Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Srd5a2 (steroid 5 alpha-reductase 2) Rattus norvegicus
Symbol: Srd5a2
Name: steroid 5 alpha-reductase 2
RGD ID: 621480
Description: Exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity and amide binding activity. Involved in several processes, including androgen biosynthetic process; animal organ development; and phthalate metabolic process. Localizes to cell body fiber; cytoplasm; and neuronal cell body. Biomarker of diabetes mellitus and hyperprolactinemia. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2); PARTICIPATES IN testosterone biosynthetic pathway; prostate cancer pathway; steroid hormone biosynthetic pathway; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; S5AR 2; SR type 2; steroid 5-alpha-reductase 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Homo sapiens (human) : SRD5A2 (steroid 5 alpha-reductase 2)  HGNC  Alliance
Mus musculus (house mouse) : Srd5a2 (steroid 5 alpha-reductase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Srd5a2 (steroid 5 alpha-reductase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SRD5A2 (steroid 5 alpha-reductase 2)
Canis lupus familiaris (dog) : SRD5A2 (steroid 5 alpha-reductase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Srd5a2 (steroid 5 alpha-reductase 2)
Sus scrofa (pig) : SRD5A2 (steroid 5 alpha-reductase 2)
Chlorocebus sabaeus (African green monkey) : SRD5A2 (steroid 5 alpha-reductase 2)
Heterocephalus glaber (naked mole-rat) : Srd5a2 (steroid 5 alpha-reductase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0625,279,635 - 25,315,501 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,279,626 - 25,315,511 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0635,127,532 - 35,163,398 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4621,453,521 - 21,489,408 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1621,456,473 - 21,492,397 (+)NCBI
Celera620,976,906 - 21,012,848 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Srd5a2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621480
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.