Srd5a2 (steroid 5 alpha-reductase 2) - Rat Genome Database

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Gene: Srd5a2 (steroid 5 alpha-reductase 2) Rattus norvegicus
Analyze
Symbol: Srd5a2
Name: steroid 5 alpha-reductase 2
RGD ID: 621480
Description: Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity and amide binding activity. Involved in several processes, including androgen biosynthetic process; limbic system development; and reproductive structure development. Located in cell body fiber and neuronal cell body. Biomarker of diabetes mellitus and hyperprolactinemia. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2); PARTICIPATES IN testosterone biosynthetic pathway; prostate cancer pathway; steroid hormone biosynthetic pathway; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; S5AR 2; SR type 2; steroid 5-alpha-reductase 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2621,426,225 - 21,465,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl621,426,215 - 21,462,112 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx621,755,011 - 21,794,514 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0622,070,851 - 22,110,348 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0621,551,287 - 21,590,788 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0625,279,635 - 25,315,501 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,279,626 - 25,315,511 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0635,127,532 - 35,163,398 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4621,453,521 - 21,489,408 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1621,456,473 - 21,492,397 (+)NCBI
Celera620,976,906 - 21,012,848 (+)NCBICelera
Cytogenetic Map6q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,17-Androstanediol glucuronide  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (EXP)
clothianidin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
D-aspartic acid  (EXP)
DDE  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
diquat  (ISO)
dutasteride  (ISO)
epoxiconazole  (ISO)
fenarimol  (ISO)
finasteride  (ISO)
fluoroethene  (ISO)
flutamide  (ISO)
furan  (EXP)
genistein  (ISO)
glyphosate  (EXP)
hydroxyflutamide  (ISO)
imidacloprid  (EXP)
lidocaine  (EXP)
linuron  (ISO)
lipopolysaccharide  (ISO)
mangiferin  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyltestosterone  (ISO)
metoclopramide  (EXP)
N-Nitrosopyrrolidine  (ISO)
O-methyleugenol  (ISO)
Osajin  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
perfluorooctanoic acid  (ISO)
piperidine  (EXP,ISO)
pirinixic acid  (ISO)
Pomiferin  (ISO)
pravastatin  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
propofol  (ISO)
puerarin  (ISO)
resveratrol  (EXP,ISO)
Rosavin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sulpiride  (EXP)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
thiabendazole  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triphenylstannane  (ISO)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inhibition of rat alpha-reductases by finasteride: evidence for isozyme differences in the mechanism of inhibition. Azzolina B, etal., J Steroid Biochem Mol Biol. 1997 Apr;61(1-2):55-64.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Regulation of prostate 5alpha-reductase-2 gene expression and prostate weight by dietary fat and caloric intake in the rat. Cai LQ, etal., Prostate. 2006 May 15;66(7):738-48.
4. Dimorphic expression of testosterone metabolizing enzymes in the hypothalamic area of developing rats. Colciago A, etal., Brain Res Dev Brain Res. 2005 Mar 31;155(2):107-16.
5. Prenatal Aroclor 1254 exposure and brain sexual differentiation: effect on the expression of testosterone metabolizing enzymes and androgen receptors in the hypothalamus of male and female rats. Colciago A, etal., Reprod Toxicol. 2006 Nov;22(4):738-45. Epub 2006 Jul 14.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. 5alpha-reductase isoenzymes 1 and 2 in the rat testis during postnatal development. Killian J, etal., Biol Reprod. 2003 May;68(5):1711-8. Epub 2002 Dec 11.
10. Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats. Kim TS, etal., J Toxicol Environ Health A. 2010 Jan;73(21-22):1544-59.
11. Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus. Kimoto T, etal., Endocrinology. 2010 Nov 3.
12. Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma. Lewis MJ, etal., BMC Cancer. 2004 Jun 22;4:27.
13. Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: implications for finasteride therapy of prostate carcinoma. Luo J, etal., Prostate. 2003 Oct 1;57(2):134-9.
14. Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA. Makridakis NM, etal., Lancet. 1999 Sep 18;354(9183):975-8.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions. Normington K and Russell DW, J Biol Chem 1992 Sep 25;267(27):19548-54.
19. Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose-dependent increase of mRNA levels of 5alpha-reductase type 2 in contrast to decrease of androgen receptor in the pubertal ventral prostate. Ohsako S, etal., Toxicol Sci. 2001 Mar;60(1):132-43.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cord. Patte-Mensah C, etal., J Comp Neurol. 2004 Sep 20;477(3):286-99.
22. N-substituted 4-(4-carboxyphenoxy)benzamides. Synthesis and evaluation as inhibitors of steroid-5alpha-reductase type 1 and 2. Picard F and Hartmann RW, J Enzyme Inhib Med Chem. 2002 Jun;17(3):187-96.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. Differential regulation of rat testicular 5alpha-reductase type 1 and 2 isoforms by testosterone and FSH. Pratis K, etal., J Endocrinol. 2003 Mar;176(3):393-403.
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Comprehensive gene review and curation RGD comprehensive gene curation
29. Effects of sulpiride on mRNA levels of steroid 5alpha-reductase isozymes in prostate of adult rats. Sanchez P, etal., IUBMB Life. 2008 Jan;60(1):68-72.
30. Effects of dihydrotestosterone on brain mRNA levels of steroid 5alpha-reductase isozymes in early postnatal life of rat. Sanchez P, etal., Neurochem Res. 2005 Apr;30(4):577-81.
31. Effects of sulpiride on prolactin and mRNA levels of steroid 5alpha-reductase isozymes in adult rat brain. Sanchez P, etal., Neurochem Res. 2008 May;33(5):820-5. Epub 2007 Oct 17.
32. Effects of metoclopramide on mRNA levels of 5alpha-reductase isozymes in rat brain. Sanchez P, etal., Neuroreport. 2009 Jan 7;20(1):93-6.
33. Rat steroid 5 alpha-reductase kinetic characteristics: extreme pH-dependency of the type II isozyme in prostate and epididymis homogenates. Span PN, etal., J Steroid Biochem Mol Biol. 1995 Aug;54(3-4):185-92.
34. Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5alpha-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat. Stuart JD, etal., Biochem Pharmacol 2001 Oct 1;62(7):933-42.
35. Expression and regulation of steroid 5 alpha-reductase in the genital tubercle of the fetal rat. Tian H and Russell DW, Dev Dyn. 1997 May;209(1):117-26.
36. Steroid 5alpha-reductase isozymes in the adult female rat brain: central role of dihydrotestosterone. Torres JM and Ortega E, J Mol Endocrinol. 2006 Apr;36(2):239-45.
37. Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation. van der Eerden BC, etal., J Endocrinol. 2004 Mar;180(3):457-67.
38. [Changes of 5 alpha-reductase type II activity in sexual gland of diabetic male rats] Wang HJ, etal., Zhonghua Nan Ke Xue. 2003 Apr;9(2):82-4.
39. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics Zhou L, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1999 Oct;16(5):311-4.
Additional References at PubMed
PMID:1944596   PMID:10898110   PMID:11606430   PMID:12899683   PMID:14592534   PMID:15249131   PMID:15576829   PMID:16818707   PMID:22131296   PMID:22776423   PMID:23122426   PMID:23405234  
PMID:27150077   PMID:27155079  


Genomics

Comparative Map Data
Srd5a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2621,426,225 - 21,465,727 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl621,426,215 - 21,462,112 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx621,755,011 - 21,794,514 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0622,070,851 - 22,110,348 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0621,551,287 - 21,590,788 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0625,279,635 - 25,315,501 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,279,626 - 25,315,511 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0635,127,532 - 35,163,398 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4621,453,521 - 21,489,408 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1621,456,473 - 21,492,397 (+)NCBI
Celera620,976,906 - 21,012,848 (+)NCBICelera
Cytogenetic Map6q13NCBI
SRD5A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38231,522,480 - 31,663,009 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl231,522,480 - 31,580,938 (-)EnsemblGRCh38hg38GRCh38
GRCh37231,747,550 - 31,806,007 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36231,603,160 - 31,659,544 (-)NCBINCBI36Build 36hg18NCBI36
Build 34231,661,306 - 31,717,691NCBI
Celera231,590,884 - 31,647,296 (-)NCBICelera
Cytogenetic Map2p23.1NCBI
HuRef231,485,637 - 31,542,001 (-)NCBIHuRef
CHM1_1231,678,089 - 31,734,473 (-)NCBICHM1_1
T2T-CHM13v2.0231,567,195 - 31,707,768 (-)NCBIT2T-CHM13v2.0
Srd5a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391774,321,886 - 74,354,855 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1774,323,950 - 74,354,911 (-)EnsemblGRCm39 Ensembl
GRCm381774,014,891 - 74,047,860 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1774,016,955 - 74,047,916 (-)EnsemblGRCm38mm10GRCm38
MGSCv371774,367,046 - 74,397,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361773,922,606 - 73,952,814 (-)NCBIMGSCv36mm8
Celera1778,309,438 - 78,339,442 (-)NCBICelera
Cytogenetic Map17E2NCBI
cM Map1745.39NCBI
Srd5a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544110,443 - 95,743 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544112,149 - 95,733 (-)NCBIChiLan1.0ChiLan1.0
SRD5A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12A94,917,555 - 94,971,145 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A31,542,646 - 31,597,394 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A31,610,487 - 31,665,718 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A31,610,487 - 31,665,718 (-)Ensemblpanpan1.1panPan2
SRD5A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11725,017,113 - 25,056,156 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1725,017,113 - 25,056,544 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1724,811,155 - 24,850,233 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01725,580,015 - 25,620,097 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1725,580,843 - 25,620,171 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11724,887,475 - 24,926,628 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01724,946,476 - 24,985,654 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01725,049,043 - 25,087,911 (-)NCBIUU_Cfam_GSD_1.0
Srd5a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629269,130,023 - 69,175,570 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364931,663,911 - 1,708,502 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364931,663,999 - 1,708,530 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRD5A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3107,840,200 - 107,918,350 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13107,840,200 - 107,918,351 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23114,644,279 - 114,657,350 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRD5A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11475,915,495 - 75,971,280 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1475,917,260 - 75,970,365 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604536,088,943 - 36,288,753 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srd5a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473813,253,729 - 13,321,448 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473813,254,998 - 13,321,360 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Srd5a2
147 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:70
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000008983
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
BE120616  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2621,456,451 - 21,456,635 (-)MAPPERmRatBN7.2
Rnor_6.0625,285,094 - 25,285,277NCBIRnor6.0
Rnor_5.0635,132,991 - 35,133,174UniSTSRnor5.0
RGSC_v3.4621,483,767 - 21,483,950UniSTSRGSC3.4
Celera621,007,206 - 21,007,389UniSTS
Cytogenetic Map6q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 2 7 5 8
Below cutoff 1 8 13 4 10 4 2 2 58 30 27 7 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008983   ⟹   ENSRNOP00000009254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl621,426,215 - 21,462,112 (+)Ensembl
Rnor_6.0 Ensembl625,279,626 - 25,315,511 (-)Ensembl
RefSeq Acc Id: NM_022711   ⟹   NP_073202
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2621,426,225 - 21,465,727 (+)NCBI
Rnor_6.0625,279,635 - 25,315,501 (-)NCBI
Rnor_5.0635,127,532 - 35,163,398 (-)NCBI
RGSC_v3.4621,453,521 - 21,489,408 (+)RGD
Celera620,976,906 - 21,012,848 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_073202 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42182 (Get FASTA)   NCBI Sequence Viewer  
  AAT67595 (Get FASTA)   NCBI Sequence Viewer  
  EDM02850 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009254
GenBank Protein P31214 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_073202   ⟸   NM_022711
- UniProtKB: P31214 (UniProtKB/Swiss-Prot),   A6H9Z5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009254   ⟸   ENSRNOT00000008983
Protein Domains
Steroid 5-alpha reductase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31214-F1-model_v2 AlphaFold P31214 1-254 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694426
Promoter ID:EPDNEW_R4951
Type:single initiation site
Name:Srd5a2_1
Description:steroid 5 alpha-reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0625,315,501 - 25,315,561EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621480 AgrOrtholog
BioCyc Gene G2FUF-38432 BioCyc
BioCyc Pathway PWY-7455 [allopregnanolone biosynthesis] BioCyc
  PWY-8200 [backdoor pathway of androgen biosynthesis] BioCyc
  PWY-8202 [11-oxyandrogens biosynthesis] BioCyc
  PWY66-378 [androgen biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000027042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008983 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.1630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 3-oxo-5-alpha-steroid_4-DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3-oxo-5_a-steroid_4-DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRD5A/TECR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64677 UniProtKB/Swiss-Prot
NCBI Gene 64677 ENTREZGENE
PANTHER 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE UniProtKB/TrEMBL
  3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10556 UniProtKB/Swiss-Prot
Pfam Steroid_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Srd5a2 PhenoGen
PIRSF 5_alpha-SR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE S5A_REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027042 RatGTEx
UniProt A6H9Z5 ENTREZGENE, UniProtKB/TrEMBL
  P31214 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Srd5a2  steroid 5 alpha-reductase 2  Srd5a2  steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Srd5a2  steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)  Srd5a2  steroid 5-alpha-reductase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Srd5a2  steroid 5-alpha-reductase 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Srd5a2  steroid 5-alpha-reductase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA abundant in male reproductive tissues 729939
gene_regulation mRNA can be induced by dihydrotestosterone 729939