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Gene: Kmt2c (lysine (K)-specific methyltransferase 2C) Mus musculus
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Symbol: Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Description: Predicted to have histone binding activity; histone methyltransferase activity (H3-K4 specific); and transcription coactivator activity. Involved in several processes, including eyelid development in camera-type eye; growth; and positive regulation of fibroblast proliferation. Predicted to localize to the MLL3/4 complex. Human ortholog(s) of this gene implicated in Kleefstra syndrome; esophagus squamous cell carcinoma; and squamous cell carcinoma. Is expressed in several structures, including eye; genitourinary system; limb; nervous system; and neural ectoderm. Orthologous to human KMT2C (lysine methyltransferase 2C); PARTICIPATES IN DNA modification pathway; histone modification pathway; lysine degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E330008K23Rik; HALR; histone-lysine N-methyltransferase 2C; histone-lysine N-methyltransferase MLL3; KIAA1506; lysine N-methyltransferase 2C; mKIAA1506; Mll3; myeloid/lymphoid or mixed-lineage leukemia 3; myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
Orthologs:
Homo sapiens (human) : KMT2C (lysine methyltransferase 2C)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kmt2c (lysine methyltransferase 2C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt2c (lysine methyltransferase 2C)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT2C (lysine methyltransferase 2C)
Canis lupus familiaris (dog) : KMT2C (lysine methyltransferase 2C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt2c (lysine methyltransferase 2C)
Sus scrofa (pig) : KMT2C (lysine methyltransferase 2C)
Chlorocebus sabaeus (green monkey) : KMT2C (lysine methyltransferase 2C)
Heterocephalus glaber (naked mole-rat) : Kmt2c (lysine methyltransferase 2C)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl525,271,798 - 25,498,783 (-)Ensembl
GRCm38525,271,795 - 25,498,855 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37524,777,612 - 25,004,601 (-)NCBIGRCm37mm9NCBIm37
MGSCv36524,781,859 - 25,008,848 (-)NCBImm8
Celera522,207,830 - 22,380,620 (-)NCBICelera
Cytogenetic Map5 A3-B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Kmt2c
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1616546
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2019-12-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.