Srsf5 (serine and arginine rich splicing factor 5) - Rat Genome Database
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Gene: Srsf5 (serine and arginine rich splicing factor 5) Rattus norvegicus
Analyze
Symbol: Srsf5
Name: serine and arginine rich splicing factor 5
RGD ID: 3664
Description: Exhibits RNA binding activity and protein kinase B binding activity. Involved in several processes, including cellular response to insulin stimulus; liver regeneration; and positive regulation of RNA splicing. Localizes to nucleus. Orthologous to human SRSF5 (serine and arginine rich splicing factor 5); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 3-chloropropane-1,2-diol; 3H-1,2-dithiole-3-thione; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: delayed-early protein HRS; HRS; insulin-induced growth response protein CL-4; pre-mRNA-splicing factor SRP40; serine/arginine-rich splicing factor 5; Sfrs5; splicing factor arginine/serine-rich 5 (SRp40 HRS); splicing factor, arginine/serine-rich 5; splicing factor, arginine/serine-rich 5 (SRp40, HRS); SRp40
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC107305674  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: Due to a potential assembly artifact, Rattus norvegicus Annotation Release 105 annotates the 5' end of this gene on chromosome 6 (NW_007905843.1) and the 3' end on chromosome 17 (NW_007906018.1) on Rnor_6.0. The correct location of this gene is on chromosome 6. [04 Mar 2016]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26100,605,165 - 100,610,192 (+)NCBI
Rnor_6.0 Ensembl6104,611,026 - 104,615,302 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06104,611,026 - 104,640,033 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01721,149,626 - 21,149,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.06112,776,230 - 112,805,142 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46104,728,286 - 104,732,982 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16104,731,761 - 104,736,439 (+)NCBI
Celera698,461,136 - 98,465,890 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antimony(0)  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dabrafenib  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
fipronil  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
GSK690693  (ISO)
indometacin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
malathion  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrobenzenes  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (EXP)
parathion-methyl  (EXP)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
quercetin  (EXP)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
Tributyltin oxide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
nuclear speck  (IBA,ISO,ISS)
nucleolus  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2. Diamond RH, etal., J Biol Chem 1993 Jul 15;268(20):15185-92.
3. Du K, etal., J Biol Chem. 1998 Dec 25;273(52):35208-15.
4. Du K, etal., Mol Cell Biol. 1997 Jul;17(7):4096-104.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Ghigna C, etal., Cancer Res. 1998 Dec 15;58(24):5818-24.
7. GOA data from the GO Consortium
8. Hamil KG and Hall SH, Endocrinology 1994 Mar;134(3):1205-12.
9. Huang CS, etal., Clin Chim Acta. 2007 Sep;384(1-2):69-74. Epub 2007 Jun 15.
10. Iborra S, etal., Int J Gynecol Cancer. 2013 Jul;23(6):990-6. doi: 10.1097/IGC.0b013e31829783e3.
11. NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Patel NA, etal., J Biol Chem. 2001 Jun 22;276(25):22648-54. Epub 2001 Mar 30.
13. Patel NA, etal., J Biol Chem. 2005 Apr 8;280(14):14302-9. Epub 2005 Jan 31.
14. Piekielko-Witkowska A, etal., PLoS One. 2010 Oct 27;5(10):e13690. doi: 10.1371/journal.pone.0013690.
15. RGD automated import pipeline for gene-chemical interactions
16. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Topalidou I, etal., PLoS Genet. 2016 May 18;12(5):e1006074. doi: 10.1371/journal.pgen.1006074. eCollection 2016 May.
18. Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
19. Walsh CM, etal., J Biol Chem. 2013 Jan 25;288(4):2816-28. doi: 10.1074/jbc.M112.410803. Epub 2012 Dec 11.
Additional References at PubMed
PMID:8889548   PMID:9434190   PMID:15057822   PMID:15489334   PMID:15798186   PMID:18758164   PMID:22658674   PMID:22681889   PMID:25931508   PMID:30053369  


Genomics

Comparative Map Data
Srsf5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26100,605,165 - 100,610,192 (+)NCBI
Rnor_6.0 Ensembl6104,611,026 - 104,615,302 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06104,611,026 - 104,640,033 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01721,149,626 - 21,149,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.06112,776,230 - 112,805,142 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46104,728,286 - 104,732,982 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16104,731,761 - 104,736,439 (+)NCBI
Celera698,461,136 - 98,465,890 (+)NCBICelera
Cytogenetic Map6q24NCBI
SRSF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1469,726,900 - 69,772,005 (+)EnsemblGRCh38hg38GRCh38
GRCh381469,767,112 - 69,772,005 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371470,233,859 - 70,238,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361469,303,582 - 69,308,475 (+)NCBINCBI36hg18NCBI36
Build 341469,303,562 - 69,308,474NCBI
Celera1450,297,941 - 50,302,834 (+)NCBI
Cytogenetic Map14q24.1NCBI
HuRef1450,402,386 - 50,407,279 (+)NCBIHuRef
CHM1_11470,171,946 - 70,176,864 (+)NCBICHM1_1
Srsf5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,992,269 - 80,997,281 (+)NCBIGRCm39mm39
GRCm39 Ensembl1280,992,278 - 80,997,281 (+)Ensembl
GRCm381280,945,495 - 80,950,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,945,504 - 80,950,507 (+)EnsemblGRCm38mm10GRCm38
MGSCv371282,046,491 - 82,051,494 (+)NCBIGRCm37mm9NCBIm37
MGSCv361281,865,424 - 81,869,347 (+)NCBImm8
Celera1282,411,025 - 82,416,029 (+)NCBICelera
Cytogenetic Map12D1NCBI
Srsf5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955466612,221 - 617,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955466612,221 - 617,087 (-)NCBIChiLan1.0ChiLan1.0
SRSF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11469,230,730 - 69,236,596 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1469,230,730 - 69,236,596 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01450,320,820 - 50,365,650 (+)NCBIMhudiblu_PPA_v0panPan3
SRSF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl843,514,076 - 43,518,481 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1843,514,048 - 43,519,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Srsf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649512,952,610 - 12,957,640 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRSF5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl793,393,426 - 93,403,015 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1793,393,379 - 93,398,510 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2799,667,698 - 99,676,353 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRSF5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12447,009,211 - 47,014,108 (+)NCBI
ChlSab1.1 Ensembl2447,009,122 - 47,013,644 (+)Ensembl
Srsf5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473431,309,647 - 31,314,923 (-)NCBI

Position Markers
A001W22  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01719,124,441 - 19,124,584NCBIRnor6.0
Rnor_5.01721,149,774 - 21,149,917UniSTSRnor5.0
RGSC_v3.46104,732,696 - 104,732,839UniSTSRGSC3.4
Celera698,465,599 - 98,465,742UniSTS
Cytogenetic Map6q24UniSTS
G19714  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01719,124,441 - 19,124,584NCBIRnor6.0
Rnor_5.01721,149,774 - 21,149,917UniSTSRnor5.0
RGSC_v3.46104,732,696 - 104,732,839UniSTSRGSC3.4
Celera698,465,599 - 98,465,742UniSTS
Cytogenetic Map6q24UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)67009971115379601Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)648432758108268790Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)660606431108154445Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)660606431108154445Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)662263348107263348Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)666129520111129520Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)671206251116206251Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)675449871120449871Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)675623277120276465Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)675623277120623277Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)675623277136143011Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)675623277136426962Rat
1581550Pur8Proteinuria QTL 8total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)675623393136142742Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)675623393136142742Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)676902247114203334Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)684763275108464097Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)684763275108464097Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)686422697115379601Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)687418448111129520Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)688507712133507712Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)688996335139410483Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)689631358134631358Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)689631358134631358Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)691703409136703409Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (VE) (CMO:0000132)692879510137879510Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)693706176111134673Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)697949772133849286Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)699273921144273921Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)699273921144792678Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)6101207574147991367Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6104363890147991367Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6104381930138066274Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:72
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000007583
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 3 43 57 41 19 41 8 11 74 35 40 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001195505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001195506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAHX01045449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE115959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM049719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM059586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM081441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L13635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L33267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000007583   ⟹   ENSRNOP00000007583
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6104,611,026 - 104,615,302 (+)Ensembl
RefSeq Acc Id: NM_001195505   ⟹   NP_001182434
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26100,605,481 - 100,610,192 (+)NCBI
Rnor_6.06104,611,026 - 104,640,033 (+)NCBI
Rnor_5.01721,149,626 - 21,149,932 (-)NCBI
Rnor_5.06112,776,230 - 112,805,142 (+)NCBI
Celera698,461,136 - 98,465,890 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001195506   ⟹   NP_001182435
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26100,605,481 - 100,610,192 (+)NCBI
Rnor_6.06104,611,026 - 104,640,033 (+)NCBI
Rnor_5.01721,149,626 - 21,149,932 (-)NCBI
Rnor_5.06112,776,230 - 112,805,142 (+)NCBI
Celera698,461,136 - 98,465,890 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019257   ⟹   NP_062130
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26100,605,481 - 100,610,192 (+)NCBI
Rnor_6.06104,611,026 - 104,640,033 (+)NCBI
Rnor_5.01721,149,626 - 21,149,932 (-)NCBI
Rnor_5.06112,776,230 - 112,805,142 (+)NCBI
RGSC_v3.46104,728,286 - 104,732,982 (+)RGD
Celera698,461,136 - 98,465,890 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039111856   ⟹   XP_038967784
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26100,605,165 - 100,610,192 (+)NCBI
RefSeq Acc Id: XM_039111857   ⟹   XP_038967785
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26100,605,165 - 100,610,192 (+)NCBI
RefSeq Acc Id: XM_039111858   ⟹   XP_038967786
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26100,605,165 - 100,610,192 (+)NCBI
RefSeq Acc Id: XM_039111859   ⟹   XP_038967787
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26100,605,753 - 100,610,192 (+)NCBI
RefSeq Acc Id: XM_039111860   ⟹   XP_038967788
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26100,607,548 - 100,610,192 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_062130   ⟸   NM_019257
- UniProtKB: Q09167 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001182434   ⟸   NM_001195505
- UniProtKB: Q09167 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001182435   ⟸   NM_001195506
- UniProtKB: Q09167 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007583   ⟸   ENSRNOT00000007583
RefSeq Acc Id: XP_038967784   ⟸   XM_039111856
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038967785   ⟸   XM_039111857
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038967786   ⟸   XM_039111858
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038967787   ⟸   XM_039111859
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038967788   ⟸   XM_039111860
- Peptide Label: isoform X2
Protein Domains
RRM

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694710
Promoter ID:EPDNEW_R5226
Type:multiple initiation site
Name:Srsf5_1
Description:serine and arginine rich splicing factor 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06104,611,036 - 104,611,096EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
6 104630941 104630942 G C snv SR/JrHsd (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3664 AgrOrtholog
Ensembl Genes ENSRNOG00000005513 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000007583 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007583 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6920786 IMAGE-MGC_LOAD
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM1_SRSF4-like UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report rno:29667 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72853 IMAGE-MGC_LOAD
NCBI Gene 29667 ENTREZGENE
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Srsf5 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt Q09167 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O35335 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Srsf5  serine and arginine rich splicing factor 5  Srsf5  serine/arginine-rich splicing factor 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Srsf5  serine/arginine-rich splicing factor 5  Sfrs5  splicing factor, arginine/serine-rich 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-22 Sfrs5  splicing factor, arginine/serine-rich 5  Srsf5  serine/arginine-rich splicing factor 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-13 Srsf5  serine/arginine-rich splicing factor 5  Sfrs5  splicing factor, arginine/serine-rich 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-20 Sfrs5  splicing factor, arginine/serine-rich 5  Srsf5  serine/arginine-rich splicing factor 5   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-14 Srsf5  serine/arginine-rich splicing factor 5   Sfrs5  splicing factor, arginine/serine-rich 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression is highly induced by insulin 729792