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Gene: Inppl1 (inositol polyphosphate phosphatase-like 1) Rattus norvegicus
Symbol: Inppl1
Name: inositol polyphosphate phosphatase-like 1
Description: Exhibits inositol-polyphosphate 5-phosphatase activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in several processes, including inositol trisphosphate metabolic process; negative regulation of signal transduction; and nervous system development. Localizes to the lamellipodium. Human ortholog(s) of this gene implicated in hypertension; obesity; and type 2 diabetes mellitus. Orthologous to human INPPL1 (inositol polyphosphate phosphatase like 1); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; phosphatidylinositol 3-kinase class I signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: inositol polyphosphate phosphatase-like protein 1; INPPL-1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SH2-containing inositol phosphatase 2; SHIP-2; Ship2
Homo sapiens (human) : INPPL1 (inositol polyphosphate phosphatase like 1)  HGNC  Alliance
Mus musculus (house mouse) : Inppl1 (inositol polyphosphate phosphatase-like 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Inppl1 (inositol polyphosphate phosphatase like 1)
Pan paniscus (bonobo/pygmy chimpanzee) : INPPL1 (inositol polyphosphate phosphatase like 1)
Canis lupus familiaris (dog) : INPPL1 (inositol polyphosphate phosphatase like 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Inppl1 (inositol polyphosphate phosphatase like 1)
Sus scrofa (pig) : INPPL1 (inositol polyphosphate phosphatase like 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01166,898,177 - 166,912,524 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,899,894 - 166,912,524 (-)Ensembl
Rnor_5.01173,087,891 - 173,102,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,278,131 - 159,292,740 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11159,357,146 - 159,371,757 (-)NCBI
Celera1154,261,664 - 154,276,489 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Inppl1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68396
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.