Septin8 (septin 8) - Rat Genome Database

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Gene: Septin8 (septin 8) Rattus norvegicus
Analyze
Symbol: Septin8
Name: septin 8
RGD ID: 1308449
Description: Enables SNARE binding activity. Involved in regulation of SNARE complex assembly. Located in myelin sheath. Is active in presynapse. Orthologous to human SEPTIN8 (septin 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC303135; Sept8; septin-8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,185,454 - 38,214,502 (+)NCBIGRCr8
mRatBN7.21037,684,649 - 37,713,704 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,684,639 - 37,713,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,376,979 - 42,400,518 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,867,032 - 41,890,570 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,370,758 - 37,394,297 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,877,422 - 38,906,480 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,877,422 - 38,906,482 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,659,245 - 38,688,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,988,030 - 39,011,730 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11038,993,612 - 39,024,558 (+)NCBI
Celera1037,030,427 - 37,054,117 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,5-hexanedione  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
ivermectin  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
morphine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
rac-lactic acid  (ISO)
rifampicin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tamoxifen  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin. Ito H, etal., J Neurochem. 2009 Feb;108(4):867-80. doi: 10.1111/j.1471-4159.2008.05849.x.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. Yamaguchi Y, etal., J Neurosci Res. 2008 Mar;86(4):766-75.
Additional References at PubMed
PMID:12477932   PMID:17634366   PMID:17709200   PMID:18809578   PMID:22871113   PMID:27084579  


Genomics

Comparative Map Data
Septin8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,185,454 - 38,214,502 (+)NCBIGRCr8
mRatBN7.21037,684,649 - 37,713,704 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,684,639 - 37,713,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,376,979 - 42,400,518 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,867,032 - 41,890,570 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,370,758 - 37,394,297 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,877,422 - 38,906,480 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,877,422 - 38,906,482 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,659,245 - 38,688,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,988,030 - 39,011,730 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11038,993,612 - 39,024,558 (+)NCBI
Celera1037,030,427 - 37,054,117 (+)NCBICelera
Cytogenetic Map10q22NCBI
SEPTIN8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,750,819 - 132,780,083 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,750,819 - 132,807,241 (-)EnsemblGRCh38hg38GRCh38
GRCh375132,086,511 - 132,113,704 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,114,408 - 132,141,460 (-)NCBINCBI36Build 36hg18NCBI36
Build 345132,119,595 - 132,140,966NCBI
Celera5128,216,608 - 128,243,585 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,279,118 - 127,306,224 (-)NCBIHuRef
CHM1_15131,519,780 - 131,546,835 (-)NCBICHM1_1
T2T-CHM13v2.05133,270,556 - 133,297,751 (-)NCBIT2T-CHM13v2.0
Septin8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,410,224 - 53,440,432 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,410,084 - 53,440,392 (+)EnsemblGRCm39 Ensembl
GRCm381153,519,397 - 53,549,605 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,519,257 - 53,549,565 (+)EnsemblGRCm38mm10GRCm38
MGSCv371153,333,302 - 53,357,598 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,363,223 - 53,387,519 (+)NCBIMGSCv36mm8
Celera1158,099,719 - 58,123,580 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.96NCBI
Septin8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554084,126,745 - 4,144,064 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554084,129,302 - 4,143,683 (-)NCBIChiLan1.0ChiLan1.0
SEPTIN8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24128,062,946 - 128,090,496 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,202,510 - 126,229,552 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,167,699 - 128,194,750 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,327,735 - 134,355,677 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,327,735 - 134,355,677 (-)Ensemblpanpan1.1panPan2
SEPTIN8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,052,833 - 21,078,721 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,054,025 - 21,113,608 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,854,451 - 19,880,893 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,838,844 - 21,865,301 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,835,529 - 21,864,799 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,557,313 - 20,583,758 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,405,017 - 20,431,448 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01121,047,382 - 21,073,891 (-)NCBIUU_Cfam_GSD_1.0
Septin8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,421,662 - 115,447,110 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,424,371 - 2,451,197 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,424,029 - 2,450,459 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SEPTIN8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2135,077,170 - 135,104,471 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12135,077,158 - 135,104,484 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,545,457 - 140,572,862 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SEPTIN8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,567,687 - 35,595,051 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,567,347 - 35,594,588 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,347,419 - 42,374,731 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Septin8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473339,315,743 - 39,340,692 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Septin8
215 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:681
Count of miRNA genes:275
Interacting mature miRNAs:368
Transcripts:ENSRNOT00000065229
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
RH129318  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,708,125 - 37,708,306 (+)MAPPERmRatBN7.2
Rnor_6.01038,900,907 - 38,901,087NCBIRnor6.0
Rnor_5.01038,682,636 - 38,682,816UniSTSRnor5.0
RGSC_v3.41039,011,515 - 39,011,695UniSTSRGSC3.4
Celera1037,053,902 - 37,054,082UniSTS
RH 3.4 Map10405.7UniSTS
Cytogenetic Map10q22UniSTS
RH131244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,706,169 - 37,706,380 (+)MAPPERmRatBN7.2
Rnor_6.01038,898,951 - 38,899,161NCBIRnor6.0
Rnor_5.01038,680,680 - 38,680,890UniSTSRnor5.0
RGSC_v3.41039,009,559 - 39,009,769UniSTSRGSC3.4
Celera1037,051,946 - 37,052,156UniSTS
RH 3.4 Map10404.7UniSTS
Cytogenetic Map10q22UniSTS
RH140301  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,707,682 - 37,707,888 (+)MAPPERmRatBN7.2
Rnor_6.01038,900,464 - 38,900,669NCBIRnor6.0
Rnor_5.01038,682,193 - 38,682,398UniSTSRnor5.0
RGSC_v3.41039,011,072 - 39,011,277UniSTSRGSC3.4
Celera1037,053,459 - 37,053,664UniSTS
RH 3.4 Map10406.2UniSTS
Cytogenetic Map10q22UniSTS
REN71571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,705,527 - 37,705,759 (+)MAPPERmRatBN7.2
Rnor_6.01038,898,309 - 38,898,540NCBIRnor6.0
Rnor_5.01038,680,038 - 38,680,269UniSTSRnor5.0
RGSC_v3.41039,008,917 - 39,009,148UniSTSRGSC3.4
Celera1037,051,304 - 37,051,535UniSTS
Cytogenetic Map10q22UniSTS
REN71570  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,705,733 - 37,705,981 (+)MAPPERmRatBN7.2
Rnor_6.01038,898,515 - 38,898,762NCBIRnor6.0
Rnor_5.01038,680,244 - 38,680,491UniSTSRnor5.0
RGSC_v3.41039,009,123 - 39,009,370UniSTSRGSC3.4
Celera1037,051,510 - 37,051,757UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC114017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000065229   ⟹   ENSRNOP00000063893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,684,639 - 37,708,341 (+)Ensembl
Rnor_6.0 Ensembl1038,877,422 - 38,901,122 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083162   ⟹   ENSRNOP00000074199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,684,639 - 37,713,174 (+)Ensembl
Rnor_6.0 Ensembl1038,877,503 - 38,906,482 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091236   ⟹   ENSRNOP00000069670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,696,102 - 37,713,174 (+)Ensembl
Rnor_6.0 Ensembl1038,889,370 - 38,898,823 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106665   ⟹   ENSRNOP00000082006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,695,470 - 37,708,341 (+)Ensembl
RefSeq Acc Id: NM_001107002   ⟹   NP_001100472
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,185,457 - 38,209,144 (+)NCBI
mRatBN7.21037,684,652 - 37,708,341 (+)NCBI
Rnor_6.01038,877,422 - 38,901,122 (+)NCBI
Rnor_5.01038,659,245 - 38,688,209 (+)NCBI
RGSC_v3.41038,988,030 - 39,011,730 (+)RGD
Celera1037,030,427 - 37,054,117 (+)RGD
Sequence:
RefSeq Acc Id: NM_001414347   ⟹   NP_001401276
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,185,457 - 38,214,502 (+)NCBI
mRatBN7.21037,684,652 - 37,713,701 (+)NCBI
RefSeq Acc Id: XM_006246268   ⟹   XP_006246330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,185,454 - 38,214,502 (+)NCBI
mRatBN7.21037,684,649 - 37,713,703 (+)NCBI
Rnor_6.01038,877,441 - 38,906,480 (+)NCBI
Rnor_5.01038,659,245 - 38,688,209 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597254   ⟹   XP_017452743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,185,659 - 38,214,502 (+)NCBI
mRatBN7.21037,696,587 - 37,713,704 (+)NCBI
Rnor_6.01038,889,370 - 38,906,480 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597255   ⟹   XP_017452744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,185,454 - 38,209,145 (+)NCBI
mRatBN7.21037,696,587 - 37,708,342 (+)NCBI
Rnor_6.01038,889,370 - 38,901,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597256   ⟹   XP_017452745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,185,454 - 38,209,145 (+)NCBI
mRatBN7.21037,696,587 - 37,705,728 (+)NCBI
Rnor_6.01038,889,370 - 38,901,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597258   ⟹   XP_017452747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,185,454 - 38,209,145 (+)NCBI
mRatBN7.21037,684,649 - 37,708,342 (+)NCBI
Rnor_6.01038,877,441 - 38,901,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063268975   ⟹   XP_063125045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,192,645 - 38,214,502 (+)NCBI
RefSeq Acc Id: XM_063268976   ⟹   XP_063125046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,185,454 - 38,214,502 (+)NCBI
RefSeq Acc Id: XM_063268977   ⟹   XP_063125047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,185,454 - 38,209,145 (+)NCBI
RefSeq Acc Id: XM_063268978   ⟹   XP_063125048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,185,454 - 38,209,145 (+)NCBI
RefSeq Acc Id: XM_063268979   ⟹   XP_063125049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,185,659 - 38,214,502 (+)NCBI
RefSeq Acc Id: XM_063268980   ⟹   XP_063125050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,185,681 - 38,214,502 (+)NCBI
RefSeq Acc Id: NP_001100472   ⟸   NM_001107002
- Peptide Label: isoform 2
- UniProtKB: B0BNF1 (UniProtKB/Swiss-Prot),   G3V9Z6 (UniProtKB/TrEMBL),   A6HED2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246330   ⟸   XM_006246268
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JVY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452747   ⟸   XM_017597258
- Peptide Label: isoform X4
- UniProtKB: B0BNF1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017452743   ⟸   XM_017597254
- Peptide Label: isoform X10
- UniProtKB: A0A0G2JVY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452745   ⟸   XM_017597256
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017452744   ⟸   XM_017597255
- Peptide Label: isoform X5
- Sequence:
Ensembl Acc Id: ENSRNOP00000063893   ⟸   ENSRNOT00000065229
Ensembl Acc Id: ENSRNOP00000069670   ⟸   ENSRNOT00000091236
Ensembl Acc Id: ENSRNOP00000074199   ⟸   ENSRNOT00000083162
Ensembl Acc Id: ENSRNOP00000082006   ⟸   ENSRNOT00000106665
RefSeq Acc Id: NP_001401276   ⟸   NM_001414347
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K7G7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125046   ⟸   XM_063268976
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063125047   ⟸   XM_063268977
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063125048   ⟸   XM_063268978
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063125049   ⟸   XM_063268979
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063125050   ⟸   XM_063268980
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063125045   ⟸   XM_063268975
- Peptide Label: isoform X1
Protein Domains
Septin-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BNF1-F1-model_v2 AlphaFold B0BNF1 1-442 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697180
Promoter ID:EPDNEW_R7703
Type:initiation region
Name:Sept8_1
Description:septin 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01038,877,435 - 38,877,495EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308449 AgrOrtholog
BioCyc Gene G2FUF-25138 BioCyc
Ensembl Genes ENSRNOG00000007462 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065229.3 UniProtKB/TrEMBL
  ENSRNOT00000083162.2 UniProtKB/TrEMBL
  ENSRNOT00000091236.2 UniProtKB/TrEMBL
  ENSRNOT00000106665.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7314654 IMAGE-MGC_LOAD
InterPro G_SEPTIN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Septin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:303135 UniProtKB/TrEMBL
MGC_CLONE MGC:188183 IMAGE-MGC_LOAD
NCBI Gene 303135 ENTREZGENE
PANTHER PTHR18884:SF54 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEPTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Septin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Septin8 PhenoGen
PIRSF Septin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_SEPTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007462 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVY6 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K7G7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G6V9_RAT UniProtKB/TrEMBL
  A6HED2 ENTREZGENE, UniProtKB/TrEMBL
  B0BNF1 ENTREZGENE
  G3V9Z6 ENTREZGENE, UniProtKB/TrEMBL
  SEPT8_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Septin8  septin 8  Sept8  septin 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Sept8  septin 8   Sept8_predicted  septin 8 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sept8_predicted  septin 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED