Sftpa1 (surfactant protein A1) - Rat Genome Database

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Gene: Sftpa1 (surfactant protein A1) Rattus norvegicus
Analyze
Symbol: Sftpa1
Name: surfactant protein A1
RGD ID: 3665
Description: Predicted to enable carbohydrate binding activity and metal ion binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in extracellular space and multivesicular body. Biomarker of asthma; congenital diaphragmatic hernia; lung disease (multiple); and obesity. Human ortholog(s) of this gene implicated in lung disease (multiple) and respiratory syncytial virus infectious disease. Orthologous to several human genes including SFTPA1 (surfactant protein A1); PARTICIPATES IN forkhead class A signaling pathway; phagocytosis pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100364823; LOC102557073; MGC105453; PSAP; PSP-A; pulmonary surfactant-associated protein A; pulmonary surfactant-associated protein A-like; Sftp1; Sftpa; Sftpl; SP-A; surfactant associated protein A; surfactant, pulmonary-associated protein A1; Surfactant-associated protein 1 (pulmonary surfactant protein SP-A); Surfactant-associated protein 1 (pulmonary surfactant protein, SP-A)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21617,008,180 - 17,011,686 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,008,180 - 17,011,685 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,072,970 - 17,076,475 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,199,439 - 18,202,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,125,874 - 17,129,379 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01618,716,019 - 18,719,404 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,716,019 - 18,719,403 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,585,631 - 18,589,016 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,570,887 - 17,574,389 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1617,235,343 - 17,236,847 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Surfactant protein deficiency in familial interstitial lung disease. Amin RS, etal., J Pediatr. 2001 Jul;139(1):85-92.
2. Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D. Atochina EN, etal., J Lab Clin Med. 2001 Jun;137(6):429-39.
3. Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization. Atochina EN, etal., Respir Res. 2003 Dec 8;4:15. Print 2003.
4. Pulmonary surfactant protein A up-regulates activity of the mannose receptor, a pattern recognition receptor expressed on human macrophages. Beharka AA, etal., J Immunol 2002 Oct 1;169(7):3565-73.
5. Molecular phenotypes distinguish patients with relatively stable from progressive idiopathic pulmonary fibrosis (IPF). Boon K, etal., PLoS One. 2009;4(4):e5134. Epub 2009 Apr 6.
6. [Effect of intrauterine acute ischemic-hypoxia on the expression of lung SP-A and SP-B in neonatal rats] Cai XX, etal., Zhonghua Er Ke Za Zhi. 2003 Mar;41(3):208-11.
7. Mild vitamin A deficiency delays fetal lung maturation in the rat. Chailley-Heu B, etal., Am J Respir Cell Mol Biol. 1999 Jul;21(1):89-96.
8. Association of common haplotypes of surfactant protein A1 and A2 (SFTPA1 and SFTPA2) genes with severity of lung disease in cystic fibrosis. Choi EH, etal., Pediatr Pulmonol. 2006 Mar;41(3):255-62.
9. Exudative lung injury is associated with decreased levels of surfactant proteins in a rat model of meconium aspiration. Cleary GM, etal., Pediatrics. 1997 Dec;100(6):998-1003.
10. Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma. Erpenbeck VJ, etal., Allergy. 2006 May;61(5):598-604.
11. Rat pulmonary surfactant protein A is expressed as two differently sized mRNA species which arise from differential polyadenylation of one transcript. Fisher JH, etal., Biochim Biophys Acta 1988 Sep 7;950(3):338-45.
12. Serum surfactant protein D is increased in acute and chronic inflammation in mice. Fujita M, etal., Cytokine. 2005 Jul 7;31(1):25-33.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Relationship between pulmonary surfactant protein and lipid peroxidation in lung injury due to paraquat intoxication in rats. Gil HW, etal., Korean J Intern Med. 2007 Jun;22(2):67-72.
15. Serial changes in surfactant-associated proteins in lung and serum before and after onset of ARDS. Greene KE, etal., Am J Respir Crit Care Med. 1999 Dec;160(6):1843-50.
16. Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis. Griese M, etal., Am J Respir Crit Care Med. 2004 Nov 1;170(9):1000-5. Epub 2004 Jul 21.
17. Antenatal dexamethasone enhances surfactant protein synthesis in the hypoplastic lung of nitrofen-induced diaphragmatic hernia in rats. Guarino N, etal., J Pediatr Surg. 2000 Oct;35(10):1468-73. doi: 10.1053/jpsu.2000.16416.
18. Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema. Gunther A, etal., Am J Respir Crit Care Med. 1996 Jan;153(1):176-84.
19. Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis. Gunther A, etal., Eur Respir J. 1999 Sep;14(3):565-73.
20. Surfactant protein gene A, B, and D marker alleles in chronic obstructive pulmonary disease of a Mexican population. Guo X, etal., Eur Respir J. 2001 Sep;18(3):482-90.
21. Continuous mechanical contraction modulates expression of alveolar epithelial cell phenotype. Gutierrez JA, etal., Am J Respir Cell Mol Biol. 2003 Jul;29(1):81-7. Epub 2003 Jan 31.
22. Surfactant proteins A and B as interactive genetic determinants of neonatal respiratory distress syndrome. Haataja R, etal., Hum Mol Genet. 2000 Nov 1;9(18):2751-60.
23. Surfactant protein A accumulating in the alveoli of patients with pulmonary alveolar proteinosis: oligomeric structure and interaction with lipids. Hattori A, etal., Am J Respir Cell Mol Biol. 1996 Jun;14(6):608-19.
24. Nihon Kyobu Shikkan Gakkai zasshi Honda Y Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Dec;34 Suppl:181-5.
25. Surfactant composition in infants and young children with cystic fibrosis. Hull J, etal., Am J Respir Crit Care Med. 1997 Jul;156(1):161-5.
26. Effects of intrauterine IL-6 and IL-8 on the expression of surfactant apoprotein mRNAs in the fetal rat lung. Ikegami T, etal., Eur J Obstet Gynecol Reprod Biol. 2000 Nov;93(1):97-103.
27. Diminished lung compliance and elevated surfactant lipids and proteins in nutritionally obese young rats. Inselman LS, etal., Lung. 2004;182(2):101-17.
28. Pulmonary alveolar proteinosis in SCID mice. Jennings VM, etal., Am J Respir Cell Mol Biol. 1995 Sep;13(3):297-306.
29. Surfactant protein levels in severe respiratory syncytial virus infection. Kerr MH and Paton JY, Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1115-8.
30. Circadian rhythm of surfactant protein A, B and C mRNA in rats. Kim CM, etal., Korean J Intern Med. 2003 Jun;18(2):76-82.
31. Pulmonary collectins enhance phagocytosis of Mycobacterium avium through increased activity of mannose receptor. Kudo K, etal., J Immunol. 2004 Jun 15;172(12):7592-602.
32. Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes. Lee JW, etal., Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L950-7. Epub 2005 Jan 7.
33. Effect of epidermal growth factor and dexamethasone on fetal rat lung development. Ma L, etal., Chin Med J (Engl). 2009 Sep 5;122(17):2013-6.
34. Association of polymorphisms in the collagen region of human SP-A1 and SP-A2 genes with pulmonary tuberculosis in Indian population. Madan T, etal., Clin Chem Lab Med. 2002 Oct;40(10):1002-8.
35. Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis. Madan T, etal., Mol Immunol. 2010 Jun;47(10):1923-30. Epub 2010 Apr 21.
36. Variants of the SFTPA1 and SFTPA2 genes and susceptibility to tuberculosis in Ethiopia. Malik S, etal., Hum Genet. 2006 Feb;118(6):752-9. Epub 2005 Nov 15.
37. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Proteomics of human lung tissue identifies surfactant protein A as a marker of chronic obstructive pulmonary disease. Ohlmeier S, etal., J Proteome Res. 2008 Oct 30.
40. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
41. Antagonistic effects of dexamethasone and retinoic acid on rat lung morphogenesis. Oshika E, etal., Pediatr Res. 1998 Mar;43(3):315-24.
42. Genetic variants of surfactant proteins A, B, C, and D in bronchopulmonary dysplasia. Pavlovic J, etal., Dis Markers. 2006;22(5-6):277-91.
43. Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes. Pettigrew MM, etal., BMC Med Genet. 2007 Apr 2;8:15.
44. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
45. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
46. Differential effects in vivo of thyroid hormone on the expression of surfactant phospholipid, surfactant protein mRNA and antioxidant enzyme mRNA in fetal rat lung. Ramadurai SM, etal., Exp Lung Res. 1998 Sep-Oct;24(5):641-57.
47. GOA pipeline RGD automated data pipeline
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia. Russo TA, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L655-63.
51. Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C. Savani RC, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Sep;281(3):L685-96.
52. Association of polymorphisms in pulmonary surfactant protein A1 and A2 genes with high-altitude pulmonary edema. Saxena S, etal., Chest. 2005 Sep;128(3):1611-9.
53. Effects of maternal dexamethasone on expression of SP-A, SP-B, and SP-C in the fetal rat lung. Schellhase DE and Shannon JM, Am J Respir Cell Mol Biol. 1991 Apr;4(4):304-12.
54. Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration. Schmidt R, etal., Respir Res. 2007 Jul 27;8:55.
55. Decrease of the surface fraction of surfactant proteins containing clara cells and type II pneumocytes in a rat asthma model. Schmiedl A, etal., Exp Toxicol Pathol. 2005 Mar;56(4-5):265-72.
56. Distribution of surfactant proteins in type II pneumocytes of newborn, 14-day old, and adult rats: an immunoelectron microscopic and stereological study. Schmiedl A, etal., Histochem Cell Biol. 2005 Dec;124(6):465-76. Epub 2005 Sep 27.
57. Increased surfactant protein a and d expression in acute ovalbumin-induced allergic airway inflammation in brown norway rats. Schmiedl A, etal., Int Arch Allergy Immunol. 2009;148(2):118-26. Epub 2008 Sep 19.
58. Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis. Selman M, etal., Hum Genet. 2003 Nov;113(6):542-50. Epub 2003 Sep 6.
59. Relationship of anti-GM-CSF antibody concentration, surfactant protein A and B levels, and serum LDH to pulmonary parameters and response to GM-CSF therapy in patients with idiopathic alveolar proteinosis. Seymour JF, etal., Thorax. 2003 Mar;58(3):252-7.
60. Sequence of rat surfactant protein A gene and functional mapping of its upstream region. Smith CI, etal., Am J Physiol 1995 Nov;269(5 Pt 1):L603-12.
61. Surfactant protein a inhibits lipopolysaccharide-induced immune cell activation by preventing the interaction of lipopolysaccharide with lipopolysaccharide-binding protein. Stamme C, etal., Am J Respir Cell Mol Biol 2002 Sep;27(3):353-60.
62. Overexpression of surfactant protein SP-A, SP-B, and SP-C mRNA in rat lungs with lipopolysaccharide-induced injury. Sugahara K, etal., Lab Invest. 1996 Jan;74(1):209-20.
63. Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury. ter Horst SA, etal., BMC Pulm Med. 2006 Apr 18;6:8.
64. Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus. Thomas NJ, etal., Pediatr Res. 2009 Jul;66(1):70-3.
65. Immunohistochemical distribution of surfactant apoproteins in hypoplastic lungs of nonimmunologic hydrops fetalis. Toki N, etal., Hum Pathol. 1995 Nov;26(11):1252-9.
66. Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate. van Diemen CC, etal., Eur Respir J. 2010 Apr;35(4):768-75. Epub 2009 Sep 24.
67. Engineering novel complement activity into a pulmonary surfactant protein. Venkatraman Girija U, etal., J Biol Chem. 2010 Apr 2;285(14):10546-52. doi: 10.1074/jbc.M109.097493. Epub 2010 Jan 29.
68. Polymorphisms of surfactant protein A genes and the risk of bronchopulmonary dysplasia in preterm infants. Weber B, etal., Turk J Pediatr. 2000 Jul-Sep;42(3):181-5.
69. Elevated expression of surfactant proteins in newborn rats during adaptation to hyperoxia. White CW, etal., Am J Respir Cell Mol Biol. 2001 Jul;25(1):51-9.
70. Sinonasal surfactant protein A1, A2, and D gene expression in cystic fibrosis: a preliminary report. Woodworth BA, etal., Otolaryngol Head Neck Surg. 2007 Jul;137(1):34-8.
71. Effect of inhaled budesonide on surfactant protein expression in asthmatic mice. Yu ZW and Zhang JH, Allergy Asthma Proc. 2008 Sep-Oct;29(5):486-92.
Additional References at PubMed
PMID:3579914   PMID:12477932   PMID:12600986   PMID:12857753   PMID:12882765   PMID:12904592   PMID:12913002   PMID:14993215   PMID:15482851   PMID:15489334   PMID:15969762   PMID:16081790  
PMID:16207426   PMID:16330552   PMID:16500946   PMID:17202387   PMID:17220308   PMID:17469149   PMID:18344412   PMID:18480979   PMID:20382745   PMID:20473679   PMID:20663300   PMID:20688121  
PMID:21047777   PMID:21123169   PMID:21166190   PMID:21248257   PMID:23894445   PMID:25242514   PMID:26196539   PMID:27660222   PMID:28719181   PMID:30055742   PMID:33267655   PMID:34777371  


Genomics

Comparative Map Data
Sftpa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21617,008,180 - 17,011,686 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,008,180 - 17,011,685 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,072,970 - 17,076,475 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,199,439 - 18,202,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,125,874 - 17,129,379 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01618,716,019 - 18,719,404 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,716,019 - 18,719,403 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,585,631 - 18,589,016 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,570,887 - 17,574,389 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1617,235,343 - 17,236,847 (+)NCBICelera
Cytogenetic Map16p14NCBI
SFTPA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381079,610,939 - 79,615,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1079,610,939 - 79,615,455 (+)EnsemblGRCh38hg38GRCh38
GRCh371081,370,695 - 81,375,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361081,040,722 - 81,045,208 (+)NCBINCBI36Build 36hg18NCBI36
Build 341081,360,663 - 81,363,921NCBI
Celera1074,655,786 - 74,660,290 (+)NCBICelera
Cytogenetic Map10q22.3NCBI
HuRef1075,365,719 - 75,370,230 (+)NCBIHuRef
CHM1_11081,653,316 - 81,657,819 (+)NCBICHM1_1
T2T-CHM13v2.01080,480,108 - 80,484,632 (+)NCBIT2T-CHM13v2.0
Sftpa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391440,853,745 - 40,858,330 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1440,853,739 - 40,858,409 (+)EnsemblGRCm39 Ensembl
GRCm381441,131,788 - 41,136,373 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1441,131,782 - 41,136,452 (+)EnsemblGRCm38mm10GRCm38
MGSCv371441,945,077 - 41,949,662 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361440,040,501 - 40,045,086 (+)NCBIMGSCv36mm8
Celera1437,291,836 - 37,296,421 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1422.36NCBI
LOC103783265
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11092,143,130 - 92,145,527 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01076,571,312 - 76,575,820 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11080,176,241 - 80,177,151 (-)NCBIpanpan1.1PanPan1.1panPan2
LOC610540
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1429,430,139 - 29,434,640 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha429,554,528 - 29,559,038 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0429,732,348 - 29,736,864 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1429,601,811 - 29,606,320 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0429,804,500 - 29,809,005 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0430,158,495 - 30,163,007 (-)NCBIUU_Cfam_GSD_1.0
SFTPA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1482,091,178 - 82,095,393 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11482,091,178 - 82,095,393 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21488,698,851 - 88,702,099 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Sftpa1
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:148
Interacting mature miRNAs:166
Transcripts:ENSRNOT00000047870
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat

Markers in Region
D16Mgh2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,007,576 - 17,007,744 (+)MAPPERmRatBN7.2
Rnor_6.01618,715,416 - 18,715,583NCBIRnor6.0
Rnor_5.01618,585,028 - 18,585,195UniSTSRnor5.0
RGSC_v3.41617,570,282 - 17,570,449UniSTSRGSC3.4
RGSC_v3.41617,570,281 - 17,570,446RGDRGSC3.4
RGSC_v3.11617,570,279 - 17,570,444RGD
RH 3.4 Map16170.6UniSTS
RH 3.4 Map16170.6RGD
RH 2.0 Map16142.7RGD
SHRSP x BN Map165.71RGD
FHH x ACI Map1612.1799RGD
Cytogenetic Map16p14UniSTS
RH136969  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,011,434 - 17,011,625 (+)MAPPERmRatBN7.2
Rnor_6.01618,719,153 - 18,719,343NCBIRnor6.0
Rnor_5.01618,588,765 - 18,588,955UniSTSRnor5.0
RGSC_v3.41617,574,140 - 17,574,330UniSTSRGSC3.4
Celera1617,236,596 - 17,236,786UniSTS
RH 3.4 Map16167.1UniSTS
Cytogenetic Map16p14UniSTS
Sftpa1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01618,717,098 - 18,717,980NCBIRnor6.0
Rnor_5.01618,586,710 - 18,587,592UniSTSRnor5.0
RGSC_v3.41617,571,964 - 17,572,967UniSTSRGSC3.4
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 11
Medium
Low 11 23 8 15 8 8 9 8 7 9 8
Below cutoff 1 5 27 26 1 26 4 2 4

Sequence


RefSeq Acc Id: ENSRNOT00000047870   ⟹   ENSRNOP00000039850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,008,180 - 17,011,685 (+)Ensembl
Rnor_6.0 Ensembl1618,716,019 - 18,719,403 (+)Ensembl
RefSeq Acc Id: NM_001270645   ⟹   NP_001257574
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21617,008,180 - 17,011,686 (+)NCBI
Rnor_6.01618,716,019 - 18,719,404 (+)NCBI
Rnor_5.01618,585,631 - 18,589,016 (+)NCBI
Celera1617,235,343 - 17,236,847 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270647   ⟹   NP_001257576
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21617,008,180 - 17,011,686 (+)NCBI
Rnor_6.01618,716,019 - 18,719,404 (+)NCBI
Rnor_5.01618,585,631 - 18,589,016 (+)NCBI
Celera1617,235,343 - 17,236,847 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017329   ⟹   NP_059025
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21617,008,180 - 17,011,686 (+)NCBI
Rnor_6.01618,716,019 - 18,719,404 (+)NCBI
Rnor_5.01618,585,631 - 18,589,016 (+)NCBI
RGSC_v3.41617,570,887 - 17,574,389 (+)RGD
Celera1617,235,343 - 17,236,847 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094199   ⟹   XP_038950127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21617,008,293 - 17,011,686 (+)NCBI
RefSeq Acc Id: NP_059025   ⟸   NM_017329
- Peptide Label: isoform 2 precursor
- UniProtKB: P08427 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257574   ⟸   NM_001270645
- Peptide Label: isoform 1 precursor
- UniProtKB: P08427 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257576   ⟸   NM_001270647
- Peptide Label: isoform 3 precursor
- UniProtKB: P08427 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000039850   ⟸   ENSRNOT00000047870
RefSeq Acc Id: XP_038950127   ⟸   XM_039094199
- Peptide Label: isoform X1
- UniProtKB: P08427 (UniProtKB/Swiss-Prot)
Protein Domains
C-type lectin   Collagen-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08427-F1-model_v2 AlphaFold P08427 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699975
Promoter ID:EPDNEW_R10497
Type:multiple initiation site
Name:Sftpa1_1
Description:surfactant protein A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01618,716,010 - 18,716,070EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3665 AgrOrtholog
BioCyc Gene G2FUF-11908 BioCyc
Ensembl Genes ENSRNOG00000011438 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047870 ENTREZGENE
  ENSRNOT00000047870.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121530 IMAGE-MGC_LOAD
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Collectin_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24773 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105453 IMAGE-MGC_LOAD
NCBI Gene 24773 ENTREZGENE
PANTHER LYMPHOCYTE ANTIGEN 75 UniProtKB/TrEMBL
  MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED UniProtKB/TrEMBL
  PULMONARY SURFACTANT-ASSOCIATED PROTEIN A UniProtKB/Swiss-Prot
  PULMONARY SURFACTANT-ASSOCIATED PROTEIN A1 UniProtKB/Swiss-Prot
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sftpa1 PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011438 RatGTEx
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP C-type lectin-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Triple coiled coil domain of C-type lectins UniProtKB/Swiss-Prot
UniProt A6K9L7_RAT UniProtKB/TrEMBL
  P08427 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-05-18 Sftpa1  surfactant protein A1  LOC102557073  pulmonary surfactant-associated protein A-like  Data merged from RGD:7634712 737654 APPROVED
2013-12-18 LOC102557073  pulmonary surfactant-associated protein A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-03-29 Sftpa1  surfactant protein A1  LOC100364823  pulmonary surfactant-associated protein A-like  Data merged from RGD:2320242 737654 PROVISIONAL
2010-05-05 LOC100364823  pulmonary surfactant-associated protein A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-02-26 Sftpa1  surfactant protein A1  Sftpa1  surfactant, pulmonary-associated protein A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Sftpa1  surfactant, pulmonary-associated protein A1    Surfactant-associated protein 1 (pulmonary surfactant protein, SP-A)  Name updated 629478 APPROVED