Gene: Srd5a2 (steroid 5 alpha-reductase 2) Rattus norvegicus
Analyze
Symbol:
Srd5a2
Name:
steroid 5 alpha-reductase 2
RGD ID:
621480
Description:
Exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity and amide binding activity. Involved in several processes, including androgen biosynthetic process; animal organ development; and phthalate metabolic process. Localizes to cell body fiber; cytoplasm; and neuronal cell body. Biomarker of diabetes mellitus and hyperprolactinemia. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2); PARTICIPATES IN testosterone biosynthetic pathway; prostate cancer pathway; steroid hormone biosynthetic pathway; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; S5AR 2; SR type 2; steroid 5-alpha-reductase 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SRD5A2 (steroid 5 alpha-reductase 2) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther, PhylomeDB
Mus musculus (house mouse):
Srd5a2 (steroid 5 alpha-reductase 2) HGNC
NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Srd5a2 (steroid 5 alpha-reductase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SRD5A2 (steroid 5 alpha-reductase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SRD5A2 (steroid 5 alpha-reductase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Srd5a2 (steroid 5 alpha-reductase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SRD5A2 (steroid 5 alpha-reductase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
SRD5A2 (steroid 5 alpha-reductase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Srd5a2 (steroid 5 alpha-reductase 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
SRD5A1 (steroid 5 alpha-reductase 1) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
SRD5A2 (steroid 5 alpha-reductase 2)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Mus musculus (house mouse):
Srd5a2 (steroid 5 alpha-reductase 2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
srd5a2a (steroid-5-alpha-reductase, alpha polypeptide 2a)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
srd5a2b (steroid-5-alpha-reductase, alpha polypeptide 2b)
Alliance
DIOPT (Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Caenorhabditis elegans (roundworm):
F19H6.4
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Caenorhabditis elegans (roundworm):
F42F12.3
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Caenorhabditis elegans (roundworm):
ZK1251.3
Alliance
DIOPT (OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 6 25,279,635 - 25,315,501 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 25,279,626 - 25,315,511 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 6 35,127,532 - 35,163,398 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 21,453,521 - 21,489,408 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 6 21,456,473 - 21,492,397 (+) NCBI Celera 6 20,976,906 - 21,012,848 (+) NCBI Celera Cytogenetic Map 6 q14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Autoinflammation with Infantile Enterocolitis ISO RGD:737503 8554872 ClinVar Annotator: match by term: Autoinflammation with infantile enterocolitis ClinVar PMID:28492532 Penis Agenesis ISO RGD:737503 8554872 ClinVar Annotator: match by synonym: Micropenis ClinVar PMID:12843198 Penis Agenesis ISO RGD:737503 8554872 ClinVar Annotator: match by term: Micropenis ClinVar PMID:10898110 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by OMIM:264600 ClinVar PMID:9467575 Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:1406794 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:10718838 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:1522235 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:28492532 , PMID:9208814 Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:23633205 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:15266301 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:1406794 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:1522235 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:21402750 , PMID:28492532 Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:1522235 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:10898110 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:25741868 , PMID:28663096 Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:11869378 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:12576851 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:10718838 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:1522235 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:1522235 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:18384427 , PMID:28492532 Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:21147889 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:10999800 , PMID:28492532 Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:25741868 Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by OMIM:264600 ClinVar PMID:1944596 Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:10501358 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by OMIM:264600 ClinVar PMID:8626825 Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by OMIM:264600 ClinVar PMID:10999800 Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:28492532 , PMID:8768837 Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by OMIM:264600 ClinVar PMID:7554313 Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:25741868 , PMID:28492532 Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 8554872 ClinVar Annotator: match by term: 3-Oxo-5 alpha-steroid delta 4-dehydrogenase deficiency ClinVar PMID:28492532
Imported Annotations - CTD
alopecia ISO RGD:737503 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17136762 Endometrial Neoplasms ISO RGD:737503 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23200943 endometriosis ISO RGD:737503 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21232532 prostatic hypertrophy ISO RGD:737503 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20823678 Prostatic Neoplasms ISO RGD:737503 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16998812 more ... Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:7554313 Imported Annotations - Genetic Association Database
Prostatic Neoplasms ISO RGD:737503 1331525 GAD Imported Annotations - OMIM
Pseudovaginal Perineoscrotal Hypospadias ISO RGD:737503 7240710 OMIM
(-)-epigallocatechin 3-gallate decreases expression ISO RGD:737503 6480464 epigallocatechin gallate results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 1,2-dimethylhydrazine decreases expression ISO RGD:737504 6480464 1, 2-Dimethylhydrazine results in decreased expression of SRD5A2 mRNA CTD PMID:22206623 17beta-estradiol decreases expression ISO RGD:737503 6480464 Estradiol results in decreased expression of SRD5A2 mRNA CTD PMID:20106945 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO RGD:737504 6480464 hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of SRD5A2 mRNA] CTD PMID:15056816 17beta-hydroxy-5alpha-androstan-3-one increases expression EXP 6480464 Dihydrotestosterone results in increased expression of SRD5A2 mRNA CTD PMID:22131296 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:737504 6480464 Dihydrotestosterone results in increased expression of SRD5A2 mRNA CTD PMID:15056816 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [3 more ... CTD PMID:19464308 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SRD5A2 mRNA CTD PMID:11222880 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:737504 6480464 Tetrachlorodibenzodioxin results in decreased expression of SRD5A2 mRNA CTD PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:737504 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SRD5A2 gene] CTD PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SRD5A2 mRNA CTD PMID:21724226 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:737503 6480464 Tetrachlorodibenzodioxin affects the expression of SRD5A2 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SRD5A2 mRNA CTD PMID:22298810 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:21724226 3,3',4,4',5-pentachlorobiphenyl multiple interactions EXP 6480464 [3 more ... CTD PMID:19464308 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of SRD5A2 mRNA CTD PMID:19162173 4-hydroxyphenyl retinamide increases expression ISO RGD:737504 6480464 Fenretinide results in increased expression of SRD5A2 mRNA CTD PMID:28973697 aflatoxin B1 affects expression ISO RGD:737503 6480464 Aflatoxin B1 affects the expression of SRD5A2 protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:737503 6480464 Aflatoxin B1 results in decreased expression of SRD5A2 mRNA CTD PMID:22100608 aflatoxin B1 decreases expression ISO RGD:737504 6480464 Aflatoxin B1 results in decreased expression of SRD5A2 mRNA CTD PMID:19770486 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SRD5A2 mRNA CTD PMID:16483693 antirheumatic drug decreases expression ISO RGD:737503 6480464 Antirheumatic Agents results in decreased expression of SRD5A2 mRNA CTD PMID:24449571 Aroclor 1254 increases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of SRD5A2 mRNA CTD PMID:16938428 benzo[a]pyrene affects methylation ISO RGD:737503 6480464 Benzo(a)pyrene affects the methylation of SRD5A2 exon, Benzo(a)pyrene affects the methylation of SRD5A2 promoter CTD PMID:27901495 benzo[a]pyrene decreases expression ISO RGD:737503 6480464 Benzo(a)pyrene results in decreased expression of SRD5A2 mRNA CTD PMID:32234424 bifenthrin decreases expression ISO RGD:737504 6480464 bifenthrin results in decreased expression of SRD5A2 mRNA CTD PMID:26071804 bisphenol A decreases expression ISO RGD:737504 6480464 bisphenol A results in decreased expression of SRD5A2 mRNA, bisphenol A results in decreased expression of SRD5A2 protein CTD PMID:25434310 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SRD5A2 mRNA CTD PMID:30816183 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SRD5A2 mRNA, bisphenol A results in decreased expression of SRD5A2 protein CTD PMID:23405234 more ... C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of SRD5A2 mRNA CTD PMID:19167457 cadmium atom increases expression ISO RGD:737503 6480464 Cadmium results in increased expression of SRD5A2 mRNA CTD PMID:21120746 chlorogenic acid decreases expression ISO RGD:737503 6480464 Chlorogenic Acid results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 clothianidin increases expression ISO RGD:737503 6480464 clothianidin results in increased expression of SRD5A2 mRNA CTD PMID:31626844 cyclosporin A decreases expression ISO RGD:737503 6480464 Cyclosporine results in decreased expression of SRD5A2 mRNA CTD PMID:20106945 cypermethrin increases expression ISO RGD:737504 6480464 cypermethrin results in increased expression of SRD5A2 mRNA CTD PMID:21142847 DDE decreases activity ISO RGD:737503 6480464 Dichlorodiphenyl Dichloroethylene results in decreased activity of SRD5A2 protein CTD PMID:17218080 dextran sulfate multiple interactions ISO RGD:737504 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SRD5A2 mRNA CTD PMID:29950665 dibutyl phthalate decreases expression ISO RGD:737504 6480464 Dibutyl Phthalate results in decreased expression of SRD5A2 mRNA, Dibutyl Phthalate results in decreased expression of SRD5A2 protein CTD PMID:25434310 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of SRD5A2 mRNA CTD PMID:26948521 , PMID:27079746 dutasteride decreases expression ISO RGD:737503 6480464 Dutasteride results in decreased expression of SRD5A2 mRNA CTD PMID:16806904 fenarimol decreases activity ISO RGD:737503 6480464 fenarimol results in decreased activity of SRD5A2 protein CTD PMID:17218080 finasteride decreases activity ISO RGD:737503 6480464 Finasteride results in decreased activity of SRD5A2 protein CTD PMID:17218080 more ... finasteride multiple interactions ISO RGD:737503 6480464 Finasteride inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA] more ... CTD PMID:23523586 fluoroethene decreases activity ISO RGD:737503 6480464 vinyl fluoride analog results in decreased activity of SRD5A2 protein CTD PMID:8689240 flutamide decreases activity ISO RGD:737503 6480464 Flutamide results in decreased activity of SRD5A2 protein CTD PMID:17218080 furan increases expression EXP 6480464 furan results in increased expression of SRD5A2 mRNA CTD PMID:22079235 genistein decreases expression ISO RGD:737503 6480464 Genistein results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 hydroxyflutamide multiple interactions ISO RGD:737504 6480464 hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of SRD5A2 mRNA] CTD PMID:15056816 linuron decreases activity ISO RGD:737503 6480464 Linuron results in decreased activity of SRD5A2 protein CTD PMID:17218080 mangiferin decreases activity ISO RGD:737503 6480464 mangiferin results in decreased activity of SRD5A2 protein CTD PMID:20823678 methyltestosterone decreases activity ISO RGD:737503 6480464 Methyltestosterone results in decreased activity of SRD5A2 protein CTD PMID:17218080 metoclopramide increases expression EXP 6480464 Metoclopramide results in increased expression of SRD5A2 mRNA CTD PMID:18978642 N-Nitrosopyrrolidine decreases expression ISO RGD:737503 6480464 N-Nitrosopyrrolidine results in decreased expression of SRD5A2 mRNA CTD PMID:32234424 O-methyleugenol decreases expression ISO RGD:737503 6480464 methyleugenol results in decreased expression of SRD5A2 mRNA CTD PMID:32234424 Osajin decreases expression ISO RGD:737503 6480464 osajin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 paracetamol increases expression ISO RGD:737504 6480464 Acetaminophen results in increased expression of SRD5A2 mRNA CTD PMID:29246445 paracetamol multiple interactions ISO RGD:737504 6480464 PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of SRD5A2 mRNA] CTD PMID:29246445 perfluorooctanoic acid multiple interactions ISO RGD:737504 6480464 [perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of SRD5A2 mRNA more ... CTD PMID:20118188 , PMID:23626681 perfluorooctanoic acid decreases expression ISO RGD:737504 6480464 perfluorooctanoic acid results in decreased expression of SRD5A2 mRNA CTD PMID:20118188 , PMID:23626681 piperidine decreases activity ISO RGD:737503 6480464 piperidine analog results in decreased activity of SRD5A2 protein CTD PMID:10896124 piperidine decreases activity EXP 6480464 piperidine analog results in decreased activity of SRD5A2 protein CTD PMID:10896124 pirinixic acid multiple interactions ISO RGD:737504 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SRD5A2 mRNA CTD PMID:19710929 Pomiferin decreases expression ISO RGD:737503 6480464 pomiferin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 pravastatin decreases expression ISO RGD:737504 6480464 Pravastatin results in decreased expression of SRD5A2 mRNA CTD PMID:27225895 prochloraz decreases activity ISO RGD:737503 6480464 prochloraz results in decreased activity of SRD5A2 protein CTD PMID:17218080 progesterone decreases activity ISO RGD:737503 6480464 Progesterone analog results in decreased activity of SRD5A2 protein CTD PMID:20359488 puerarin decreases expression ISO RGD:737503 6480464 puerarin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 resveratrol decreases expression ISO RGD:737503 6480464 resveratrol results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA] CTD PMID:25714330 Rosavin decreases expression ISO RGD:737503 6480464 rosavin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 sulpiride increases expression EXP 6480464 Sulpiride results in increased expression of SRD5A2 mRNA CTD PMID:18978642 testosterone multiple interactions ISO RGD:737503 6480464 Finasteride inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA] more ... CTD PMID:23523586 testosterone increases expression EXP 6480464 Testosterone results in increased expression of SRD5A2 mRNA CTD PMID:22131296 more ... testosterone multiple interactions EXP 6480464 resveratrol inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA] CTD PMID:25714330 testosterone increases expression ISO RGD:737503 6480464 Testosterone results in increased expression of SRD5A2 mRNA CTD PMID:23523586 tetrachloroethene decreases expression ISO RGD:737504 6480464 Tetrachloroethylene results in decreased expression of SRD5A2 mRNA CTD PMID:28973375 titanium dioxide multiple interactions ISO RGD:737504 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SRD5A2 mRNA CTD PMID:29950665 tributylstannane decreases activity ISO RGD:737503 6480464 tributyltin results in decreased activity of SRD5A2 protein CTD PMID:12231121 tributylstannane multiple interactions ISO RGD:737503 6480464 Finasteride promotes the reaction [tributyltin inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]] more ... CTD PMID:23523586 tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of SRD5A2 mRNA CTD PMID:21683754 Tributyltin oxide decreases activity ISO RGD:737503 6480464 bis(tri-n-butyltin)oxide results in decreased activity of SRD5A2 protein CTD PMID:17218080 triphenylstannane decreases activity ISO RGD:737503 6480464 triphenyltin results in decreased activity of SRD5A2 protein CTD PMID:17218080 zaragozic acid A decreases expression ISO RGD:737504 6480464 squalestatin 1 results in decreased expression of SRD5A2 mRNA CTD PMID:27225895 zaragozic acid A increases expression EXP 6480464 squalestatin 1 results in increased expression of SRD5A2 mRNA CTD PMID:27225895 zoledronic acid increases expression ISO RGD:737503 6480464 zoledronic acid results in increased expression of SRD5A2 mRNA CTD PMID:24714768
Gene-Chemical Interaction Annotations
