 Gene-Chemical Interaction Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations |
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Analyze GeneStrainQTL List |
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Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
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MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
Gene Ontology AnnotationsDisease AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology AnnotationsBiological Process
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Cellular Component
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Molecular Function
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References - curated| 1. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 2. | RGD automated data pipeline |
| 3. | RGD automated import pipeline for gene-chemical interactions |
| 4. | Yao Q, etal., Cell Mol Neurobiol. 2008 Feb;28(2):205-21. Epub 2007 Aug 21. |
References - uncuratedGenomics
Comparative Map Data| Srgap2 (Rattus norvegicus - Norway rat) |
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| SRGAP2 (Homo sapiens - human) |
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| Srgap2 (Mus musculus - house mouse) |
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| Srgap2 (Chinchilla lanigera - long-tailed chinchilla) |
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| SRGAP2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| SRGAP2 (Canis lupus familiaris - dog) |
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| Srgap2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| SRGAP2 (Sus scrofa - pig) |
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| SRGAP2 (Chlorocebus sabaeus - African green monkey) |
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| Srgap2 (Heterocephalus glaber - naked mole-rat) |
No map positions available. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Position Markers| BE108135 |
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| BE109592 |
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| AU046573 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
| High | |||||||||||||
| Medium | 1 | 31 | 30 | 17 | 19 | 17 | 1 | 1 | 74 | 26 | 34 | 11 | 1 |
| Low | 2 | 12 | 27 | 24 | 24 | 7 | 10 | 9 | 7 | 7 | |||
| Below cutoff |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_001134958 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006249782 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006249783 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006249785 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008769479 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008769480 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR07072323 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AAHX01075060 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01075061 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01075062 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AC113752 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| BC168690 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473958 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FQ212420 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FQ213536 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | ENSRNOT00000008976 ⟹ ENSRNOP00000008976 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | ENSRNOT00000085967 ⟹ ENSRNOP00000068925 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | ENSRNOT00000086928 ⟹ ENSRNOP00000070956 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | NM_001134958 ⟹ NP_001128430 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
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| Sequence: |
GGCGGAGTCTCCTTAGGGAACTGGGGGGCCGAACTGCGTAGAAGAGGGTGGCGGGGAGGAGAGChide sequence |
| RefSeq Acc Id: | XM_006249782 ⟹ XP_006249844 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
CTAGGCAGCTAGTGTTCGCCACACCTCTAAGTTTCGTCAGCCCCGCCTCTATTCCTGGCGTCTAhide sequence |
| RefSeq Acc Id: | XM_006249783 ⟹ XP_006249845 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
TGGAGCTCTTCCCTCAGCCTTCCTGCGGTCGCCTCTCGCGCCTCCTGGAGCGACTATCACTGAThide sequence |
| RefSeq Acc Id: | XM_006249785 ⟹ XP_006249847 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
GAGATGGACTACTCTCGCAACCTGGAGAAGCTAGCCGAGCGCTTTCTAGCCAAGACACGAAGCAhide sequence |
| RefSeq Acc Id: | XM_008769479 ⟹ XP_008767701 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
CTAGGCAGCTAGTGTTCGCCACACCTCTAAGTTTCGTCAGCCCCGCCTCTATTCCTGGCGTCTAhide sequence |
| RefSeq Acc Id: | XM_008769480 ⟹ XP_008767702 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
GAAAGAAATTAAGCCTGGAGAAACAGACCAGAGCAGCCAAATTACAGCAAATGCTGGTGTTTGAhide sequence |
Protein Sequences| Protein RefSeqs | NP_001128430 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006249844 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006249845 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006249847 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_008767701 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_008767702 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | AAI68690 | (Get FASTA) | NCBI Sequence Viewer |
| D4A208 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM09828 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_001128430 ⟸ NM_001134958 |
| - UniProtKB: | B5DEJ1 (UniProtKB/TrEMBL) |
| - Sequence: |
MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYShide sequence |
| RefSeq Acc Id: | XP_006249844 ⟸ XM_006249782 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | D4A208 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYShide sequence |
| RefSeq Acc Id: | XP_006249845 ⟸ XM_006249783 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | D4A208 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYShide sequence |
| RefSeq Acc Id: | XP_006249847 ⟸ XM_006249785 |
| - Peptide Label: | isoform X2 |
| - Sequence: |
MYKTLVQSTDALATPPIFFNRKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQhide sequence |
| RefSeq Acc Id: | XP_008767702 ⟸ XM_008769480 |
| - Peptide Label: | isoform X4 |
| - Sequence: |
MKALFEKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQhide sequence |
| RefSeq Acc Id: | XP_008767701 ⟸ XM_008769479 |
| - Peptide Label: | isoform X3 |
| - UniProtKB: | A0A0G2JZ92 (UniProtKB/TrEMBL) |
| - Sequence: |
MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYShide sequence |
| RefSeq Acc Id: | ENSRNOP00000008976 ⟸ ENSRNOT00000008976 |
| RefSeq Acc Id: | ENSRNOP00000068925 ⟸ ENSRNOT00000085967 |
| RefSeq Acc Id: | ENSRNOP00000070956 ⟸ ENSRNOT00000086928 |
Protein Domains
F-BAR Rho-GAP SH3
TranscriptomePromoters| RGD ID: | 13698796 | ||||||||
| Promoter ID: | EPDNEW_R9321 | ||||||||
| Type: | initiation region | ||||||||
| Name: | Srgap2_1 | ||||||||
| Description: | SLIT-ROBO Rho GTPase activating protein 2 | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
| Experiment Methods: | Single-end sequencing. | ||||||||
| Position: |
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Strain Variation
Strain Sequence Variants (Rnor 6.0)
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Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:1566016 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000006733 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000008976 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000068925 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| ENSRNOP00000070956 | ENTREZGENE, UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000008976 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000085967 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| ENSRNOT00000086928 | ENTREZGENE, UniProtKB/TrEMBL | |
| Gene3D-CATH | 1.10.555.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| InterPro | AH/BAR_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| F_BAR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| FCH_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| Rho_GTPase_activation_prot | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| RhoGAP_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| SH3-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| SH3_domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| srGAP1/2/3_SH3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| srGAP2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| KEGG Report | rno:360840 | UniProtKB/TrEMBL |
| NCBI Gene | 360840 | ENTREZGENE |
| PANTHER | PTHR14166:SF6 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| Pfam | FCH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| RhoGAP | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| SH3_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| PhenoGen | Srgap2 | PhenoGen |
| PROSITE | F_BAR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| RHOGAP | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| SH3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| SMART | FCH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| RhoGAP | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| SH3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| Superfamily-SCOP | SSF103657 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| SSF48350 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| SSF50044 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| UniGene | Rn.12700 | ENTREZGENE |
| UniProt | A0A0G2JZ92 | ENTREZGENE, UniProtKB/TrEMBL |
| B5DEJ1 | ENTREZGENE, UniProtKB/TrEMBL | |
| D4A208 | ENTREZGENE, UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-10-02 | Srgap2 | SLIT-ROBO Rho GTPase activating protein 2 | RGD1566016 | similar to KIAA0456 protein | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2008-04-30 | RGD1566016 | similar to KIAA0456 protein | RGD1566016_predicted | similar to KIAA0456 protein (predicted) | 'predicted' is removed | 2292626 | APPROVED |
| 2006-03-07 | RGD1566016_predicted | similar to KIAA0456 protein (predicted) | LOC360840 | similar to KIAA0456 protein | Symbol and Name status set to approved | 1299863 | APPROVED |
| 2006-02-09 | LOC360840 | similar to KIAA0456 protein | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
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| More on Srgap2 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 1566016 |
| Created: | 2006-02-09 |
| Species: | Rattus norvegicus |
| Last Modified: | 2020-08-20 |
| Status: | ACTIVE |
