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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3665
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sftpa1
Name: surfactant protein A1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sftpa1decreases expressionEXP 6480464CTDOzone results in decreased expression of SFTPA1 mRNAPMID:28549673
Sftpa1affects response to substanceISOSFTPA1 (Homo sapiens)6480464CTDSFTPA1 protein affects the susceptibility to OzonePMID:11781168
Sftpa1increases expressionISOSftpa1 (Mus musculus)6480464CTDOzone results in increased expression of SFTPA1 mRNAPMID:17307210
Sftpa1increases oxidationISOSftpa1 (Mus musculus)6480464CTDOzone results in increased oxidation of SFTPA1 proteinPMID:17307210
Sftpa1increases oxidationISOSFTPA1 (Homo sapiens)6480464CTDOzone results in increased oxidation of SFTPA1 protein polymorphismPMID:14617519 PMID:15065867
Sftpa1multiple interactionsISOSftpa1 (Mus musculus)6480464CTDOzone results in increased oxidation of [SFTPA1 protein binds to SFTPA1 protein]; SFTPA1 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL2 mRNA]PMID:17307210
Sftpa1multiple interactionsISOSFTPA1 (Homo sapiens)6480464CTDOzone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; Ozone inhibits the reaction [SFTPA1 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; Ozone inhibits the reaction [SFTPA1 protein polymorphism results in increased expression of TNF protein]; Ozone promotes the reaction [SFTPA1 protein polymorphism binds to SFTPA1 protein polymorphism]; SFTPA1 protein promotes the reaction [Ozone results in increased expression of CXCL8 protein]; SFTPA1 protein promotes the reaction [Ozone results in increased expression of TNF protein]PMID:11781168 PMID:14617519 PMID:15065867
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