Ascl1 (achaete-scute family bHLH transcription factor 1) - Rat Genome Database

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Gene: Ascl1 (achaete-scute family bHLH transcription factor 1) Rattus norvegicus
Symbol: Ascl1
Name: achaete-scute family bHLH transcription factor 1
RGD ID: 71010
Description: Enables double-stranded DNA binding activity and identical protein binding activity. Involved in several processes, including cellular response to magnetism; regulation of neuron differentiation; and response to retinoic acid. Predicted to be located in neuronal cell body and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Biomarker of status epilepticus. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1); INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: achaete-scute complex (Drosophila) homolog-like 1; achaete-scute complex homolog 1; achaete-scute complex homolog 1 (Drosophila); achaete-scute complex homolog-like 1; achaete-scute complex homolog-like 1 (Drosophila); achaete-scute homolog 1; Mash1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2721,903,136 - 21,906,003 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl721,903,126 - 21,905,993 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx723,897,825 - 23,900,692 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0726,060,505 - 26,063,372 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0725,837,585 - 25,840,452 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0728,038,662 - 28,040,504 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,038,662 - 28,040,510 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0728,152,425 - 28,154,275 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,145,578 - 24,168,494 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1724,165,848 - 24,167,679 (-)NCBI
Celera719,079,344 - 19,081,186 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,8-cineole  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
Actein  (EXP)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
ammonium chloride  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (ISO)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
cortisol  (ISO)
Cyclopamine  (EXP)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
ellagic acid  (ISO)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
maneb  (ISO)
methylmercury chloride  (ISO)
naphthalene  (ISO)
nicotine  (EXP)
nitrofen  (EXP)
ochratoxin A  (EXP)
panobinostat  (ISO)
paraquat  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
poly(ethylene)  (ISO)
propionic acid  (ISO)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tamoxifen  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
uranium atom  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal chromaffin cell differentiation  (ISO)
carotid body glomus cell differentiation  (ISO)
cell maturation  (ISO)
cellular response to magnetism  (IEP)
central nervous system neuron development  (ISO)
cerebral cortex development  (ISO)
cerebral cortex GABAergic interneuron differentiation  (ISO)
commitment of neuronal cell to specific neuron type in forebrain  (ISO)
forebrain neuron differentiation  (IDA)
GABAergic neuron differentiation  (ISO)
generation of neurons  (ISO)
heart development  (IEP)
lung neuroendocrine cell differentiation  (ISO)
motor neuron migration  (ISO)
musculoskeletal movement, spinal reflex action  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of neuron differentiation  (IDA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
nervous system development  (IDA,ISO)
neural precursor cell proliferation  (ISO)
neuroblast fate determination  (ISO)
neuroblast proliferation  (ISO)
neuroendocrine cell differentiation  (ISO)
neurogenesis  (ISO)
neuron development  (ISO,ISS)
neuron differentiation  (IBA,ISO)
neuron fate commitment  (ISO,ISS)
neuron fate specification  (ISO,ISS)
noradrenergic neuron development  (ISO,ISS)
noradrenergic neuron fate commitment  (ISO)
Notch signaling pathway  (ISO)
olfactory pit development  (ISO)
oligodendrocyte cell fate commitment  (ISO)
oligodendrocyte development  (ISO)
oligodendrocyte differentiation  (ISO)
pattern specification process  (ISO)
peripheral nervous system neuron development  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron differentiation  (IDA)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of cell population proliferation  (ISO)
regulation of epithelial cell differentiation  (ISO)
regulation of gene expression  (ISO,ISS)
regulation of mitotic cell cycle  (ISO)
regulation of neurogenesis  (IBA,ISO)
regulation of Notch signaling pathway  (ISO)
regulation of timing of subpallium neuron differentiation  (ISO)
regulation of transcription by RNA polymerase II  (ISO,ISS)
response to epidermal growth factor  (IEP)
response to folic acid  (IEP)
response to retinoic acid  (IEP,ISO)
sensory organ development  (IBA)
spinal cord association neuron differentiation  (ISO)
spinal cord oligodendrocyte cell differentiation  (ISO)
spinal cord oligodendrocyte cell fate specification  (ISO)
stomach neuroendocrine cell differentiation  (ISO)
subpallium neuron fate commitment  (ISO)
sympathetic ganglion development  (ISO,ISS)
ventral spinal cord interneuron fate commitment  (ISO,ISS)
vestibular nucleus development  (ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Involvement of Mash1 in EGF-mediated regulation of differentiation in the vertebrate retina. Ahmad I, etal., Dev Biol. 1998 Feb 1;194(1):86-98.
2. Vitamin A deficiency leads to increased cell proliferation in olfactory epithelium of mature rats. Asson-Batres MA, etal., J Neurobiol 2003 Mar;54(4):539-54.
3. Vascular endothelial growth factor mediates atorvastatin-induced mammalian achaete-scute homologue-1 gene expression and neuronal differentiation after stroke in retired breeder rats. Chen J, etal., Neuroscience. 2006 Aug 25;141(2):737-44. Epub 2006 May 30.
4. Differential regulation of basic helix-loop-helix mRNAs in the dentate gyrus following status epilepticus. Elliott RC, etal., Neuroscience. 2001;106(1):79-88.
5. Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Farah MH, etal., Development. 2000 Feb;127(4):693-702.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Guillemot F, etal., Cell 1993 Nov 5;75(3):463-76.
9. Contrasting and brain region-specific roles of neurogenin2 and mash1 in GABAergic neuron differentiation in vitro. Jo AY, etal., Exp Cell Res. 2007 Nov 15;313(19):4066-81. Epub 2007 Sep 8.
10. Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors. Johnson JE, etal., Nature 1990 Aug 30;346(6287):858-61.
11. Thermodynamics of the DNA binding reaction of transcription factor MASH-1. K-unne AG, etal., Biochemistry. 1998 Mar 24;37(12):4217-23.
12. Lithium ions: a novel treatment for pheochromocytomas and paragangliomas. Kappes A, etal., Surgery. 2007 Feb;141(2):161-5; discussion 165.
13. Mammalian achaete scute homolog 2 is expressed in the adult sciatic nerve and regulates the expression of Krox24, Mob-1, CXCR4, and p57kip2 in Schwann cells. Kury P, etal., J Neurosci 2002 Sep 1;22(17):7586-95.
14. Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells. Lo L, etal., Development 2002 Apr;129(7):1553-67.
15. Gene Data Set MGD Curation, June 12, 2002
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Possible promotion of neuronal differentiation in fetal rat brain neural progenitor cells after sustained exposure to static magnetism. Nakamichi N, etal., J Neurosci Res. 2009 Aug 15;87(11):2406-17.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Retinoic acid influences the expression of the neuronal regulatory genes Mash-1 and c-ret in the developing rat heart. Shoba T, etal., Neurosci Lett 2002 Feb 1;318(3):129-32.
24. Effects of folate on notch signaling and cell proliferation in neural stem cells of neonatal rats in vitro. Zhang X, etal., J Nutr Sci Vitaminol (Tokyo). 2008 Oct;54(5):353-6.
Additional References at PubMed
PMID:1576967   PMID:8845150   PMID:8900141   PMID:9108377   PMID:9126746   PMID:9876181   PMID:10903890   PMID:10952889   PMID:11032813   PMID:11073877   PMID:11133151   PMID:11736660  
PMID:11940670   PMID:12000752   PMID:12050665   PMID:12361965   PMID:12397111   PMID:12629181   PMID:12858003   PMID:12885554   PMID:14532329   PMID:15065125   PMID:15071116   PMID:15133515  
PMID:15169849   PMID:15854743   PMID:15878769   PMID:15930101   PMID:15976074   PMID:16020526   PMID:16160079   PMID:16469766   PMID:16715081   PMID:16723737   PMID:16766700   PMID:17141158  
PMID:17488716   PMID:17507989   PMID:17678855   PMID:17727826   PMID:18094025   PMID:18173746   PMID:18184563   PMID:18287202   PMID:18311112   PMID:18781144   PMID:19008346   PMID:19097999  
PMID:19191219   PMID:19399893   PMID:19793887   PMID:19796622   PMID:20144606   PMID:20599619   PMID:21536733   PMID:22583763   PMID:22991444   PMID:23284756   PMID:23434913   PMID:23616538  
PMID:23639443   PMID:23792135   PMID:24144723   PMID:24243019   PMID:25124043   PMID:25751153   PMID:26437572   PMID:28276447   PMID:31317490   PMID:33631250   PMID:37385615  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2721,903,136 - 21,906,003 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl721,903,126 - 21,905,993 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx723,897,825 - 23,900,692 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0726,060,505 - 26,063,372 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0725,837,585 - 25,840,452 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0728,038,662 - 28,040,504 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,038,662 - 28,040,510 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0728,152,425 - 28,154,275 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,145,578 - 24,168,494 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1724,165,848 - 24,167,679 (-)NCBI
Celera719,079,344 - 19,081,186 (-)NCBICelera
Cytogenetic Map7q13NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3812102,957,674 - 102,960,513 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12102,957,674 - 102,960,513 (+)EnsemblGRCh38hg38GRCh38
GRCh3712103,351,452 - 103,354,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612101,875,594 - 101,878,421 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412101,853,930 - 101,856,754NCBI
Celera12103,015,725 - 103,018,566 (+)NCBICelera
Cytogenetic Map12q23.2NCBI
HuRef12100,410,703 - 100,413,544 (+)NCBIHuRef
CHM1_112103,318,246 - 103,321,086 (+)NCBICHM1_1
T2T-CHM13v2.012102,918,498 - 102,921,335 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391087,326,681 - 87,329,522 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1087,326,681 - 87,329,522 (-)EnsemblGRCm39 Ensembl
GRCm381087,490,819 - 87,493,660 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1087,490,819 - 87,493,660 (-)EnsemblGRCm38mm10GRCm38
MGSCv371086,953,786 - 86,956,405 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361086,920,621 - 86,922,980 (-)NCBIMGSCv36mm8
Celera1089,464,389 - 89,467,010 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1043.64NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540537,941,243 - 37,943,641 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540537,941,243 - 37,943,641 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan112111,019,172 - 111,022,010 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012100,536,895 - 100,539,737 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112103,931,707 - 103,934,554 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12103,932,302 - 103,932,999 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11541,694,021 - 41,696,933 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1541,694,269 - 41,695,391 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1542,062,179 - 42,065,075 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01542,349,900 - 42,352,808 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11541,619,328 - 41,622,224 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01541,717,251 - 41,720,147 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01541,986,771 - 41,989,679 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494518,304,396 - 18,306,779 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649211,316,417 - 11,317,166 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493649211,315,929 - 11,317,166 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl581,358,969 - 81,359,673 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1581,357,431 - 81,360,335 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11198,182,213 - 98,185,057 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1198,182,787 - 98,183,506 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037146,827,687 - 146,830,550 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247505,487,053 - 5,493,339 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247505,487,046 - 5,489,399 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ascl1
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:41
Interacting mature miRNAs:43
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)71816950526029351Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)72055570529891047Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2721,904,669 - 21,905,151 (+)MAPPERmRatBN7.2
Rnor_6.0728,039,179 - 28,039,660NCBIRnor6.0
Rnor_5.0728,152,942 - 28,153,423UniSTSRnor5.0
RGSC_v3.4724,146,095 - 24,146,576UniSTSRGSC3.4
Celera719,079,861 - 19,080,342UniSTS
Cytogenetic Map7q13UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 4 4 4 45 4
Low 2 22 10 8 10 29 14
Below cutoff 3 6 8 4 1 4 3 4 4 9 11 3


RefSeq Acc Id: ENSRNOT00000005674   ⟹   ENSRNOP00000005674
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl721,903,126 - 21,905,993 (-)Ensembl
Rnor_6.0 Ensembl728,038,662 - 28,040,510 (-)Ensembl
RefSeq Acc Id: NM_022384   ⟹   NP_071779
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2721,903,136 - 21,906,003 (-)NCBI
Rnor_6.0728,038,662 - 28,040,504 (-)NCBI
Rnor_5.0728,152,425 - 28,154,275 (-)NCBI
RGSC_v3.4724,145,578 - 24,168,494 (-)RGD
Celera719,079,344 - 19,081,186 (-)RGD
Protein Sequences
Protein RefSeqs NP_071779 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA37760 (Get FASTA)   NCBI Sequence Viewer  
  EDM17037 (Get FASTA)   NCBI Sequence Viewer  
  P19359 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071779   ⟸   NM_022384
- UniProtKB: P19359 (UniProtKB/Swiss-Prot),   A6IFL1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005674   ⟸   ENSRNOT00000005674
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19359-F1-model_v2 AlphaFold P19359 1-233 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71010 AgrOrtholog
BioCyc Gene G2FUF-34529 BioCyc
Ensembl Genes ENSRNOG00000004294 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000005674 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005674 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64186 UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ascl1 PhenoGen
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP HLH, helix-loop-helix DNA-binding domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Ascl1  achaete-scute family bHLH transcription factor 1  Ascl1  achaete-scute complex homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Ascl1  achaete-scute complex homolog 1 (Drosophila)  Ascl1  achaete-scute complex homolog-like 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Ascl1  achaete-scute complex homolog-like 1 (Drosophila)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference