Pias3 (protein inhibitor of activated STAT, 3) - Rat Genome Database

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Gene: Pias3 (protein inhibitor of activated STAT, 3) Rattus norvegicus
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Symbol: Pias3
Name: protein inhibitor of activated STAT, 3
RGD ID: 708413
Description: Enables potassium channel regulator activity; protein C-terminus binding activity; and protein N-terminus binding activity. Involved in positive regulation of gene expression; positive regulation of membrane potential; and response to hormone. Located in dendrite; nucleus; and synapse. Orthologous to human PIAS3 (protein inhibitor of activated STAT 3); PARTICIPATES IN sumoylation pathway; interleukin-6 signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 SUMO-protein ligase PIAS3; E3 SUMO-protein transferase PIAS3; KChAP; LOC83614; potassium channel regulatory protein KChAP; potassium channel-associated protein; protein inhibitor of activated STAT 3; protein inhibitor of activated STAT protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22184,232,546 - 184,241,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,232,571 - 184,241,480 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,904,229 - 191,912,395 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02189,697,396 - 189,705,728 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02184,536,790 - 184,544,956 (+)NCBIRnor_WKY
Rnor_6.02198,821,377 - 198,831,533 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,823,366 - 198,836,372 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,309,595 - 218,318,467 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,499,057 - 191,507,221 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,461,810 - 191,469,975 (+)NCBI
Celera2176,757,800 - 176,765,964 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KChAP as a chaperone for specific K(+) channels. Kuryshev YA, etal., Am J Physiol Cell Physiol. 2000 May;278(5):C931-41.
4. SUMOylation regulates kainate-receptor-mediated synaptic transmission. Martin S, etal., Nature. 2007 May 17;447(7142):321-5. Epub 2007 May 7.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Leptin receptor expression and suppressor of cytokine signaling transcript levels in high-fat-fed rats. Peiser C, etal., Life Sci. 2000 Nov 3;67(24):2971-81.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. JAK/STAT signal transduction: regulators and implication in hematological malignancies. Valentino L and Pierre J, Biochem Pharmacol. 2006 Mar 14;71(6):713-21. Epub 2006 Jan 19.
13. Cloning and expression of a novel K+ channel regulatory protein, KChAP. Wible BA, etal., J Biol Chem 1998 May 8;273(19):11745-51.
14. Inhibitors of cytokine signal transduction. Wormald S and Hilton DJ, J Biol Chem 2004 Jan 9;279(2):821-4. Epub 2003 Nov 7.
Additional References at PubMed
PMID:11709556   PMID:11997457   PMID:14596924   PMID:14715251   PMID:15507434   PMID:15767674   PMID:17087506   PMID:17442941   PMID:17696781   PMID:18555800   PMID:19201870   PMID:21812053  
PMID:21965678   PMID:24651376   PMID:30942400   PMID:31642335   PMID:34288124  


Genomics

Comparative Map Data
Pias3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22184,232,546 - 184,241,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,232,571 - 184,241,480 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,904,229 - 191,912,395 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02189,697,396 - 189,705,728 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02184,536,790 - 184,544,956 (+)NCBIRnor_WKY
Rnor_6.02198,821,377 - 198,831,533 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,823,366 - 198,836,372 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,309,595 - 218,318,467 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,499,057 - 191,507,221 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,461,810 - 191,469,975 (+)NCBI
Celera2176,757,800 - 176,765,964 (+)NCBICelera
Cytogenetic Map2q34NCBI
PIAS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381145,848,522 - 145,859,081 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1145,848,522 - 145,859,836 (-)EnsemblGRCh38hg38GRCh38
GRCh371145,575,988 - 145,586,546 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361144,287,345 - 144,297,903 (+)NCBINCBI36Build 36hg18NCBI36
Build 341143,065,075 - 143,075,590NCBI
Celera1119,779,357 - 119,789,916 (+)NCBICelera
Cytogenetic Map1q21.1NCBI
HuRef1119,539,725 - 119,550,284 (+)NCBIHuRef
CHM1_11147,216,648 - 147,227,207 (-)NCBICHM1_1
T2T-CHM13v2.01144,965,325 - 144,975,891 (-)NCBIT2T-CHM13v2.0
Pias3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,603,679 - 96,613,386 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,603,700 - 96,613,386 (+)EnsemblGRCm39 Ensembl
GRCm38396,696,361 - 96,706,070 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,696,384 - 96,706,070 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,500,298 - 96,509,993 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,781,874 - 96,791,367 (+)NCBIMGSCv36mm8
Celera398,105,407 - 98,115,104 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
Pias3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568227,476 - 237,396 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955568227,603 - 237,396 (+)NCBIChiLan1.0ChiLan1.0
PIAS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11113,758,338 - 113,769,496 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1113,758,691 - 113,768,714 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01121,900,224 - 121,911,513 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PIAS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,650,791 - 58,660,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,571,694 - 58,660,663 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,119,050 - 58,129,713 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01759,647,669 - 59,658,338 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1759,563,372 - 59,658,305 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,520,427 - 58,531,086 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01758,581,386 - 58,592,221 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01759,307,976 - 59,318,645 (-)NCBIUU_Cfam_GSD_1.0
Pias3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,726,890 - 20,736,385 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936867602,956 - 612,489 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936867603,007 - 612,488 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIAS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,465,690 - 99,475,140 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,463,418 - 99,475,141 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24109,107,025 - 109,117,229 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIAS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12012,884,475 - 12,902,014 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2012,885,205 - 12,902,243 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603815,564,267 - 15,575,444 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pias3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477217,217,986 - 17,224,020 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477217,217,068 - 17,226,757 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pias3
85 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:105
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000028814
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 8 6 5 6 66 28 34 11
Low 15 49 35 14 35 8 11 8 7 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028814   ⟹   ENSRNOP00000028814
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2184,232,596 - 184,241,480 (+)Ensembl
Rnor_6.0 Ensembl2198,823,367 - 198,831,533 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083769   ⟹   ENSRNOP00000068665
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2184,232,571 - 184,240,495 (+)Ensembl
Rnor_6.0 Ensembl2198,823,366 - 198,836,372 (+)Ensembl
RefSeq Acc Id: NM_031784   ⟹   NP_113972
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22184,233,289 - 184,241,455 (+)NCBI
Rnor_6.02198,823,369 - 198,831,533 (+)NCBI
Rnor_5.02218,309,595 - 218,318,467 (+)NCBI
RGSC_v3.42191,499,057 - 191,507,221 (+)RGD
Celera2176,757,800 - 176,765,964 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232992   ⟹   XP_006233054
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22184,232,546 - 184,241,384 (+)NCBI
Rnor_6.02198,821,377 - 198,831,442 (+)NCBI
Rnor_5.02218,309,595 - 218,318,467 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232993   ⟹   XP_006233055
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22184,233,621 - 184,241,384 (+)NCBI
Rnor_6.02198,823,681 - 198,831,442 (+)NCBI
Rnor_5.02218,309,595 - 218,318,467 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005500380
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22184,232,788 - 184,241,384 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_113972   ⟸   NM_031784
- UniProtKB: O70260 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233054   ⟸   XM_006232992
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006233055   ⟸   XM_006232993
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000028814   ⟸   ENSRNOT00000028814
RefSeq Acc Id: ENSRNOP00000068665   ⟸   ENSRNOT00000083769
Protein Domains
PINIT   SAP   SP-RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70260-F1-model_v2 AlphaFold O70260 1-628 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691595
Promoter ID:EPDNEW_R2112
Type:initiation region
Name:Pias3_1
Description:protein inhibitor of activated STAT, 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02198,823,337 - 198,823,397EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708413 AgrOrtholog
BioCyc Gene G2FUF-51966 BioCyc
Ensembl Genes ENSRNOG00000021218 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028814 ENTREZGENE
  ENSRNOP00000028814.4 UniProtKB/TrEMBL
  ENSRNOP00000068665.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028814 ENTREZGENE
  ENSRNOT00000028814.6 UniProtKB/TrEMBL
  ENSRNOT00000083769.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PIAS1/PIAS3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PINIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PINIT_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_MIZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83614 UniProtKB/Swiss-Prot
NCBI Gene 83614 ENTREZGENE
PANTHER PTHR10782:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PINIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-MIZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pias3 PhenoGen
PROSITE PINIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_SP_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF68906 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JTD5_RAT UniProtKB/TrEMBL
  A0A8L2QFJ6_RAT UniProtKB/TrEMBL
  O70260 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-06 Pias3  protein inhibitor of activated STAT, 3  Pias3  protein inhibitor of activated STAT 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Pias3  protein inhibitor of activated STAT 3  LOC83614  potassium channel regulatory protein KChAP  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function may function as a chaperone protein to facilitate the cell surface expression of Kv2 channels 1299426
gene_physical_interaction interacts with the N termini of Kvalpha2 subunits 1299426