Kmt2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554916,247,249 - 6,402,470 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554916,245,408 - 6,420,535 (-)NCBIChiLan1.0ChiLan1.0
KMT2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1740,560,348 - 40,862,006 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07143,714,716 - 144,016,188 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17155,860,699 - 156,081,038 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7155,862,610 - 156,081,043 (-)Ensemblpanpan1.1panPan2
KMT2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,962,045 - 16,117,601 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,963,901 - 16,158,408 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1616,575,056 - 16,858,922 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01617,685,626 - 17,972,552 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11616,062,320 - 16,346,556 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01616,643,550 - 16,927,359 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01616,694,819 - 16,978,785 (-)NCBIUU_Cfam_GSD_1.0
Kmt2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051185,323,045 - 5,592,544 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365277,312,721 - 7,506,365 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365277,310,885 - 7,508,032 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KMT2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl184,993,227 - 5,278,723 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1184,993,213 - 5,279,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2185,538,409 - 5,587,967 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KMT2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121120,299,295 - 120,587,843 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21120,301,188 - 120,587,137 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607216,283,079 - 16,504,530 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kmt2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248004,511,549 - 4,784,053 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248004,510,669 - 4,785,909 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kmt2c
663 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat

Markers in Region
RH133147  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.249,833,857 - 9,834,042 (+)MAPPERmRatBN7.2
Rnor_6.046,293,484 - 6,293,668NCBIRnor6.0
Rnor_5.046,314,410 - 6,314,594UniSTSRnor5.0
RGSC_v3.445,238,090 - 5,238,274UniSTSRGSC3.4
Celera4485,694 - 485,878UniSTS
Cytogenetic Map4q11UniSTS
RH139525  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.249,834,444 - 9,834,641 (+)MAPPERmRatBN7.2
Rnor_6.046,294,071 - 6,294,267NCBIRnor6.0
Rnor_5.046,314,997 - 6,315,193UniSTSRnor5.0
RGSC_v3.445,238,677 - 5,238,873UniSTSRGSC3.4
Celera4485,095 - 485,291UniSTS
Cytogenetic Map4q11UniSTS
RH137632  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q11UniSTS
D7S3202  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.249,834,309 - 9,834,727 (+)MAPPERmRatBN7.2
Rnor_6.046,293,936 - 6,294,353NCBIRnor6.0
Rnor_5.046,314,862 - 6,315,279UniSTSRnor5.0
RGSC_v3.445,238,542 - 5,238,959UniSTSRGSC3.4
Celera4485,009 - 485,426UniSTS
Cytogenetic Map4q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 26 10 17 10 8 8 71 28 33 8 8
Low 3 31 30 30 2 30 3 3 7 8 3
Below cutoff 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_006224786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005504104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005504105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005504106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide FQ219148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000010349   ⟹   ENSRNOP00000010349
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl46,282,278 - 6,292,487 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077289   ⟹   ENSRNOP00000072878
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl46,159,006 - 6,201,526 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093625
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl49,620,538 - 9,833,539 (+)Ensembl
Rnor_6.0 Ensembl46,083,736 - 6,292,516 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101551   ⟹   ENSRNOP00000089164
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl49,609,627 - 9,833,539 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103015   ⟹   ENSRNOP00000078989
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl49,620,487 - 9,833,539 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108916   ⟹   ENSRNOP00000086031
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl49,620,634 - 9,833,539 (+)Ensembl
RefSeq Acc Id: XM_008762670   ⟹   XP_008760892
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,833,088 (+)NCBI
Rnor_6.046,083,650 - 6,294,413 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108963   ⟹   XP_038964891
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,834,787 (+)NCBI
RefSeq Acc Id: XM_039108964   ⟹   XP_038964892
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108965   ⟹   XP_038964893
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108966   ⟹   XP_038964894
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108967   ⟹   XP_038964895
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108968   ⟹   XP_038964896
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,654,534 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108969   ⟹   XP_038964897
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108970   ⟹   XP_038964898
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,654,535 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108971   ⟹   XP_038964899
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108972   ⟹   XP_038964900
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108973   ⟹   XP_038964901
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108974   ⟹   XP_038964902
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108975   ⟹   XP_038964903
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108976   ⟹   XP_038964904
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,909 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108977   ⟹   XP_038964905
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,909 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108978   ⟹   XP_038964906
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108979   ⟹   XP_038964907
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,640 - 9,833,088 (+)NCBI
RefSeq Acc Id: XM_039108981   ⟹   XP_038964909
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,638 - 9,812,490 (+)NCBI
RefSeq Acc Id: XM_039108982   ⟹   XP_038964910
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,638 - 9,807,803 (+)NCBI
RefSeq Acc Id: XR_005504104
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,638 - 9,814,979 (+)NCBI
RefSeq Acc Id: XR_005504105
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,638 - 9,814,980 (+)NCBI
RefSeq Acc Id: XR_005504106
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.249,620,638 - 9,814,955 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_008760892   ⟸   XM_008762670
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: ENSRNOP00000072878   ⟸   ENSRNOT00000077289
RefSeq Acc Id: ENSRNOP00000010349   ⟸   ENSRNOT00000010349
RefSeq Acc Id: XP_038964909   ⟸   XM_039108981
- Peptide Label: isoform X19
RefSeq Acc Id: XP_038964910   ⟸   XM_039108982
- Peptide Label: isoform X20
RefSeq Acc Id: XP_038964891   ⟸   XM_039108963
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A4Z1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964897   ⟸   XM_039108969
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038964894   ⟸   XM_039108966
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038964899   ⟸   XM_039108971
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038964893   ⟸   XM_039108965
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038964902   ⟸   XM_039108974
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038964906   ⟸   XM_039108978
- Peptide Label: isoform X17
RefSeq Acc Id: XP_038964907   ⟸   XM_039108979
- Peptide Label: isoform X18
RefSeq Acc Id: XP_038964903   ⟸   XM_039108975
- Peptide Label: isoform X14
RefSeq Acc Id: XP_038964901   ⟸   XM_039108973
- Peptide Label: isoform X12
- UniProtKB: A0A8I6A825 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964900   ⟸   XM_039108972
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038964895   ⟸   XM_039108967
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038964892   ⟸   XM_039108964
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038964904   ⟸   XM_039108976
- Peptide Label: isoform X15
RefSeq Acc Id: XP_038964905   ⟸   XM_039108977
- Peptide Label: isoform X16
RefSeq Acc Id: XP_038964896   ⟸   XM_039108968
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038964898   ⟸   XM_039108970
- Peptide Label: isoform X8
RefSeq Acc Id: ENSRNOP00000078989   ⟸   ENSRNOT00000103015
RefSeq Acc Id: ENSRNOP00000086031   ⟸   ENSRNOT00000108916
RefSeq Acc Id: ENSRNOP00000089164   ⟸   ENSRNOT00000101551
Protein Domains
FYR C-terminal   FYR N-terminal   PHD-type   Post-SET   RING-type   SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K426-F1-model_v2 AlphaFold A0A0G2K426 1-738 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587205 AgrOrtholog
BioCyc Gene G2FUF-46086 BioCyc
Ensembl Genes ENSRNOG00000061080 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000078989 ENTREZGENE
  ENSRNOP00000078989.1 UniProtKB/TrEMBL
  ENSRNOP00000086031 ENTREZGENE
  ENSRNOP00000086031.1 UniProtKB/TrEMBL
  ENSRNOP00000089164 ENTREZGENE
  ENSRNOP00000089164.1 UniProtKB/TrEMBL
  ENSRNOP00000089859 ENTREZGENE
  ENSRNOP00000089859.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000093625 ENTREZGENE
  ENSRNOT00000093625.2 UniProtKB/TrEMBL
  ENSRNOT00000101551 ENTREZGENE
  ENSRNOT00000101551.1 UniProtKB/TrEMBL
  ENSRNOT00000103015 ENTREZGENE
  ENSRNOT00000103015.1 UniProtKB/TrEMBL
  ENSRNOT00000108916 ENTREZGENE
  ENSRNOT00000108916.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
  2.170.270.10 UniProtKB/TrEMBL
  3.30.160.360 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro EPHD UniProtKB/TrEMBL
  FYrich_C UniProtKB/TrEMBL
  FYrich_N UniProtKB/TrEMBL
  HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  HMGI/Y_DNA-bd_CS UniProtKB/TrEMBL
  KMT2C UniProtKB/TrEMBL
  KMT2C_ePHD1 UniProtKB/TrEMBL
  KMT2C_ePHD2 UniProtKB/TrEMBL
  KMT2C_PHD2 UniProtKB/TrEMBL
  KMT2C_PHD6 UniProtKB/TrEMBL
  Post-SET_dom UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene 502710 ENTREZGENE
PANTHER HL01030P-RELATED UniProtKB/TrEMBL
  PTHR45888:SF1 UniProtKB/TrEMBL
Pfam FYRC UniProtKB/TrEMBL
  FYRN UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  zf-HC5HC2H UniProtKB/TrEMBL
  zf-HC5HC2H_2 UniProtKB/TrEMBL
PhenoGen Kmt2c PhenoGen
PROSITE DHHC UniProtKB/TrEMBL
  EPHD UniProtKB/TrEMBL
  FYRC UniProtKB/TrEMBL
  FYRN UniProtKB/TrEMBL
  HMGI_Y UniProtKB/TrEMBL
  POST_SET UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART FYRC UniProtKB/TrEMBL
  FYRN UniProtKB/TrEMBL
  HMG UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  PostSET UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
  SET UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
UniProt A0A8I6A4Z1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A825 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A900_RAT UniProtKB/TrEMBL
  A0A8I6G4C0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kmt2c  lysine methyltransferase 2C  Kmt2c  lysine (K)-specific methyltransferase 2C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-09 Kmt2c  lysine (K)-specific methyltransferase 2C  LOC502710  similar to Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 LOC502710  similar to Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3)  LOC100364718  myeloid/lymphoid or mixed-lineage leukemia 3-like  Data Merged 1643240 APPROVED
2010-05-05 LOC100364718  myeloid/lymphoid or mixed-lineage leukemia 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC502710  similar to Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3)  LOC679252  similar to Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3)  Data Merged 1643240 APPROVED
2006-11-20 LOC679252  similar to Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC502710  similar to Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3)      Symbol and Name status set to provisional 70820 PROVISIONAL