Gene: Srgap2 (SLIT-ROBO Rho GTPase activating protein 2) Rattus norvegicus
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Symbol:
Srgap2
Name:
SLIT-ROBO Rho GTPase activating protein 2
RGD ID:
1566016
Description:
Predicted to enable GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to be involved in several processes, including plasma membrane bounded cell projection organization; substrate adhesion-dependent cell spreading; and synapse assembly. Located in cytoplasm and nucleus. Orthologous to human SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC360840; MGC188551; RGD1566016; similar to KIAA0456 protein; SLIT-ROBO Rho GTPase-activating protein 2
RGD Orthologs
Alliance Orthologs
More Info
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More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 13 45,298,192 - 45,519,330 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 13 45,298,192 - 45,519,330 (-) Ensembl GRCr8 mRatBN7.2 13 42,745,956 - 42,967,091 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 13 42,745,947 - 42,967,058 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 13 45,354,029 - 45,577,291 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 13 46,642,156 - 46,865,413 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 13 43,905,845 - 44,129,315 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 13 48,065,280 - 48,286,888 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 13 48,068,158 - 48,286,720 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 13 53,141,198 - 53,362,657 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 13 44,239,946 - 44,452,446 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 13 43,100,229 - 43,312,451 (-) NCBI Celera Cytogenetic Map 13 q13 NCBI
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Imported Disease Annotations - ClinVar
Only show annotations with direct experimental evidence (0 objects hidden)
Srgap2 Rat (-)-epigallocatechin 3-gallate multiple interactions ISO SRGAP2 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SRGAP2 mRNA CTD PMID:22079256 Srgap2 Rat (S)-nicotine decreases expression ISO Srgap2 (Mus musculus) 6480464 Nicotine results in decreased expression of SRGAP2 mRNA CTD PMID:17997037 Srgap2 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Srgap2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Srgap2 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Srgap2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Srgap2 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Srgap2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Srgap2 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SRGAP2 mRNA CTD PMID:32109520|PMID:34747641 Srgap2 Rat 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of SRGAP2 mRNA CTD PMID:32109520 Srgap2 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Srgap2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Srgap2 Rat 2-hydroxypropanoic acid decreases expression ISO SRGAP2 (Homo sapiens) 6480464 Lactic Acid results in decreased expression of SRGAP2 mRNA CTD PMID:30851411 Srgap2 Rat 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of SRGAP2 protein CTD PMID:34915118 Srgap2 Rat 4,4'-sulfonyldiphenol decreases expression ISO Srgap2 (Mus musculus) 6480464 bisphenol S results in decreased expression of SRGAP2 mRNA CTD PMID:39298647 Srgap2 Rat 4-hydroxyphenyl retinamide increases expression ISO Srgap2 (Mus musculus) 6480464 Fenretinide results in increased expression of SRGAP2 mRNA CTD PMID:28973697 Srgap2 Rat acetamide increases expression EXP 6480464 acetamide results in increased expression of SRGAP2 mRNA CTD PMID:31881176 Srgap2 Rat acrolein multiple interactions ISO SRGAP2 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... CTD PMID:32699268 Srgap2 Rat acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of SRGAP2 mRNA CTD PMID:28959563 Srgap2 Rat alpha-pinene multiple interactions ISO SRGAP2 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... CTD PMID:32699268 Srgap2 Rat antirheumatic drug increases expression ISO SRGAP2 (Homo sapiens) 6480464 Antirheumatic Agents results in increased expression of SRGAP2 mRNA CTD PMID:24449571 Srgap2 Rat arachidonic acid decreases expression ISO SRGAP2 (Homo sapiens) 6480464 Arachidonic Acid results in decreased expression of SRGAP2 mRNA CTD PMID:16704987 Srgap2 Rat arsenite(3-) multiple interactions ISO SRGAP2 (Homo sapiens) 6480464 arsenite inhibits the reaction [G3BP1 protein binds to SRGAP2 mRNA] CTD PMID:32406909 Srgap2 Rat benzo[a]pyrene decreases expression ISO Srgap2 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of SRGAP2 mRNA CTD PMID:19770486 Srgap2 Rat benzo[a]pyrene decreases expression ISO SRGAP2 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of SRGAP2 mRNA CTD PMID:20064835|PMID:21632981|PMID:22316170|PMID:26238291 Srgap2 Rat beta-lapachone decreases expression ISO SRGAP2 (Homo sapiens) 6480464 beta-lapachone results in decreased expression of SRGAP2 mRNA CTD PMID:38218311 Srgap2 Rat bisphenol A increases expression ISO SRGAP2 (Homo sapiens) 6480464 bisphenol A results in increased expression of SRGAP2 mRNA CTD PMID:25047013 Srgap2 Rat bisphenol A decreases expression ISO SRGAP2 (Homo sapiens) 6480464 bisphenol A results in decreased expression of SRGAP2 mRNA CTD PMID:33670352 Srgap2 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SRGAP2 mRNA CTD PMID:30816183|PMID:32528016|PMID:34947998 Srgap2 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SRGAP2 mRNA CTD PMID:25181051 Srgap2 Rat C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of SRGAP2 mRNA CTD PMID:19167457 Srgap2 Rat cadmium dichloride decreases expression ISO SRGAP2 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of SRGAP2 mRNA CTD PMID:38568856 Srgap2 Rat caffeine affects phosphorylation ISO SRGAP2 (Homo sapiens) 6480464 Caffeine affects the phosphorylation of SRGAP2 protein CTD PMID:35688186 Srgap2 Rat calcitriol increases expression ISO SRGAP2 (Homo sapiens) 6480464 Calcitriol results in increased expression of SRGAP2 mRNA CTD PMID:16002434 Srgap2 Rat CGP 52608 multiple interactions ISO SRGAP2 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to SRGAP2 gene] CTD PMID:28238834 Srgap2 Rat cisplatin decreases expression ISO SRGAP2 (Homo sapiens) 6480464 Cisplatin results in decreased expression of SRGAP2 mRNA CTD PMID:19561079 Srgap2 Rat cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of SRGAP2 mRNA CTD PMID:24386269 Srgap2 Rat copper(II) sulfate decreases expression ISO SRGAP2 (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of SRGAP2 mRNA CTD PMID:19549813 Srgap2 Rat CU-O LINKAGE decreases expression ISO SRGAP2 (Homo sapiens) 6480464 cupric oxide results in decreased expression of SRGAP2 mRNA CTD PMID:22077320 Srgap2 Rat cyclosporin A decreases expression ISO Srgap2 (Mus musculus) 6480464 Cyclosporine results in decreased expression of SRGAP2 mRNA CTD PMID:19770486 Srgap2 Rat Dibutyl phosphate affects expression ISO SRGAP2 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of SRGAP2 mRNA CTD PMID:37042841 Srgap2 Rat dicrotophos increases expression ISO SRGAP2 (Homo sapiens) 6480464 dicrotophos results in increased expression of SRGAP2 mRNA CTD PMID:28302478 Srgap2 Rat diuron increases expression EXP 6480464 Diuron results in increased expression of SRGAP2 mRNA CTD PMID:25152437 Srgap2 Rat dorsomorphin multiple interactions ISO SRGAP2 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Srgap2 Rat doxorubicin decreases expression ISO SRGAP2 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of SRGAP2 mRNA CTD PMID:29803840 Srgap2 Rat enzyme inhibitor multiple interactions ISO SRGAP2 (Homo sapiens) 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ... CTD PMID:23301498 Srgap2 Rat ethanol affects expression ISO Srgap2 (Mus musculus) 6480464 Ethanol affects the expression of SRGAP2 mRNA CTD PMID:30319688 Srgap2 Rat fipronil increases expression EXP 6480464 fipronil results in increased expression of SRGAP2 mRNA CTD PMID:34044035 Srgap2 Rat hydrogen peroxide affects expression ISO SRGAP2 (Homo sapiens) 6480464 Hydrogen Peroxide affects the expression of SRGAP2 mRNA CTD PMID:20044591 Srgap2 Rat ivermectin decreases expression ISO SRGAP2 (Homo sapiens) 6480464 Ivermectin results in decreased expression of SRGAP2 protein CTD PMID:32959892 Srgap2 Rat lead(0) affects expression ISO SRGAP2 (Homo sapiens) 6480464 Lead affects the expression of SRGAP2 mRNA CTD PMID:28903495 Srgap2 Rat melphalan decreases expression ISO SRGAP2 (Homo sapiens) 6480464 Melphalan results in decreased expression of SRGAP2 mRNA CTD PMID:22363485 Srgap2 Rat menadione affects expression ISO SRGAP2 (Homo sapiens) 6480464 Vitamin K 3 affects the expression of SRGAP2 mRNA CTD PMID:20044591 Srgap2 Rat methamphetamine increases methylation ISO Srgap2 (Mus musculus) 6480464 Methamphetamine results in increased methylation of SRGAP2 promoter CTD PMID:26307267 Srgap2 Rat methamphetamine increases expression ISO Srgap2 (Mus musculus) 6480464 Methamphetamine results in increased expression of SRGAP2 mRNA CTD PMID:26307267 Srgap2 Rat methidathion decreases expression ISO Srgap2 (Mus musculus) 6480464 methidathion results in decreased expression of SRGAP2 mRNA CTD PMID:34813904 Srgap2 Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of SRGAP2 gene CTD PMID:35440735 Srgap2 Rat methylmercury chloride decreases expression ISO SRGAP2 (Homo sapiens) 6480464 methylmercuric chloride results in decreased expression of SRGAP2 mRNA CTD PMID:28001369 Srgap2 Rat nickel atom decreases expression ISO SRGAP2 (Homo sapiens) 6480464 Nickel results in decreased expression of SRGAP2 mRNA CTD PMID:25583101 Srgap2 Rat nicotine decreases expression ISO Srgap2 (Mus musculus) 6480464 Nicotine results in decreased expression of SRGAP2 mRNA CTD PMID:17997037 Srgap2 Rat ozone multiple interactions ISO SRGAP2 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... CTD PMID:32699268 Srgap2 Rat ozone decreases expression EXP 6480464 Ozone results in decreased expression of SRGAP2 mRNA CTD PMID:35737395 Srgap2 Rat paracetamol increases expression ISO SRGAP2 (Homo sapiens) 6480464 Acetaminophen results in increased expression of SRGAP2 mRNA CTD PMID:22230336|PMID:25704631|PMID:29067470 Srgap2 Rat PCB138 multiple interactions ISO Srgap2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Srgap2 Rat potassium chromate decreases expression ISO SRGAP2 (Homo sapiens) 6480464 potassium chromate(VI) results in decreased expression of SRGAP2 mRNA CTD PMID:22079256 Srgap2 Rat potassium chromate multiple interactions ISO SRGAP2 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SRGAP2 mRNA CTD PMID:22079256 Srgap2 Rat rac-lactic acid decreases expression ISO SRGAP2 (Homo sapiens) 6480464 Lactic Acid results in decreased expression of SRGAP2 mRNA CTD PMID:30851411 Srgap2 Rat rotenone increases expression EXP 6480464 Rotenone results in increased expression of SRGAP2 mRNA CTD PMID:19013527 Srgap2 Rat SB 431542 multiple interactions ISO SRGAP2 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Srgap2 Rat Soman increases expression EXP 6480464 Soman results in increased expression of SRGAP2 mRNA CTD PMID:19281266 Srgap2 Rat titanium dioxide decreases methylation ISO Srgap2 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of SRGAP2 gene CTD PMID:35295148 Srgap2 Rat triacsin C decreases expression ISO SRGAP2 (Homo sapiens) 6480464 triacsin C results in decreased expression of SRGAP2 mRNA CTD PMID:16704987 Srgap2 Rat trichostatin A increases expression ISO SRGAP2 (Homo sapiens) 6480464 trichostatin A results in increased expression of SRGAP2 mRNA CTD PMID:24935251 Srgap2 Rat triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of SRGAP2 mRNA CTD PMID:30589522 Srgap2 Rat triptonide decreases expression ISO Srgap2 (Mus musculus) 6480464 triptonide results in decreased expression of SRGAP2 mRNA CTD PMID:33045310 Srgap2 Rat tungsten decreases expression ISO Srgap2 (Mus musculus) 6480464 Tungsten results in decreased expression of SRGAP2 mRNA CTD PMID:30912803 Srgap2 Rat urethane increases expression ISO SRGAP2 (Homo sapiens) 6480464 Urethane results in increased expression of SRGAP2 mRNA CTD PMID:28818685 Srgap2 Rat valproic acid increases expression ISO SRGAP2 (Homo sapiens) 6480464 Valproic Acid results in increased expression of SRGAP2 mRNA CTD PMID:23179753|PMID:26272509 Srgap2 Rat valproic acid multiple interactions ISO SRGAP2 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386