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Gene: Npl (N-acetylneuraminate pyruvate lyase) Rattus norvegicus

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Symbol:

Npl

Name:

N-acetylneuraminate pyruvate lyase

RGD ID:

1549702

Description:

Predicted to enable N-acetylneuraminate lyase activity and identical protein binding activity. Predicted to be involved in N-acetylneuraminate catabolic process. Predicted to be located in cytoplasm. Orthologous to human NPL (N-acetylneuraminate pyruvate lyase); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; sialic acid storage disease pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC304860; N-acetylneuraminate lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NALase; sialate lyase; sialate-pyruvate lyase; sialic acid aldolase; sialic acid lyase; similar to N-acetylneuraminate pyruvate lyase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NPL (N-acetylneuraminate pyruvate lyase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Npl (N-acetylneuraminate pyruvate lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Npl (N-acetylneuraminate pyruvate lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NPL (N-acetylneuraminate pyruvate lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NPL (N-acetylneuraminate pyruvate lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Npl (N-acetylneuraminate pyruvate lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NPL (N-acetylneuraminate pyruvate lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NPL (N-acetylneuraminate pyruvate lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Npl (N-acetylneuraminate pyruvate lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	POLE (DNA polymerase epsilon, catalytic subunit)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	NPL (N-acetylneuraminate pyruvate lyase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NPL (N-acetylneuraminate pyruvate lyase)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Npl (N-acetylneuraminate pyruvate lyase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Npl (N-acetylneuraminate pyruvate lyase)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	npl (N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	npl (N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase))	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	npl	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	npl	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	68,205,602 - 68,247,940 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	68,205,603 - 68,247,999 (-)	Ensembl				GRCr8
mRatBN7.2	13	65,655,099 - 65,697,464 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	65,655,118 - 65,697,372 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	68,258,125 - 68,300,390 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	69,546,594 - 69,588,750 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	66,798,071 - 66,840,251 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	70,938,073 - 70,981,179 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	70,938,082 - 70,980,913 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	75,903,277 - 75,946,223 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	68,524,023 - 68,567,312 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	65,558,454 - 65,600,109 (-)	NCBI		Celera
Cytogenetic Map	13	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

1q24 Deletion Syndrome (ISO)

autosomal recessive chronic granulomatous disease 2 (ISO)

cholestasis (ISO)

gastrointestinal stromal tumor (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(S)-nicotine (ISO)

1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

3',5'-cyclic AMP (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

actinomycin D (ISO)

aflatoxin B1 (ISO)

allethrin (EXP)

amphetamine (EXP)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Bufotalin (ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

camptothecin (ISO)

carbon nanotube (ISO)

carmustine (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

cyhalothrin (EXP)

cypermethrin (EXP)

dextran sulfate (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diethyl phthalate (ISO)

diethylstilbestrol (EXP)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (EXP)

endosulfan (ISO)

entinostat (ISO)

erianin (ISO)

ethyl methanesulfonate (ISO)

fenvalerate (EXP)

formaldehyde (ISO)

isotretinoin (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

nickel sulfate (ISO)

nicotine (ISO)

Nutlin-3 (ISO)

okadaic acid (ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

progesterone (ISO)

propanal (ISO)

pyrethrins (EXP)

rotenone (ISO)

SB 431542 (ISO)

senecionine (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

Soman (EXP)

sunitinib (ISO)

temozolomide (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

N-acetylneuraminate catabolic process (IBA,IEA,ISO,ISS)

Cellular Component

cytoplasm (IEA)

Molecular Function

identical protein binding (IEA,ISO)

lyase activity (IEA)

N-acetylneuraminate lyase activity (IBA,IEA,ISO,ISS)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

amino sugar metabolic pathway (IEA,ISO)

french type sialuria pathway (ISO)

nucleotide sugar metabolic pathway (IEA)

sialic acid storage disease pathway (ISO)

Tay-Sachs disease pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:11737202	PMID:15489334	PMID:22692205	PMID:25416956

Genomics

Comparative Map Data

Npl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	68,205,602 - 68,247,940 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	68,205,603 - 68,247,999 (-)	Ensembl				GRCr8
mRatBN7.2	13	65,655,099 - 65,697,464 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	65,655,118 - 65,697,372 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	68,258,125 - 68,300,390 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	69,546,594 - 69,588,750 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	66,798,071 - 66,840,251 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	70,938,073 - 70,981,179 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	70,938,082 - 70,980,913 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	75,903,277 - 75,946,223 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	68,524,023 - 68,567,312 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	65,558,454 - 65,600,109 (-)	NCBI		Celera
Cytogenetic Map	13	q21	NCBI

NPL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	182,789,773 - 182,830,384 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	182,789,293 - 182,830,384 (+)	Ensembl			hg38	GRCh38
GRCh37	1	182,758,908 - 182,799,519 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	181,028,017 - 181,065,211 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	179,493,050 - 179,530,245	NCBI
Celera	1	155,872,543 - 155,909,737 (+)	NCBI		Celera
Cytogenetic Map	1	q25.3	NCBI
HuRef	1	153,994,259 - 154,035,194 (+)	NCBI		HuRef
CHM1_1	1	184,181,835 - 184,222,761 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	182,148,939 - 182,189,548 (+)	NCBI		T2T-CHM13v2.0

Npl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	153,378,762 - 153,425,460 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	153,378,761 - 153,425,791 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	153,503,016 - 153,549,714 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	153,503,015 - 153,550,045 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	155,350,146 - 155,396,844 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	155,265,234 - 155,311,932 (-)	NCBI		MGSCv36	mm8
Celera	1	155,927,936 - 155,974,856 (-)	NCBI		Celera
Cytogenetic Map	1	G3	NCBI
cM Map	1	65.38	NCBI

Npl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	21,633,032 - 21,670,958 (+)	Ensembl
ChiLan1.0	NW_004955406	21,633,979 - 21,670,279 (+)	NCBI	ChiLan1.0	ChiLan1.0

NPL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	66,901,458 - 66,944,704 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	66,584,984 - 66,626,297 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	158,305,203 - 158,346,531 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	161,957,118 - 161,997,635 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	161,958,896 - 161,997,222 (+)	Ensembl			panPan2	panpan1.1

NPL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	16,186,693 - 16,226,658 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	16,192,005 - 16,224,033 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	15,773,528 - 15,812,293 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	15,916,535 - 15,955,524 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	15,915,242 - 15,952,901 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	15,828,310 - 15,866,959 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	15,937,498 - 15,975,727 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	16,066,339 - 16,105,552 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Npl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	89,095,379 - 89,129,855 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936481	6,942,282 - 6,972,775 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936481	6,942,128 - 6,977,042 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NPL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	124,093,604 - 124,132,860 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	124,093,579 - 124,132,862 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

NPL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	46,543,645 - 46,582,700 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	46,541,401 - 46,581,767 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	47,760,165 - 47,800,243 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Npl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624814	10,968,329 - 10,994,001 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624814	10,968,218 - 11,006,637 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Npl
295 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	518
Count of miRNA genes:	258
Interacting mature miRNAs:	318
Transcripts:	ENSRNOT00000003713
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	48749814	87285480	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	24853925	69853925	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	39968211	83286298	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	40983585	85983585	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	62424592	88113509	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	26244808	71244808	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	39968211	84968211	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	26244808	71244808	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Markers in Region

RH133413

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	65,655,378 - 65,655,572 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	70,938,335 - 70,938,528	NCBI	Rnor6.0
Rnor_5.0	13	75,903,539 - 75,903,732	UniSTS	Rnor5.0
RGSC_v3.4	13	68,524,285 - 68,524,478	UniSTS	RGSC3.4
Celera	13	65,558,716 - 65,558,909	UniSTS
RH 3.4 Map	13	301.2	UniSTS
Cytogenetic Map	13	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	90	59	6	354	190	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC082004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003713 ⟹ ENSRNOP00000003713

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	68,205,603 - 68,247,999 (-)	Ensembl
mRatBN7.2 Ensembl	13	65,655,118 - 65,697,372 (-)	Ensembl
Rnor_6.0 Ensembl	13	70,938,082 - 70,980,913 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102662 ⟹ ENSRNOP00000076598

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	68,205,603 - 68,243,116 (-)	Ensembl
mRatBN7.2 Ensembl	13	65,655,118 - 65,684,851 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109291 ⟹ ENSRNOP00000097337

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	68,205,603 - 68,247,707 (-)	Ensembl
mRatBN7.2 Ensembl	13	65,655,118 - 65,697,232 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000167584 ⟹ ENSRNOP00000109780

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	68,205,603 - 68,247,707 (-)	Ensembl

RefSeq Acc Id:

NM_001013984 ⟹ NP_001014006

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	68,205,602 - 68,247,707 (-)	NCBI
mRatBN7.2	13	65,655,117 - 65,697,232 (-)	NCBI
Rnor_6.0	13	70,938,073 - 70,980,852 (-)	NCBI
Rnor_5.0	13	75,903,277 - 75,946,223 (-)	NCBI
RGSC_v3.4	13	68,524,023 - 68,567,312 (-)	RGD
Celera	13	65,558,454 - 65,600,109 (-)	RGD

Sequence:

show sequence

CAGGAACAACTCGGTAGCCAAGGTTAGCGCGGCGCCGCCGACCAGAGGAGTGAAGACCTTCCAA
CAGCCTGATGGCCTTCCCTAAGAAGAAACTCCAGGGTCTTGTTGCTGCCACCATCACTCCAATG
ACAGAGAATGGAGAAATCAACTTTCCTGTCATTGGTCAGTATGTGGATTACTTGGTGAAGGAAC
AGGGAGTGAAGAACATTTTCGTGAACGGCACCACGGGAGAAGGCCTGTCCCTGAGCATCTCCGA
ACGTCGCCAGGTCGCAGAGGAATGGGTTCGTCAAGGGAAGAACAAGTTGGACCAAGTGGTGATT
CACGTGGGAGCACTAAACTTGAAGGAGTCACAAGAACTGGCCCAACATGCAGCAGAAATTGGAG
CTGATGGCATTGCTGTCATTGCGCCTTTCTTTTTCAAGTCACAGAACAAAGATGCCCTGATAAG
TTTCCTGAGGGAGGTGGCTGCCGCAGCCCCTGCTTTGCCATTTTACTACTATCACATCCCCTCA
CTGACCGGGGTGAAGATTCGTGCTGAGGAGCTGCTCGACGGGATTCAGGATAAGATCCCCTCCT
TTCAAGGACTGAAGTTCAGTGACACTGACCTCTTAGATTTCGGCCAGTGTGTCGATCAGAATCA
CCAGCGACAGTTTGCTTTGCTGTTCGGGGTGGACGAGCAACTGTTGAGTGCTCTGGTCCTGGGA
GCAACTGGAGCAGTAGGCAGTACCTATAACTACCTGGGAAAAAAGACAAACCAGATGTTGGAGG
CTTTTGAACAGAAGGACTTGGCGTCAGCACTAAGTTACCAGTTCCGCATCCAGAGATTTATCAA
CTACGTGATCAAGCTAGGTTTTGGAGTGTCGCAGACCAAAGCCATCATGACCCTGGTCTCTGGG
ATTCCAATGGGCCCACCCCGGCTTCCTCTGCAGAAAGCCACCCAGGAGTTTACTGCTAATGCTG
AGGCCAAGCTGAAGAGCCTGAATTTCCTTTCTTTCCCTGGTTTAAAGGATGGGAACATGGAAGC
CTGTAGCTAGTGCCTGATAAAGTCTGAGACTTTATCTTCAATAGTTCATTCTTTTCTCAGGGAT
TTTTTAGGTGAATGTGAACTAAGCTTTCTTTTAGCAAGTAGAACCCCACACTAATCAAGAAATA
TTTAAGTATCACATATGAACCTAAACTTTTTTGTTATAAAGGAGTCACAAACTTTCAAAAGAAA
TAAGGAATCTATTGTAAATGTATATGCGCTTTATCCTTTAAAATGTCTTTCCAAAGGAATCCAT
AACTGAAGTCAAGATATATTGAAAGCTTTAGTTATCCAAGAGAGAAGCCTTTAGGAATTGCTGT
TCGACTTGTAGGTAACTTTACAAATGAAAACTTTTCAAATAGGAGAAAATAGAATTTATCATCA
GATAGCTAAAGATTACCTTCTTTGCCTGAAAACCAGAGTGCTGATGTTAGCCACCCCTGTGTAT
TGTGAGCGTCTTCTCACAGGTGCTCCCCTCGCACATTCCTCGGACGCTGAAAGGAAAAGAAGCA
ATCCTTCTACCTTGACTGGGACGGTTGTAGTGATATGAGCAATGACAGCAATGCCTTCTTATTT
GACCCCTTTCTATTTAAACACTACTTGATACCTCTTTCATAAGACTACATGATGAACAGTAGTC
CCTAACGCCACACACACTCAACAAAAACTGTCAGCGTGTAATTAGTAGGGCAGCAAGAGAGGGG
TGAAACTACAGACAGAAAATATAATTCACTGTGTAAGTATAATACGGAAGTTTTTGTAGACTAA
AAATAAAATGTTTAACCTAAACTTAAATCTTAGTATCAAATTAATTTTACACGCTAGTGAGAAG
TCCTATTTAAAGTACCTGTGTATATTGTTTTGTATACGCGCAGTATACACAGAAATACATAAGC
AGATTATTAATCCTTCTAAACATGAAAATTTGATGTACTGAGTCCTTTTATAGTGAACTCCAAT
GGCCAATAAAGATCTAAAGTCACATTAATTAGAGTGGAACACAAACTATGTCCCATTTTCCTTG
CTTTATGGGTCTGTTGGTTTTTCTTTATATTTCATTTCAATGTAATGGACCAAAGTGTCATCCA
ACACTAATAAAGGGATGCATAAATTTTTATAGTTACATTTTGTACAAACAATTGCCACTACTGT
TAATACCTAAAGCCTCACCCCTACCTCTATCCTGGGGTAGGATCTAATTAAAATTAATATATTC
CATGTGTAAAACAAAATAAATACAAATAAAGGAATCTCAAGCCCTAAGCCATTCATTTCATAAA
ATTATTGTAGAGAAATCACTCCTTATACAGATGCAATGGAACCAAGTGAAAATTGTAATAATAA
TTACAATTATTAATTAATTACATTAGTTAACATAATTCATATTACTATATTAAATGCTGTGTTG
GTTATATTATTCTGAATAAATTTCATCTGCCTTTTGGGAGCAAAAAAAAAAAAAAAAAAAAAAA
AA

hide sequence

RefSeq Acc Id:

XM_006249997 ⟹ XP_006250059

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	68,205,602 - 68,247,940 (-)	NCBI
mRatBN7.2	13	65,655,099 - 65,697,464 (-)	NCBI
Rnor_6.0	13	70,938,073 - 70,981,179 (-)	NCBI
Rnor_5.0	13	75,903,277 - 75,946,223 (-)	NCBI

Sequence:

show sequence

GCTGGAGCAGTGTCAGCCTAGAGATCGTTTGTGACACAACATCTCACATCCCGTGCAGCCAAGA
CTCGCTCTTACAGGACGGGAGAACTCCAGGAGTAGTAAGTACAGTGGGTGTCCAAGAGGTGCAG
GAACCTTTCTGAAAATAGGCTCTGGCCACACCCAGGAAGGAGCAACTAGTGCACTGTCTCGGGA
TTCCATCCCGTGAAACAGCGCCCGGCCGAAGTGGAACTACAACCCCCAGGCTCCCCGCGCAGCC
GCACATGGTCCCGCAGCCCCTGAGATAAAAGCGCAACGGCGCTGCTCGGTGGAGACCGGGTCCC
CAGTGCACAGGAACAACTCGGTAGCCAAGGTTAGCGCGGCGCCGCCGACCAGAGGAGTGAAGAC
CTTCCAACAGCCTGATGGCCTTCCCTAAGAAGAAACTCCAGGGTCTTGTTGCTGCCACCATCAC
TCCAATGACAGAGAATGGAGAAATCAACTTTCCTGTCATTGGTCAGTATGTGGATTACTTGGTG
AAGGAACAGGGAGTGAAGAACATTTTCGTGAACGGCACCACGGGAGAAGGCCTGTCCCTGAGCA
TCTCCGAACGTCGCCAGGTCGCAGAGGAATGGGTTCGTCAAGGGAAGAACAAGTTGGACCAAGT
GGTGATTCACGTGGGAGCACTAAACTTGAAGGAGTCACAAGAACTGGCCCAACATGCAGCAGAA
ATTGGAGCTGATGGCATTGCTGTCATTGCGCCTTTCTTTTTCAAGTCACAGAACAAAGTTCGTG
CTGAGGAGCTGCTCGACGGGATTCAGGATAAGATCCCCTCCTTTCAAGGACTGAAGTTCAGTGA
CACTGACCTCTTAGATTTCGGCCAGTGTGTCGATCAGAATCACCAGCGACAGTTTGCTTTGCTG
TTCGGGGTGGACGAGCAACTGTTGAGTGCTCTGGTCCTGGGAGCAACTGGAGCAGTAGGCAGTA
CCTATAACTACCTGGGAAAAAAGACAAACCAGATGTTGGAGGCTTTTGAACAGAAGGACTTGGC
GTCAGCACTAAGTTACCAGTTCCGCATCCAGAGATTTATCAACTACGTGATCAAGCTAGGTTTT
GGAGTGTCGCAGACCAAAGCCATCATGACCCTGGTCTCTGGGATTCCAATGGGCCCACCCCGGC
TTCCTCTGCAGAAAGCCACCCAGGAGTTTACTGCTAATGCTGAGGCCAAGCTGAAGAGCCTGAA
TTTCCTTTCTTTCCCTGGTTTAAAGGATGGGAACATGGAAGCCTGTAGCTAGTGCCTGATAAAG
TCTGAGACTTTATCTTCAATAGTTCATTCTTTTCTCAGGGATTTTTTAGGTGAATGTGAACTAA
GCTTTCTTTTAGCAAGTAGAACCCCACACTAATCAAGAAATATTTAAGTATCACATATGAACCT
AAACTTTTTTGTTATAAAGGAGTCACAAACTTTCAAAAGAAATAAGGAATCTATTGTAAATGTA
TATGCGCTTTATCCTTTAAAATGTCTTTCCAAAGGAATCCATAACTGAAGTCAAGATATATTGA
AAGCTTTAGTTATCCAAGAGAGAAGCCTTTAGGAATTGCTGTTCGACTTGTAGGTAACTTTACA
AATGAAAACTTTTCAAATAGGAGAAAATAGAATTTATCATCAGATAGCTAAAGATTACCTTCTT
TGCCTGAAAACCAGAGTGCTGATGTTAGCCACCCCTGTGTATTGTGAGCGTCTTCTCACAGGTG
CTCCCCTCGCACATTCCTCGGACGCTGAAAGGAAAAGAAGCAATCCTTCTACCTTGACTGGGAC
GGTTGTAGTGATATGAGCAATGACAGCAATGCCTTCTTATTTGACCCCTTTCTATTTAAACACT
ACTTGATACCTCTTTCATAAGACTACATGATGAACAGTAGTCCCTAACGCCACACACACTCAAC
AAAAACTGTCAGCGTGTAATTAGTAGGGCAGCAAGAGAGGGGTGAAACTACAGACAGAAAATAT
AATTCACTGTGTAAGTATAATACGGAAGTTTTTGTAGACTAAAAATAAAATGTTTAACCTAAAC
TTAAATCTTAGTATCAAATTAATTTTACACGCTAGTGAGAAGTCCTATTTAAAGTACCTGTGTA
TATTGTTTTGTATACGCGCAGTATACACAGAAATACATAAGCAGATTATTAATCCTTCTAAACA
TGAAAATTTGATGTACTGAGTCCTTTTATAGTGAACTCCAATGGCCAATAAAGATCTAAAGTCA
CATTAATTAGAGTGGAACACAAACTATGTCCCATTTTCCTTGCTTTATGGGTCTGTTGGTTTTT
CTTTATATTTCATTTCAATGTAATGGACCAAAGTGTCATCCAACACTAATAAAGGGATGCATAA
ATTTTTATAGTTACATTTTGTACAAACAATTGCCACTACTGTTAATACCTAAAGCCTCACCCCT
ACCTCTATCCTGGGGTAGGATCTAATTAAAATTAATATATTCCATGTGTAAAACAAAATAAATA
CAAATAAAGGAATCTCAAGCCCTAAGCCATTCATTTCATAAAATTATTGTAGAGAAATCACTCC
TTATACAGATGCAATGGAACCAAGTGAAAATTGTAATAATAATTACAATTATTAATTAATTACA
TTAGTTAACATAATTCATATTACTATATTAAATGCTGTGTTGGTTATATTATTCTGAATAAATT
TCATCTGCCTTTTGGGAGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001014006	(Get FASTA)	NCBI Sequence Viewer
	XP_006250059	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH82004	(Get FASTA)	NCBI Sequence Viewer
	EDM09546	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000097337
	ENSRNOP00000097337.1
	ENSRNOP00000109780
GenBank Protein	Q66H59	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001014006 ⟸ NM_001013984

- UniProtKB:

Q66H59 (UniProtKB/Swiss-Prot), A0A8L2Q119 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAFPKKKLQGLVAATITPMTENGEINFPVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSISERR
QVAEEWVRQGKNKLDQVVIHVGALNLKESQELAQHAAEIGADGIAVIAPFFFKSQNKDALISFL
REVAAAAPALPFYYYHIPSLTGVKIRAEELLDGIQDKIPSFQGLKFSDTDLLDFGQCVDQNHQR
QFALLFGVDEQLLSALVLGATGAVGSTYNYLGKKTNQMLEAFEQKDLASALSYQFRIQRFINYV
IKLGFGVSQTKAIMTLVSGIPMGPPRLPLQKATQEFTANAEAKLKSLNFLSFPGLKDGNMEACS

hide sequence

RefSeq Acc Id:	XP_006250059 ⟸ XM_006249997
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q119 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAFPKKKLQGLVAATITPMTENGEINFPVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSISERR QVAEEWVRQGKNKLDQVVIHVGALNLKESQELAQHAAEIGADGIAVIAPFFFKSQNKVRAEELL DGIQDKIPSFQGLKFSDTDLLDFGQCVDQNHQRQFALLFGVDEQLLSALVLGATGAVGSTYNYL GKKTNQMLEAFEQKDLASALSYQFRIQRFINYVIKLGFGVSQTKAIMTLVSGIPMGPPRLPLQK ATQEFTANAEAKLKSLNFLSFPGLKDGNMEACS hide sequence

Ensembl Acc Id:

ENSRNOP00000003713 ⟸ ENSRNOT00000003713

Ensembl Acc Id:

ENSRNOP00000097337 ⟸ ENSRNOT00000109291

Ensembl Acc Id:

ENSRNOP00000076598 ⟸ ENSRNOT00000102662

Ensembl Acc Id:

ENSRNOP00000109780 ⟸ ENSRNOT00000167584

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66H59-F1-model_v2	AlphaFold	Q66H59	1-320	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698898

Promoter ID:

EPDNEW_R9423

Type:

single initiation site

Name:

Npl_1

Description:

N-acetylneuraminate pyruvate lyase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	70,980,871 - 70,980,931	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1549702	AgrOrtholog
BioCyc Gene	G2FUF-17880	BioCyc
Ensembl Genes	ENSRNOG00000002775	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000109291	ENTREZGENE
	ENSRNOT00000109291.1	UniProtKB/Swiss-Prot
	ENSRNOT00000167584	ENTREZGENE
Gene3D-CATH	3.20.20.70	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7131519	IMAGE-MGC_LOAD
InterPro	Aldolase_TIM	UniProtKB/Swiss-Prot
	DapA-like	UniProtKB/Swiss-Prot
KEGG Report	rno:304860	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94250	IMAGE-MGC_LOAD
NCBI Gene	304860	ENTREZGENE
PANTHER	N-ACETYLNEURAMINATE LYASE	UniProtKB/Swiss-Prot
	PTHR12128	UniProtKB/Swiss-Prot
Pfam	DHDPS	UniProtKB/Swiss-Prot
PhenoGen	Npl	PhenoGen
PIRSF	DHDPS	UniProtKB/Swiss-Prot
PRINTS	DHPICSNTHASE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000002775	RatGTEx
SMART	DHDPS	UniProtKB/Swiss-Prot
Superfamily-SCOP	Aldolase	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZK42_RAT	UniProtKB/TrEMBL
	A0A8L2Q119	ENTREZGENE, UniProtKB/TrEMBL
	NPL_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Npl	N-acetylneuraminate pyruvate lyase	LOC304860	similar to N-acetylneuraminate pyruvate lyase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-15	LOC304860	similar to N-acetylneuraminate pyruvate lyase			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)