Srgap2 (SLIT-ROBO Rho GTPase activating protein 2) - Rat Genome Database

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Gene: Srgap2 (SLIT-ROBO Rho GTPase activating protein 2) Rattus norvegicus
Analyze
Symbol: Srgap2
Name: SLIT-ROBO Rho GTPase activating protein 2
RGD ID: 1566016
Description: Predicted to enable GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to be involved in several processes, including plasma membrane bounded cell projection organization; substrate adhesion-dependent cell spreading; and synapse assembly. Located in cytoplasm and nucleus. Orthologous to human SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC360840; MGC188551; RGD1566016; similar to KIAA0456 protein; SLIT-ROBO Rho GTPase-activating protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,298,192 - 45,519,330 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1345,298,192 - 45,519,330 (-)EnsemblGRCr8
mRatBN7.21342,745,956 - 42,967,091 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,745,947 - 42,967,058 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1345,354,029 - 45,577,291 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,642,156 - 46,865,413 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,905,845 - 44,129,315 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,065,280 - 48,286,888 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,068,158 - 48,286,720 (-)Ensemblrn6Rnor6.0
Rnor_5.01353,141,198 - 53,362,657 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41344,239,946 - 44,452,446 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1343,100,229 - 43,312,451 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fipronil  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
melphalan  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
PCB138  (ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
Soman  (EXP)
titanium dioxide  (ISO)
triacsin C  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell projection  (IEA)
cytoplasm  (IDA,IEA)
cytoplasmic vesicle  (IEA)
cytosol  (IEA,ISO,ISS)
dendritic spine  (IBA,IEA,ISO)
dendritic spine head  (IEA,ISO,ISS)
glutamatergic synapse  (IBA,IEA,ISO)
lamellipodium  (IEA,ISO)
membrane  (IEA)
nucleus  (IDA,IEA)
phagocytic vesicle  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO,ISS)
postsynaptic density  (IEA,ISO,ISS)
postsynaptic membrane  (IEA,ISO,ISS)
synapse  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Dynamic expression of srGAP2 in cell nuclei and cytoplasm during the differentiation of rat neural stem cells in vitro. Jiao Q, etal., Mol Med Rep. 2016 Nov;14(5):4599-4605. doi: 10.3892/mmr.2016.5795. Epub 2016 Oct 4.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Regulated shuttling of Slit-Robo-GTPase activating proteins between nucleus and cytoplasm during brain development. Yao Q, etal., Cell Mol Neurobiol. 2008 Feb;28(2):205-21. Epub 2007 Aug 21.
Additional References at PubMed
PMID:12477932   PMID:12865426   PMID:19737524   PMID:20810653   PMID:21148482   PMID:22559944   PMID:26365803   PMID:30685845   PMID:32357304  


Genomics

Comparative Map Data
Srgap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,298,192 - 45,519,330 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1345,298,192 - 45,519,330 (-)EnsemblGRCr8
mRatBN7.21342,745,956 - 42,967,091 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,745,947 - 42,967,058 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1345,354,029 - 45,577,291 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,642,156 - 46,865,413 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,905,845 - 44,129,315 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,065,280 - 48,286,888 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,068,158 - 48,286,720 (-)Ensemblrn6Rnor6.0
Rnor_5.01353,141,198 - 53,362,657 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41344,239,946 - 44,452,446 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1343,100,229 - 43,312,451 (-)NCBICelera
Cytogenetic Map13q13NCBI
SRGAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,203,541 - 206,464,436 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,203,346 - 206,464,436 (+)Ensemblhg38GRCh38
GRCh371206,516,197 - 206,637,776 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,582,823 - 204,704,406 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1179,840,685 - 179,889,229 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,269,281 - 177,336,031 (+)NCBIHuRef
CHM1_11207,651,212 - 207,909,982 (+)NCBICHM1_1
T2T-CHM13v2.01205,467,727 - 205,728,612 (+)NCBIT2T-CHM13v2.0
Srgap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,212,989 - 131,455,269 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1131,212,989 - 131,455,090 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381131,285,251 - 131,527,531 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,285,251 - 131,527,352 (-)Ensemblmm10GRCm38
MGSCv371133,181,828 - 133,423,938 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361133,112,797 - 133,354,907 (-)NCBIMGSCv36mm8
Celera1133,908,005 - 134,139,712 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.93NCBI
Srgap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540641,801,235 - 42,050,731 (+)Ensembl
ChiLan1.0NW_00495540641,801,235 - 42,050,731 (+)NCBIChiLan1.0ChiLan1.0
SRGAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,913,844 - 43,168,344 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,879,341 - 43,133,846 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,808,318 - 182,064,583 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,090,389 - 186,346,012 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,092,113 - 186,346,019 (+)EnsemblpanPan2panpan1.1
SRGAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,506,617 - 2,741,866 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,599,173 - 2,834,184 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0382,504,091 - 2,739,418 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,504,099 - 2,739,408 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,497,737 - 2,732,688 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0382,890,316 - 3,126,035 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0383,090,840 - 3,326,253 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srgap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,855,976 - 69,097,751 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365576,096,246 - 6,338,108 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365576,096,258 - 6,338,024 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRGAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl966,838,123 - 67,117,315 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1966,838,062 - 67,117,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,085,753 - 73,361,203 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRGAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,897,699 - 23,147,097 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,897,469 - 23,145,218 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605523,596,464 - 23,848,743 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srgap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,935,472 - 5,169,050 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248074,937,573 - 5,169,104 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Srgap2
891 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:55
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000008976
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat

Markers in Region
BE108135  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,963,130 - 42,963,286 (+)MAPPERmRatBN7.2
Rnor_6.01348,282,793 - 48,282,948NCBIRnor6.0
Rnor_5.01353,358,711 - 53,358,866UniSTSRnor5.0
RGSC_v3.41344,448,519 - 44,448,674UniSTSRGSC3.4
Celera1343,308,524 - 43,308,679UniSTS
RH 3.4 Map13111.3UniSTS
Cytogenetic Map13q13UniSTS
BE109592  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,789,446 - 42,789,622 (+)MAPPERmRatBN7.2
Rnor_6.01348,108,771 - 48,108,946NCBIRnor6.0
Rnor_5.01353,184,689 - 53,184,864UniSTSRnor5.0
RGSC_v3.41344,274,793 - 44,274,968UniSTSRGSC3.4
Celera1343,135,071 - 43,135,246UniSTS
RH 3.4 Map13110.2UniSTS
Cytogenetic Map13q13UniSTS
AU046573  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,801,095 - 42,801,267 (+)MAPPERmRatBN7.2
Rnor_6.01348,120,419 - 48,120,590NCBIRnor6.0
Rnor_5.01353,196,337 - 53,196,508UniSTSRnor5.0
RGSC_v3.41344,286,441 - 44,286,612UniSTSRGSC3.4
Celera1343,146,719 - 43,146,890UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 13 83 215 91 90 59 136 59 6 455 260 20 195 112 116 31 34 34

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001134958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC168690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000008976   ⟹   ENSRNOP00000008976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1345,306,839 - 45,519,297 (-)Ensembl
mRatBN7.2 Ensembl1342,754,603 - 42,967,058 (-)Ensembl
Rnor_6.0 Ensembl1348,073,927 - 48,286,720 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085967   ⟹   ENSRNOP00000068925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1345,298,192 - 45,519,330 (-)Ensembl
mRatBN7.2 Ensembl1342,745,959 - 42,967,022 (-)Ensembl
Rnor_6.0 Ensembl1348,068,158 - 48,284,408 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086928   ⟹   ENSRNOP00000070956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1345,298,192 - 45,410,443 (-)Ensembl
mRatBN7.2 Ensembl1342,745,947 - 42,967,022 (-)Ensembl
Rnor_6.0 Ensembl1348,070,362 - 48,284,990 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118487   ⟹   ENSRNOP00000078553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1345,298,192 - 45,519,330 (-)Ensembl
mRatBN7.2 Ensembl1342,745,947 - 42,967,022 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000127076   ⟹   ENSRNOP00000112019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1345,303,274 - 45,519,330 (-)Ensembl
RefSeq Acc Id: NM_001134958   ⟹   NP_001128430
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,306,838 - 45,519,297 (-)NCBI
mRatBN7.21342,754,602 - 42,967,058 (-)NCBI
Rnor_6.01348,073,926 - 48,286,720 (-)NCBI
Rnor_5.01353,141,198 - 53,362,657 (-)NCBI
RGSC_v3.41344,239,946 - 44,452,446 (-)RGD
Celera1343,100,229 - 43,312,451 (-)RGD
Sequence:
RefSeq Acc Id: NM_001401376   ⟹   NP_001388305
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,298,192 - 45,519,330 (-)NCBI
mRatBN7.21342,745,956 - 42,967,091 (-)NCBI
RefSeq Acc Id: XM_006249783   ⟹   XP_006249845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,298,192 - 45,518,438 (-)NCBI
mRatBN7.21342,745,956 - 42,966,205 (-)NCBI
Rnor_6.01348,065,280 - 48,285,808 (-)NCBI
Rnor_5.01353,141,198 - 53,362,657 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249785   ⟹   XP_006249847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,298,192 - 45,430,156 (-)NCBI
mRatBN7.21342,745,956 - 42,877,914 (-)NCBI
Rnor_6.01348,065,280 - 48,197,183 (-)NCBI
Rnor_5.01353,141,198 - 53,362,657 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090884   ⟹   XP_038946812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,298,192 - 45,519,323 (-)NCBI
mRatBN7.21342,745,956 - 42,967,083 (-)NCBI
RefSeq Acc Id: XM_039090885   ⟹   XP_038946813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,301,312 - 45,519,323 (-)NCBI
mRatBN7.21342,749,079 - 42,967,083 (-)NCBI
RefSeq Acc Id: XM_039090886   ⟹   XP_038946814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,303,438 - 45,519,323 (-)NCBI
mRatBN7.21342,751,163 - 42,967,083 (-)NCBI
RefSeq Acc Id: XM_039090887   ⟹   XP_038946815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,298,192 - 45,369,615 (-)NCBI
mRatBN7.21342,745,956 - 42,817,378 (-)NCBI
RefSeq Acc Id: XM_039090888   ⟹   XP_038946816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,308,093 - 45,519,323 (-)NCBI
mRatBN7.21342,755,856 - 42,967,083 (-)NCBI
RefSeq Acc Id: NP_001128430   ⟸   NM_001134958
- Peptide Label: isoform 2
- UniProtKB: B5DEJ1 (UniProtKB/TrEMBL),   A0A8I5ZL53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249845   ⟸   XM_006249783
- Peptide Label: isoform X1
- UniProtKB: D4A208 (UniProtKB/Swiss-Prot),   A0A8I5ZL53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249847   ⟸   XM_006249785
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZL53 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008976   ⟸   ENSRNOT00000008976
Ensembl Acc Id: ENSRNOP00000068925   ⟸   ENSRNOT00000085967
Ensembl Acc Id: ENSRNOP00000070956   ⟸   ENSRNOT00000086928
RefSeq Acc Id: XP_038946812   ⟸   XM_039090884
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZL53 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946815   ⟸   XM_039090887
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZL53 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946813   ⟸   XM_039090885
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JZ92 (UniProtKB/TrEMBL),   A0A8I5ZL53 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946814   ⟸   XM_039090886
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZL53 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946816   ⟸   XM_039090888
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZL53 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078553   ⟸   ENSRNOT00000118487
RefSeq Acc Id: NP_001388305   ⟸   NM_001401376
- Peptide Label: isoform 1
- UniProtKB: D4A208 (UniProtKB/Swiss-Prot),   A0A8I5ZL53 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112019   ⟸   ENSRNOT00000127076
Protein Domains
F-BAR   Rho-GAP   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A208-F1-model_v2 AlphaFold D4A208 1-1071 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698796
Promoter ID:EPDNEW_R9321
Type:initiation region
Name:Srgap2_1
Description:SLIT-ROBO Rho GTPase activating protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01348,286,702 - 48,286,762EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566016 AgrOrtholog
BioCyc Gene G2FUF-18352 BioCyc
Ensembl Genes ENSRNOG00000006733 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008976 ENTREZGENE
  ENSRNOT00000085967 ENTREZGENE
  ENSRNOT00000085967.2 UniProtKB/Swiss-Prot
  ENSRNOT00000086928 ENTREZGENE
  ENSRNOT00000127076 ENTREZGENE
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot
  1.20.1270.60 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot
  F_BAR UniProtKB/Swiss-Prot
  FCH_dom UniProtKB/Swiss-Prot
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot
  RhoGAP_dom UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  SLIT-ROBO_RhoGAP UniProtKB/Swiss-Prot
  srGAP1/2/3_SH3 UniProtKB/Swiss-Prot
NCBI Gene 360840 ENTREZGENE
PANTHER SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN UniProtKB/Swiss-Prot
Pfam FCH UniProtKB/Swiss-Prot
  RhoGAP UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Srgap2 PhenoGen
PROSITE F_BAR UniProtKB/Swiss-Prot
  RHOGAP UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006733 RatGTEx
SMART FCH UniProtKB/Swiss-Prot
  RhoGAP UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot
  SSF48350 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
UniProt A0A0G2JZ92 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZL53 ENTREZGENE, UniProtKB/TrEMBL
  B5DEJ1 ENTREZGENE, UniProtKB/TrEMBL
  D4A208 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-02 Srgap2   SLIT-ROBO Rho GTPase activating protein 2   RGD1566016  similar to KIAA0456 protein   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1566016  similar to KIAA0456 protein   RGD1566016_predicted  similar to KIAA0456 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1566016_predicted  similar to KIAA0456 protein (predicted)  LOC360840  similar to KIAA0456 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC360840  similar to KIAA0456 protein      Symbol and Name status set to provisional 70820 PROVISIONAL