G6pd (glucose-6-phosphate dehydrogenase) - Rat Genome Database

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Gene: G6pd (glucose-6-phosphate dehydrogenase) Rattus norvegicus
Analyze
Symbol: G6pd
Name: glucose-6-phosphate dehydrogenase
RGD ID: 2645
Description: Exhibits NADP binding activity; glucose binding activity; and glucose-6-phosphate dehydrogenase activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; pentose-phosphate shunt, oxidative branch; and positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Localizes to cytosol and nucleus. Used to study cataract and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); hepatic encephalopathy; hyperhomocysteinemia; obesity; and phenylketonuria. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase); PARTICIPATES IN pentose phosphate pathway; pentose phosphate pathway - oxidative phase; ribose 5-phosphate isomerase deficiency pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; (S)-naringenin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G6pdx; glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate dehydrogenase X-linked
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC366715  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X152,201,081 - 152,220,863 (-)NCBI
Rnor_6.0 EnsemblX156,274,800 - 156,293,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X156,274,800 - 156,293,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01152,015,532 - 152,034,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,186,450 - 160,192,316 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1135,676,941 - 135,696,556 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adrenoleukodystrophy  (ISO)
ALAD-Deficiency Porphyria  (IEP)
anemia  (ISO)
Angioedema Induced by ACE Inhibitors  (ISO)
autistic disorder  (ISO)
Bloch-Sulzberger syndrome  (ISO)
Brain Injuries  (IEP)
cataract  (IDA)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (IEP)
cholestasis  (IEP)
chronic granulomatous disease  (ISO)
congenital hemolytic anemia  (ISO)
congenital hypothyroidism  (IEP)
congenital nonspherocytic hemolytic anemia  (ISO)
contact dermatitis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IEP)
Ectodermal Dysplasia and Immunodeficiency 1  (ISO)
Experimental Diabetes Mellitus  (IEP)
favism  (ISO)
Fever  (ISO)
genetic disease  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
Hemolysis  (ISO)
hemolytic anemia  (ISO)
hepatic encephalopathy  (IEP)
hepatocellular carcinoma  (IEP)
Hypercholesterolemia  (IEP)
hyperhomocysteinemia  (IEP)
Hypertriglyceridemia  (IEP)
hypomelanosis of Ito  (ISO)
immunodeficiency 33  (ISO)
Insulin Resistance  (IEP)
kidney disease  (IEP)
Liver Injury  (IEP)
malaria  (ISO)
Metabolic Syndrome  (IEP)
Multi-Infarct Dementia  (IEP)
myocardial infarction  (IEP)
Neonatal Hyperbilirubinemia  (ISO)
neonatal jaundice  (ISO)
non-alcoholic fatty liver disease  (IEP)
obesity  (IEP,ISO)
osteoporosis  (ISO)
phagocyte bactericidal dysfunction  (ISO)
phenylketonuria  (IEP)
Plasmodium falciparum malaria  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (IMP)
renovascular hypertension  (IEP)
Reperfusion Injury  (IEP)
severe congenital encephalopathy due to MECP2 mutation  (ISO)
Testicular Injury  (IEP)
transient cerebral ischemia  (IMP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
X-linked parkinsonism-spasticity syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP)
(E)-cinnamyl alcohol  (ISO)
(R)-noradrenaline  (EXP)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methylphenanthrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,5-dihydroxybenzoic acid  (ISO)
2-(4-hydroxyphenyl)ethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-chlorobiphenyl  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-formyltetrahydrofolic acid  (EXP)
5-methylphenazinium methyl sulfate  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
albuterol  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
aluminium atom  (EXP,ISO)
aluminium phosphide  (EXP)
aluminium(0)  (EXP,ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
androsterone  (EXP)
arjunolic acid  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
astaxanthin  (EXP)
atenolol  (EXP)
Bandrowski's base  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoic acid  (ISO)
Benzoyl peroxide  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium nitrate  (EXP)
calcitriol  (ISO)
carbaryl  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chelerythrine  (EXP)
chlorite  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP,ISO)
cinnamyl alcohol  (ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
citronellol  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
coenzyme Q10  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cumene hydroperoxide  (EXP)
curcumin  (EXP)
cycloartenol  (ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
dapsone  (ISO)
DDT  (EXP)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP)
digoxin  (EXP)
dihydroartemisinin  (ISO)
dimethoate  (EXP)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
dobutamine  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
eugenol  (ISO)
fenoterol  (EXP)
fenvalerate  (EXP)
ferulic acid  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
Gallopamil  (EXP)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP)
geraniol  (EXP,ISO)
glafenine  (EXP)
gliclazide  (EXP)
glutaraldehyde  (ISO)
glutathione  (EXP,ISO)
glyburide  (EXP)
glyoxylic acid  (EXP)
glyphosate  (EXP)
herbacetin  (ISO)
herbicide  (EXP)
hesperetin  (EXP)
hesperidin  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hexane  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
inositol  (EXP)
iron trichloride  (EXP)
iron(III) nitrilotriacetate  (EXP)
isoeugenol  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP)
isosorbide dinitrate  (ISO)
isotretinoin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-glutamine  (EXP)
lead diacetate  (EXP)
lead nitrate  (EXP)
lovastatin  (ISO)
malathion  (EXP)
melatonin  (EXP,ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl salicylate  (ISO)
methylene blue  (ISO)
methylmercury chloride  (ISO)
metoprolol  (EXP)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
myo-inositol hexakisphosphate  (EXP)
myricetin  (EXP)
N,N'-diphenyl-1,4-phenylenediamine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
naringin  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nicotinamide  (EXP)
nicotine  (EXP)
nitroprusside  (ISO)
Nonylphenol  (EXP)
norfenefrine  (EXP)
ochratoxin A  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
prazosin  (EXP)
primaquine  (ISO)
promethazine  (EXP)
propan-2-ol  (ISO)
propetamphos  (EXP)
pyrroles  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinalphos  (EXP)
quinolinic acid  (EXP)
rac-lactic acid  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
serpentine asbestos  (EXP,ISO)
silibinin  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (EXP)
sinapic acid  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chlorate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium nitrate  (EXP)
sodium nitrite  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tadalafil  (EXP)
tamoxifen  (EXP,ISO)
taurine  (EXP,ISO)
terbutaline  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
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Additional References at PubMed
PMID:743300   PMID:943046   PMID:1953691   PMID:2297768   PMID:2420826   PMID:2606104   PMID:3243423   PMID:3377761   PMID:5643703   PMID:5764873   PMID:7439685   PMID:7489710  
PMID:8491670   PMID:9067418   PMID:9169132   PMID:9330624   PMID:9539108   PMID:9627357   PMID:10627286   PMID:10745013   PMID:12027950   PMID:12521604   PMID:12829617   PMID:12838507  
PMID:14751857   PMID:14757696   PMID:15155459   PMID:15225644   PMID:15271799   PMID:15489334   PMID:15817708   PMID:15858258   PMID:15998684   PMID:16210322   PMID:17516514   PMID:19038868  
PMID:19056867   PMID:19946888   PMID:20387083   PMID:21248143   PMID:22926577   PMID:23233666   PMID:23533145   PMID:24769394   PMID:25076344   PMID:25109721   PMID:25228019   PMID:25416956  
PMID:25480333   PMID:26291555   PMID:26921441   PMID:28557068   PMID:33416454  


Genomics

Comparative Map Data
G6pd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X152,201,081 - 152,220,863 (-)NCBI
Rnor_6.0 EnsemblX156,274,800 - 156,293,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X156,274,800 - 156,293,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01152,015,532 - 152,034,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,186,450 - 160,192,316 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1135,676,941 - 135,696,556 (+)NCBICelera
Cytogenetic MapXq37NCBI
G6PD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX154,531,391 - 154,547,572 (-)EnsemblGRCh38hg38GRCh38
GRCh38X154,531,390 - 154,547,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,759,605 - 153,775,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,412,800 - 153,428,981 (-)NCBINCBI36hg18NCBI36
Build 34X153,323,309 - 153,339,173NCBI
CeleraX153,920,654 - 153,936,836 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,336,102 - 142,352,295 (-)NCBIHuRef
CHM1_1X153,671,374 - 153,687,570 (-)NCBICHM1_1
G6pdx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,453,089 - 73,472,486 (-)NCBIGRCm39mm39
GRCm39 EnsemblX73,453,089 - 73,472,800 (-)Ensembl
GRCm38X74,409,483 - 74,428,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,409,483 - 74,429,194 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,654,825 - 71,674,500 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X70,662,206 - 70,681,881 (-)NCBImm8
CeleraX65,663,679 - 65,683,364 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.0NCBI
G6pd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555801,045,294 - 1,057,083 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555801,045,294 - 1,058,129 (-)NCBIChiLan1.0ChiLan1.0
G6PD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X153,843,092 - 153,860,675 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,843,092 - 153,860,674 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X143,972,798 - 143,988,960 (-)NCBIMhudiblu_PPA_v0panPan3
G6PD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X122,217,317 - 122,231,862 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX122,205,683 - 122,231,678 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X125,358,989 - 125,373,645 (-)NCBI
UMICH_Zoey_3.1X121,127,964 - 121,142,608 (-)NCBI
UNSW_CanFamBas_1.0X123,643,041 - 123,657,679 (-)NCBI
UU_Cfam_GSD_1.0X123,404,813 - 123,419,460 (-)NCBI
G6pd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,532,130 - 119,548,019 (-)NCBI
SpeTri2.0NW_0049368091,269,900 - 1,285,853 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
G6PD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,025,257 - 125,041,033 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,029,147 - 125,041,040 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,553,693 - 143,556,137 (+)NCBISscrofa10.2Sscrofa10.2susScr3
G6PD
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,768,028 - 128,788,366 (-)NCBI
ChlSab1.1 EnsemblX128,770,268 - 128,786,961 (-)Ensembl
G6pd
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624946989,376 - 1,001,787 (-)NCBI

Position Markers
RH142193  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,221,330 - 152,221,514 (-)MAPPER
Rnor_6.0X156,274,149 - 156,274,332NCBIRnor6.0
Rnor_5.01152,014,881 - 152,015,064UniSTSRnor5.0
Celera1135,676,290 - 135,676,473UniSTS
Cytogenetic MapXq37UniSTS
BI284751  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,201,230 - 152,201,390 (-)MAPPER
Rnor_6.0X156,293,626 - 156,293,785NCBIRnor6.0
Rnor_5.01152,034,367 - 152,034,526UniSTSRnor5.0
RGSC_v3.4X160,192,007 - 160,192,166UniSTSRGSC3.4
Celera1135,696,247 - 135,696,406UniSTS
Cytogenetic MapXq37UniSTS
PMC311070P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,201,365 - 152,201,695 (-)MAPPER
mRatBN7.26120,475,884 - 120,476,214 (+)MAPPER
Rnor_6.06125,212,363 - 125,212,692NCBIRnor6.0
Rnor_6.0X156,293,321 - 156,293,650NCBIRnor6.0
Rnor_5.06134,431,064 - 134,431,393UniSTSRnor5.0
Rnor_5.01152,034,062 - 152,034,391UniSTSRnor5.0
RGSC_v3.46125,501,696 - 125,502,025UniSTSRGSC3.4
RGSC_v3.4X160,191,702 - 160,192,031UniSTSRGSC3.4
Celera1135,695,942 - 135,696,271UniSTS
Celera6117,995,079 - 117,995,408UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic MapXq37UniSTS
PMC85812P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,203,604 - 152,204,044 (-)MAPPER
mRatBN7.26120,474,842 - 120,475,052 (+)MAPPER
Rnor_6.06125,211,321 - 125,211,530NCBIRnor6.0
Rnor_6.0X156,290,972 - 156,291,411NCBIRnor6.0
Rnor_5.06134,430,022 - 134,430,231UniSTSRnor5.0
Rnor_5.01152,031,713 - 152,032,152UniSTSRnor5.0
RGSC_v3.46125,500,654 - 125,500,863UniSTSRGSC3.4
RGSC_v3.4X160,189,353 - 160,189,792UniSTSRGSC3.4
Celera1135,693,593 - 135,694,032UniSTS
Celera6117,994,037 - 117,994,246UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic MapXq37UniSTS
UniSTS:256936  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,220,019 - 152,220,797 (-)MAPPER
Rnor_6.0X156,274,866 - 156,275,643NCBIRnor6.0
Rnor_5.01152,015,598 - 152,016,375UniSTSRnor5.0
Celera1135,677,007 - 135,677,784UniSTS
Cytogenetic MapXq37UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X44320616158345622Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118715462159970021Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X134627816159970021Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:390
Count of miRNA genes:185
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000056317
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 55 39 19 39 1 1 74 35 34 11 1
Low 8 2 2 2 7 10 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000080887   ⟹   ENSRNOP00000075297
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX156,274,800 - 156,293,926 (+)Ensembl
RefSeq Acc Id: NM_017006   ⟹   NP_058702
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,201,081 - 152,220,863 (-)NCBI
Rnor_6.0X156,274,800 - 156,293,935 (+)NCBI
Rnor_5.01152,015,532 - 152,034,676 (+)NCBI
RGSC_v3.4X160,186,450 - 160,192,316 (+)RGD
Celera1135,676,941 - 135,696,556 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058702 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41179 (Get FASTA)   NCBI Sequence Viewer  
  AAH81820 (Get FASTA)   NCBI Sequence Viewer  
  CAA30355 (Get FASTA)   NCBI Sequence Viewer  
  EDL84965 (Get FASTA)   NCBI Sequence Viewer  
  P05370 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058702   ⟸   NM_017006
- UniProtKB: P05370 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075297   ⟸   ENSRNOT00000080887

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702038
Promoter ID:EPDNEW_R12562
Type:multiple initiation site
Name:G6pd_1
Description:glucose-6-phosphate dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X156,274,850 - 156,274,910EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 152031738 152031739 C T snv HWY/Slc (KyushuU), F344/Stm (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2645 AgrOrtholog
Ensembl Genes ENSRNOG00000056728 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000075297 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000080887 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108556 IMAGE-MGC_LOAD
InterPro G6P_DH UniProtKB/Swiss-Prot
  G6P_DH_AS UniProtKB/Swiss-Prot
  G6P_DH_C UniProtKB/Swiss-Prot
  G6P_DH_NAD-bd UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:24377 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93535 IMAGE-MGC_LOAD
NCBI Gene 24377 ENTREZGENE
PANTHER PTHR23429 UniProtKB/Swiss-Prot
Pfam G6PD_C UniProtKB/Swiss-Prot
  G6PD_N UniProtKB/Swiss-Prot
PharmGKB G6PD RGD
PhenoGen G6pd PhenoGen
PIRSF G6PD UniProtKB/Swiss-Prot
PRINTS G6PDHDRGNASE UniProtKB/Swiss-Prot
PROSITE G6P_DEHYDROGENASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
TIGRFAMs zwf UniProtKB/Swiss-Prot
UniProt G6PD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 G6pd  glucose-6-phosphate dehydrogenase  G6pdx  glucose-6-phosphate dehydrogenase X-linked  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 G6pdx  glucose-6-phosphate dehydrogenase X-linked    glucose-6-phosphate dehydrogenase  Name updated 1299863 APPROVED
2002-11-06 G6pdx  glucose-6-phosphate dehydrogenase  G6pd  Glucose-6-phosphate dehydrogenase  Symbol and Name updated 625702 APPROVED
2002-06-10 G6pd  Glucose-6-phosphate dehydrogenase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression induces NADPH accumulation and pormotes resistance against nitric oxide-mediated apoptosis 632733