Sfrp2 (secreted frizzled-related protein 2)

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Gene: Sfrp2 (secreted frizzled-related protein 2) Rattus norvegicus

Analyze

Symbol:

Sfrp2

Name:

secreted frizzled-related protein 2

RGD ID:

735163

Description:

Predicted to enable several functions, including Wnt-protein binding activity; fibronectin binding activity; and signaling receptor binding activity. Involved in negative regulation of canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; and response to nutrient. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular space. Biomarker of myocardial infarction. Orthologous to human SFRP2 (secreted frizzled related protein 2); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 17beta-estradiol; 2-amino-2-deoxy-D-glucopyranose; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

putative secreted frizzled related protein

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SFRP2 (secreted frizzled related protein 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Sfrp2 (secreted frizzled-related protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sfrp2 (secreted frizzled related protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SFRP2 (secreted frizzled related protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SFRP2 (secreted frizzled related protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sfrp2 (secreted frizzled related protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SFRP2 (secreted frizzled related protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SFRP2 (secreted frizzled related protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sfrp2 (secreted frizzled related protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SFRP2 (secreted frizzled related protein 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sfrp2 (secreted frizzled-related protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sfrp2 (secreted frizzled-related protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sfrp-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sfrp2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	169,089,517 - 169,097,064 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	169,089,517 - 169,097,063 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	176,277,331 - 176,284,893 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	174,297,265 - 174,304,827 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	168,898,730 - 168,906,293 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	182,723,732 - 182,731,277 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	182,723,854 - 182,731,764 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	202,136,233 - 202,143,778 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	175,479,320 - 175,486,865 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	175,435,856 - 175,436,574 (+)	NCBI
Celera	2	163,105,875 - 163,113,424 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Colorectal Neoplasms (ISO)

genetic disease (ISO)

inflammatory bowel disease (ISO)

myocardial infarction (IEP,ISO)

Myocardial Reperfusion Injury (IEP)

renal cell carcinoma (ISO)

syndromic microphthalmia 5 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-amino-2-deoxy-D-glucopyranose (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroperoxycyclophosphamide (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP,ISO)

7,12-dimethyltetraphene (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (EXP)

all-trans-retinoic acid (EXP,ISO)

ammonium chloride (EXP)

androgen antagonist (EXP)

antirheumatic drug (ISO)

aristolochic acid A (EXP)

arotinoid acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

azoxystrobin (EXP)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

beta-D-glucosamine (EXP)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromochloroacetic acid (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

CHIR 99021 (ISO)

chlorpyrifos (EXP,ISO)

chrysene (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

corn oil (EXP)

cortisol (ISO)

Cuprizon (EXP)

curcumin (EXP)

cyclosporin A (EXP)

cytarabine (ISO)

deguelin (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (EXP)

dioxygen (EXP)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

fenvalerate (EXP)

folic acid (ISO)

fonofos (ISO)

fulvestrant (ISO)

furan (EXP)

genistein (EXP)

glyphosate (EXP)

hydrazine (ISO)

imidacloprid (EXP)

indole-3-methanol (EXP)

indometacin (ISO)

L-ascorbic acid (ISO)

L-ascorbic acid 2-phosphate (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

lithium chloride (ISO)

losartan (EXP)

methamphetamine (EXP)

methylmercury chloride (ISO)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP)

ochratoxin A (EXP)

panobinostat (ISO)

parathion (ISO)

phenylmercury acetate (ISO)

phorbol 13-acetate 12-myristate (ISO)

pioglitazone (ISO)

rotenone (ISO)

SB 431542 (ISO)

SCH 23390 (EXP)

silicon dioxide (EXP)

sodium arsenite (ISO)

tamoxifen (ISO)

terbufos (ISO)

tetraphene (ISO)

thalidomide (ISO)

thiabendazole (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triptonide (ISO)

troglitazone (ISO)

valproic acid (ISO)

vinclozolin (EXP)

XAV939 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior pattern specification (ISO)

apoptotic process (ISO)

BMP signaling pathway (ISO)

branching involved in blood vessel morphogenesis (ISO)

canonical Wnt signaling pathway (IBA,ISO)

cardiac left ventricle morphogenesis (ISO)

cardiac muscle cell apoptotic process (ISO)

cartilage development (ISO)

cell-cell signaling (ISO)

cellular response to extracellular stimulus (ISO)

cellular response to X-ray (ISO)

chondrocyte development (ISO)

collagen fibril organization (ISO)

convergent extension involved in axis elongation (ISO)

development of primary male sexual characteristics (ISO)

digestive tract morphogenesis (ISO)

embryonic digit morphogenesis (ISO)

hematopoietic stem cell proliferation (ISO)

male gonad development (ISO)

mesodermal cell fate specification (ISO)

negative regulation of BMP signaling pathway (ISO)

negative regulation of canonical Wnt signaling pathway (IGI,ISO)

negative regulation of cardiac muscle cell apoptotic process (ISO)

negative regulation of cell growth (ISO)

negative regulation of cell migration (ISO)

negative regulation of cell population proliferation (ISO)

negative regulation of dermatome development (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of epithelial cell proliferation (ISO)

negative regulation of epithelial to mesenchymal transition (ISO)

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ISO)

negative regulation of gene expression (ISO)

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ISO)

negative regulation of mesodermal cell fate specification (ISO)

negative regulation of peptidyl-tyrosine phosphorylation (ISO)

negative regulation of planar cell polarity pathway involved in axis elongation (ISO)

negative regulation of Wnt signaling pathway (ISO)

neural tube closure (ISO)

neural tube development (ISO)

non-canonical Wnt signaling pathway (IBA)

outflow tract morphogenesis (ISO)

planar cell polarity pathway involved in axis elongation (ISO)

planar cell polarity pathway involved in neural tube closure (ISO)

positive regulation of angiogenesis (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of canonical Wnt signaling pathway (IGI,ISO)

positive regulation of cell adhesion mediated by integrin (ISO)

positive regulation of cell growth (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of fat cell differentiation (ISO)

positive regulation of osteoblast differentiation (ISO)

positive regulation of peptidyl-serine phosphorylation (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

post-anal tail morphogenesis (ISO)

regulation of apoptotic process (ISO)

regulation of cell population proliferation (ISO)

regulation of establishment of planar polarity (ISO)

regulation of midbrain dopaminergic neuron differentiation (ISO)

regulation of neuron projection development (ISO)

regulation of stem cell division (ISO)

regulation of Wnt signaling pathway (ISO)

response to nutrient (IEP)

response to xenobiotic stimulus (ISO)

sclerotome development (ISO)

somitogenesis (ISO)

stem cell fate specification (ISO)

Wnt signaling pathway involved in somitogenesis (ISO)

Cellular Component

collagen-containing extracellular matrix (ISO)

extracellular space (IBA,ISO)

Molecular Function

endopeptidase activator activity (ISO)

enzyme activator activity (ISO)

fibronectin binding (ISO)

integrin binding (ISO)

protein binding (ISO)

receptor ligand activity (ISO)

Wnt-protein binding (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling pathway (IEA)

Wnt signaling, canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor.	Brophy PD, etal., J Biol Chem 2003 Dec 26;278(52):52401-5. Epub 2003 Oct 15.
2.	Secreted and transmembrane wnt inhibitors and activators.	Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction.	Kobayashi K, etal., Nat Cell Biol. 2009 Jan;11(1):46-55. doi: 10.1038/ncb1811. Epub 2008 Dec 14.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors.	Su Y, etal., Physiol Genomics. 2007 Jun 19;30(1):8-16. Epub 2007 Mar 6.
10.	Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/beta-catenin signaling.	Xavier CP, etal., Cell Signal. 2014 Jan;26(1):94-101. doi: 10.1016/j.cellsig.2013.09.016. Epub 2013 Sep 28.
11.	Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a.	Zhang Z, etal., J Mol Cell Cardiol. 2009 Mar;46(3):370-7. Epub 2008 Dec 9.

Additional References at PubMed

PMID:9038166	PMID:9391078	PMID:10322635	PMID:10654605	PMID:10980594	PMID:11357136	PMID:12055200	PMID:12477932	PMID:14709558	PMID:16077992	PMID:16467359	PMID:17251350
PMID:17462603	PMID:17471511	PMID:17804636	PMID:17848950	PMID:18166153	PMID:18257070	PMID:18729207	PMID:19001373	PMID:19095296	PMID:19100252	PMID:19300477	PMID:19458075
PMID:19593212	PMID:19778523	PMID:19850029	PMID:19896444	PMID:20208569	PMID:20723538	PMID:21078975	PMID:22290867	PMID:27113532	PMID:30291843	PMID:31918758

Genomics

Comparative Map Data

Sfrp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	169,089,517 - 169,097,064 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	169,089,517 - 169,097,063 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	176,277,331 - 176,284,893 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	174,297,265 - 174,304,827 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	168,898,730 - 168,906,293 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	182,723,732 - 182,731,277 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	182,723,854 - 182,731,764 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	202,136,233 - 202,143,778 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	175,479,320 - 175,486,865 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	175,435,856 - 175,436,574 (+)	NCBI
Celera	2	163,105,875 - 163,113,424 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

SFRP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	153,780,591 - 153,789,083 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	153,780,591 - 153,789,083 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	154,701,743 - 154,710,235 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	154,921,192 - 154,929,678 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	155,059,346 - 155,067,833	NCBI
Celera	4	152,026,238 - 152,034,728 (-)	NCBI		Celera
Cytogenetic Map	4	q31.3	NCBI
HuRef	4	150,432,908 - 150,441,398 (-)	NCBI		HuRef
CHM1_1	4	154,680,045 - 154,688,529 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	157,105,099 - 157,113,596 (-)	NCBI		T2T-CHM13v2.0

Sfrp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	83,673,628 - 83,681,621 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	83,673,628 - 83,681,623 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	83,765,750 - 83,774,314 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	83,766,321 - 83,774,316 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	83,570,243 - 83,578,236 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	83,852,248 - 83,860,242 (+)	NCBI		MGSCv36	mm8
Celera	3	83,778,926 - 83,786,923 (+)	NCBI		Celera
Cytogenetic Map	3	E3	NCBI
cM Map	3	37.37	NCBI

Sfrp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955471	8,103,783 - 8,112,321 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955471	8,103,937 - 8,112,596 (-)	NCBI	ChiLan1.0	ChiLan1.0

SFRP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	4	152,024,677 - 152,032,604 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	146,123,075 - 146,131,543 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	157,944,733 - 157,953,258 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	157,944,733 - 157,953,258 (-)	Ensembl	panpan1.1		panPan2

SFRP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	51,541,197 - 51,548,765 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	51,540,500 - 51,548,765 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	51,886,301 - 51,894,431 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	52,226,638 - 52,234,922 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	52,226,643 - 52,235,106 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	51,482,317 - 51,490,435 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	51,588,474 - 51,596,595 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	51,900,564 - 51,908,708 (-)	NCBI		UU_Cfam_GSD_1.0

Sfrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	38,934,030 - 38,942,739 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936576	604,069 - 613,021 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936576	604,174 - 612,440 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SFRP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	75,337,144 - 75,345,921 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	75,337,311 - 75,345,926 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	79,743,347 - 79,751,962 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SFRP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	100,336,442 - 100,345,093 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	100,336,119 - 100,345,086 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	79,988,717 - 79,997,279 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sfrp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624858	5,052,518 - 5,061,591 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624858	5,052,736 - 5,061,495 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sfrp2
40 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	101
Count of miRNA genes:	80
Interacting mature miRNAs:	95
Transcripts:	ENSRNOT00000012658
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	114837527	185876470	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	185876470	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
6907363	Bp357	Blood pressure QTL 357	4.1	0.002	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	129540907	174540907	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	133914684	202447032	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	135552573	202446871	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	136445150	202447032	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	136916935	189599348	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	136916935	213594495	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	141596551	202447032	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	143157029	210020885	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	143657411	190602963	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	143657411	190602963	Rat
6903312	Bw112	Body weight QTL 112	3.2	0.0013	body mass (VT:0001259)	body weight (CMO:0000012)	2	143657569	184114274	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	144599348	189599348	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147798556	192798556	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150341585	189039377	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150341684	202446871	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150540301	202447032	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	150540301	202447032	Rat
12879845	Cm89	Cardiac mass QTL 89		0.008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	175950118	Rat
12879846	Cm90	Cardiac mass QTL 90		0.011	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	2	152413072	175950118	Rat
12879847	Am4	Aortic mass QTL 4		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	175950118	Rat
11565180	Kidm56	Kidney mass QTL 56		0.003	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	175950118	Rat
11565181	Bw176	Body weight QTL 176		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	175950118	Rat
2301415	Cm67	Cardiac mass QTL 67		0.003	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	175950118	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	185122374	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	185122374	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	185122374	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	185122374	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	185122374	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	157142078	192625452	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	157142078	211086598	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	157142209	202446871	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	160564068	205564068	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	161699179	222436696	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	162765032	207765032	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
1598838	Bp290	Blood pressure QTL 290	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166539266	211539266	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168354880	185122374	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168358098	223265385	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	168594495	213594495	Rat

Markers in Region

RH141998

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	169,096,834 - 169,097,029 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	182,731,048 - 182,731,242	NCBI	Rnor6.0
Rnor_5.0	2	202,143,549 - 202,143,743	UniSTS	Rnor5.0
RGSC_v3.4	2	175,486,636 - 175,486,830	UniSTS	RGSC3.4
Celera	2	163,113,195 - 163,113,389	UniSTS
RH 3.4 Map	2	1105.0	UniSTS
Cytogenetic Map	2	q34	UniSTS

UniSTS:471844

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	169,095,932 - 169,096,074 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	182,730,146 - 182,730,287	NCBI	Rnor6.0
Rnor_5.0	2	202,142,647 - 202,142,788	UniSTS	Rnor5.0
RGSC_v3.4	2	175,485,734 - 175,485,875	UniSTS	RGSC3.4
Celera	2	163,112,293 - 163,112,434	UniSTS
Cytogenetic Map	2	q34	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		19	7	6	1	6			51	29	27	7
Low	3	23	23	8	18	8	7	10	21	6	13	4	7
Below cutoff		1	21	21		21	1	1	2		1		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ560715	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC161900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000012658 ⟹ ENSRNOP00000012659

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	169,089,517 - 169,097,063 (+)	Ensembl
Rnor_6.0 Ensembl	2	182,723,854 - 182,731,764 (+)	Ensembl

RefSeq Acc Id:

NM_001100700 ⟹ NP_001094170

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	169,089,517 - 169,097,064 (+)	NCBI
Rnor_6.0	2	182,723,732 - 182,731,277 (+)	NCBI
Rnor_5.0	2	202,136,233 - 202,143,778 (+)	NCBI
RGSC_v3.4	2	175,479,320 - 175,486,865 (+)	RGD
Celera	2	163,105,875 - 163,113,424 (+)	RGD

Sequence:

show sequence

CTCCCCCGGGTCGGAGCCCCCCGGAGCTGCGCGCGGGCTTGCAGTGCCTTGCCCGCGCCGACCT
CCTGGCTCCCGGCTTCGCGCGCTCGCGCCACCGACTGTCCAGAGCCCACGAGCAGAGCGAGCGA
GTCCGGGACGAGCTCGGGCTCCGATCGCCACTCGCTTCCCCAGCTCGGCTCCCTCAGCCCCCCG
GGGGTCGCTAGTCCACGATGCTGCGGGGCCCTGCCTCGCTGCTTCTGCTAGTCCTCGCCTCGCA
CTGCTGCCTGGGCTCGGCGCGTGGGCTCTTCCTCTTCGGCCAGCCCGACTTCTCCTACAAGCGC
AGCAACTGCAAGCCCATCCCCGCCAACCTGCAGCTGTGCCACGGCATCGAGTACCAGAACATGC
GGCTGCCCAACCTGCTGGGCCACGAGACCATGAAGGAGGTGCTGGAGCAAGCGGGCGCCTGGAT
TCCGCTGGTCATGAAGCAGTGCCACCCGGACACCAAGAAGTTCCTGTGCTCGCTCTTCGCCCCT
GTCTGTCTCGACGACCTAGACGAGACCATCCAGCCGTGTCACTCGCTCTGCGTGCAGGTGAAGG
ACCGTTGTGCCCCGGTCATGTCCGCCTTCGGCTTCCCCTGGCCAGACATGCTGGAGTGCGACCG
CTTCCCGCAGGACAACGATCTCTGCATCCCCCTTGCTAGCAGCGACCACCTCCTGCCGCCCACA
GAGGAAGCTCCCAAGGTGTGTGAAGCCTGCAAAACTAAGAACGAGGATGACAACGACATAATGG
AAACTCTTTGTAAAAATGACTTCGCACTGAAAATCAAAGTGAAGGAGATAACCTACATCAACAG
AGACACCAAAATCATCCTGGAGACAAAGAGCAAGACCATTTACAAGCTGAACGGGGTGTCCGAT
AGGGACCTGAAGAAATCAGTGCTGTGGCTCAAAGACAGCCTGCAGTGCACCTGTGAGGAGATGA
ACGACATCAACGCTCCCTATCTGGTCATGGGACAGAAACAGGGTGGAGAGCTGGTGATCACCTC
CGTGAAACGGTGGCAGAAGGGCCAGAGAGAGTTCAAGCGCATCTCCCGCAGCATCCGCAAGCTG
CAATGCTAGTTTCCTAGTGGAGTGGCTTCTCGCCGACCAGGCCCTGGGCTCCGTGGACCACTTC
CACTCTGCGACCTCATTTCCGGTTTCCCAAGTACTGTCGGGAGAGCTACAGTCTCAGCTTGGAG
CAGCTTGCCCTGCCTTTTGCATGTGTGTATCCTAACGTGTCCTGAGTTATAAGGCCCTAGGAGG
CCCCGGGAACAGATAGCTATTTTCACATAAAGCGAAAAGTCCATCCAGATCTTGTAGAAATATT
CACAACTAATAAAATCATGACTGTTTTTTATGAAGTTTTAAAACAGCTCATTTTAAGGGTAGTT
TTGAATAGCTGTAGTACTGTGACCCGAGGGGCATTTTCTCTCTTTGGTCAGTCTGTTGGTTTAT
ACTGTGCCCTTAGGTTGCCATGTCAGGCAAATTGTTTCTTTTTTTTTCCCCTCTGTGGTCTAAG
CGTGTGGGTCCCAGACTTGGTGGTTGAGATAAAGCTGGCTGTTATCTCAAAGGCTCCCTCTGTT
CCAGCCTGAGACTCGGCGTCTAAATCTTCAAAGGTTTTCATTGCTCATTTTACACCCTCATTAA
CTCCGACCGTTGCATGCATCCCAGCCCAGCTACAGAACTTCATTTTATAAGCACACATTAACCA
TTCCTCATTGCATGATGCCTTCAAATAAAGGGCAACGTGAATACAGTTTATAAATCAACGAGTA
TTTTAAGCCTTGTTTAAAACATCTTTTTACTCCATTTTTTTTCTTTTTTTTTTTCTTCAAACTA
AATCATTGTAGCTAACCTGTAATATACGTAGTAGTTGACCTGGAAAAGTTGTAAAAATATTGCT
TTAACCGACACTGTAAATATTTCAGATAAACATTATATTCTTTGTATATAAACTTTAAAAAAAA
AAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001094170	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI61900	(Get FASTA)	NCBI Sequence Viewer
	CAD90761	(Get FASTA)	NCBI Sequence Viewer
	EDM00833	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001094170 ⟸ NM_001100700
- Peptide Label:	precursor
- UniProtKB:	B1WBV2 (UniProtKB/TrEMBL), F7EPG0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLRGPASLLLLVLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLL GHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKDRCAPV MSAFGFPWPDMLECDRFPQDNDLCIPLASSDHLLPPTEEAPKVCEACKTKNEDDNDIMETLCKN DFALKIKVKEITYINRDTKIILETKSKTIYKLNGVSDRDLKKSVLWLKDSLQCTCEEMNDINAP YLVMGQKQGGELVITSVKRWQKGQREFKRISRSIRKLQC hide sequence

RefSeq Acc Id:

ENSRNOP00000012659 ⟸ ENSRNOT00000012658

Protein Domains

FZ NTR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B1WBV2-F1-model_v2	AlphaFold	B1WBV2	1-295	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735163	AgrOrtholog
BioCyc Gene	G2FUF-52649	BioCyc
Ensembl Genes	ENSRNOG00000009465	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000012659	ENTREZGENE
	ENSRNOP00000012659.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012658	ENTREZGENE
	ENSRNOT00000012658.7	UniProtKB/TrEMBL
Gene3D-CATH	1.10.2000.10	UniProtKB/TrEMBL
	2.40.50.120	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:8367121	IMAGE-MGC_LOAD
InterPro	Frizzled/SFRP	UniProtKB/TrEMBL
	Frizzled_dom	UniProtKB/TrEMBL
	Frizzled_dom_sf	UniProtKB/TrEMBL
	Netrin_domain	UniProtKB/TrEMBL
	Netrin_module_non-TIMP	UniProtKB/TrEMBL
	SFRP2_CRD	UniProtKB/TrEMBL
	TIMP-like_OB-fold	UniProtKB/TrEMBL
KEGG Report	rno:310552	UniProtKB/TrEMBL
MGC_CLONE	MGC:187620	IMAGE-MGC_LOAD
NCBI Gene	310552	ENTREZGENE
PANTHER	PTHR11309	UniProtKB/TrEMBL
	PTHR11309:SF45	UniProtKB/TrEMBL
Pfam	NTR	UniProtKB/TrEMBL
	PF01392	UniProtKB/TrEMBL
PhenoGen	Sfrp2	PhenoGen
PROSITE	NTR	UniProtKB/TrEMBL
	PS50038	UniProtKB/TrEMBL
SMART	C345C	UniProtKB/TrEMBL
	FRI	UniProtKB/TrEMBL
Superfamily-SCOP	Frizzled_Cys-rich	UniProtKB/TrEMBL
	TIMP_like	UniProtKB/TrEMBL
UniProt	B1WBV2	ENTREZGENE, UniProtKB/TrEMBL
	F7EPG0	ENTREZGENE, UniProtKB/TrEMBL
	Q80W55_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-07-08	Sfrp2	secreted frizzled-related protein 2			Symbol and Name status set to approved	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)