Rb1 (RB transcriptional corepressor 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Rb1 (RB transcriptional corepressor 1) Rattus norvegicus
Analyze
Symbol: Rb1
Name: RB transcriptional corepressor 1
RGD ID: 3540
Description: Predicted to enable several functions, including disordered domain specific binding activity; enzyme binding activity; and importin-alpha family protein binding activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of protein kinase activity; and spermatogenesis. Located in nucleus. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in nervous system cancer (multiple); osteosarcoma; prostate cancer; small cell carcinoma; and urinary bladder cancer. Orthologous to human RB1 (RB transcriptional corepressor 1); PARTICIPATES IN ceramide signaling pathway; G1/S transition pathway; RNA polymerase III transcription pathway; INTERACTS WITH (Z)-3-butylidenephthalide; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: pp105; pRb; rb; retinoblastoma 1; Retinoblastoma 1 (including osteosarcoma); retinoblastoma-associated protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21548,371,295 - 48,502,473 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1548,371,296 - 48,502,302 (-)Ensembl
Rnor_6.01555,081,582 - 55,209,060 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1555,083,140 - 55,209,342 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01558,804,731 - 58,931,886 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41553,828,881 - 53,962,099 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11553,844,684 - 53,977,640 (-)NCBI
Celera1548,020,828 - 48,147,805 (-)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Erythroleukemia  (ISO)
acute kidney failure  (IEP)
acute lymphoblastic leukemia  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
Animal Mammary Neoplasms  (ISO)
Autosomal Recessive Woolly Hair  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1  (ISO)
basal cell carcinoma  (ISO)
bone osteosarcoma  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cervix uteri carcinoma in situ  (ISO)
chromosome 13q14 deletion syndrome  (ISO)
disease of cellular proliferation  (ISO)
ductal carcinoma in situ  (ISO)
embryonal carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
familial adenomatous polyposis 2  (ISO)
familial retinoblastoma  (ISO)
gastrointestinal stromal tumor  (ISO)
glioblastoma  (ISO)
glioblastoma proneural subtype  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hereditary nonpolyposis colorectal cancer type 4  (ISO)
hypotrichosis 8  (ISO)
in situ carcinoma  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
intestinal pseudo-obstruction  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
medulloblastoma  (ISO)
mitochondrial DNA depletion syndrome 5  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (ISO)
oligodendroglioma  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
Phyllodes Tumor  (ISO)
Pituitary Neoplasms  (IEP)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
retinoblastoma  (ISO)
seminoma  (ISO)
Sezary's disease  (ISO)
small cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
trilateral retinoblastoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,3-thiazolidine-2,4-dione  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-cyclopenten-1-one  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-O-methylguanine  (ISO)
6-oxocampestanol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
Actein  (ISO)
acteoside  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
albuterol  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alvocidib  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
andrographolide  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arotinoid acid  (ISO)
arsenic trichloride  (ISO)
arsenous acid  (ISO)
Aspidin  (ISO)
atorvastatin calcium  (ISO)
auranofin  (ISO)
baicalein  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
benzophenanthridine  (ISO)
beta-naphthoflavone  (EXP)
betulinic acid  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
BMS-754807  (ISO)
bortezomib  (ISO)
brassinolide  (ISO)
bucladesine  (EXP,ISO)
buspirone  (EXP)
busulfan  (ISO)
butyric acid  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calix[6]arene  (ISO)
calmidazolium  (ISO)
calyculin a  (ISO)
camptothecin  (ISO)
canertinib  (ISO)
capecitabine  (ISO)
captan  (ISO)
carbamazepine  (ISO)
cefaloridine  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
Chloramine  (ISO)
chlordecone  (ISO)
chlorohydrocarbon  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cudraflavone B  (ISO)
cumene  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
dactolisib  (ISO)
daunorubicin  (ISO)
DDT  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
Diacetoxyscirpenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicoumarol  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
doxazosin  (EXP,ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (EXP)
emodin  (ISO)
endosulfan  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethyl trans-caffeate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
everolimus  (ISO)
fenhexamid  (ISO)
ferulic acid  (EXP,ISO)
flavanone  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
folpet  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gadolinium trichloride  (ISO)
galangin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
glafenine  (EXP)
glutathione  (ISO)
GW 4064  (ISO)
heparin  (ISO)
heptachlor  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
ibuprofen  (EXP)
ICI 118551  (ISO)
indirubin  (ISO)
indoles  (ISO)
indometacin  (EXP,ISO)
irinotecan  (ISO)
isocyanates  (ISO)
isoeugenol  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
KN-93  (ISO)
L-cysteine  (ISO)
lapatinib  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
letrozole  (ISO)
levamisole  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lonafarnib  (ISO)
lopinavir  (ISO)
lovastatin  (EXP,ISO)
LY294002  (ISO)
lycopene  (ISO)
magnesium atom  (EXP)
maneb  (EXP)
masoprocol  (ISO)
Maxacalcitol  (ISO)
menadione  (ISO)
menaquinone  (ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
methylseleninic acid  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
monosodium L-glutamate  (EXP)
motexafin gadolinium  (ISO)
myo-inositol hexakisphosphate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nelfinavir  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrogen dioxide  (ISO)
Nonylphenol  (ISO)
O-(chloroacetylcarbamoyl)fumagillol  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
olomoucine  (ISO)
orlistat  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
panaxydol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (EXP)
pentobarbital  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP)
phenylephrine  (EXP)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosalone  (EXP)
picoxystrobin  (ISO)
pinosylvin  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
piroxicam  (ISO)
prednisone  (ISO)
proanthocyanidin  (EXP)
procyanidin  (ISO)
progesterone  (ISO)
promethazine  (EXP)
pterostilbene  (EXP)
quercetin  (EXP,ISO)
radicicol  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
Ro 41-5253  (ISO)
romidepsin  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
silibinin  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sorafenib  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (EXP)
tazarotene  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
terephthalic acid  (EXP)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
tocopherol  (ISO)
tolbutamide  (EXP)
toluene  (EXP)
toxaphene  (ISO)
trametinib  (ISO)
trans-isoeugenol  (ISO)
trans-pinosylvin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vinyl carbamate  (ISO)
vorinostat  (ISO)
wortmannin  (EXP,ISO)
Y-27632  (ISO)
zebularine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (IEA,ISO)
apoptotic process  (ISO)
cell differentiation  (IBA)
cell division  (IEA,ISO)
cell morphogenesis involved in neuron differentiation  (IBA,IEA,ISO)
cell population proliferation  (ISO)
cellular response to insulin stimulus  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
chondrocyte differentiation  (IEA,ISO)
digestive tract development  (IEA,ISO)
enucleate erythrocyte differentiation  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
G1/S transition of mitotic cell cycle  (ISO)
glial cell apoptotic process  (IEA,ISO)
glial cell proliferation  (IEA,ISO)
hepatocyte apoptotic process  (IEA,ISO)
heterochromatin assembly  (IEA,ISO)
maintenance of mitotic sister chromatid cohesion  (IEA,ISO)
myoblast differentiation  (IEA,ISO,ISS)
negative regulation of apoptotic signaling pathway  (IMP)
negative regulation of cell cycle  (IMP,ISO)
negative regulation of cell growth  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of DNA-binding transcription factor activity  (IEA,ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IBA,IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (IEA,ISO)
negative regulation of hepatocyte apoptotic process  (IMP)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of myofibroblast differentiation  (IEA,ISO)
negative regulation of protein kinase activity  (IEA,ISO,ISS)
negative regulation of protein serine/threonine kinase activity  (IMP)
negative regulation of smoothened signaling pathway  (IEA,ISO)
negative regulation of tau-protein kinase activity  (IMP)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of transcription involved in G1/S transition of mitotic cell cycle  (IEA,ISO)
negative regulation of transcription, DNA-templated  (ISO)
neuron apoptotic process  (IEA,ISO)
neuron differentiation  (ISO)
neuron maturation  (IEA,ISO)
neuron projection development  (IBA,IEA,ISO)
positive regulation of collagen fibril organization  (IEA,ISO)
positive regulation of extracellular matrix organization  (ISO)
positive regulation of macrophage differentiation  (IEA,ISO)
positive regulation of mitotic metaphase/anaphase transition  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription regulatory region DNA binding  (IEA,ISO)
protein localization to chromosome, centromeric region  (IEA,ISO)
Ras protein signal transduction  (IEA,ISO)
regulation of cell cycle  (ISO)
regulation of cell growth  (ISO)
regulation of cohesin loading  (IEA,ISO)
regulation of lipid kinase activity  (IEA,ISO,ISS)
regulation of mitotic cell cycle  (ISO)
sister chromatid biorientation  (IEA,ISO)
skeletal muscle cell differentiation  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
spermatogenesis  (IEP)
striated muscle cell differentiation  (IEA,ISO)
tissue homeostasis  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. Absalon S, etal., J Neurosci. 2013 Sep 11;33(37):14645-59. doi: 10.1523/JNEUROSCI.1327-13.2013.
2. A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium. Angelis E, etal., Circ Res. 2008 May 23;102(10):1222-9. doi: 10.1161/CIRCRESAHA.107.163550. Epub 2008 Apr 17.
3. Deregulation of the RB pathway in human testicular germ cell tumours. Bartkova J, etal., J Pathol. 2003 Jun;200(2):149-56.
4. Chromosomal imbalances, loss of heterozygosity, and immunohistochemical expression of TP53, RB1, and PTEN in intraductal cancer, intraepithelial neoplasia, and invasive adenocarcinoma of the prostate. Bettendorf O, etal., Genes Chromosomes Cancer. 2008 Jul;47(7):565-72.
5. Loss of heterozygosity at 13q14 correlates with RB1 gene underexpression in human breast cancer. Bieche I and Lidereau R, Mol Carcinog. 2000 Nov;29(3):151-8.
6. Mutations in Rb1 pathway-related genes are associated with poor prognosis in anaplastic astrocytomas. B├Ącklund LM, etal., Br J Cancer. 2005 Jul 11;93(1):124-30. doi: 10.1038/sj.bjc.6602661.
7. Loss of heterozygosity and mutations are the major mechanisms of RB1 gene inactivation in Chinese with sporadic retinoblastoma. Choy KW, etal., Hum Mutat. 2002 Nov;20(5):408.
8. Estrogen-induced rat pituitary tumor is associated with loss of retinoblastoma susceptibility gene product. Chun TY, etal., Mol Cell Endocrinol. 1998 Nov 25;146(1-2):87-92.
9. Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. Daikoku T, etal., Cancer Res. 2006 Mar 1;66(5):2527-31.
10. The retinoblastoma gene product inhibits TGF-beta1 induced apoptosis in primary rat hepatocytes and human HuH-7 hepatoma cells. Fan G, etal., Oncogene. 1996 May 2;12(9):1909-19.
11. A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis. Francis SM, etal., PLoS One. 2011 Feb 22;6(2):e16434. doi: 10.1371/journal.pone.0016434.
12. Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction. Fu M, etal., J Clin Invest. 2013 Dec 2;123(12):5152-64. doi: 10.1172/JCI67653. Epub 2013 Nov 1.
13. Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells. Fujita N, etal., Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H204-12.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Subcellular compartmentalization of E2F family members is required for maintenance of the postmitotic state in terminally differentiated muscle. Gill RM and Hamel PA, J Cell Biol. 2000 Mar 20;148(6):1187-201.
16. RNA polymerase III repression by the retinoblastoma tumor suppressor protein. Gjidoda A and Henry RW, Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):385-92. doi: 10.1016/j.bbagrm.2012.09.011. Epub 2012 Oct 12.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Clinical stratification of glioblastoma based on alterations in retinoblastoma tumor suppressor protein (RB1) and association with the proneural subtype. Goldhoff P, etal., J Neuropathol Exp Neurol. 2012 Jan;71(1):83-9. doi: 10.1097/NEN.0b013e31823fe8f1.
19. Expression of the cell cycle proteins p21, p27, and pRb in clear cell renal cell carcinoma and their prognostic significance. Haitel A, etal., Urology. 2001 Sep;58(3):477-81.
20. Phase II trial of adjuvant gemcitabine plus cisplatin-based chemotherapy in patients with locally advanced bladder cancer. Jin JO, etal., Clin Genitourin Cancer. 2006 Sep;5(2):150-4.
21. Independent prognostic significance of cell cycle regulator proteins p16(INK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: a translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group. Kommoss S, etal., Br J Cancer. 2007 Jan 29;96(2):306-13.
22. Low p53 and retinoblastoma protein expression in cervical intraepithelial neoplasia grade 3 lesions is associated with coexistent adenocarcinoma in situ. Kruse AJ, etal., Hum Pathol. 2008 Apr;39(4):573-8. Epub 2008 Jan 30.
23. Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors. Kuijper A, etal., Am J Clin Pathol. 2005 May;123(5):690-8.
24. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
25. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Marino S, etal., Genes Dev 2000 Apr 15;14(8):994-1004.
26. Haploinsufficiency of the retinoblastoma protein gene reduces diet-induced obesity, insulin resistance, and hepatosteatosis in mice. Mercader J, etal., Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E184-93. doi: 10.1152/ajpendo.00163.2009. Epub 2009 May 5.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Decreased RB1 mRNA, protein, and activity reflect obesity-induced altered adipogenic capacity in human adipose tissue. Moreno-Navarrete JM, etal., Diabetes. 2013 Jun;62(6):1923-31. doi: 10.2337/db12-0977. Epub 2013 Jan 11.
29. Promoter hypermethylation of the RB1 gene in glioblastomas. Nakamura M, etal., Lab Invest. 2001 Jan;81(1):77-82.
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. [Correlation of E2F-1 and Rb expression with papillomatosis and ductal carcinoma in situ of the breast] Niu Y, etal., Zhonghua Zhong Liu Za Zhi. 2004 May;26(5):290-3.
32. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
33. Interaction of rat Cdc37-related protein with retinoblastoma gene product. Ozaki T and Sakiyama S, DNA Cell Biol. 1996 Nov;15(11):975-9.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
36. A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Qiu Z and Ghosh A, Neuron. 2008 Dec 10;60(5):775-87. doi: 10.1016/j.neuron.2008.09.040.
37. GOA pipeline RGD automated data pipeline
38. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Expression of the cell-cycle regulatory proteins (pRb, cyclin D1, p16INK4A and cdk4) in human endometrial cancer: correlation with clinicopathological features. Semczuk A, etal., Arch Gynecol Obstet. 2004 Jan;269(2):104-10. Epub 2002 Nov 22.
41. Common variants in RB1 gene and risk of invasive ovarian cancer. Song H, etal., Cancer Res. 2006 Oct 15;66(20):10220-6.
42. Expression of ras Rb1 and p53 proteins in human breast cancer. Spandidos DA, etal., Anticancer Res. 1992 Jan-Feb;12(1):81-9.
43. Androgen regulation of stage-dependent cyclin D2 expression in Sertoli cells suggests a role in modulating androgen action on spermatogenesis. Tan KA, etal., Biol Reprod. 2005 May;72(5):1151-60. Epub 2005 Jan 19.
44. Genotype-phenotype correlations in hereditary familial retinoblastoma. Taylor M, etal., Hum Mutat. 2007 Mar;28(3):284-93.
45. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
46. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Woitach JT, etal., Nat Genet 1998 Aug;19(4):371-4.
47. Acute renal failure during sepsis: potential role of cell cycle regulation. Yang QH, etal., J Infect. 2009 Jun;58(6):459-64. doi: 10.1016/j.jinf.2009.04.003. Epub 2009 Apr 17.
Additional References at PubMed
PMID:7665085   PMID:7797074   PMID:7958874   PMID:8245034   PMID:8288605   PMID:8336704   PMID:8441612   PMID:8612582   PMID:8889548   PMID:9054499   PMID:9178770   PMID:9448006  
PMID:9858607   PMID:10082561   PMID:10783144   PMID:10888886   PMID:10944455   PMID:11246230   PMID:11301474   PMID:11331592   PMID:11549719   PMID:12037672   PMID:12065415   PMID:12200151  
PMID:12221087   PMID:12695505   PMID:12757710   PMID:12853964   PMID:14693709   PMID:15069084   PMID:15084472   PMID:15169903   PMID:15459751   PMID:15509711   PMID:15541338   PMID:15542848  
PMID:15616565   PMID:15640164   PMID:15701640   PMID:15735701   PMID:15735762   PMID:15831459   PMID:15843406   PMID:15870077   PMID:15898111   PMID:16126730   PMID:16286473   PMID:16360038  
PMID:16407335   PMID:16513252   PMID:16616919   PMID:16896691   PMID:17257418   PMID:17540172   PMID:17989570   PMID:18348166   PMID:18351461   PMID:18364697   PMID:18583990   PMID:18656278  
PMID:18692063   PMID:18700867   PMID:19123049   PMID:19223331   PMID:19505811   PMID:20023236   PMID:20213763   PMID:20224733   PMID:20485545   PMID:20551165   PMID:20924203   PMID:21504794  
PMID:22147266   PMID:22885065   PMID:23371354   PMID:23487765   PMID:24068000   PMID:24726645   PMID:25100735   PMID:27056896   PMID:29304157  


Genomics

Comparative Map Data
Rb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21548,371,295 - 48,502,473 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1548,371,296 - 48,502,302 (-)Ensembl
Rnor_6.01555,081,582 - 55,209,060 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1555,083,140 - 55,209,342 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01558,804,731 - 58,931,886 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41553,828,881 - 53,962,099 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11553,844,684 - 53,977,640 (-)NCBI
Celera1548,020,828 - 48,147,805 (-)NCBICelera
Cytogenetic Map15q11NCBI
RB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381348,303,751 - 48,481,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1348,303,744 - 48,599,436 (+)EnsemblGRCh38hg38GRCh38
GRCh371348,877,887 - 49,056,026 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,775,884 - 47,954,027 (+)NCBINCBI36hg18NCBI36
Build 341347,775,911 - 47,954,023NCBI
Celera1329,932,627 - 30,110,747 (+)NCBI
Cytogenetic Map13q14.2NCBI
HuRef1329,670,144 - 29,848,118 (+)NCBIHuRef
CHM1_11348,845,597 - 49,023,603 (+)NCBICHM1_1
T2T-CHM13v2.01347,524,085 - 47,702,182 (+)NCBI
Rb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391473,430,298 - 73,563,446 (-)NCBIGRCm39mm39
GRCm39 Ensembl1473,421,113 - 73,563,262 (-)Ensembl
GRCm381473,192,858 - 73,325,951 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1473,183,673 - 73,325,822 (-)EnsemblGRCm38mm10GRCm38
MGSCv371473,595,309 - 73,725,598 (-)NCBIGRCm37mm9NCBIm37
MGSCv361471,929,656 - 72,059,895 (-)NCBImm8
Celera1470,715,843 - 70,870,859 (-)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1438.73NCBI
Rb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554311,960,661 - 2,124,576 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554311,960,765 - 2,124,576 (+)NCBIChiLan1.0ChiLan1.0
RB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11348,155,608 - 48,326,396 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1348,155,795 - 48,324,575 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01329,453,872 - 29,624,665 (+)NCBIMhudiblu_PPA_v0panPan3
RB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1223,061,621 - 3,204,625 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl223,063,239 - 3,257,726 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha223,090,617 - 3,235,458 (-)NCBI
ROS_Cfam_1.0223,143,918 - 3,320,581 (-)NCBI
ROS_Cfam_1.0 Ensembl223,050,839 - 3,321,505 (-)Ensembl
UMICH_Zoey_3.1222,960,514 - 3,106,149 (-)NCBI
UNSW_CanFamBas_1.0223,023,421 - 3,169,707 (-)NCBI
UU_Cfam_GSD_1.0223,028,586 - 3,174,226 (-)NCBI
Rb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945158,103,473 - 158,265,512 (+)NCBI
SpeTri2.0NW_0049365651,596,227 - 1,746,706 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,186,759 - 19,317,690 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,186,754 - 19,317,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21119,648,360 - 19,770,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1326,220,783 - 26,393,671 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl326,220,803 - 26,394,546 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605717,512,606 - 17,688,151 (-)NCBIVero_WHO_p1.0
Rb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247486,358,180 - 6,533,249 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247486,358,588 - 6,533,217 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH94875  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,372,696 - 48,372,923 (+)MAPPERmRatBN7.2
Rnor_6.01555,082,984 - 55,083,210NCBIRnor6.0
Rnor_5.01558,806,133 - 58,806,359UniSTSRnor5.0
RGSC_v3.41553,830,283 - 53,830,509UniSTSRGSC3.4
Celera1548,022,230 - 48,022,456UniSTS
Cytogenetic Map15q12UniSTS
PMC104404P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41553,962,001 - 53,962,504UniSTSRGSC3.4
Cytogenetic Map15q12UniSTS
M26391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,372,900 - 48,372,983 (+)MAPPERmRatBN7.2
Rnor_6.01555,083,188 - 55,083,270NCBIRnor6.0
Rnor_5.01558,806,337 - 58,806,419UniSTSRnor5.0
RGSC_v3.41553,830,487 - 53,830,569UniSTSRGSC3.4
Celera1548,022,434 - 48,022,516UniSTS
Cytogenetic Map15q12UniSTS
BE098816  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,428,262 - 48,428,442 (+)MAPPERmRatBN7.2
Rnor_6.01555,138,656 - 55,138,835NCBIRnor6.0
Rnor_5.01558,861,789 - 58,861,968UniSTSRnor5.0
RGSC_v3.41553,887,416 - 53,887,595UniSTSRGSC3.4
Celera1548,077,756 - 48,077,935UniSTS
Cytogenetic Map15q12UniSTS
RH94505  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,372,062 - 48,372,257 (+)MAPPERmRatBN7.2
mRatBN7.21548,372,108 - 48,372,257 (+)MAPPERmRatBN7.2
Rnor_6.01555,082,396 - 55,082,544NCBIRnor6.0
Rnor_6.01555,082,350 - 55,082,544NCBIRnor6.0
Rnor_5.01558,805,545 - 58,805,693UniSTSRnor5.0
Rnor_5.01558,805,499 - 58,805,693UniSTSRnor5.0
RGSC_v3.41553,829,649 - 53,829,843UniSTSRGSC3.4
RGSC_v3.41553,829,695 - 53,829,843UniSTSRGSC3.4
Celera1548,021,642 - 48,021,790UniSTS
Celera1548,021,596 - 48,021,790UniSTS
Cytogenetic Map15q12UniSTS
RH138574  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,416,875 - 48,417,014 (+)MAPPERmRatBN7.2
Rnor_6.01555,127,281 - 55,127,419NCBIRnor6.0
Rnor_5.01558,850,398 - 58,850,536UniSTSRnor5.0
RGSC_v3.41553,875,791 - 53,875,929UniSTSRGSC3.4
Celera1548,066,406 - 48,066,544UniSTS
Cytogenetic Map15p11UniSTS
Cytogenetic Map15q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:677
Count of miRNA genes:300
Interacting mature miRNAs:381
Transcripts:ENSRNOT00000021752
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 38 22 19 22 8 9 74 35 38 11 8
Low 11 19 19 19 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021752   ⟹   ENSRNOP00000021752
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1548,371,296 - 48,502,302 (-)Ensembl
Rnor_6.0 Ensembl1555,083,140 - 55,209,342 (-)Ensembl
RefSeq Acc Id: NM_017045   ⟹   NP_058741
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21548,371,295 - 48,502,302 (-)NCBI
Rnor_6.01555,081,582 - 55,209,060 (-)NCBI
Rnor_5.01558,804,731 - 58,931,886 (-)NCBI
RGSC_v3.41553,828,881 - 53,962,099 (-)RGD
Celera1548,020,828 - 48,147,805 (-)RGD
Sequence:
RefSeq Acc Id: XM_039092994   ⟹   XP_038948922
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21548,431,120 - 48,502,473 (-)NCBI
RefSeq Acc Id: XR_005493691
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21548,382,594 - 48,502,468 (-)NCBI
Protein Sequences
Protein RefSeqs NP_058741 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948922 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42090 (Get FASTA)   NCBI Sequence Viewer  
  BAA04958 (Get FASTA)   NCBI Sequence Viewer  
  EDM02266 (Get FASTA)   NCBI Sequence Viewer  
  P33568 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058741   ⟸   NM_017045
- Sequence:
RefSeq Acc Id: ENSRNOP00000021752   ⟸   ENSRNOT00000021752
RefSeq Acc Id: XP_038948922   ⟸   XM_039092994
- Peptide Label: isoform X1
Protein Domains
CYCLIN   DUF3452   RB_A   Rb_C

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33568-F1-model_v2 AlphaFold P33568 1-920 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3540 AgrOrtholog
BioCyc Gene G2FUF-13166 BioCyc
Ensembl Genes ENSRNOG00000016029 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021752 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021752 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24708 UniProtKB/Swiss-Prot
NCBI Gene 24708 ENTREZGENE
PANTHER PTHR13742 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rb_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB RB1 RGD
PhenoGen Rb1 PhenoGen
SMART CYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RB_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rb_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC230434
UniProt P33568 ENTREZGENE
  R9PXV5_RAT UniProtKB/TrEMBL
  RB_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63527 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-03 Rb1  RB transcriptional corepressor 1  Rb1  retinoblastoma 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Rb1  Retinoblastoma 1 (including osteosarcoma)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog is inactivated in many tumors 734501