Stc2 (stanniocalcin 2) - Rat Genome Database

Name: Stc2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Stc2 (stanniocalcin 2) Rattus norvegicus

Analyze

Symbol:

Stc2

Name:

stanniocalcin 2

RGD ID:

621777

Description:

Predicted to enable enzyme binding activity; heme binding activity; and protein homodimerization activity. Involved in several processes, including decidualization; embryo implantation; and response to vitamin D. Acts upstream of or within cellular calcium ion homeostasis. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Predicted to be active in extracellular space. Orthologous to human STC2 (stanniocalcin 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

stanniocalcin-2; STC-2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	STC2 (stanniocalcin 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Stc2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Stc2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	STC2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	STC2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Stc2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	STC2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	STC2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Stc2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Stc2 (stanniocalcin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	STC2 (stanniocalcin 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	stc2b (stanniocalcin 2b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	stc2a (stanniocalcin 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	W01A8.8	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	16,251,046 - 16,260,815 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	16,250,853 - 16,262,973 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	20,999,993 - 21,009,760 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	20,488,943 - 20,498,710 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	15,978,545 - 15,988,328 (+)	NCBI	Rnor_WKY
Rnor_6.0	10	16,542,909 - 16,552,675 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	16,542,882 - 16,553,295 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	16,432,189 - 16,441,955 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	16,514,603 - 16,524,369 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	16,515,651 - 16,525,418 (+)	NCBI
Celera	10	15,912,872 - 15,922,638 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

endometriosis (ISO)

Experimental Mammary Neoplasms (IEP)

hepatocellular carcinoma (ISO)

non-alcoholic fatty liver disease (ISO)

Reperfusion Injury (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(E)-thiamethoxam (ISO)

(S)-nicotine (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

1,2-dimethylhydrazine (ISO)

1-nitropyrene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-azacytidine (ISO)

8-Br-cAMP (ISO)

acrylamide (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arachidonic acid (ISO)

aristolochic acid (ISO)

arsenous acid (ISO)

avobenzone (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

butanal (ISO)

cadmium atom (ISO)

caffeine (ISO)

calcitriol (ISO)

cannabidiol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

chloroquine (EXP)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

Didecyldimethylammonium (ISO)

diethylstilbestrol (EXP)

dioxygen (ISO)

diphenylcyclopropenone (ISO)

diquat (ISO)

disodium selenite (ISO)

disulfiram (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP,ISO)

enniatin (ISO)

entinostat (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

genistein (ISO)

gentamycin (EXP)

GW 4064 (ISO)

hydrogen peroxide (ISO)

hydroquinone (ISO)

Indeno[1,2,3-cd]pyrene (ISO)

L-methionine (ISO)

lamivudine (ISO)

lead diacetate (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

lithium atom (ISO)

lithium hydride (ISO)

mercury dibromide (ISO)

methamphetamine (EXP)

methylmercury chloride (ISO)

miconazole (ISO)

mitomycin C (ISO)

Muraglitazar (EXP)

N-methyl-4-phenylpyridinium (EXP,ISO)

nickel atom (ISO)

nickel dichloride (ISO)

nicotine (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP)

perfluorononanoic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

picene (ISO)

piroxicam (ISO)

potassium chromate (ISO)

progesterone (ISO)

prothioconazole (ISO)

quercetin (ISO)

raloxifene (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

succimer (ISO)

sulindac (ISO)

sulindac sulfide (ISO)

sunitinib (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

Tesaglitazar (EXP)

testosterone (EXP,ISO)

tetrachloroethene (ISO)

thapsigargin (ISO)

thiamethoxam (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triacsin C (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

troglitazone (EXP,ISO)

trovafloxacin (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vincaleukoblastine (ISO)

vorinostat (ISO)

XL147 (ISO)

zidovudine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion homeostasis (ISO)

cellular calcium ion homeostasis (IBA,IMP,ISO)

cellular response to hypoxia (IEP)

decidualization (IEP)

embryo implantation (IEP)

endoplasmic reticulum unfolded protein response (ISO)

negative regulation of gene expression (ISO)

negative regulation of multicellular organism growth (ISO)

regulation of hormone biosynthetic process (ISO)

regulation of store-operated calcium entry (ISO)

response to endoplasmic reticulum stress (ISO)

response to oxidative stress (ISO)

response to peptide hormone (IEP)

response to vitamin D (IEP)

signal transduction (IEA)

Cellular Component

cellular_component (ND)

endoplasmic reticulum (ISO)

extracellular region (IEA)

extracellular space (IBA)

Golgi apparatus (ISO)

perinuclear region of cytoplasm (ISO)

Molecular Function

enzyme binding (ISO)

heme binding (ISO)

hormone activity (IEA)

molecular_function (ND)

protein binding (ISO)

protein homodimerization activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Regulation by 1alpha,25-dihydroxyvitamin D(3) of expression of stanniocalcin messages in the rat kidney and ovary.	Honda S, etal., FEBS Lett 1999 Oct 1;459(1):119-22.
4.	Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties.	Ito D, etal., Mol Cell Biol. 2004 Nov;24(21):9456-69.
5.	Differential gene signatures in rat mammary tumors induced by DMBA and those induced by fractionated gamma radiation.	Lee HJ, etal., Radiat Res. 2008 Nov;170(5):579-90.
6.	Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary.	Luo CW, etal., Endocrinology. 2005 Jan;146(1):469-76. Epub 2004 Oct 14.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm.	Wang T, etal., Front Immunol. 2022 May 27;13:843408. doi: 10.3389/fimmu.2022.843408. eCollection 2022.
14.	Expression and regulation of stanniocalcin 1 and 2 in rat uterus during embryo implantation and decidualization.	Xiao LJ, etal., Reproduction. 2006 Jun;131(6):1137-49.
15.	Stanniocalcin 2 is a negative modulator of store-operated calcium entry.	Zeiger W, etal., Mol Cell Biol. 2011 Sep;31(18):3710-22. doi: 10.1128/MCB.05140-11. Epub 2011 Jul 11.

Additional References at PubMed

PMID:9753616	PMID:16502470	PMID:18258678	PMID:22285620	PMID:22503972

Genomics

Comparative Map Data

Stc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	16,251,046 - 16,260,815 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	16,250,853 - 16,262,973 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	20,999,993 - 21,009,760 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	20,488,943 - 20,498,710 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	15,978,545 - 15,988,328 (+)	NCBI	Rnor_WKY
Rnor_6.0	10	16,542,909 - 16,552,675 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	16,542,882 - 16,553,295 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	16,432,189 - 16,441,955 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	16,514,603 - 16,524,369 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	16,515,651 - 16,525,418 (+)	NCBI
Celera	10	15,912,872 - 15,922,638 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

STC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	173,314,723 - 173,328,414 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	5	173,314,723 - 173,328,447 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	172,741,726 - 172,755,417 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	172,674,332 - 172,689,112 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	172,660,711 - 172,687,936	NCBI
Celera	5	168,774,827 - 168,789,607 (-)	NCBI		Celera
Cytogenetic Map	5	q35.2	NCBI
HuRef	5	167,836,956 - 167,851,740 (-)	NCBI		HuRef
CHM1_1	5	172,174,113 - 172,188,892 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	173,854,781 - 173,868,472 (-)	NCBI		T2T-CHM13v2.0

Stc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	31,309,441 - 31,320,061 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	31,307,307 - 31,320,074 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	31,359,441 - 31,370,061 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	31,357,307 - 31,370,074 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	31,259,441 - 31,270,061 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	31,259,441 - 31,270,061 (-)	NCBI		MGSCv36	mm8
Celera	11	33,778,331 - 33,788,980 (-)	NCBI		Celera
Cytogenetic Map	11	A4	NCBI

Stc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	25,934,932 - 25,949,399 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	25,937,174 - 25,950,221 (-)	NCBI	ChiLan1.0	ChiLan1.0

STC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	5	175,575,412 - 175,587,832 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	175,575,419 - 175,587,832 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	5	168,668,851 - 168,681,274 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

STC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	39,151,951 - 39,165,514 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	39,152,503 - 39,162,343 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	39,097,951 - 39,109,709 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	39,523,070 - 39,537,223 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	39,524,206 - 39,534,846 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	39,341,084 - 39,355,222 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	39,529,915 - 39,543,843 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	40,038,732 - 40,052,874 (+)	NCBI		UU_Cfam_GSD_1.0

Stc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	93,596,596 - 93,607,949 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936609	2,319,111 - 2,332,988 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936609	2,319,546 - 2,331,049 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	50,989,433 - 51,004,481 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	50,989,676 - 51,001,412 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	55,330,021 - 55,341,757 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	75,475,020 - 75,489,727 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	75,475,022 - 75,488,678 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	3,118,074 - 3,132,787 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Stc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	16,773,644 - 16,785,214 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	16,773,422 - 16,787,475 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Stc2
22 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	88
Count of miRNA genes:	78
Interacting mature miRNAs:	81
Transcripts:	ENSRNOT00000028146
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
1576304	Schws7	Schwannoma susceptibility QTL 7		0.0115	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	4765527	19816042	Rat
737820	Alc9	Alcohol consumption QTL 9	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	19233348	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	cortical volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631828	Alc5	Alcohol consumption QTL 5	2.4		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	17245662	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		2			10			2		5	8
Low	2	41	21	10	4	10	8	9	68	30	30	11	8
Below cutoff	1		35	30	5	30			6		3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022230	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB030707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC119699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000028146 ⟹ ENSRNOP00000028146

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	16,250,853 - 16,262,973 (+)	Ensembl
Rnor_6.0 Ensembl	10	16,542,882 - 16,553,295 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103133 ⟹ ENSRNOP00000093400

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	16,251,052 - 16,262,702 (+)	Ensembl

RefSeq Acc Id:

NM_022230 ⟹ NP_071566

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	16,251,046 - 16,260,815 (+)	NCBI
Rnor_6.0	10	16,542,909 - 16,552,675 (+)	NCBI
Rnor_5.0	10	16,432,189 - 16,441,955 (+)	NCBI
RGSC_v3.4	10	16,514,603 - 16,524,369 (+)	RGD
Celera	10	15,912,872 - 15,922,638 (+)	RGD

Sequence:

show sequence

ATACCAAGAACCATGTGTGCGGAGCGGCTGGGCCAGTTCGTGACCCTGGCTTTGGTGTTTGCCA
CCTTGGACCCTGCGCGAGGGACGGACTCCACGAACCCTCCGGAAGGTCCCCAAGACAGGGGCTC
CCAGCAGAAAGGCCGCCTGTCCCTGCAGAACACAGCGGAGATCCAGCACTGTTTGGTCAACGCC
GGGGACGTGGGGTGTGGTGTGTTTGAGTGCTTCGAGAACAACTCTTGTGAAATCCAGGGCTTAC
ATGGGATTTGCATGACGTTTCTGCACAACGCTGGAAAATTTGATGCCCAGGGCAAGTCATTCAT
CAAGGATGCCCTGAGGTGCAAGGCCCATGCCCTGCGGCATAAATTTGGCTGCATCAGCAGGAAG
TGTCCGGCAATTAGGGAAATGGTTTACCAGTTGCAGAGGGAATGCTATCTCAAGCACGACCTGT
GCTCGGCAGCGCAGGAGAACGTCGTCGTGATTGTGGAGATGATTCATTTCAAGGATCTCCTGCT
GCATGAACCCTACGTGGACCTTGTAAACCTGCTGCTGACCTGTGGGGAAGACGTGAGGGAGGCG
GTCACCCGAAGCGTCCAGGCTCAGTGTGAACAGAGCTGGGGAGGCCTCTGCTCCATCCTGAGTT
TCTGCACCTCCAACATACAGAGACCCCCTACCGCAGCCCCGGAGCATCAGCCCCTGGCAGACAG
GGCCCAGCTCTCCAGACCTTACCACCGGGACACCGACCACCACCTAACAGCCAACAGAGGTGCC
AAGGGTGAGCGAGGGAGCAAAAGCCACCTGCATGCCCATGCTCGAGGCGGAGCAGGTGGCCAGA
GTGCCCAAGGACCCTCTGGAAGCAGTGAGTGGGAAGACGAACAGTCTGAGTATTCCGACATCCG
GAGGTGAAATGAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_071566	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA85251	(Get FASTA)	NCBI Sequence Viewer
	EDM04038	(Get FASTA)	NCBI Sequence Viewer
	Q9R0K8	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_071566 ⟸ NM_022230
- Peptide Label:	precursor
- UniProtKB:	Q9R0K8 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MCAERLGQFVTLALVFATLDPARGTDSTNPPEGPQDRGSQQKGRLSLQNTAEIQHCLVNAGDVG CGVFECFENNSCEIQGLHGICMTFLHNAGKFDAQGKSFIKDALRCKAHALRHKFGCISRKCPAI REMVYQLQRECYLKHDLCSAAQENVVVIVEMIHFKDLLLHEPYVDLVNLLLTCGEDVREAVTRS VQAQCEQSWGGLCSILSFCTSNIQRPPTAAPEHQPLADRAQLSRPYHRDTDHHLTANRGAKGER GSKSHLHAHARGGAGGQSAQGPSGSSEWEDEQSEYSDIRR hide sequence

RefSeq Acc Id:

ENSRNOP00000028146 ⟸ ENSRNOT00000028146

RefSeq Acc Id:

ENSRNOP00000093400 ⟸ ENSRNOT00000103133

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9R0K8-F1-model_v2	AlphaFold	Q9R0K8	1-296	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697086

Promoter ID:

EPDNEW_R7610

Type:

initiation region

Name:

Stc2_1

Description:

stanniocalcin 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	16,542,915 - 16,542,975	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621777	AgrOrtholog
BioCyc Gene	G2FUF-25652	BioCyc
Ensembl Genes	ENSRNOG00000020729	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000028146	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000093400.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000028146	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000103133.1	UniProtKB/TrEMBL
InterPro	Stanniocalcin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:63878	UniProtKB/Swiss-Prot
NCBI Gene	63878	ENTREZGENE
PANTHER	PTHR11245	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Stanniocalcin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Stc2	PhenoGen
UniProt	A0A8I6AKX3_RAT	UniProtKB/TrEMBL
	Q9R0K8	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Stc2	stanniocalcin 2		stanniocalcin-2	Name updated	1299863	APPROVED
2002-08-07	Stc2	stanniocalcin-2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD