Pllp (plasmolipin) - Rat Genome Database

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Pathways
Gene: Pllp (plasmolipin) Rattus norvegicus
Analyze
Symbol: Pllp
Name: plasmolipin
RGD ID: 621478
Description: Predicted to be a structural constituent of myelin sheath. Involved in monoatomic ion transport and myelination. Located in compact myelin. Orthologous to human PLLP (plasmolipin); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: plasma membrane proteolipid; plasma membrane proteolipid (plasmolipin); Tm4sf11; transmembrane 4 superfamily member 11; Z49858
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21910,315,104 - 10,335,892 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,315,104 - 10,335,892 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,278,287 - 10,299,166 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,045,134 - 11,066,015 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,332,082 - 10,352,963 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,731,855 - 10,752,641 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,731,855 - 10,752,641 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,725,892 - 10,746,753 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,754,737 - 10,776,134 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,759,562 - 10,780,960 (+)NCBI
Celera1910,204,761 - 10,225,276 (+)NCBICelera
Cytogenetic Map19p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
compact myelin  (IDA)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Proteolipid plasmolipin: localization in polarized cells, regulated expression and lipid raft association in CNS and PNS myelin. Bosse F, etal., J Neurochem 2003 Jul;86(2):508-18.
2. Molecular cloning of plasmolipin. Characterization of a novel proteolipid restricted to brain and kidney. Fischer I and Sapirstein VS, J Biol Chem 1994 Oct 7;269(40):24912-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Full-lenth cloning, expression and cellular localization of rat plasmolipin mRNA, a proteolipid of PNS and CNS. Gillen C, etal., Eur J Neurosci 1996 Feb;8(2):405-14.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:22871113   PMID:23376485  


Genomics

Comparative Map Data
Pllp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21910,315,104 - 10,335,892 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,315,104 - 10,335,892 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,278,287 - 10,299,166 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,045,134 - 11,066,015 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,332,082 - 10,352,963 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,731,855 - 10,752,641 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,731,855 - 10,752,641 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,725,892 - 10,746,753 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,754,737 - 10,776,134 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,759,562 - 10,780,960 (+)NCBI
Celera1910,204,761 - 10,225,276 (+)NCBICelera
Cytogenetic Map19p13NCBI
PLLP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,256,097 - 57,284,672 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,248,547 - 57,284,672 (-)EnsemblGRCh38hg38GRCh38
GRCh371657,290,009 - 57,318,584 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,847,511 - 55,876,071 (-)NCBINCBI36Build 36hg18NCBI36
Build 341655,847,509 - 55,876,072NCBI
Celera1641,789,697 - 41,818,338 (-)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1643,159,649 - 43,188,192 (-)NCBIHuRef
CHM1_11658,698,255 - 58,726,816 (-)NCBICHM1_1
T2T-CHM13v2.01663,052,086 - 63,080,643 (-)NCBIT2T-CHM13v2.0
Pllp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,401,523 - 95,422,870 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,401,522 - 95,422,906 (-)EnsemblGRCm39 Ensembl
GRCm38894,674,895 - 94,696,242 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,674,894 - 94,696,278 (-)EnsemblGRCm38mm10GRCm38
MGSCv37897,198,795 - 97,220,142 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,564,024 - 97,585,371 (-)NCBIMGSCv36mm8
Celera899,003,368 - 99,024,674 (-)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.66NCBI
Pllp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543314,896,087 - 14,915,794 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543314,896,087 - 14,915,794 (-)NCBIChiLan1.0ChiLan1.0
PLLP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11672,646,074 - 72,674,763 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,531,102 - 37,559,762 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,663,878 - 56,692,784 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,663,791 - 56,692,784 (-)Ensemblpanpan1.1panPan2
PLLP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,102,689 - 59,125,165 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,102,770 - 59,124,614 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha255,731,975 - 55,753,382 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,641,500 - 59,663,504 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,641,517 - 59,717,246 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,473,412 - 56,495,146 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,480,400 - 57,502,199 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,374,374 - 58,396,245 (+)NCBIUU_Cfam_GSD_1.0
Pllp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,214,238 - 50,235,529 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,353,542 - 9,375,042 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364759,353,546 - 9,374,826 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLLP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl619,211,761 - 19,241,228 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1619,214,037 - 19,241,251 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,207,773 - 17,232,191 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLLP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1543,204,815 - 43,232,558 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,204,612 - 43,232,380 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604733,087,690 - 33,114,787 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pllp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,779,173 - 28,797,638 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474628,779,154 - 28,797,828 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pllp
126 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:228
Count of miRNA genes:160
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000022277
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat

Markers in Region
D19Mgh4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,323,102 - 10,323,180 (+)MAPPERmRatBN7.2
Rnor_6.01910,739,852 - 10,739,929NCBIRnor6.0
Rnor_5.01910,733,889 - 10,733,966UniSTSRnor5.0
RGSC_v3.41910,762,733 - 10,762,811RGDRGSC3.4
RGSC_v3.41910,762,734 - 10,762,811UniSTSRGSC3.4
RGSC_v3.11910,767,559 - 10,767,637RGD
Celera1910,212,702 - 10,212,779UniSTS
RH 3.4 Map19102.5UniSTS
RH 3.4 Map19102.5RGD
Cytogenetic Map19p12UniSTS
RH127623  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,335,457 - 10,335,673 (+)MAPPERmRatBN7.2
Rnor_6.01910,752,207 - 10,752,422NCBIRnor6.0
Rnor_5.01910,746,319 - 10,746,534UniSTSRnor5.0
RGSC_v3.41910,775,700 - 10,775,915UniSTSRGSC3.4
Celera1910,224,842 - 10,225,057UniSTS
RH 3.4 Map19103.7UniSTS
Cytogenetic Map19p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 1 1 29 29 6
Low 3 30 19 4 18 4 8 11 43 6 35 11 8
Below cutoff 10 30 30 30 2

Sequence


RefSeq Acc Id: ENSRNOT00000022277   ⟹   ENSRNOP00000022277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1910,315,104 - 10,335,892 (+)Ensembl
Rnor_6.0 Ensembl1910,731,855 - 10,752,641 (+)Ensembl
RefSeq Acc Id: NM_022533   ⟹   NP_071978
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21910,315,104 - 10,335,892 (+)NCBI
Rnor_6.01910,731,855 - 10,752,641 (+)NCBI
Rnor_5.01910,725,892 - 10,746,753 (+)NCBI
RGSC_v3.41910,754,737 - 10,776,134 (+)RGD
Celera1910,204,761 - 10,225,276 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_071978 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA62133 (Get FASTA)   NCBI Sequence Viewer  
  AAH78823 (Get FASTA)   NCBI Sequence Viewer  
  CAA90017 (Get FASTA)   NCBI Sequence Viewer  
  EDL87329 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022277
GenBank Protein P47987 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071978   ⟸   NM_022533
- UniProtKB: P47987 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022277   ⟸   ENSRNOT00000022277
Protein Domains
MARVEL

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47987-F1-model_v2 AlphaFold P47987 1-182 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700944
Promoter ID:EPDNEW_R11468
Type:initiation region
Name:Pllp_1
Description:plasmolipin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01910,731,996 - 10,732,056EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621478 AgrOrtholog
BioCyc Gene G2FUF-6504 BioCyc
Ensembl Genes ENSRNOG00000016558 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022277 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108239 IMAGE-MGC_LOAD
InterPro MAL UniProtKB/Swiss-Prot
  Marvel UniProtKB/Swiss-Prot
KEGG Report rno:64364 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93437 IMAGE-MGC_LOAD
NCBI Gene 64364 ENTREZGENE
PANTHER MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN UniProtKB/Swiss-Prot
  PLASMOLIPIN UniProtKB/Swiss-Prot
Pfam MARVEL UniProtKB/Swiss-Prot
PhenoGen Pllp PhenoGen
PRINTS MALPROTEIN UniProtKB/Swiss-Prot
PROSITE MARVEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016558 RatGTEx
UniProt A6JY51_RAT UniProtKB/TrEMBL
  P47987 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Pllp  plasmolipin  Pllp  plasma membrane proteolipid (plasmolipin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Pllp  plasma membrane proteolipid (plasmolipin)  Pllp  plasma membrane proteolipid  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Pllp  plasma membrane proteolipid  Tm4sf11  transmembrane 4 superfamily member 11  Symbol and Name updated 1299863 APPROVED
2004-12-14 Tm4sf11  transmembrane 4 superfamily member 11  Z49858  plasmolipin  Symbol and Name updated 1299863 APPROVED
2002-08-07 Z49858  plasmolipin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression differentially expressed during sciatic nerve development and regeneration 634524
gene_expression mRNA is expressed in sciatic nerve Schwann cells and in glial cells of myelinated brain structures 634524
gene_expression expression is restricted to kidney and brain 634525