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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3910
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tshb
Name: thyroid stimulating hormone subunit beta
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tshbdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of TSHB mRNAPMID:25181051 PMID:28167136 PMID:30099086 PMID:30352396
Tshbincreases expressionEXP 6480464CTDbisphenol A results in increased expression of TSHB mRNAPMID:31697385 PMID:34973380
Tshbincreases secretionEXP 6480464CTDbisphenol A results in increased secretion of TSHB proteinPMID:29305326
Tshbmultiple interactionsEXP 6480464CTD[Estradiol co-treated with bisphenol A] results in increased expression of TSHB mRNA; bisphenol A inhibits the reaction [TRH protein results in increased secretion of TSHB protein]PMID:29305326 PMID:30099086
Tshbmultiple interactionsISOTSHB (Homo sapiens)6480464CTDbisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]PMID:19766106
Tshbmultiple interactionsISOTshb (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased expression of TSHB mRNAPMID:22828881
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