Tshb (thyroid stimulating hormone subunit beta) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Tshb (thyroid stimulating hormone subunit beta) Rattus norvegicus
Analyze
Symbol: Tshb
Name: thyroid stimulating hormone subunit beta
RGD ID: 3910
Description: Predicted to enable hormone activity. Involved in response to calcium ion; response to estrogen; and response to vitamin A. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 4 and hypothyroidism. Orthologous to human TSHB (thyroid stimulating hormone subunit beta); PARTICIPATES IN autoimmune thyroiditis pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: thyroid stimulating hormone beta subunit; thyroid stimulating hormone, beta; thyroid stimulating hormone, beta subunit; thyroid-stimulating hormone subunit beta; thyrotropin beta chain; thyrotropin subunit beta; TSH-B; TSH-beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82192,913,171 - 192,918,054 (-)NCBIGRCr8
mRatBN7.22190,224,676 - 190,229,559 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2190,224,676 - 190,229,559 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2197,842,312 - 197,847,195 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02195,706,354 - 195,711,234 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02190,532,005 - 190,536,888 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02205,207,799 - 205,215,199 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2205,207,799 - 205,212,681 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,638,392 - 224,643,274 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,908,308 - 197,913,186 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12197,871,064 - 197,875,940 (-)NCBI
Celera2182,644,695 - 182,649,578 (-)NCBICelera
RH 3.4 Map21301.7RGD
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-Diaminoanisole  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid  (ISO)
3-phenoxybenzoic acid  (ISO)
4'-epidoxorubicin  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
aflatoxin B1  (ISO)
alachlor  (EXP)
aldehydo-D-glucose  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsenous acid  (EXP)
ATP  (ISO)
atrazine  (ISO)
atropine  (EXP)
benzo[a]pyrene  (EXP)
benzo[b]fluoranthene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (EXP)
Butylparaben  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbendazim  (EXP)
chlorohydrocarbon  (EXP)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
cobalt atom  (ISO)
cyclohexane  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (ISO)
DDE  (EXP,ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
diethyl hydrogen phosphate  (EXP)
diethylstilbestrol  (ISO)
diiodine  (EXP,ISO)
diisobutyl phthalate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (EXP)
diuron  (ISO)
efavirenz  (ISO)
endosulfan  (EXP)
erythrosin B  (EXP)
fenvalerate  (EXP)
fluoxetine  (EXP)
fructose  (ISO)
gallic acid  (EXP)
glucose  (ISO)
glyphosate  (EXP,ISO)
hexachlorobenzene  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (ISO)
iodide salt  (EXP,ISO)
L-ascorbic acid  (EXP)
lead diacetate  (EXP)
lead(II) chloride  (EXP)
linalool  (EXP)
lycopene  (EXP)
mancozeb  (ISO)
masoprocol  (EXP)
melatonin  (EXP,ISO)
methamidophos  (EXP)
methimazole  (EXP,ISO)
methoxychlor  (EXP)
Methylthiouracil  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
nevirapine  (ISO)
nitrates  (ISO)
octreotide  (ISO)
Oxyfluorfen  (EXP)
ozone  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perchlorate  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (EXP)
Pexacerfont  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
potassium iodide  (EXP)
pralidoxime  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
prostaglandin D2  (ISO)
prostaglandin J2  (ISO)
pyrethrins  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP)
resveratrol  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium perchlorate  (EXP,ISO)
sulfasalazine  (ISO)
syringic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
thimerosal  (ISO)
thiocyanate  (ISO)
thyroxine  (EXP,ISO)
toxaphene  (EXP)
trifluralin  (EXP)
triphenyl phosphate  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
valproic acid  (ISO)
vemurafenib  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
vorinostat  (ISO)
zearalenone  (EXP)
zinc oxide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
hormone activity  (IEA,TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Vitamin A repletion in rats with concurrent vitamin A and iodine deficiency affects pituitary TSHbeta gene expression and reduces thyroid hyperstimulation and thyroid size. Biebinger R, etal., J Nutr. 2007 Mar;137(3):573-7.
2. Chronic treatment with low doses of estradiol affects pituitary and thyroid function in young and middle-aged ovariectomized rats. Bottner M and Wuttke W, Biogerontology. 2005;6(4):261-9.
3. Isolation and characterization of the rat thyrotropin beta-subunit gene. Differential regulation of two transcriptional start sites by thyroid hormone. Carr FE, etal., J Biol Chem 1987 Jan 25;262(3):981-7.
4. Evidence for a single rat thyrotropin-beta-subunit gene: thyroidectomy increases its mRNA. Chin WW, etal., Biochem Biophys Res Commun 1985 May 16;128(3):1152-8.
5. Thyroid hormone decreases thyrotropin subunit mRNA levels in rat anterior pituitary. Croyle ML and Maurer RA, DNA 1984 Jun;3(3):231-6.
6. Analysis of the organization and nucleotide sequence of the chromosomal gene for the beta-subunit of rat thyrotropin. Croyle ML, etal., DNA 1986 Aug;5(4):299-304.
7. Familial hypothyroidism caused by a nonsense mutation in the thyroid-stimulating hormone beta-subunit gene. Dacou-Voutetakis C, etal., Am J Hum Genet 1990 May;46(5):988-93.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. beta-Endorphin and some hormonal levels in children with acute stress hyperglycaemia. Gunoz H, etal., Diabetes Res Clin Pract. 1994 Jun;24(2):97-101.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Immunoreactive TSH cells in the pituitary of female middle-aged rats after treatment with estradiol or calcium. Sekulic M, etal., Acta Histochem. 1998 Apr;100(2):185-91.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS). Wei L, etal., Biochem Cell Biol. 2010 Aug;88(4):723-30. doi: 10.1139/O10-022.
Additional References at PubMed
PMID:2484718   PMID:2824501   PMID:16806148   PMID:16910874   PMID:17927662   PMID:18437010   PMID:21078364  


Genomics

Comparative Map Data
Tshb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82192,913,171 - 192,918,054 (-)NCBIGRCr8
mRatBN7.22190,224,676 - 190,229,559 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2190,224,676 - 190,229,559 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2197,842,312 - 197,847,195 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02195,706,354 - 195,711,234 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02190,532,005 - 190,536,888 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02205,207,799 - 205,215,199 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2205,207,799 - 205,212,681 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,638,392 - 224,643,274 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,908,308 - 197,913,186 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12197,871,064 - 197,875,940 (-)NCBI
Celera2182,644,695 - 182,649,578 (-)NCBICelera
RH 3.4 Map21301.7RGD
Cytogenetic Map2q34NCBI
TSHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381115,029,826 - 115,034,309 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1115,029,826 - 115,034,302 (+)EnsemblGRCh38hg38GRCh38
GRCh371115,572,447 - 115,576,930 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,373,938 - 115,378,464 (+)NCBINCBI36Build 36hg18NCBI36
Build 341115,284,456 - 115,288,983NCBI
Celera1113,801,633 - 113,806,160 (+)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1113,430,739 - 113,435,225 (+)NCBIHuRef
CHM1_11115,687,686 - 115,692,176 (+)NCBICHM1_1
T2T-CHM13v2.01115,041,260 - 115,045,748 (+)NCBIT2T-CHM13v2.0
Tshb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393102,684,621 - 102,718,175 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3102,682,781 - 102,690,034 (-)EnsemblGRCm39 Ensembl
GRCm383102,777,398 - 102,789,082 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3102,775,465 - 102,782,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv373102,581,321 - 102,586,637 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363102,906,459 - 102,911,775 (-)NCBIMGSCv36mm8
Celera3104,982,812 - 104,987,788 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.25NCBI
Tshb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543518,316,585 - 18,339,935 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543518,316,585 - 18,339,935 (+)NCBIChiLan1.0ChiLan1.0
TSHB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21107,685,126 - 107,689,672 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11107,284,277 - 107,288,822 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0187,527,267 - 87,531,813 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11122,575,546 - 122,580,028 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1122,575,546 - 122,580,028 (-)Ensemblpanpan1.1panPan2
TSHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11752,659,137 - 52,685,388 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1752,681,357 - 52,685,390 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1752,306,371 - 52,332,583 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01753,525,777 - 53,563,370 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1753,559,339 - 53,563,372 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11752,571,137 - 52,597,347 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01752,616,291 - 52,641,625 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01753,186,781 - 53,212,984 (+)NCBIUU_Cfam_GSD_1.0
Tshb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505814,087,322 - 14,090,893 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936627396,215 - 401,650 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936627399,191 - 404,371 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4105,553,076 - 105,554,015 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14105,553,070 - 105,558,769 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24115,691,689 - 115,697,380 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12018,660,683 - 18,665,226 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2018,657,535 - 18,665,185 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603821,406,905 - 21,411,461 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tshb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477210,737,464 - 10,742,555 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477210,732,527 - 10,742,575 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tshb
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:10
Count of miRNA genes:9
Interacting mature miRNAs:10
Transcripts:ENSRNOT00000022575
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2184974550193094998Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat

Markers in Region
Tshb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22190,227,786 - 190,228,048 (+)MAPPERmRatBN7.2
Rnor_6.02205,210,909 - 205,211,170NCBIRnor6.0
Rnor_5.02224,641,502 - 224,641,763UniSTSRnor5.0
RGSC_v3.42197,911,414 - 197,911,675UniSTSRGSC3.4
Celera2182,647,806 - 182,648,067UniSTS
Cytogenetic Map2q34UniSTS
RH94521  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22190,224,625 - 190,224,783 (+)MAPPERmRatBN7.2
Rnor_6.02205,207,749 - 205,207,906NCBIRnor6.0
Rnor_5.02224,638,342 - 224,638,499UniSTSRnor5.0
RGSC_v3.42197,908,253 - 197,908,410UniSTSRGSC3.4
Celera2182,644,645 - 182,644,802UniSTS
RH 3.4 Map21301.7UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 16 43 38 38 8 25 8 6 95 61 24 9 35 30

Sequence


Ensembl Acc Id: ENSRNOT00000022575   ⟹   ENSRNOP00000022575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2190,224,676 - 190,229,559 (-)Ensembl
Rnor_6.0 Ensembl2205,207,799 - 205,212,681 (-)Ensembl
RefSeq Acc Id: NM_013116   ⟹   NP_037248
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82192,913,171 - 192,918,054 (-)NCBI
mRatBN7.22190,224,676 - 190,229,559 (-)NCBI
Rnor_6.02205,207,799 - 205,212,681 (-)NCBI
Rnor_5.02224,638,392 - 224,643,274 (-)NCBI
RGSC_v3.42197,908,308 - 197,913,186 (-)RGD
Celera2182,644,695 - 182,649,578 (-)NCBI
Sequence:
RefSeq Acc Id: NP_037248   ⟸   NM_013116
- Peptide Label: precursor
- UniProtKB: Q6GTA8 (UniProtKB/Swiss-Prot),   P04652 (UniProtKB/Swiss-Prot),   A0A0F7RQR3 (UniProtKB/TrEMBL),   A6K3J3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022575   ⟸   ENSRNOT00000022575
Protein Domains
Glycoprotein hormone subunit beta

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04652-F1-model_v2 AlphaFold P04652 1-138 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6850012
Promoter ID:EP30070
Type:single initiation site
Name:RN_TSHB_2
Description:Thyroid stimulating hormone-beta, TSHB gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 179; Mammalian thyrotropin beta chain, promoter 2
Alternative Promoters:alternative promoter #2 of 2; 5' exon 1; site 2; major promoter.; see alsoEP30069  
Experiment Methods:Nuclease protection; Primer extension
Regulation:pituitary; (repressed by or weakly expressed in) thyroxine, (induced by or strongly expressed in) TRH
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.42197,913,142 - 197,913,202EPD
RGD ID:6850016
Promoter ID:EP30069
Type:single initiation site
Name:RN_TSHB_1
Description:Thyroid stimulating hormone-beta, TSHB gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 178; Mammalian thyrotropin beta chain, promoter 1
Alternative Promoters:alternative promoter #1 of 2; 5' exon 1; site 1.; see alsoEP30070  
Tissues & Cell Lines:pituitary, constitutive
Experiment Methods:Nuclease protection; Sequencing of a full-length cDNA; Primer extension
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.42197,913,186 - 197,913,246EPD

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3910 AgrOrtholog
BioCyc Gene G2FUF-51832 BioCyc
Ensembl Genes ENSRNOG00000016793 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022575 ENTREZGENE
  ENSRNOT00000022575.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6921292 IMAGE-MGC_LOAD
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Glyco_hormone_CN UniProtKB/Swiss-Prot
  Gonadotropin_bsu UniProtKB/Swiss-Prot
  Gonadotropin_bsu_CS UniProtKB/Swiss-Prot
KEGG Report rno:25653 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72898 IMAGE-MGC_LOAD
NCBI Gene 25653 ENTREZGENE
PANTHER PTHR11515 UniProtKB/Swiss-Prot
  THYROTROPIN SUBUNIT BETA UniProtKB/Swiss-Prot
Pfam Cys_knot UniProtKB/Swiss-Prot
PhenoGen Tshb PhenoGen
PROSITE GLYCO_HORMONE_BETA_1 UniProtKB/Swiss-Prot
  GLYCO_HORMONE_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016793 RatGTEx
SMART GHB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A0A0F7RQR3 ENTREZGENE, UniProtKB/TrEMBL
  A6K3J3 ENTREZGENE, UniProtKB/TrEMBL
  P04652 ENTREZGENE
  Q6GTA8 ENTREZGENE
  TSHB_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6GTA8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Tshb  thyroid stimulating hormone subunit beta  Tshb  thyroid stimulating hormone, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Tshb  thyroid stimulating hormone, beta  Tshb  thyroid stimulating hormone, beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Tshb  Thyroid stimulating hormone, beta subunit      Symbol and Name status set to approved 70586 APPROVED