G6pd (glucose-6-phosphate dehydrogenase) - Rat Genome Database

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Gene: G6pd (glucose-6-phosphate dehydrogenase) Rattus norvegicus
Analyze
Symbol: G6pd
Name: glucose-6-phosphate dehydrogenase
RGD ID: 2645
Description: Enables NADP binding activity; glucose binding activity; and glucose-6-phosphate dehydrogenase activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; pentose-phosphate shunt, oxidative branch; and positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Located in cytosol and nucleus. Used to study cataract and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); hepatic encephalopathy; hyperhomocysteinemia; obesity; and phenylketonuria. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); diabetes mellitus; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase); PARTICIPATES IN pentose phosphate pathway; pentose phosphate pathway - oxidative phase; ribose 5-phosphate isomerase deficiency pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; (S)-naringenin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G6pdx; glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate dehydrogenase X-linked
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC366715  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X152,201,081 - 152,220,863 (-)NCBImRatBN7.2
mRatBN7.2 EnsemblX152,201,098 - 152,220,801 (-)Ensembl
Rnor_6.0X156,274,800 - 156,293,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,274,800 - 156,293,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,015,532 - 152,034,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,186,450 - 160,192,316 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1135,676,941 - 135,696,556 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired angioedema  (ISO)
acute kidney failure  (ISO)
adrenoleukodystrophy  (ISO)
ALAD-Deficiency Porphyria  (IEP)
anemia  (ISO)
autistic disorder  (ISO)
Brain Injuries  (IEP)
cataract  (IDA)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (IEP)
cholestasis  (IEP)
chronic granulomatous disease  (ISO)
congenital hemolytic anemia  (ISO)
congenital hypothyroidism  (IEP)
congenital nonspherocytic hemolytic anemia  (ISO)
contact dermatitis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IEP)
Experimental Diabetes Mellitus  (IEP)
favism  (ISO)
Fever  (ISO)
genetic disease  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
Hemolysis  (ISO)
hemolytic anemia  (ISO)
hepatic encephalopathy  (IEP)
hepatocellular carcinoma  (IEP)
Hypercholesterolemia  (IEP)
hyperhomocysteinemia  (IEP)
Hypertriglyceridemia  (IEP)
immunodeficiency 33  (ISO)
Insulin Resistance  (IEP)
kidney disease  (IEP)
Liver Injury  (IEP)
malaria  (ISO)
Metabolic Syndrome  (IEP)
Multi-Infarct Dementia  (IEP)
myocardial infarction  (IEP)
Neonatal Hyperbilirubinemia  (ISO)
neonatal jaundice  (ISO)
non-alcoholic fatty liver disease  (IEP)
obesity  (IEP,ISO)
osteoporosis  (ISO)
phagocyte bactericidal dysfunction  (ISO)
phenylketonuria  (IEP)
Plasmodium falciparum malaria  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (IMP)
renovascular hypertension  (IEP)
Reperfusion Injury  (IEP)
severe congenital encephalopathy due to MECP2 mutation  (ISO)
Splenomegaly  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
Testicular Injury  (IEP)
transient cerebral ischemia  (IMP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
X-linked parkinsonism-spasticity syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP)
(E)-cinnamyl alcohol  (ISO)
(R)-noradrenaline  (EXP)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methylphenanthrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2,5-dihydroxybenzoic acid  (ISO)
2-(4-hydroxyphenyl)ethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-chlorobiphenyl  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-formyltetrahydrofolic acid  (EXP)
5-methylphenazinium methyl sulfate  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
albuterol  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
aluminium atom  (EXP,ISO)
aluminium phosphide  (EXP)
aluminium(0)  (EXP,ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
androsterone  (EXP)
antimycin A  (ISO)
aristolochic acid  (ISO)
arjunolic acid  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astaxanthin  (EXP)
atenolol  (EXP)
Augmentin  (ISO)
azoxystrobin  (ISO)
Bandrowski's base  (ISO)
benzatropine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoic acid  (ISO)
Benzoyl peroxide  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium nitrate  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
carbaryl  (EXP)
carbon nanotube  (ISO)
carnosine  (ISO)
cefaloridine  (EXP)
chelerythrine  (EXP)
chlorite  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (EXP)
cinnamyl alcohol  (ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
citronellol  (EXP)
clavulanic acid  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
coenzyme Q10  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
cumene hydroperoxide  (EXP)
curcumin  (EXP)
cycloartenol  (ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
dapsone  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP)
Diallyl sulfide  (EXP)
Diallyltetrasulfane  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP,ISO)
digoxin  (EXP)
dihydroartemisinin  (ISO)
dimethoate  (EXP)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
dobutamine  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
eugenol  (ISO)
fenoterol  (EXP)
fenpyroximate  (ISO)
fenvalerate  (EXP)
ferulic acid  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
gallic acid  (EXP)
Gallopamil  (EXP)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP)
geraniol  (EXP,ISO)
glafenine  (EXP)
gliclazide  (EXP)
glutaraldehyde  (ISO)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (EXP)
glyburide  (EXP)
glyoxylic acid  (EXP)
glyphosate  (EXP)
herbacetin  (ISO)
herbicide  (EXP)
hesperetin  (EXP)
hesperidin  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hexane  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
inositol  (EXP)
iron trichloride  (EXP)
iron(III) nitrilotriacetate  (EXP)
isoeugenol  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP)
isosorbide dinitrate  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-glutamine  (EXP)
lead diacetate  (EXP)
lead nitrate  (EXP)
lovastatin  (ISO)
malathion  (EXP)
melatonin  (EXP,ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl salicylate  (ISO)
methylene blue  (ISO)
methylmercury chloride  (ISO)
metoprolol  (EXP)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
myo-inositol hexakisphosphate  (EXP)
myricetin  (EXP)
N,N'-diphenyl-1,4-phenylenediamine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
naringin  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nicotinamide  (EXP)
nicotine  (EXP)
nitroprusside  (ISO)
Nonylphenol  (EXP)
norfenefrine  (EXP)
ochratoxin A  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
prazosin  (EXP)
primaquine  (ISO)
promethazine  (EXP)
propan-2-ol  (ISO)
propetamphos  (EXP)
pyrroles  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinalphos  (EXP)
quinolinic acid  (EXP)
rac-lactic acid  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
serpentine asbestos  (EXP,ISO)
silibinin  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (EXP)
sinapic acid  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chlorate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium nitrate  (EXP)
sodium nitrite  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tadalafil  (EXP)
tamoxifen  (EXP,ISO)
taurine  (EXP,ISO)
terbutaline  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
trichloroethene  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zearalenone  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Protective effect of Satureja montana extract on cyclophosphamide-induced testicular injury in rats. Abd El Tawab AM, etal., Chem Biol Interact. 2014 Nov 11;224C:196-205. doi: 10.1016/j.cbi.2014.11.001.
2. Cardioprotective effects of aqueous extract of Oxalis corniculata in experimental myocardial infarction. Abhilash PA, etal., Exp Toxicol Pathol. 2011 Sep;63(6):535-40. doi: 10.1016/j.etp.2010.04.004. Epub 2010 May 11.
3. Purification of rat kidney glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase enzymes using 2',5'-ADP Sepharose 4B affinity in a single chromatography step. Adem S and Ciftci M, Protein Expr Purif. 2012 Jan;81(1):1-4. doi: 10.1016/j.pep.2011.08.031. Epub 2011 Sep 10.
4. Changes in white adipose tissue metabolism induced by resveratrol in rats. Alberdi G, etal., Nutr Metab (Lond). 2011 May 10;8(1):29. doi: 10.1186/1743-7075-8-29.
5. Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury. Ansari MA, etal., Free Radic Biol Med. 2008 Aug 15;45(4):443-52. Epub 2008 May 3.
6. Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case-control study. Apinjoh TO, etal., Malar J. 2014 Jun 16;13:236. doi: 10.1186/1475-2875-13-236.
7. Hyperbaric oxygen preconditioning protects rats against CNS oxygen toxicity. Arieli Y, etal., Respir Physiol Neurobiol. 2014 Jun 15;197:29-35. doi: 10.1016/j.resp.2014.03.006. Epub 2014 Mar 24.
8. Adequate hemodialysis improves anemia by enhancing glucose-6-phosphate dehydrogenase activity in patients with end-stage renal disease. Ayesh Haj Yousef MH, etal., BMC Nephrol. 2014 Sep 26;15:155. doi: 10.1186/1471-2369-15-155.
9. DNA sequence abnormalities of human glucose-6-phosphate dehydrogenase variants. Beutler E, etal., J Biol Chem. 1991 Mar 5;266(7):4145-50.
10. Quantification of G6PD in small and large intestine of rat during aging. Biagiotti E, etal., Acta Histochem 2002;104(3):225-34.
11. The cellular fate of glucose and its relevance in type 2 diabetes. Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30.
12. Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). Brand IA and Heinickel A, J Biol Chem. 1991 Nov 5;266(31):20984-9.
13. The pentose phosphate pathway in the endoplasmic reticulum. Bublitz C and Steavenson S, J Biol Chem. 1988 Sep 15;263(26):12849-53.
14. Expression of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in oxidative stress induced by long-term iron toxicity in rat liver. Budak H, etal., J Biochem Mol Toxicol. 2014 May;28(5):217-23. doi: 10.1002/jbt.21556. Epub 2014 Mar 5.
15. Prevalence of glucose-6-phosphate dehydrogenase deficiency and its association with Plasmodium falciparum infection among children in Iganga distric in Uganda. Bwayo D, etal., BMC Res Notes. 2014 Jun 18;7:372. doi: 10.1186/1756-0500-7-372.
16. Cimicifuga racemosa impairs fatty acid beta-oxidation and induces oxidative stress in livers of ovariectomized rats with renovascular hypertension. Campos LB, etal., Free Radic Biol Med. 2012 Aug 15;53(4):680-9. doi: 10.1016/j.freeradbiomed.2012.05.043. Epub 2012 Jun 7.
17. Congenital hypothyroidism alters the oxidative status, enzyme activities and morphological parameters in the hippocampus of developing rats. Cattani D, etal., Mol Cell Endocrinol. 2013 Aug 15;375(1-2):14-26. doi: 10.1016/j.mce.2013.05.001. Epub 2013 May 18.
18. Glucose-6-phosphate dehydrogenase plays a critical role in hypoxia-induced CD133+ progenitor cells self-renewal and stimulates their accumulation in the lungs of pulmonary hypertensive rats. Chettimada S, etal., Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L545-56. doi: 10.1152/ajplung.00303.2013. Epub 2014 Jul 25.
19. Chronic hyperhomocysteinemia induces oxidative damage in the rat lung. da Cunha AA, etal., Mol Cell Biochem. 2011 Dec;358(1-2):153-60. doi: 10.1007/s11010-011-0930-2. Epub 2011 Jun 30.
20. Glucose-6-phosphate dehydrogenase activity and NADPH/NADP+ ratio in liver and pancreas are dependent on the severity of hyperglycemia in rat. Diaz-Flores M, etal., Life Sci. 2006 Apr 25;78(22):2601-7. Epub 2005 Dec 2.
21. Alterations of the redox state, pentose pathway and glutathione metabolism in an acute porphyria model. Their impact on heme pathway. Faut M, etal., Exp Biol Med (Maywood). 2013 Feb;238(2):133-43. doi: 10.1177/1535370212473702. Epub 2013 Feb 6.
22. Peroxynitrite protects neurons against nitric oxide-mediated apoptosis. A key role for glucose-6-phosphate dehydrogenase activity in neuroprotection. Garcia-Nogales P, etal., J Biol Chem 2003 Jan 10;278(2):864-74.
23. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
24. Direct detection for G6PD Bangkok and G6PD Bangkok Noi mutations in the families with chronic nonspherocytic hemolytic anemia (CNSHA). Glomglao W, etal., Int J Lab Hematol. 2015 Apr;37(2):e21-4. doi: 10.1111/ijlh.12264. Epub 2014 Jun 13.
25. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
26. Suppression of interleukin-1 beta-induced nitric oxide production in RINm5F cells by inhibition of glucose-6-phosphate dehydrogenase. Guo L, etal., Biochemistry 2002 Dec 17;41(50):14726-33.
27. Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver. Gupte RS, etal., Free Radic Biol Med. 2009 Feb 20.
28. Stobadine protects rat kidney against ischaemia/reperfusion injury. Guz G, etal., Clin Exp Pharmacol Physiol. 2007 Mar;34(3):210-6.
29. Cloning and sequence of a cDNA encoding rat glucose-6-phosphate dehydrogenase. Ho YS, etal., Nucleic Acids Res 1988 Aug 11;16(15):7746.
30. Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling. Hu XQ, etal., Lipids Health Dis. 2010 Mar 9;9:25. doi: 10.1186/1476-511X-9-25.
31. Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Huong DT and Ide T, Br J Nutr. 2008 Jul;100(1):79-87. Epub 2007 Dec 7.
32. The protective role of ellagitannins flavonoids pretreatment against N-nitrosodiethylamine induced-hepatocellular carcinoma. Hussein RH and Khalifa FK, Saudi J Biol Sci. 2014 Dec;21(6):589-96. doi: 10.1016/j.sjbs.2014.03.004. Epub 2014 Mar 31.
33. G6PD deficiency and absence of alpha-thalassemia increase the risk for cerebral vasculopathy in children with sickle cell anemia. Joly P, etal., Eur J Haematol. 2015 Jun 13. doi: 10.1111/ejh.12607.
34. Antihyperglycemic effect of 18 beta-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats. Kalaiarasi P and Pugalendi KV, Eur J Pharmacol. 2009 Mar 15;606(1-3):269-73. Epub 2009 Jan 21.
35. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
36. Protective effect of omega-3 polyunsaturated fatty acids (PUFAs) on sodium nitroprusside-induced nephrotoxicity and oxidative damage in rat kidney. Khan MW, etal., Hum Exp Toxicol. 2012 Oct;31(10):1035-49. doi: 10.1177/0960327112444475. Epub 2012 May 1.
37. Fenugreek seed extract inhibit fat accumulation and ameliorates dyslipidemia in high fat diet-induced obese rats. Kumar P, etal., Biomed Res Int. 2014;2014:606021. doi: 10.1155/2014/606021. Epub 2014 Apr 29.
38. Incidence, etiology, and outcomes of hazardous hyperbilirubinemia in newborns. Kuzniewicz MW, etal., Pediatrics. 2014 Sep;134(3):504-9. doi: 10.1542/peds.2014-0987. Epub 2014 Aug 4.
39. [Tissue-specific features of the pentose phosphate pathway in rats under acute alcoholic intoxication conditions] Lelevich SV Eksp Klin Farmakol. 2008 Mar-Apr;71(2):53-5.
40. Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali. Maiga B, etal., Malar J. 2014 Jul 11;13:270. doi: 10.1186/1475-2875-13-270.
41. Grape seed extract and zinc containing nutritional food supplement prevents onset and progression of age-related cataract in wistar rats. Mani Satyam S, etal., J Nutr Health Aging. 2014 May;18(5):524-30. doi: 10.1007/s12603-014-0020-8.
42. Cardiac-specific hexokinase 2 overexpression attenuates hypertrophy by increasing pentose phosphate pathway flux. McCommis KS, etal., J Am Heart Assoc. 2013 Nov 4;2(6):e000355. doi: 10.1161/JAHA.113.000355.
43. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
44. Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency in Greek newborns: the Mediterranean C563T mutation screening. Molou E, etal., Scand J Clin Lab Invest. 2014 Apr;74(3):259-63. doi: 10.3109/00365513.2013.879733. Epub 2014 Jan 24.
45. Glutathione metabolism enzymes in brain and liver of hyperphenylalaninemic rats and the effect of lipoic acid treatment. Moraes TB, etal., Metab Brain Dis. 2014 Sep;29(3):609-15. doi: 10.1007/s11011-014-9491-x. Epub 2014 Feb 2.
46. Effect of cold acclimation on brown adipose tissue fatty acid synthesis in rats adapted to a high-protein, carbohydrate-free diet. Moura MA, etal., Metabolism. 2001 Dec;50(12):1493-8.
47. High prevalence of anaemia among African migrants in Germany persists after exclusion of iron deficiency and erythrocyte polymorphisms. Muller SA, etal., Trop Med Int Health. 2015 Sep;20(9):1180-1189. doi: 10.1111/tmi.12530. Epub 2015 May 21.
48. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
49. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
50. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
51. Hepatoprotective role of naringin on nickel-induced toxicity in male Wistar rats. Pari L and Amudha K, Eur J Pharmacol. 2011 Jan 10;650(1):364-70. doi: 10.1016/j.ejphar.2010.09.068. Epub 2010 Oct 13.
52. Protective role of sinapic acid against arsenic: induced toxicity in rats. Pari L and Mohamed Jalaludeen A, Chem Biol Interact. 2011 Oct 15;194(1):40-7. doi: 10.1016/j.cbi.2011.08.004. Epub 2011 Aug 16.
53. Overexpression of glucose-6-phosphate dehydrogenase is associated with lipid dysregulation and insulin resistance in obesity. Park J, etal., Mol Cell Biol. 2005 Jun;25(12):5146-57.
54. Hypolipidemic Effect of Celastrus paniculatus in Experimentally Induced Hypercholesterolemic Wistar Rats. Patil RH, etal., Indian J Clin Biochem. 2010 Oct;25(4):405-10. doi: 10.1007/s12291-010-0050-x. Epub 2010 Sep 14.
55. Spironolactone improves nephropathy by enhancing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rat. Pessoa BS, etal., J Renin Angiotensin Aldosterone Syst. 2012 Mar;13(1):56-66. doi: 10.1177/1470320311422581. Epub 2011 Oct 10.
56. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
57. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
58. Long-term effect of Trigonella foenum graecum and its combination with sodium orthovanadate in preventing histopathological and biochemical abnormalities in diabetic rat ocular tissues. Preet A, etal., Mol Cell Biochem. 2006 Sep;289(1-2):137-47. Epub 2006 May 23.
59. Involvement of mitochondrial permeability transition, glutathione status, pentose phosphate pathway, and oxidative damage in the protective effect of fasting on the ischaemic-reperfused rat heart. Prendes MG, etal., Clin Exp Pharmacol Physiol. 2008 Nov 28.
60. Glucose-6-phosphate dehydrogenase and NADPH redox regulates cardiac myocyte L-type calcium channel activity and myocardial contractile function. Rawat DK, etal., PLoS One. 2012;7(10):e45365. doi: 10.1371/journal.pone.0045365. Epub 2012 Oct 5.
61. GOA pipeline RGD automated data pipeline
62. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
63. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
64. Dietary chia seed induced changes in hepatic transcription factors and their target lipogenic and oxidative enzyme activities in dyslipidaemic insulin-resistant rats. Rossi AS, etal., Br J Nutr. 2013 May;109(9):1617-27. doi: 10.1017/S0007114512003558. Epub 2012 Sep 5.
65. The antioxidant status during maturation of reticulocytes to erythrocytes in type 2 diabetics. Sailaja YR, etal., Free Radic Biol Med. 2003 Jul 15;35(2):133-9.
66. High frequency of diabetes and impaired fasting glucose in patients with glucose-6-phosphate dehydrogenase deficiency in the Western brazilian Amazon. Santana MS, etal., Am J Trop Med Hyg. 2014 Jul;91(1):74-6. doi: 10.4269/ajtmh.13-0032. Epub 2014 May 27.
67. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
68. Hypoglycaemic role of wheatgrass and its effect on carbohydrate metabolic enzymes in type II diabetic rats. Shakya G, etal., Toxicol Ind Health. 2014 Aug 12. pii: 0748233714545202.
69. Activation of neuronal nitric oxide synthase in cerebellum of chronic hepatic encephalopathy rats is associated with up-regulation of NADPH-producing pathway. Singh S and Trigun SK, Cerebellum. 2010 Sep;9(3):384-97. doi: 10.1007/s12311-010-0172-y.
70. G6PD A- deficiency and severe malaria in The Gambia: heterozygote advantage and possible homozygote disadvantage. Sirugo G, etal., Am J Trop Med Hyg. 2014 May;90(5):856-9. doi: 10.4269/ajtmh.13-0622. Epub 2014 Mar 10.
71. High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes. Sobngwi E, etal., J Clin Endocrinol Metab. 2005 Aug;90(8):4446-51. Epub 2005 May 24.
72. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
73. Beneficial effects of modified egg* on oxidative stress in F1- generation of metabolic syndrome-X induced Wistar rat. Taneja SK and Singh KB, Indian J Exp Biol. 2009 Feb;47(2):104-12.
74. Effect of Anabolic Steroid Nandrolone Decanoate on the Properties of Certain Enzymes in the Heart, Liver, and Muscle of Rats, and their Effect on Rats' Cardiac Electrophysiology. Tylicki A, etal., Horm Metab Res. 2007 Apr;39(4):268-72.
75. Activated glucose-6-phosphate dehydrogenase is associated with insulin resistance by upregulating pentose and pentosidine in diet-induced obesity of rats. Wang F, etal., Horm Metab Res. 2012 Dec;44(13):938-42. doi: 10.1055/s-0032-1323727. Epub 2012 Sep 26.
76. The involvement of glucose metabolism in the regulation of inducible nitric oxide synthase gene expression in glial cells: possible role of glucose-6-phosphate dehydrogenase and CCAAT/enhancing binding protein. Won JS, etal., J Neurosci 2003 Aug 20;23(20):7470-8.
77. Knockdown of glucose-6-phosphate dehydrogenase (G6PD) following cerebral ischemic reperfusion: the pros and cons. Zhao G, etal., Neurochem Int. 2012 Jul;61(2):146-55. doi: 10.1016/j.neuint.2012.05.003. Epub 2012 May 8.
78. Effects of acupuncture on glycometabolic enzymes in multi-infarct dementia rats. Zhao L, etal., Neurochem Res. 2011 May;36(5):693-700. doi: 10.1007/s11064-010-0378-x. Epub 2011 Jan 30.
79. Metabolic changes in rat brain histaminergic neurons during subhepatic cholestasis. Zimatkin SM, etal., Neurosci Behav Physiol. 2008 Oct;38(8):807-10. Epub 2008 Sep 18.
80. Significance of the 5-phosphoribosyl-1-pyrophosphate pool for cardiac purine and pyrimidine nucleotide synthesis: studies with ribose, adenine, inosine, and orotic acid in rats. Zimmer HG Cardiovasc Drugs Ther. 1998 Sep;12 Suppl 2:179-87.
Additional References at PubMed
PMID:743300   PMID:943046   PMID:1953691   PMID:2297768   PMID:2420826   PMID:2606104   PMID:3243423   PMID:3377761   PMID:5643703   PMID:5764873   PMID:7439685   PMID:7489710  
PMID:8491670   PMID:9067418   PMID:9169132   PMID:9330624   PMID:9539108   PMID:9627357   PMID:10627286   PMID:10745013   PMID:12027950   PMID:12521604   PMID:12829617   PMID:12838507  
PMID:14751857   PMID:14757696   PMID:15155459   PMID:15225644   PMID:15271799   PMID:15489334   PMID:15817708   PMID:15858258   PMID:15998684   PMID:16210322   PMID:17516514   PMID:19038868  
PMID:19056867   PMID:19946888   PMID:20387083   PMID:21248143   PMID:22926577   PMID:23233666   PMID:23533145   PMID:24769394   PMID:25076344   PMID:25109721   PMID:25228019   PMID:25416956  
PMID:25480333   PMID:26291555   PMID:26921441   PMID:28557068   PMID:33416454   PMID:33450132  


Genomics

Comparative Map Data
G6pd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X152,201,081 - 152,220,863 (-)NCBImRatBN7.2
mRatBN7.2 EnsemblX152,201,098 - 152,220,801 (-)Ensembl
Rnor_6.0X156,274,800 - 156,293,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,274,800 - 156,293,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,015,532 - 152,034,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,186,450 - 160,192,316 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1135,676,941 - 135,696,556 (+)NCBICelera
Cytogenetic MapXq37NCBI
G6PD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,531,390 - 154,547,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX154,517,825 - 154,547,572 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,759,605 - 153,775,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,412,800 - 153,428,981 (-)NCBINCBI36hg18NCBI36
Build 34X153,323,309 - 153,339,173NCBI
CeleraX153,920,654 - 153,936,836 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,336,102 - 142,352,295 (-)NCBIHuRef
CHM1_1X153,671,375 - 153,687,556 (-)NCBICHM1_1
T2T-CHM13v2.0X152,767,773 - 152,783,952 (-)NCBI
G6pdx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,453,089 - 73,472,486 (-)NCBIGRCm39mm39
GRCm39 EnsemblX73,453,089 - 73,472,800 (-)Ensembl
GRCm38X74,409,483 - 74,428,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,409,483 - 74,429,194 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,654,825 - 71,674,500 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X70,662,206 - 70,681,881 (-)NCBImm8
CeleraX65,663,679 - 65,683,364 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.0NCBI
G6pd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555801,045,294 - 1,057,083 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555801,045,294 - 1,058,129 (-)NCBIChiLan1.0ChiLan1.0
G6PD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X153,843,092 - 153,860,675 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,843,092 - 153,860,674 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X143,972,798 - 143,988,960 (-)NCBIMhudiblu_PPA_v0panPan3
G6PD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X122,217,317 - 122,231,862 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX122,205,683 - 122,231,678 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X125,358,989 - 125,373,645 (-)NCBI
ROS_Cfam_1.0 EnsemblX125,346,698 - 125,373,679 (-)Ensembl
UMICH_Zoey_3.1X121,127,964 - 121,142,608 (-)NCBI
UNSW_CanFamBas_1.0X123,643,041 - 123,657,679 (-)NCBI
UU_Cfam_GSD_1.0X123,404,813 - 123,419,460 (-)NCBI
G6pd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,532,130 - 119,548,019 (-)NCBI
SpeTri2.0NW_0049368091,269,900 - 1,285,853 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
G6PD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,029,150 - 125,041,040 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,029,147 - 125,041,040 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,553,693 - 143,556,137 (+)NCBISscrofa10.2Sscrofa10.2susScr3
G6PD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,768,028 - 128,788,366 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,770,268 - 128,786,961 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606566,762,820 - 66,779,827 (-)NCBIVero_WHO_p1.0
G6pd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946986,107 - 1,001,955 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624946989,376 - 1,001,787 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH142193  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,221,330 - 152,221,514 (-)MAPPERmRatBN7.2
Rnor_6.0X156,274,149 - 156,274,332NCBIRnor6.0
Rnor_5.01152,014,881 - 152,015,064UniSTSRnor5.0
Celera1135,676,290 - 135,676,473UniSTS
Cytogenetic MapXq37UniSTS
BI284751  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,201,230 - 152,201,390 (-)MAPPERmRatBN7.2
Rnor_6.0X156,293,626 - 156,293,785NCBIRnor6.0
Rnor_5.01152,034,367 - 152,034,526UniSTSRnor5.0
RGSC_v3.4X160,192,007 - 160,192,166UniSTSRGSC3.4
Celera1135,696,247 - 135,696,406UniSTS
Cytogenetic MapXq37UniSTS
PMC311070P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,201,365 - 152,201,695 (-)MAPPERmRatBN7.2
mRatBN7.26120,475,884 - 120,476,214 (+)MAPPERmRatBN7.2
Rnor_6.06125,212,363 - 125,212,692NCBIRnor6.0
Rnor_6.0X156,293,321 - 156,293,650NCBIRnor6.0
Rnor_5.06134,431,064 - 134,431,393UniSTSRnor5.0
Rnor_5.01152,034,062 - 152,034,391UniSTSRnor5.0
RGSC_v3.46125,501,696 - 125,502,025UniSTSRGSC3.4
RGSC_v3.4X160,191,702 - 160,192,031UniSTSRGSC3.4
Celera1135,695,942 - 135,696,271UniSTS
Celera6117,995,079 - 117,995,408UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic MapXq37UniSTS
PMC85812P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,203,604 - 152,204,044 (-)MAPPERmRatBN7.2
mRatBN7.26120,474,842 - 120,475,052 (+)MAPPERmRatBN7.2
Rnor_6.06125,211,321 - 125,211,530NCBIRnor6.0
Rnor_6.0X156,290,972 - 156,291,411NCBIRnor6.0
Rnor_5.06134,430,022 - 134,430,231UniSTSRnor5.0
Rnor_5.01152,031,713 - 152,032,152UniSTSRnor5.0
RGSC_v3.46125,500,654 - 125,500,863UniSTSRGSC3.4
RGSC_v3.4X160,189,353 - 160,189,792UniSTSRGSC3.4
Celera1135,693,593 - 135,694,032UniSTS
Celera6117,994,037 - 117,994,246UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic MapXq37UniSTS
UniSTS:256936  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,220,019 - 152,220,797 (-)MAPPERmRatBN7.2
Rnor_6.0X156,274,866 - 156,275,643NCBIRnor6.0
Rnor_5.01152,015,598 - 152,016,375UniSTSRnor5.0
Celera1135,677,007 - 135,677,784UniSTS
Cytogenetic MapXq37UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:390
Count of miRNA genes:185
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000056317
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 55 39 19 39 1 1 74 35 34 11 1
Low 8 2 2 2 7 10 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000080887   ⟹   ENSRNOP00000075297
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX152,201,098 - 152,220,801 (-)Ensembl
Rnor_6.0 EnsemblX156,274,800 - 156,293,926 (+)Ensembl
RefSeq Acc Id: NM_017006   ⟹   NP_058702
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,201,081 - 152,220,863 (-)NCBI
Rnor_6.0X156,274,800 - 156,293,935 (+)NCBI
Rnor_5.01152,015,532 - 152,034,676 (+)NCBI
RGSC_v3.4X160,186,450 - 160,192,316 (+)RGD
Celera1135,676,941 - 135,696,556 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058702 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41179 (Get FASTA)   NCBI Sequence Viewer  
  AAH81820 (Get FASTA)   NCBI Sequence Viewer  
  CAA30355 (Get FASTA)   NCBI Sequence Viewer  
  EDL84965 (Get FASTA)   NCBI Sequence Viewer  
  P05370 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058702   ⟸   NM_017006
- UniProtKB: P05370 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075297   ⟸   ENSRNOT00000080887

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05370-F1-model_v2 AlphaFold P05370 1-515 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702038
Promoter ID:EPDNEW_R12562
Type:multiple initiation site
Name:G6pd_1
Description:glucose-6-phosphate dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X156,274,850 - 156,274,910EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 152031738 152031739 C T snv HWY/Slc (KyushuU), F344/Stm (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2645 AgrOrtholog
BioCyc Gene G2FUF-619 BioCyc
BioCyc Pathway OXIDATIVEPENT-PWY [pentose phosphate pathway (oxidative branch) I] BioCyc
Ensembl Genes ENSRNOG00000056728 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000075297 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000080887 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108556 IMAGE-MGC_LOAD
InterPro G6P_DH UniProtKB/Swiss-Prot
  G6P_DH_AS UniProtKB/Swiss-Prot
  G6P_DH_C UniProtKB/Swiss-Prot
  G6P_DH_NAD-bd UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:24377 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93535 IMAGE-MGC_LOAD
NCBI Gene 24377 ENTREZGENE
PANTHER PTHR23429 UniProtKB/Swiss-Prot
Pfam G6PD_C UniProtKB/Swiss-Prot
  G6PD_N UniProtKB/Swiss-Prot
PharmGKB G6PD RGD
PhenoGen G6pd PhenoGen
PIRSF G6PD UniProtKB/Swiss-Prot
PRINTS G6PDHDRGNASE UniProtKB/Swiss-Prot
PROSITE G6P_DEHYDROGENASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
TIGRFAMs zwf UniProtKB/Swiss-Prot
UniProt G6PD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 G6pd  glucose-6-phosphate dehydrogenase  G6pdx  glucose-6-phosphate dehydrogenase X-linked  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 G6pdx  glucose-6-phosphate dehydrogenase X-linked    glucose-6-phosphate dehydrogenase  Name updated 1299863 APPROVED
2002-11-06 G6pdx  glucose-6-phosphate dehydrogenase  G6pd  Glucose-6-phosphate dehydrogenase  Symbol and Name updated 625702 APPROVED
2002-06-10 G6pd  Glucose-6-phosphate dehydrogenase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression induces NADPH accumulation and pormotes resistance against nitric oxide-mediated apoptosis 632733