Gene: Srd5a2 (steroid 5 alpha-reductase 2) Rattus norvegicus
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Symbol: Srd5a2
Name: steroid 5 alpha-reductase 2
Description: ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity; amide binding; sterol 5-alpha reductase activity (ortholog); INVOLVED IN androgen biosynthetic process; androgen metabolic process; biphenyl metabolic process; PARTICIPATES IN testosterone biosynthetic pathway; prostate cancer pathway; steroid hormone biosynthetic pathway; ASSOCIATED WITH diabetes mellitus; hyperprolactinemia; alopecia (ortholog); FOUND IN cell body fiber; cytoplasm; neuronal cell body; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine
AGR Description: Exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity and amide binding activity; involved in several processes, including androgen biosynthetic process, animal organ development, and biphenyl metabolic process; localizes to the cell body fiber, cytoplasm, and neuronal cell body; biomarker of diabetes mellitus and hyperprolactinemia; orthologous to human SRD5A2 (steroid 5 alpha-reductase 2).
Merged Description: Exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity and amide binding activity; involved in several processes, including androgen biosynthetic process, animal organ development, and biphenyl metabolic process; localizes to the cell body fiber, cytoplasm, and neuronal cell body; biomarker of diabetes mellitus and hyperprolactinemia; orthologous to human SRD5A2 (steroid 5 alpha-reductase 2); PARTICIPATES IN testosterone biosynthetic pathway; prostate cancer pathway; steroid hormone biosynthetic pathway; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; S5AR 2; SR type 2; steroid 5-alpha-reductase 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Orthologs:
Homo sapiens (human) : SRD5A2 (steroid 5 alpha-reductase 2)  HGNC  Alliance
Mus musculus (house mouse) : Srd5a2 (steroid 5 alpha-reductase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Srd5a2 (steroid 5 alpha-reductase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SRD5A2 (steroid 5 alpha-reductase 2)
Canis lupus familiaris (dog) : SRD5A2 (steroid 5 alpha-reductase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Srd5a2 (steroid 5 alpha-reductase 2)
Sus scrofa (pig) : SRD5A2 (steroid 5 alpha-reductase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0625,279,635 - 25,315,501 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0635,127,532 - 35,163,398 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4621,453,521 - 21,489,408 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1621,456,473 - 21,492,397 (+)NCBI
Celera620,976,906 - 21,012,848 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Strain Sequence Variants (Rnor 5.0)

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More on Srd5a2
Alliance Gene
NCBI Gene
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RGD Object Information
RGD ID: 621480
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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