Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Kmt2c (lysine (K)-specific methyltransferase 2C) Mus musculus
Symbol: Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Description: Predicted to have histone binding activity; histone methyltransferase activity (H3-K4 specific); and transcription coactivator activity. Involved in several processes, including eyelid development in camera-type eye; growth; and positive regulation of fibroblast proliferation. Predicted to localize to the MLL3/4 complex. Human ortholog(s) of this gene implicated in Kleefstra syndrome; esophagus squamous cell carcinoma; and squamous cell carcinoma. Is expressed in several structures, including eye; genitourinary system; limb; nervous system; and neural ectoderm. Orthologous to human KMT2C (lysine methyltransferase 2C); PARTICIPATES IN DNA modification pathway; histone modification pathway; lysine degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E330008K23Rik; HALR; histone-lysine N-methyltransferase 2C; histone-lysine N-methyltransferase MLL3; KIAA1506; lysine N-methyltransferase 2C; mKIAA1506; Mll3; myeloid/lymphoid or mixed-lineage leukemia 3; myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
Homo sapiens (human) : KMT2C (lysine methyltransferase 2C)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kmt2c (lysine methyltransferase 2C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt2c (lysine methyltransferase 2C)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT2C (lysine methyltransferase 2C)
Canis lupus familiaris (dog) : KMT2C (lysine methyltransferase 2C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt2c (lysine methyltransferase 2C)
Sus scrofa (pig) : KMT2C (lysine methyltransferase 2C)
Chlorocebus sabaeus (green monkey) : KMT2C (lysine methyltransferase 2C)
Heterocephalus glaber (naked mole-rat) : Kmt2c (lysine methyltransferase 2C)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl525,271,798 - 25,498,783 (-)Ensembl
GRCm38525,271,795 - 25,498,855 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37524,777,612 - 25,004,601 (-)NCBIGRCm37mm9NCBIm37
MGSCv36524,781,859 - 25,008,848 (-)NCBImm8
Celera522,207,830 - 22,380,620 (-)NCBICelera
Cytogenetic Map5 A3-B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Kmt2c
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1616546
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2019-12-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.